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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for STK10 |
 Gene summary |
| Gene information | Gene symbol | STK10 | Gene ID | 6793 |
| Gene name | serine/threonine kinase 10 | |
| Synonyms | LOK|PRO2729 | |
| Cytomap | 5q35.1 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase 10lymphocyte-oriented kinase | |
| Modification date | 20180523 | |
| UniProtAcc | O94804 | |
| Context | PubMed: STK10 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| STK10 | GO:0046777 | protein autophosphorylation | 12639966|18239682 |
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Exon skipping events across known transcript of Ensembl for STK10 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for STK10 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for STK10 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_446192 | 5 | 171471689:171472026:171472429:171472484:171479932:171480046 | 171472429:171472484 | ENSG00000072786.8 | ENST00000520476.1 |
| exon_skip_446193 | 5 | 171481572:171481698:171482591:171482780:171484352:171484477 | 171482591:171482780 | ENSG00000072786.8 | ENST00000520476.1,ENST00000176763.5 |
| exon_skip_446194 | 5 | 171509964:171510088:171517235:171517366:171520415:171520581 | 171517235:171517366 | ENSG00000072786.8 | ENST00000176763.5 |
| exon_skip_446198 | 5 | 171517235:171517366:171520415:171520964:171523429:171523564 | 171520415:171520964 | ENSG00000072786.8 | ENST00000176763.5 |
| exon_skip_446204 | 5 | 171520700:171520964:171523429:171523564:171532659:171532741 | 171523429:171523564 | ENSG00000072786.8 | ENST00000176763.5 |
| exon_skip_446205 | 5 | 171532661:171532741:171533623:171533818:171534783:171534856 | 171533623:171533818 | ENSG00000072786.8 | ENST00000517524.1,ENST00000522936.1,ENST00000176763.5 |
| exon_skip_446206 | 5 | 171533665:171533818:171534783:171534856:171544484:171544634 | 171534783:171534856 | ENSG00000072786.8 | ENST00000176763.5 |
| exon_skip_446207 | 5 | 171544484:171544634:171554376:171554425:171583627:171583729 | 171554376:171554425 | ENSG00000072786.8 | ENST00000176763.5,ENST00000519710.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for STK10 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_446192 | 5 | 171471689:171472026:171472429:171472484:171479932:171480046 | 171472429:171472484 | ENSG00000072786.8 | ENST00000520476.1 |
| exon_skip_446193 | 5 | 171481572:171481698:171482591:171482780:171484352:171484477 | 171482591:171482780 | ENSG00000072786.8 | ENST00000176763.5,ENST00000520476.1 |
| exon_skip_446194 | 5 | 171509964:171510088:171517235:171517366:171520415:171520581 | 171517235:171517366 | ENSG00000072786.8 | ENST00000176763.5 |
| exon_skip_446198 | 5 | 171517235:171517366:171520415:171520964:171523429:171523564 | 171520415:171520964 | ENSG00000072786.8 | ENST00000176763.5 |
| exon_skip_446204 | 5 | 171520700:171520964:171523429:171523564:171532659:171532741 | 171523429:171523564 | ENSG00000072786.8 | ENST00000176763.5 |
| exon_skip_446205 | 5 | 171532661:171532741:171533623:171533818:171534783:171534856 | 171533623:171533818 | ENSG00000072786.8 | ENST00000176763.5,ENST00000517524.1,ENST00000522936.1 |
| exon_skip_446206 | 5 | 171533665:171533818:171534783:171534856:171544484:171544634 | 171534783:171534856 | ENSG00000072786.8 | ENST00000176763.5 |
| exon_skip_446207 | 5 | 171544484:171544634:171554376:171554425:171583627:171583729 | 171554376:171554425 | ENSG00000072786.8 | ENST00000176763.5,ENST00000519710.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for STK10 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000176763 | 171517235 | 171517366 | Frame-shift |
| ENST00000176763 | 171534783 | 171534856 | Frame-shift |
| ENST00000176763 | 171554376 | 171554425 | Frame-shift |
| ENST00000176763 | 171482591 | 171482780 | In-frame |
| ENST00000176763 | 171520415 | 171520964 | In-frame |
| ENST00000176763 | 171523429 | 171523564 | In-frame |
| ENST00000176763 | 171533623 | 171533818 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000176763 | 171517235 | 171517366 | Frame-shift |
| ENST00000176763 | 171534783 | 171534856 | Frame-shift |
| ENST00000176763 | 171554376 | 171554425 | Frame-shift |
| ENST00000176763 | 171482591 | 171482780 | In-frame |
| ENST00000176763 | 171520415 | 171520964 | In-frame |
| ENST00000176763 | 171523429 | 171523564 | In-frame |
| ENST00000176763 | 171533623 | 171533818 | In-frame |
