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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for STK4 |
 Gene summary |
| Gene information | Gene symbol | STK4 | Gene ID | 6789 |
| Gene name | serine/threonine kinase 4 | |
| Synonyms | KRS2|MST1|YSK3 | |
| Cytomap | 20q13.12 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase 4STE20-like kinase MST1kinase responsive to stress 2mammalian STE20-like protein kinase 1mammalian sterile 20-like 1serine/threonine-protein kinase Krs-2 | |
| Modification date | 20180523 | |
| UniProtAcc | Q13043 | |
| Context | PubMed: STK4 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| STK4 | GO:0000902 | cell morphogenesis | 11805089 |
| STK4 | GO:0001934 | positive regulation of protein phosphorylation | 19962960 |
| STK4 | GO:0006468 | protein phosphorylation | 8566796|11805089 |
| STK4 | GO:0006915 | apoptotic process | 21212262 |
| STK4 | GO:0018105 | peptidyl-serine phosphorylation | 16751106 |
| STK4 | GO:0032092 | positive regulation of protein binding | 22292086 |
| STK4 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 19962960 |
| STK4 | GO:0035329 | hippo signaling | 20412773 |
| STK4 | GO:0035556 | intracellular signal transduction | 8566796 |
| STK4 | GO:0043065 | positive regulation of apoptotic process | 15109305 |
| STK4 | GO:0046777 | protein autophosphorylation | 11805089 |
| STK4 | GO:0050821 | protein stabilization | 19962960 |
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Exon skipping events across known transcript of Ensembl for STK4 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for STK4 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for STK4 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_352358 | 20 | 43607083:43607212:43610469:43610584:43615772:43615937 | 43610469:43610584 | ENSG00000101109.7 | ENST00000396731.4,ENST00000372801.1,ENST00000474717.1,ENST00000372806.3 |
| exon_skip_352359 | 20 | 43610469:43610584:43615772:43615937:43623730:43623898 | 43615772:43615937 | ENSG00000101109.7 | ENST00000396731.4,ENST00000372801.1,ENST00000474717.1,ENST00000372806.3 |
| exon_skip_352361 | 20 | 43623730:43623898:43625809:43625947:43629032:43629161 | 43625809:43625947 | ENSG00000101109.7 | ENST00000396731.4,ENST00000372801.1,ENST00000499879.2,ENST00000372806.3 |
| exon_skip_352362 | 20 | 43653617:43653771:43681726:43681821:43703658:43704249 | 43681726:43681821 | ENSG00000101109.7 | ENST00000372801.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for STK4 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_352358 | 20 | 43607083:43607212:43610469:43610584:43615772:43615937 | 43610469:43610584 | ENSG00000101109.7 | ENST00000372806.3,ENST00000396731.4,ENST00000372801.1,ENST00000474717.1 |
| exon_skip_352359 | 20 | 43610469:43610584:43615772:43615937:43623730:43623898 | 43615772:43615937 | ENSG00000101109.7 | ENST00000372806.3,ENST00000396731.4,ENST00000372801.1,ENST00000474717.1 |
| exon_skip_352361 | 20 | 43623730:43623898:43625809:43625947:43629032:43629161 | 43625809:43625947 | ENSG00000101109.7 | ENST00000372806.3,ENST00000396731.4,ENST00000372801.1,ENST00000499879.2 |
| exon_skip_352362 | 20 | 43653617:43653771:43681726:43681821:43703658:43704249 | 43681726:43681821 | ENSG00000101109.7 | ENST00000372801.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for STK4 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000372806 | 43610469 | 43610584 | Frame-shift |
| ENST00000372806 | 43615772 | 43615937 | In-frame |
| ENST00000372806 | 43625809 | 43625947 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000372806 | 43610469 | 43610584 | Frame-shift |
| ENST00000372806 | 43615772 | 43615937 | In-frame |
| ENST00000372806 | 43625809 | 43625947 | In-frame |
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Infer the effects of exon skipping event on protein functional features for STK4 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000372806 | 6359 | 487 | 43615772 | 43615937 | 456 | 620 | 120 | 175 |
| ENST00000372806 | 6359 | 487 | 43625809 | 43625947 | 789 | 926 | 231 | 277 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000372806 | 6359 | 487 | 43615772 | 43615937 | 456 | 620 | 120 | 175 |
| ENST00000372806 | 6359 | 487 | 43625809 | 43625947 | 789 | 926 | 231 | 277 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13043 | 120 | 175 | 149 | 149 | Active site | Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q13043 | 120 | 175 | 155 | 157 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM |
| Q13043 | 120 | 175 | 163 | 165 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM |
| Q13043 | 120 | 175 | 1 | 487 | Chain | ID=PRO_0000086691;Note=Serine/threonine-protein kinase 4 |
| Q13043 | 120 | 175 | 1 | 326 | Chain | ID=PRO_0000413735;Note=Serine/threonine-protein kinase 4 37kDa subunit |
| Q13043 | 120 | 175 | 30 | 281 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q13043 | 120 | 175 | 123 | 142 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM |
| Q13043 | 120 | 175 | 152 | 154 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM |
| Q13043 | 120 | 175 | 175 | 175 | Mutagenesis | Note=No effect on activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15109305;Dbxref=PMID:15109305 |
| Q13043 | 120 | 175 | 162 | 162 | Natural variant | ID=VAR_041123;Note=H->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55850759,PMID:17344846 |
| Q13043 | 231 | 277 | 1 | 487 | Chain | ID=PRO_0000086691;Note=Serine/threonine-protein kinase 4 |
| Q13043 | 231 | 277 | 1 | 326 | Chain | ID=PRO_0000413735;Note=Serine/threonine-protein kinase 4 37kDa subunit |
