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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for AURKA |
 Gene summary |
| Gene information | Gene symbol | AURKA | Gene ID | 6790 |
| Gene name | aurora kinase A | |
| Synonyms | AIK|ARK1|AURA|BTAK|PPP1R47|STK15|STK6|STK7 | |
| Cytomap | 20q13.2 | |
| Type of gene | protein-coding | |
| Description | aurora kinase Aaurora 2aurora/IPL1-like kinaseaurora/IPL1-related kinase 1breast tumor-amplified kinaseprotein phosphatase 1, regulatory subunit 47serine/threonine protein kinase 15serine/threonine-protein kinase 6serine/threonine-protein kinase a | |
| Modification date | 20180527 | |
| UniProtAcc | O14965 | |
| Context | PubMed: AURKA [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| AURKA | GO:0006468 | protein phosphorylation | 21600873|21820309 |
| AURKA | GO:0009611 | response to wounding | 19435814 |
| AURKA | GO:0032091 | negative regulation of protein binding | 21820309 |
| AURKA | GO:0097421 | liver regeneration | 19435814 |
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Exon skipping events across known transcript of Ensembl for AURKA from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for AURKA |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for AURKA |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_358218 | 20 | 54945540:54945715:54948463:54948612:54956488:54956627 | 54948463:54948612 | ENSG00000087586.13 | ENST00000395909.4,ENST00000395907.1,ENST00000371356.2,ENST00000312783.6,ENST00000395911.1,ENST00000395914.1,ENST00000395915.3,ENST00000347343.2,ENST00000395913.3 |
| exon_skip_358223 | 20 | 54958166:54958232:54959325:54959380:54961312:54961589 | 54959325:54959380 | ENSG00000087586.13 | ENST00000395909.4,ENST00000395907.1,ENST00000371356.2,ENST00000312783.6,ENST00000395911.1,ENST00000395914.1,ENST00000395915.3,ENST00000347343.2,ENST00000441357.1,ENST00000422322.1,ENST00000420474.1,ENST00000395913.3 |
| exon_skip_358224 | 20 | 54963211:54963258:54963367:54963562:54965611:54965721 | 54963367:54963562 | ENSG00000087586.13 | ENST00000451915.1 |
| exon_skip_358226 | 20 | 54963211:54963258:54963742:54963840:54965611:54965721 | 54963742:54963840 | ENSG00000087586.13 | ENST00000395909.4,ENST00000456249.1,ENST00000420474.1 |
| exon_skip_358228 | 20 | 54963211:54963258:54963742:54963840:54967209:54967271 | 54963742:54963840 | ENSG00000087586.13 | ENST00000395911.1 |
| exon_skip_358229 | 20 | 54963211:54963258:54963742:54963840:54967223:54967252 | 54963742:54963840 | ENSG00000087586.13 | ENST00000371356.2 |
| exon_skip_358233 | 20 | 54963211:54963258:54965611:54965721:54966998:54967187 | 54965611:54965721 | ENSG00000087586.13 | ENST00000422322.1 |
| exon_skip_358235 | 20 | 54963211:54963258:54965611:54965721:54967209:54967271 | 54965611:54965721 | ENSG00000087586.13 | ENST00000395914.1,ENST00000441357.1 |
| exon_skip_358236 | 20 | 54963211:54963258:54965611:54965721:54967223:54967252 | 54965611:54965721 | ENSG00000087586.13 | ENST00000312783.6 |
| exon_skip_358242 | 20 | 54963742:54963840:54965611:54965721:54966998:54967187 | 54965611:54965721 | ENSG00000087586.13 | ENST00000456249.1 |
| exon_skip_358244 | 20 | 54963742:54963840:54965611:54965721:54967223:54967252 | 54965611:54965721 | ENSG00000087586.13 | ENST00000420474.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for AURKA |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_358218 | 20 | 54945540:54945715:54948463:54948612:54956488:54956627 | 54948463:54948612 | ENSG00000087586.13 | ENST00000395909.4,ENST00000395914.1,ENST00000371356.2,ENST00000347343.2,ENST00000395911.1,ENST00000312783.6,ENST00000395915.3,ENST00000395913.3,ENST00000395907.1 |
| exon_skip_358223 | 20 | 54958166:54958232:54959325:54959380:54961312:54961589 | 54959325:54959380 | ENSG00000087586.13 | ENST00000395909.4,ENST00000395914.1,ENST00000371356.2,ENST00000347343.2,ENST00000395911.1,ENST00000312783.6,ENST00000395915.3,ENST00000395913.3,ENST00000395907.1,ENST00000441357.1,ENST00000420474.1,ENST00000422322.1 |
| exon_skip_358226 | 20 | 54963211:54963258:54963742:54963840:54965611:54965721 | 54963742:54963840 | ENSG00000087586.13 | ENST00000395909.4,ENST00000420474.1,ENST00000456249.1 |
| exon_skip_358228 | 20 | 54963211:54963258:54963742:54963840:54967209:54967271 | 54963742:54963840 | ENSG00000087586.13 | ENST00000395911.1 |
| exon_skip_358229 | 20 | 54963211:54963258:54963742:54963840:54967223:54967252 | 54963742:54963840 | ENSG00000087586.13 | ENST00000371356.2 |
| exon_skip_358233 | 20 | 54963211:54963258:54965611:54965721:54966998:54967187 | 54965611:54965721 | ENSG00000087586.13 | ENST00000422322.1 |
