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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for STK11 |
 Gene summary |
| Gene information | Gene symbol | STK11 | Gene ID | 6794 |
| Gene name | serine/threonine kinase 11 | |
| Synonyms | LKB1|PJS|hLKB1 | |
| Cytomap | 19p13.3 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase STK11liver kinase B1polarization-related protein LKB1renal carcinoma antigen NY-REN-19serine/threonine-protein kinase 11serine/threonine-protein kinase LKB1 | |
| Modification date | 20180522 | |
| UniProtAcc | Q15831 | |
| Context | PubMed: STK11 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| STK11 | GO:0006468 | protein phosphorylation | 12805220|25329316 |
| STK11 | GO:0007050 | cell cycle arrest | 12805220|17216128 |
| STK11 | GO:0046777 | protein autophosphorylation | 11430832 |
| STK11 | GO:0071493 | cellular response to UV-B | 25329316 |
| STK11 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator | 11430832 |
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Exon skipping events across known transcript of Ensembl for STK11 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for STK11 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for STK11 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_300401 | 19 | 1207089:1207202:1216266:1216397:1218415:1218499 | 1216266:1216397 | ENSG00000118046.10 | ENST00000593219.1 |
| exon_skip_300402 | 19 | 1219322:1219412:1220371:1220504:1220579:1220616 | 1220371:1220504 | ENSG00000118046.10 | ENST00000589152.1,ENST00000593219.1,ENST00000326873.7 |
| exon_skip_300423 | 19 | 1221211:1221339:1221947:1222005:1222983:1223171 | 1221947:1222005 | ENSG00000118046.10 | ENST00000593219.1,ENST00000586243.1,ENST00000326873.7 |
| exon_skip_300435 | 19 | 1223146:1223171:1223636:1226662:1227591:1227856 | 1223636:1226662 | ENSG00000118046.10 | ENST00000585465.1 |
| exon_skip_300436 | 19 | 1223146:1223171:1226452:1226662:1227591:1227856 | 1226452:1226662 | ENSG00000118046.10 | ENST00000326873.7 |
| exon_skip_300437 | 19 | 1223146:1223171:1226457:1226662:1227591:1227856 | 1226457:1226662 | ENSG00000118046.10 | ENST00000586243.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for STK11 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_300401 | 19 | 1207089:1207202:1216266:1216397:1218415:1218499 | 1216266:1216397 | ENSG00000118046.10 | ENST00000593219.1 |
| exon_skip_300402 | 19 | 1219322:1219412:1220371:1220504:1220579:1220616 | 1220371:1220504 | ENSG00000118046.10 | ENST00000326873.7,ENST00000593219.1,ENST00000589152.1 |
| exon_skip_300423 | 19 | 1221211:1221339:1221947:1222005:1222983:1223171 | 1221947:1222005 | ENSG00000118046.10 | ENST00000326873.7,ENST00000593219.1,ENST00000586243.1 |
| exon_skip_300435 | 19 | 1223146:1223171:1223636:1226662:1227591:1227856 | 1223636:1226662 | ENSG00000118046.10 | ENST00000585465.1 |
| exon_skip_300436 | 19 | 1223146:1223171:1226452:1226662:1227591:1227856 | 1226452:1226662 | ENSG00000118046.10 | ENST00000326873.7 |
| exon_skip_300437 | 19 | 1223146:1223171:1226457:1226662:1227591:1227856 | 1226457:1226662 | ENSG00000118046.10 | ENST00000586243.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for STK11 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000326873 | 1226452 | 1226662 | 3UTR-3CDS |
| ENST00000326873 | 1220371 | 1220504 | Frame-shift |
| ENST00000326873 | 1221947 | 1222005 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000326873 | 1226452 | 1226662 | 3UTR-3CDS |
| ENST00000326873 | 1220371 | 1220504 | Frame-shift |