| Q13043 | 231 | 277 | 30 | 281 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q13043 | 231 | 277 | 229 | 238 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM |
| Q13043 | 231 | 277 | 247 | 249 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM |
| Q13043 | 231 | 277 | 252 | 261 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM |
| Q13043 | 231 | 277 | 272 | 275 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM |
| Q13043 | 231 | 277 | 265 | 265 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976 |
| Q13043 | 231 | 277 | 266 | 268 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13043 | 120 | 175 | 149 | 149 | Active site | Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q13043 | 120 | 175 | 155 | 157 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM |
| Q13043 | 120 | 175 | 163 | 165 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM |
| Q13043 | 120 | 175 | 1 | 487 | Chain | ID=PRO_0000086691;Note=Serine/threonine-protein kinase 4 |
| Q13043 | 120 | 175 | 1 | 326 | Chain | ID=PRO_0000413735;Note=Serine/threonine-protein kinase 4 37kDa subunit |
| Q13043 | 120 | 175 | 30 | 281 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q13043 | 120 | 175 | 123 | 142 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM |
| Q13043 | 120 | 175 | 152 | 154 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM |
| Q13043 | 120 | 175 | 175 | 175 | Mutagenesis | Note=No effect on activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15109305;Dbxref=PMID:15109305 |
| Q13043 | 120 | 175 | 162 | 162 | Natural variant | ID=VAR_041123;Note=H->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55850759,PMID:17344846 |
| Q13043 | 231 | 277 | 1 | 487 | Chain | ID=PRO_0000086691;Note=Serine/threonine-protein kinase 4 |
| Q13043 | 231 | 277 | 1 | 326 | Chain | ID=PRO_0000413735;Note=Serine/threonine-protein kinase 4 37kDa subunit |
| Q13043 | 231 | 277 | 30 | 281 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q13043 | 231 | 277 | 229 | 238 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM |
| Q13043 | 231 | 277 | 247 | 249 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM |
| Q13043 | 231 | 277 | 252 | 261 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM |
| Q13043 | 231 | 277 | 272 | 275 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM |
| Q13043 | 231 | 277 | 265 | 265 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976 |
| Q13043 | 231 | 277 | 266 | 268 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM |
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SNVs in the skipped exons for STK4 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_352359 | 43615773 | 43615937 | 43615901 | 43615901 | Frame_Shift_Del | A | - | p.A163fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_352361 | 43625810 | 43625947 | 43625851 | 43625851 | Frame_Shift_Del | A | - | p.R245fs |
| HNSC | TCGA-4P-AA8J-01 | exon_skip_352359 | 43615773 | 43615937 | 43615932 | 43615933 | Frame_Shift_Ins | - | T | p.Y174fs |
| UCEC | TCGA-D1-A16X-01 | exon_skip_352358 | 43610470 | 43610584 | 43610567 | 43610567 | Nonsense_Mutation | C | T | p.R115* |
| UCEC | TCGA-B5-A0JZ-01 | exon_skip_352359 | 43615773 | 43615937 | 43615854 | 43615854 | Nonsense_Mutation | C | T | p.R148* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HEC6_ENDOMETRIUM | 43615773 | 43615937 | 43615843 | 43615844 | Frame_Shift_Ins | - | A | p.RK144fs |
| HCT15_LARGE_INTESTINE | 43610470 | 43610584 | 43610556 | 43610556 | Missense_Mutation | C | A | p.S111Y |
| NCIH2172_LUNG | 43610470 | 43610584 | 43610568 | 43610568 | Missense_Mutation | G | T | p.R115L |
| KHYG_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 43610470 | 43610584 | 43610574 | 43610574 | Missense_Mutation | G | A | p.R117Q |
| HUH1_LIVER | 43610470 | 43610584 | 43610574 | 43610574 | Missense_Mutation | G | A | p.R117Q |
| KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 43610470 | 43610584 | 43610574 | 43610574 | Missense_Mutation | G | A | p.R117Q |
| KP2_PANCREAS | 43610470 | 43610584 | 43610574 | 43610574 | Missense_Mutation | G | A | p.R117Q |
| MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 43610470 | 43610584 | 43610574 | 43610574 | Missense_Mutation | G | A | p.R117Q |
| OVMANA_OVARY | 43610470 | 43610584 | 43610574 | 43610574 | Missense_Mutation | G | A | p.R117Q |
| OVSAHO_OVARY | 43610470 | 43610584 | 43610574 | 43610574 | Missense_Mutation | G | A | p.R117Q |
| RKN_SOFT_TISSUE | 43610470 | 43610584 | 43610574 | 43610574 | Missense_Mutation | G | A | p.R117Q |
| CW2_LARGE_INTESTINE | 43610470 | 43610584 | 43610574 | 43610574 | Missense_Mutation | G | A | p.R117Q |
| KNS42_CENTRAL_NERVOUS_SYSTEM | 43610470 | 43610584 | 43610574 | 43610574 | Missense_Mutation | G | A | p.R117Q |
| RERFLCSQ1_LUNG | 43610470 | 43610584 | 43610574 | 43610574 | Missense_Mutation | G | A | p.R117Q |
| HPBALL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 43610470 | 43610584 | 43610580 | 43610580 | Missense_Mutation | A | G | p.K119R |
| NCIH1781_LUNG | 43625810 | 43625947 | 43625841 | 43625841 | Missense_Mutation | C | T | p.P242L |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for STK4 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STK4 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STK4 |
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RelatedDrugs for STK4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STK4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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