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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for STAT2 |
 Gene summary |
| Gene information | Gene symbol | STAT2 | Gene ID | 6773 |
| Gene name | signal transducer and activator of transcription 2 | |
| Synonyms | IMD44|ISGF-3|P113|STAT113 | |
| Cytomap | 12q13.3 | |
| Type of gene | protein-coding | |
| Description | signal transducer and activator of transcription 2interferon alpha induced transcriptional activatorsignal transducer and activator of transcription 2, 113kDa | |
| Modification date | 20180523 | |
| UniProtAcc | P52630 | |
| Context | PubMed: STAT2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for STAT2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for STAT2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for STAT2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_93640 | 12 | 56737868:56737919:56739929:56739987:56740225:56740408 | 56739929:56739987 | ENSG00000170581.9 | ENST00000314128.4,ENST00000556539.1,ENST00000555488.1,ENST00000557235.1 |
| exon_skip_93642 | 12 | 56742312:56742407:56742535:56742588:56742707:56742843 | 56742535:56742588 | ENSG00000170581.9 | ENST00000314128.4,ENST00000556539.1,ENST00000557235.1 |
| exon_skip_93662 | 12 | 56742781:56742843:56742946:56743045:56743209:56743283 | 56742946:56743045 | ENSG00000170581.9 | ENST00000314128.4,ENST00000556539.1,ENST00000557235.1 |
| exon_skip_93665 | 12 | 56743284:56743293:56743372:56743420:56743880:56743974 | 56743372:56743420 | ENSG00000170581.9 | ENST00000314128.4,ENST00000555519.1,ENST00000418572.2,ENST00000557235.1 |
| exon_skip_93669 | 12 | 56743372:56743420:56743880:56743974:56744195:56744216 | 56743880:56743974 | ENSG00000170581.9 | ENST00000314128.4,ENST00000418572.2,ENST00000557235.1 |
| exon_skip_93672 | 12 | 56743880:56743974:56744195:56744216:56744612:56744672 | 56744195:56744216 | ENSG00000170581.9 | ENST00000314128.4,ENST00000418572.2,ENST00000557235.1 |
| exon_skip_93677 | 12 | 56744960:56744974:56745075:56745234:56748249:56748291 | 56745075:56745234 | ENSG00000170581.9 | ENST00000314128.4,ENST00000418572.2,ENST00000556140.1,ENST00000557235.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for STAT2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_93640 | 12 | 56737868:56737919:56739929:56739987:56740225:56740408 | 56739929:56739987 | ENSG00000170581.9 | ENST00000556539.1,ENST00000314128.4,ENST00000557235.1,ENST00000555488.1 |
| exon_skip_93642 | 12 | 56742312:56742407:56742535:56742588:56742707:56742843 | 56742535:56742588 | ENSG00000170581.9 | ENST00000556539.1,ENST00000314128.4,ENST00000557235.1 |
| exon_skip_93662 | 12 | 56742781:56742843:56742946:56743045:56743209:56743283 | 56742946:56743045 | ENSG00000170581.9 | ENST00000556539.1,ENST00000314128.4,ENST00000557235.1 |
| exon_skip_93665 | 12 | 56743284:56743293:56743372:56743420:56743880:56743974 | 56743372:56743420 | ENSG00000170581.9 | ENST00000314128.4,ENST00000557235.1,ENST00000418572.2,ENST00000555519.1 |
| exon_skip_93669 | 12 | 56743372:56743420:56743880:56743974:56744195:56744216 | 56743880:56743974 | ENSG00000170581.9 | ENST00000314128.4,ENST00000557235.1,ENST00000418572.2 |
| exon_skip_93672 | 12 | 56743880:56743974:56744195:56744216:56744612:56744672 | 56744195:56744216 | ENSG00000170581.9 | ENST00000314128.4,ENST00000557235.1,ENST00000418572.2 |
| exon_skip_93677 | 12 | 56744960:56744974:56745075:56745234:56748249:56748291 | 56745075:56745234 | ENSG00000170581.9 | ENST00000314128.4,ENST00000557235.1,ENST00000418572.2,ENST00000556140.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for STAT2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for STAT2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for STAT2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_93662 | 56742947 | 56743045 | 56742966 | 56742966 | Frame_Shift_Del | A | - | p.L475fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_93669 | 56743881 | 56743974 | 56743906 | 56743906 | Frame_Shift_Del | C | - | p.G395fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_93677 | 56745076 | 56745234 | 56745142 | 56745142 | Frame_Shift_Del | G | - | p.P292fs |
| LUSC | TCGA-18-3409-01 | exon_skip_93642 | 56742536 | 56742588 | 56742562 | 56742563 | Frame_Shift_Ins | - | T | p.P534fs |
| HNSC | TCGA-BA-6871-01 | exon_skip_93669 | 56743881 | 56743974 | 56743976 | 56743977 | Splice_Site | TG | AA | p.G372_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| MOLT3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 56742536 | 56742588 | 56742571 | 56742572 | Frame_Shift_Del | CA | - | p.E532fs |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 56742536 | 56742588 | 56742571 | 56742572 | Frame_Shift_Del | CA | - | p.E532fs |
| HEC108_ENDOMETRIUM | 56739930 | 56739987 | 56739972 | 56739972 | Missense_Mutation | C | T | p.R687Q |
| WSUNHL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 56742536 | 56742588 | 56742557 | 56742557 | Missense_Mutation | C | A | p.L536F |
| MELHO_SKIN | 56742947 | 56743045 | 56743033 | 56743033 | Missense_Mutation | G | A | p.P452S |
| PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 56743881 | 56743974 | 56743915 | 56743915 | Missense_Mutation | T | C | p.Q392R |
| PC9_LUNG | 56745076 | 56745234 | 56745119 | 56745119 | Missense_Mutation | G | A | p.R300C |
| PC14_LUNG | 56745076 | 56745234 | 56745119 | 56745119 | Missense_Mutation | G | A | p.R300C |
| UACC257_SKIN | 56743373 | 56743420 | 56743373 | 56743373 | Splice_Site | C | T | p.K419K |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for STAT2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STAT2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STAT2 |
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RelatedDrugs for STAT2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STAT2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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