| ENST00000326873 | 1221947 | 1222005 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for STK11 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for STK11 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
STK11_ESCA_exon_skip_300435_psi_boxplot.png |
STK11_LUAD_exon_skip_300402_psi_boxplot.png |
STK11_SKCM_exon_skip_300402_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SKCM | TCGA-EB-A1NK-01 | exon_skip_300402 | 1220372 | 1220504 | 1220396 | 1220403 | Frame_Shift_Del | CCTGGAGT | - | p.GLEY163fs |
| LUAD | TCGA-86-7701-01 | exon_skip_300402 | 1220372 | 1220504 | 1220410 | 1220410 | Frame_Shift_Del | A | - | p.H168fs |
| LUAD | TCGA-78-7537-01 | exon_skip_300402 | 1220372 | 1220504 | 1220432 | 1220432 | Frame_Shift_Del | G | - | p.K175fs |
| LUAD | TCGA-75-6206-01 | exon_skip_300402 | 1220372 | 1220504 | 1220465 | 1220466 | Frame_Shift_Ins | - | G | p.W187fs |
| LUAD | TCGA-55-7913-01 | exon_skip_300402 | 1220372 | 1220504 | 1220430 | 1220430 | Nonsense_Mutation | A | T | p.K175* |
| KIRP | TCGA-B9-5155-01 | exon_skip_300402 | 1220372 | 1220504 | 1220439 | 1220439 | Nonsense_Mutation | A | T | p.K178* |
| KIRP | TCGA-B9-5155-01 | exon_skip_300402 | 1220372 | 1220504 | 1220439 | 1220439 | Nonsense_Mutation | A | T | p.K178X |
| LUAD | TCGA-44-8120-01 | exon_skip_300402 | 1220372 | 1220504 | 1220502 | 1220502 | Nonsense_Mutation | G | T | p.E199* |
| ESCA | TCGA-Z6-A8JD-01 | exon_skip_300435 | 1223637 | 1226662 | 1226530 | 1226530 | Nonsense_Mutation | G | T | p.E396* |
| ESCA | TCGA-Z6-A8JD-01 | exon_skip_300435 | 1223637 | 1226662 | 1226530 | 1226530 | Nonsense_Mutation | G | T | p.E396X |
| ESCA | TCGA-Z6-A8JD-01 | exon_skip_300437 exon_skip_300436 | 1226453 | 1226662 | 1226530 | 1226530 | Nonsense_Mutation | G | T | p.E396* |
| ESCA | TCGA-Z6-A8JD-01 | exon_skip_300437 exon_skip_300436 | 1226453 | 1226662 | 1226530 | 1226530 | Nonsense_Mutation | G | T | p.E396X |
| ESCA | TCGA-Z6-A8JD-01 | exon_skip_300437 exon_skip_300436 | 1226458 | 1226662 | 1226530 | 1226530 | Nonsense_Mutation | G | T | p.E396* |
| ESCA | TCGA-Z6-A8JD-01 | exon_skip_300437 exon_skip_300436 | 1226458 | 1226662 | 1226530 | 1226530 | Nonsense_Mutation | G | T | p.E396X |
| LUAD | TCGA-78-7161-01 | exon_skip_300402 | 1220372 | 1220504 | 1220370 | 1220370 | Splice_Site | A | T | p.G155_splice |
| LUAD | TCGA-91-6849-01 | exon_skip_300423 | 1221948 | 1222005 | 1221946 | 1221946 | Splice_Site | A | T | p.G288_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-Z6-A8JD-01 |
| Cancer type: ESCA | |
| ESID: exon_skip_300435 | |
| Skipped exon start: 1223637 | |
| Skipped exon end: 1226662 | |
| Mutation start: 1226530 | |
| Mutation end: 1226530 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: T | |
| AAchange: p.E396X | |
| Sample: TCGA-Z6-A8JD-01 |
| Cancer type: ESCA | |
| ESID: exon_skip_300436 | |
| Skipped exon start: 1226458 | |
| Skipped exon end: 1226662 | |
| Mutation start: 1226530 | |
| Mutation end: 1226530 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: T | |
| AAchange: p.E396X | |
| Sample: TCGA-Z6-A8JD-01 |
| Cancer type: ESCA | |
| ESID: exon_skip_300436 | |
| Skipped exon start: 1226453 | |
| Skipped exon end: 1226662 | |
| Mutation start: 1226530 | |
| Mutation end: 1226530 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: T | |
| AAchange: p.E396X | |
| Sample: TCGA-Z6-A8JD-01 |
| Cancer type: ESCA | |
| ESID: exon_skip_300435 | |
| Skipped exon start: 1223637 | |
| Skipped exon end: 1226662 | |
| Mutation start: 1226530 | |
| Mutation end: 1226530 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: T | |
| AAchange: p.E396* | |
| Sample: TCGA-Z6-A8JD-01 |
| Cancer type: ESCA | |
| ESID: exon_skip_300436 | |
| Skipped exon start: 1226458 | |