| exon_skip_358235 | 20 | 54963211:54963258:54965611:54965721:54967209:54967271 | 54965611:54965721 | ENSG00000087586.13 | ENST00000395914.1,ENST00000441357.1 |
| exon_skip_358236 | 20 | 54963211:54963258:54965611:54965721:54967223:54967252 | 54965611:54965721 | ENSG00000087586.13 | ENST00000312783.6 |
| exon_skip_358242 | 20 | 54963742:54963840:54965611:54965721:54966998:54967187 | 54965611:54965721 | ENSG00000087586.13 | ENST00000456249.1 |
| exon_skip_358244 | 20 | 54963742:54963840:54965611:54965721:54967223:54967252 | 54965611:54965721 | ENSG00000087586.13 | ENST00000420474.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for AURKA |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000371356 | 54963742 | 54963840 | 3UTR-3UTR |
| ENST00000395911 | 54963742 | 54963840 | 3UTR-3UTR |
| ENST00000312783 | 54965611 | 54965721 | 3UTR-3UTR |
| ENST00000395914 | 54965611 | 54965721 | 3UTR-3UTR |
| ENST00000312783 | 54948463 | 54948612 | Frame-shift |
| ENST00000347343 | 54948463 | 54948612 | Frame-shift |
| ENST00000371356 | 54948463 | 54948612 | Frame-shift |
| ENST00000395911 | 54948463 | 54948612 | Frame-shift |
| ENST00000395913 | 54948463 | 54948612 | Frame-shift |
| ENST00000395914 | 54948463 | 54948612 | Frame-shift |
| ENST00000395915 | 54948463 | 54948612 | Frame-shift |
| ENST00000312783 | 54959325 | 54959380 | Frame-shift |
| ENST00000347343 | 54959325 | 54959380 | Frame-shift |
| ENST00000371356 | 54959325 | 54959380 | Frame-shift |
| ENST00000395911 | 54959325 | 54959380 | Frame-shift |
| ENST00000395913 | 54959325 | 54959380 | Frame-shift |
| ENST00000395914 | 54959325 | 54959380 | Frame-shift |
| ENST00000395915 | 54959325 | 54959380 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000371356 | 54963742 | 54963840 | 3UTR-3UTR |
| ENST00000395911 | 54963742 | 54963840 | 3UTR-3UTR |
| ENST00000312783 | 54965611 | 54965721 | 3UTR-3UTR |
| ENST00000395914 | 54965611 | 54965721 | 3UTR-3UTR |
| ENST00000312783 | 54948463 | 54948612 | Frame-shift |
| ENST00000347343 | 54948463 | 54948612 | Frame-shift |
| ENST00000371356 | 54948463 | 54948612 | Frame-shift |
| ENST00000395911 | 54948463 | 54948612 | Frame-shift |
| ENST00000395913 | 54948463 | 54948612 | Frame-shift |
| ENST00000395914 | 54948463 | 54948612 | Frame-shift |
| ENST00000395915 | 54948463 | 54948612 | Frame-shift |
| ENST00000312783 | 54959325 | 54959380 | Frame-shift |
| ENST00000347343 | 54959325 | 54959380 | Frame-shift |
| ENST00000371356 | 54959325 | 54959380 | Frame-shift |
| ENST00000395911 | 54959325 | 54959380 | Frame-shift |
| ENST00000395913 | 54959325 | 54959380 | Frame-shift |
| ENST00000395914 | 54959325 | 54959380 | Frame-shift |
| ENST00000395915 | 54959325 | 54959380 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for AURKA |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for AURKA |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_358223 | 54959326 | 54959380 | 54959341 | 54959341 | Frame_Shift_Del | T | - | p.N120fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| M14_SKIN | 54948464 | 54948612 | 54948582 | 54948582 | Missense_Mutation | A | G | p.Y246H |
| MDAMB435S_SKIN | 54948464 | 54948612 | 54948582 | 54948582 | Missense_Mutation | A | G | p.Y246H |
| COLO684_ENDOMETRIUM | 54959326 | 54959380 | 54959371 | 54959371 | Missense_Mutation | G | T | p.P110H |
| COLO704_OVARY | 54959326 | 54959380 | 54959371 | 54959371 | Missense_Mutation | G | T | p.P110H |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for AURKA |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for AURKA |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for AURKA |
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RelatedDrugs for AURKA |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| O14965 | DB12010 | Fostamatinib | Aurora kinase A | small molecule | approved|investigational |
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RelatedDiseases for AURKA |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| AURKA | C0002938 | Aneuploidy | 1 | CTD_human |
| AURKA | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| AURKA | C0022665 | Kidney Neoplasm | 1 | CTD_human |
| AURKA | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| AURKA | C0025202 | melanoma | 1 | CTD_human |
| AURKA | C0027819 | Neuroblastoma | 1 | CTD_human |
| AURKA | C0031117 | Peripheral Neuropathy | 1 | CTD_human |
| AURKA | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| AURKA | C1257806 | Chromosomal Instability | 1 | CTD_human |
| AURKA | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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