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Infer the effects of exon skipping event on protein functional features for STK10 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000176763 | 6077 | 968 | 171533623 | 171533818 | 938 | 1132 | 198 | 262 |
| ENST00000176763 | 6077 | 968 | 171523429 | 171523564 | 1215 | 1349 | 290 | 335 |
| ENST00000176763 | 6077 | 968 | 171520415 | 171520964 | 1350 | 1898 | 335 | 518 |
| ENST00000176763 | 6077 | 968 | 171482591 | 171482780 | 2682 | 2870 | 779 | 842 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000176763 | 6077 | 968 | 171533623 | 171533818 | 938 | 1132 | 198 | 262 |
| ENST00000176763 | 6077 | 968 | 171523429 | 171523564 | 1215 | 1349 | 290 | 335 |
| ENST00000176763 | 6077 | 968 | 171520415 | 171520964 | 1350 | 1898 | 335 | 518 |
| ENST00000176763 | 6077 | 968 | 171482591 | 171482780 | 2682 | 2870 | 779 | 842 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O94804 | 198 | 262 | 1 | 968 | Chain | ID=PRO_0000086697;Note=Serine/threonine-protein kinase 10 |
| O94804 | 198 | 262 | 36 | 294 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O94804 | 198 | 262 | 196 | 198 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM |
| O94804 | 198 | 262 | 201 | 207 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM |
| O94804 | 198 | 262 | 213 | 216 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM |
| O94804 | 198 | 262 | 217 | 232 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM |
| O94804 | 198 | 262 | 242 | 251 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM |
| O94804 | 198 | 262 | 260 | 262 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM |
| O94804 | 198 | 262 | 175 | 224 | Region | Note=Activation segment |
| O94804 | 198 | 262 | 208 | 211 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM |
| O94804 | 198 | 262 | 236 | 239 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM |
| O94804 | 290 | 335 | 1 | 968 | Chain | ID=PRO_0000086697;Note=Serine/threonine-protein kinase 10 |
| O94804 | 290 | 335 | 36 | 294 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O94804 | 290 | 335 | 301 | 314 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM |
| O94804 | 290 | 335 | 322 | 322 | Natural variant | ID=VAR_041132;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56214442,PMID:17344846 |
| O94804 | 290 | 335 | 317 | 317 | Sequence conflict | Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| O94804 | 290 | 335 | 292 | 296 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM |
| O94804 | 335 | 518 | 1 | 968 | Chain | ID=PRO_0000086697;Note=Serine/threonine-protein kinase 10 |
| O94804 | 335 | 518 | 438 | 438 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19367720,ECO:0000244|PubMe |
| O94804 | 335 | 518 | 450 | 450 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
| O94804 | 335 | 518 | 454 | 454 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648 |
| O94804 | 335 | 518 | 485 | 485 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569 |
| O94804 | 335 | 518 | 514 | 514 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569 |
| O94804 | 335 | 518 | 336 | 336 | Natural variant | ID=VAR_041133;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55972616,PMID:17344846 |
| O94804 | 335 | 518 | 467 | 467 | Natural variant | ID=VAR_041134;Note=N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56063773,PMID:17344846 |
| O94804 | 335 | 518 | 480 | 480 | Natural variant | ID=VAR_051671;Note=P->L;Dbxref=dbSNP:rs34505340 |
| O94804 | 779 | 842 | 1 | 968 | Chain | ID=PRO_0000086697;Note=Serine/threonine-protein kinase 10 |
| O94804 | 779 | 842 | 573 | 947 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O94804 | 779 | 842 | 750 | 884 | Compositional bias | Note=Gln-rich |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O94804 | 198 | 262 | 1 | 968 | Chain | ID=PRO_0000086697;Note=Serine/threonine-protein kinase 10 |
| O94804 | 198 | 262 | 36 | 294 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O94804 | 198 | 262 | 196 | 198 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM |
| O94804 | 198 | 262 | 201 | 207 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM |
| O94804 | 198 | 262 | 213 | 216 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM |
| O94804 | 198 | 262 | 217 | 232 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM |
| O94804 | 198 | 262 | 242 | 251 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM |
| O94804 | 198 | 262 | 260 | 262 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM |
| O94804 | 198 | 262 | 175 | 224 | Region | Note=Activation segment |
| O94804 | 198 | 262 | 208 | 211 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM |
| O94804 | 198 | 262 | 236 | 239 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM |
| O94804 | 290 | 335 | 1 | 968 | Chain | ID=PRO_0000086697;Note=Serine/threonine-protein kinase 10 |
| O94804 | 290 | 335 | 36 | 294 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O94804 | 290 | 335 | 301 | 314 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM |
| O94804 | 290 | 335 | 322 | 322 | Natural variant | ID=VAR_041132;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56214442,PMID:17344846 |
| O94804 | 290 | 335 | 317 | 317 | Sequence conflict | Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| O94804 | 290 | 335 | 292 | 296 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM |
| O94804 | 335 | 518 | 1 | 968 | Chain | ID=PRO_0000086697;Note=Serine/threonine-protein kinase 10 |
| O94804 | 335 | 518 | 438 | 438 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19367720,ECO:0000244|PubMe |
| O94804 | 335 | 518 | 450 | 450 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
| O94804 | 335 | 518 | 454 | 454 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648 |
| O94804 | 335 | 518 | 485 | 485 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569 |
| O94804 | 335 | 518 | 514 | 514 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569 |
| O94804 | 335 | 518 | 336 | 336 | Natural variant | ID=VAR_041133;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55972616,PMID:17344846 |
| O94804 | 335 | 518 | 467 | 467 | Natural variant | ID=VAR_041134;Note=N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56063773,PMID:17344846 |
| O94804 | 335 | 518 | 480 | 480 | Natural variant | ID=VAR_051671;Note=P->L;Dbxref=dbSNP:rs34505340 |
| O94804 | 779 | 842 | 1 | 968 | Chain | ID=PRO_0000086697;Note=Serine/threonine-protein kinase 10 |
| O94804 | 779 | 842 | 573 | 947 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O94804 | 779 | 842 | 750 | 884 | Compositional bias | Note=Gln-rich |
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SNVs in the skipped exons for STK10 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
STK10_SKCM_exon_skip_446198_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| STAD | TCGA-BR-4184-01 | exon_skip_446194 | 171517236 | 171517366 | 171517345 | 171517345 | Frame_Shift_Del | T | - | p.T526fs |
| STAD | TCGA-CG-5733-01 | exon_skip_446194 | 171517236 | 171517366 | 171517345 | 171517345 | Frame_Shift_Del | T | - | p.T526fs |
| LUSC | TCGA-33-4566-01 | exon_skip_446205 | 171533624 | 171533818 | 171533644 | 171533644 | Frame_Shift_Del | C | - | p.T256fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_446205 | 171533624 | 171533818 | 171533700 | 171533700 | Frame_Shift_Del | G | - | p.H238fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_446205 | 171533624 | 171533818 | 171533761 | 171533761 | Frame_Shift_Del | T | - | p.K217fs |
| KICH | TCGA-KN-8428-01 | exon_skip_446193 | 171482592 | 171482780 | 171482625 | 171482626 | Frame_Shift_Ins | - | C | p.G831fs |
| STAD | TCGA-CG-5726-01 | exon_skip_446194 | 171517236 | 171517366 | 171517344 | 171517345 | Frame_Shift_Ins | - | T | p.T526fs |
| STAD | TCGA-CG-5726-01 | exon_skip_446194 | 171517236 | 171517366 | 171517345 | 171517346 | Frame_Shift_Ins | - | T | p.T526fs |
| COAD | TCGA-G4-6586-01 | exon_skip_446194 | 171517236 | 171517366 | 171517246 | 171517246 | Nonsense_Mutation | T | A | p.R559X |
| SKCM | TCGA-D3-A8GQ-06 | exon_skip_446198 | 171520416 | 171520964 | 171520703 | 171520703 | Nonsense_Mutation | G | A | p.Q423* |
| SKCM | TCGA-FS-A4FC-06 | exon_skip_446198 | 171520416 | 171520964 | 171520703 | 171520703 | Nonsense_Mutation | G | A | p.Q423* |
| SKCM | TCGA-FS-A4FC-06 | exon_skip_446198 | 171520416 | 171520964 | 171520703 | 171520703 | Nonsense_Mutation | G | A | p.Q423X |
| STAD | TCGA-HU-A4GQ-01 | exon_skip_446194 | 171517236 | 171517366 | 171517367 | 171517367 | Splice_Site | C | A | . |
| STAD | TCGA-HU-A4GQ-01 | exon_skip_446194 | 171517236 | 171517366 | 171517367 | 171517367 | Splice_Site | C | A | p.D519_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-D3-A8GQ-06 |
| Cancer type: SKCM | |
| ESID: exon_skip_446198 | |
| Skipped exon start: 171520416 | |
| Skipped exon end: 171520964 | |
| Mutation start: 171520703 | |
| Mutation end: 171520703 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.Q423* | |