| Skipped exon end: 1226662 | |
| Mutation start: 1226530 | |
| Mutation end: 1226530 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: T | |
| AAchange: p.E396* | |
| Sample: TCGA-Z6-A8JD-01 |
| Cancer type: ESCA | |
| ESID: exon_skip_300436 | |
| Skipped exon start: 1226453 | |
| Skipped exon end: 1226662 | |
| Mutation start: 1226530 | |
| Mutation end: 1226530 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: T | |
| AAchange: p.E396* | |
exon_skip_300435_ESCA_TCGA-Z6-A8JD-01.png | |
 | Sample: TCGA-78-7161-01 |
| Cancer type: LUAD | |
| ESID: exon_skip_300402 | |
| Skipped exon start: 1220372 | |
| Skipped exon end: 1220504 | |
| Mutation start: 1220370 | |
| Mutation end: 1220370 | |
| Mutation type: Splice_Site | |
| Reference seq: A | |
| Mutation seq: T | |
| AAchange: p.G155_splice | |
exon_skip_300402_LUAD_TCGA-78-7161-01.png | |
exon_skip_69695_LUAD_TCGA-78-7161-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| DU145_PROSTATE | 1220372 | 1220504 | 1220438 | 1220442 | Frame_Shift_Del | CAAGC | - | p.KP178fs |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1223637 | 1226662 | 1226495 | 1226495 | Frame_Shift_Del | G | - | p.R384fs |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1226458 | 1226662 | 1226495 | 1226495 | Frame_Shift_Del | G | - | p.R384fs |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1226453 | 1226662 | 1226495 | 1226495 | Frame_Shift_Del | G | - | p.R384fs |
| SNU1040_LARGE_INTESTINE | 1220372 | 1220504 | 1220427 | 1220427 | Missense_Mutation | C | T | p.H174Y |
| CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1220372 | 1220504 | 1220431 | 1220431 | Missense_Mutation | A | T | p.K175M |
| NCIH810_LUNG | 1220372 | 1220504 | 1220442 | 1220442 | Missense_Mutation | C | T | p.P179S |
| SNU1040_LARGE_INTESTINE | 1220372 | 1220504 | 1220454 | 1220454 | Missense_Mutation | C | G | p.L183V |
| DMS53_LUNG | 1220372 | 1220504 | 1220487 | 1220487 | Missense_Mutation | G | T | p.D194Y |
| NCIH2286_LUNG | 1220372 | 1220504 | 1220487 | 1220487 | Missense_Mutation | G | C | p.D194H |
| PLCPRF5_LIVER | 1220372 | 1220504 | 1220487 | 1220487 | Missense_Mutation | G | A | p.D194N |
| SKGIIIA_CERVIX | 1220372 | 1220504 | 1220487 | 1220487 | Missense_Mutation | G | A | p.D194N |
| SW13_ADRENAL_CORTEX | 1220372 | 1220504 | 1220491 | 1220491 | Missense_Mutation | T | A | p.L195Q |
| NCIH1435_LUNG | 1221948 | 1222005 | 1221981 | 1221981 | Missense_Mutation | C | T | p.S299F |
| NCIH727_LUNG | 1221948 | 1222005 | 1221990 | 1221990 | Missense_Mutation | A | C | p.Q302P |
| SNU840_OVARY | 1221948 | 1222005 | 1221995 | 1221995 | Missense_Mutation | C | T | p.R304W |
| MEC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1223637 | 1226662 | 1226473 | 1226473 | Missense_Mutation | G | C | p.A377P |
| MEC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1226458 | 1226662 | 1226473 | 1226473 | Missense_Mutation | G | C | p.A377P |
| MEC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1226453 | 1226662 | 1226473 | 1226473 | Missense_Mutation | G | C | p.A377P |
| MOLT3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1223637 | 1226662 | 1226481 | 1226481 | Missense_Mutation | C | A | p.H379Q |
| MOLT3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1226458 | 1226662 | 1226481 | 1226481 | Missense_Mutation | C | A | p.H379Q |
| MOLT3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1226453 | 1226662 | 1226481 | 1226481 | Missense_Mutation | C | A | p.H379Q |
| MOLT3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1223637 | 1226662 | 1226488 | 1226488 | Missense_Mutation | C | A | p.Q382K |