exon_skip_446198_SKCM_TCGA-D3-A8GQ-06.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| NO10_CENTRAL_NERVOUS_SYSTEM | 171517236 | 171517366 | 171517354 | 171517355 | Frame_Shift_Del | AC | - | p.Y523fs |
| HCC202_BREAST | 171520416 | 171520964 | 171520895 | 171520898 | Frame_Shift_Del | CGAG | - | p.LE358fs |
| HCC202_BREAST | 171520416 | 171520964 | 171520895 | 171520895 | Frame_Shift_Del | C | - | p.E360fs |
| HEC151_ENDOMETRIUM | 171554377 | 171554425 | 171554400 | 171554400 | Frame_Shift_Del | C | - | p.G116fs |
| HCC202_BREAST | 171520416 | 171520964 | 171520897 | 171520899 | In_Frame_Del | AGA | - | p.L358del |
| SMZ1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 171482592 | 171482780 | 171482608 | 171482608 | Missense_Mutation | C | T | p.R837H |
| CW2_LARGE_INTESTINE | 171482592 | 171482780 | 171482632 | 171482632 | Missense_Mutation | C | T | p.G829D |
| HEC108_ENDOMETRIUM | 171482592 | 171482780 | 171482708 | 171482708 | Missense_Mutation | C | A | p.A804S |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 171482592 | 171482780 | 171482742 | 171482742 | Missense_Mutation | T | C | p.I792M |
| SNU1040_LARGE_INTESTINE | 171482592 | 171482780 | 171482761 | 171482761 | Missense_Mutation | C | T | p.R786H |
| HEC108_ENDOMETRIUM | 171482592 | 171482780 | 171482777 | 171482777 | Missense_Mutation | G | A | p.R781W |
| SW1271_LUNG | 171517236 | 171517366 | 171517260 | 171517260 | Missense_Mutation | T | G | p.K554T |
| SNU1040_LARGE_INTESTINE | 171517236 | 171517366 | 171517318 | 171517318 | Missense_Mutation | C | T | p.V535M |
| SNU175_LARGE_INTESTINE | 171517236 | 171517366 | 171517329 | 171517329 | Missense_Mutation | C | T | p.R531H |
| SNU349_KIDNEY | 171517236 | 171517366 | 171517330 | 171517330 | Missense_Mutation | G | A | p.R531C |
| DG75_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 171520416 | 171520964 | 171520511 | 171520511 | Missense_Mutation | A | C | p.C487G |
| HEC59_ENDOMETRIUM | 171520416 | 171520964 | 171520564 | 171520564 | Missense_Mutation | C | T | p.S469N |
| SNGM_ENDOMETRIUM | 171520416 | 171520964 | 171520606 | 171520606 | Missense_Mutation | C | T | p.S455N |
| PL4_PANCREAS | 171520416 | 171520964 | 171520645 | 171520645 | Missense_Mutation | T | C | p.N442S |
| TK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 171520416 | 171520964 | 171520729 | 171520729 | Missense_Mutation | C | T | p.R414Q |
| NCIH1184_LUNG | 171520416 | 171520964 | 171520879 | 171520879 | Missense_Mutation | G | A | p.T364I |
| WM1552C_SKIN | 171520416 | 171520964 | 171520890 | 171520890 | Missense_Mutation | C | A | p.E360D |
| A2780_OVARY | 171520416 | 171520964 | 171520907 | 171520907 | Missense_Mutation | C | T | p.D355N |
| CAL51_BREAST | 171523430 | 171523564 | 171523435 | 171523435 | Missense_Mutation | C | T | p.A334T |
| SNU1040_LARGE_INTESTINE | 171533624 | 171533818 | 171533664 | 171533664 | Missense_Mutation | C | T | p.A250T |
| SNUC5_LARGE_INTESTINE | 171533624 | 171533818 | 171533717 | 171533717 | Missense_Mutation | T | G | p.Q232P |
| 639V_URINARY_TRACT | 171533624 | 171533818 | 171533728 | 171533728 | Missense_Mutation | A | C | p.I228M |
| CAL39_VULVA | 171533624 | 171533818 | 171533739 | 171533739 | Missense_Mutation | T | C | p.I225V |
| SNU175_LARGE_INTESTINE | 171554377 | 171554425 | 171554389 | 171554389 | Missense_Mutation | C | T | p.A120T |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 171482592 | 171482780 | 171482765 | 171482765 | Nonsense_Mutation | G | A | p.Q785* |
| RERFLCAD2_LUNG | 171520416 | 171520964 | 171520934 | 171520934 | Nonsense_Mutation | C | A | p.E346* |
| PECAPJ15_UPPER_AERODIGESTIVE_TRACT | 171520416 | 171520964 | 171520417 | 171520417 | Splice_Site | T | G | p.K518T |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for STK10 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STK10 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STK10 |
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RelatedDrugs for STK10 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| O94804 | DB12010 | Fostamatinib | Serine/threonine-protein kinase 10 | small molecule | approved|investigational |
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RelatedDiseases for STK10 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| STK10 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| STK10 | C1336708 | Testicular Germ Cell Tumor | 1 | UNIPROT |
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