| MOLT3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1226458 | 1226662 | 1226488 | 1226488 | Missense_Mutation | C | A | p.Q382K |
| MOLT3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1226453 | 1226662 | 1226488 | 1226488 | Missense_Mutation | C | A | p.Q382K |
| NCIH2030_LUNG | 1223637 | 1226662 | 1226520 | 1226520 | Missense_Mutation | G | A | p.M392I |
| NCIH2030_LUNG | 1226458 | 1226662 | 1226520 | 1226520 | Missense_Mutation | G | A | p.M392I |
| NCIH2030_LUNG | 1226453 | 1226662 | 1226520 | 1226520 | Missense_Mutation | G | A | p.M392I |
| CHSA8926_BONE | 1223637 | 1226662 | 1226520 | 1226520 | Missense_Mutation | G | A | p.M392I |
| CHSA8926_BONE | 1226458 | 1226662 | 1226520 | 1226520 | Missense_Mutation | G | A | p.M392I |
| CHSA8926_BONE | 1226453 | 1226662 | 1226520 | 1226520 | Missense_Mutation | G | A | p.M392I |
| BICR56_UPPER_AERODIGESTIVE_TRACT | 1223637 | 1226662 | 1226537 | 1226537 | Missense_Mutation | C | G | p.A398G |
| BICR56_UPPER_AERODIGESTIVE_TRACT | 1226458 | 1226662 | 1226537 | 1226537 | Missense_Mutation | C | G | p.A398G |
| BICR56_UPPER_AERODIGESTIVE_TRACT | 1226453 | 1226662 | 1226537 | 1226537 | Missense_Mutation | C | G | p.A398G |
| KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1223637 | 1226662 | 1226552 | 1226552 | Missense_Mutation | A | T | p.K403I |
| KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1226458 | 1226662 | 1226552 | 1226552 | Missense_Mutation | A | T | p.K403I |
| KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1226453 | 1226662 | 1226552 | 1226552 | Missense_Mutation | A | T | p.K403I |
| 22RV1_PROSTATE | 1223637 | 1226662 | 1226565 | 1226565 | Missense_Mutation | G | T | p.E407D |
| 22RV1_PROSTATE | 1226458 | 1226662 | 1226565 | 1226565 | Missense_Mutation | G | T | p.E407D |
| 22RV1_PROSTATE | 1226453 | 1226662 | 1226565 | 1226565 | Missense_Mutation | G | T | p.E407D |
| DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1223637 | 1226662 | 1226618 | 1226618 | Missense_Mutation | G | A | p.R425H |
| DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1226458 | 1226662 | 1226618 | 1226618 | Missense_Mutation | G | A | p.R425H |
| DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1226453 | 1226662 | 1226618 | 1226618 | Missense_Mutation | G | A | p.R425H |
| EMCBAC1_LUNG | 1220372 | 1220504 | 1220399 | 1220400 | Nonsense_Mutation | GG | TT | p.E165* |
| NCIH2073_LUNG | 1220372 | 1220504 | 1220502 | 1220502 | Nonsense_Mutation | G | T | p.E199* |
| NCIH1993_LUNG | 1220372 | 1220504 | 1220502 | 1220502 | Nonsense_Mutation | G | T | p.E199* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for STK11 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STK11 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STK11 |
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RelatedDrugs for STK11 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STK11 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| STK11 | C0031269 | Peutz-Jeghers Syndrome | 7 | CTD_human;ORPHANET;UNIPROT |
| STK11 | C1336708 | Testicular Germ Cell Tumor | 3 | CTD_human;UNIPROT |
| STK11 | C0001418 | Adenocarcinoma | 1 | CTD_human |
| STK11 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| STK11 | C0020538 | Hypertensive disease | 1 | CTD_human |
| STK11 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| STK11 | C0030297 | Pancreatic Neoplasm | 1 | CTD_human;HPO |
| STK11 | C0149721 | Left Ventricular Hypertrophy | 1 | CTD_human |
| STK11 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
| STK11 | C1257915 | Intestinal Polyposis | 1 | CTD_human |
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