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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ST13 |
 Gene summary |
| Gene information | Gene symbol | ST13 | Gene ID | 6767 |
| Gene name | ST13, Hsp70 interacting protein | |
| Synonyms | AAG2|FAM10A1|FAM10A4|HIP|HOP|HSPABP|HSPABP1|P48|PRO0786|SNC6 | |
| Cytomap | 22q13.2 | |
| Type of gene | protein-coding | |
| Description | hsc70-interacting proteinHsp70-interacting proteinaging-associated protein 2heat shock 70kD protein binding proteinprogesterone receptor-associated p48 proteinputative tumor suppressor ST13renal carcinoma antigen NY-REN-33suppression of tumorigenic | |
| Modification date | 20180523 | |
| UniProtAcc | P50502 | |
| Context | PubMed: ST13 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for ST13 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ST13 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ST13 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_369735 | 22 | 41223224:41223233:41225629:41225678:41226843:41226954 | 41225629:41225678 | ENSG00000100380.8 | ENST00000216218.3,ENST00000455824.1,ENST00000480048.1 |
| exon_skip_369742 | 22 | 41225629:41225678:41226843:41226960:41228572:41228675 | 41226843:41226960 | ENSG00000100380.8 | ENST00000216218.3,ENST00000455824.1 |
| exon_skip_369743 | 22 | 41225629:41225678:41226843:41226960:41231563:41231674 | 41226843:41226960 | ENSG00000100380.8 | ENST00000480048.1 |
| exon_skip_369748 | 22 | 41226882:41226960:41228090:41228220:41228572:41228675 | 41228090:41228220 | ENSG00000100380.8 | ENST00000413424.1 |
| exon_skip_369749 | 22 | 41226882:41226960:41228572:41228675:41231563:41231674 | 41228572:41228675 | ENSG00000100380.8 | ENST00000216218.3,ENST00000455824.1 |
| exon_skip_369750 | 22 | 41231563:41231674:41231806:41231891:41236629:41236696 | 41231806:41231891 | ENSG00000100380.8 | ENST00000216218.3,ENST00000411695.1,ENST00000455824.1,ENST00000413424.1 |
| exon_skip_369752 | 22 | 41236629:41236696:41240842:41240913:41252434:41252620 | 41240842:41240913 | ENSG00000100380.8 | ENST00000455824.1 |
| exon_skip_369758 | 22 | 41240842:41240913:41244297:41244373:41246826:41246884 | 41244297:41244373 | ENSG00000100380.8 | ENST00000216218.3,ENST00000411695.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ST13 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_369735 | 22 | 41223224:41223233:41225629:41225678:41226843:41226954 | 41225629:41225678 | ENSG00000100380.8 | ENST00000216218.3,ENST00000480048.1,ENST00000455824.1 |
| exon_skip_369742 | 22 | 41225629:41225678:41226843:41226960:41228572:41228675 | 41226843:41226960 | ENSG00000100380.8 | ENST00000216218.3,ENST00000455824.1 |
| exon_skip_369743 | 22 | 41225629:41225678:41226843:41226960:41231563:41231674 | 41226843:41226960 | ENSG00000100380.8 | ENST00000480048.1 |
| exon_skip_369748 | 22 | 41226882:41226960:41228090:41228220:41228572:41228675 | 41228090:41228220 | ENSG00000100380.8 | ENST00000413424.1 |
| exon_skip_369749 | 22 | 41226882:41226960:41228572:41228675:41231563:41231674 | 41228572:41228675 | ENSG00000100380.8 | ENST00000216218.3,ENST00000455824.1 |
| exon_skip_369750 | 22 | 41231563:41231674:41231806:41231891:41236629:41236696 | 41231806:41231891 | ENSG00000100380.8 | ENST00000216218.3,ENST00000455824.1,ENST00000413424.1,ENST00000411695.1 |
| exon_skip_369752 | 22 | 41236629:41236696:41240842:41240913:41252434:41252620 | 41240842:41240913 | ENSG00000100380.8 | ENST00000455824.1 |
| exon_skip_369758 | 22 | 41240842:41240913:41244297:41244373:41246826:41246884 | 41244297:41244373 | ENSG00000100380.8 | ENST00000216218.3,ENST00000411695.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ST13 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000216218 | 41225629 | 41225678 | Frame-shift |
| ENST00000216218 | 41228572 | 41228675 | Frame-shift |
| ENST00000216218 | 41231806 | 41231891 | Frame-shift |
| ENST00000216218 | 41244297 | 41244373 | Frame-shift |
| ENST00000216218 | 41226843 | 41226960 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000216218 | 41225629 | 41225678 | Frame-shift |
| ENST00000216218 | 41228572 | 41228675 | Frame-shift |
| ENST00000216218 | 41231806 | 41231891 | Frame-shift |
| ENST00000216218 | 41244297 | 41244373 | Frame-shift |
| ENST00000216218 | 41226843 | 41226960 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ST13 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000216218 | 3612 | 369 | 41226843 | 41226960 | 1164 | 1280 | 227 | 266 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000216218 | 3612 | 369 | 41226843 | 41226960 | 1164 | 1280 | 227 | 266 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P50502 | 227 | 266 | 1 | 369 | Chain | ID=PRO_0000190811;Note=Hsc70-interacting protein |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P50502 | 227 | 266 | 1 | 369 | Chain | ID=PRO_0000190811;Note=Hsc70-interacting protein |
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SNVs in the skipped exons for ST13 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| UCEC | TCGA-BS-A0UV-01 | exon_skip_369742 exon_skip_369743 | 41226844 | 41226960 | 41226870 | 41226870 | Nonsense_Mutation | G | A | p.R258* |
| BLCA | TCGA-ZF-AA51-01 | exon_skip_369749 | 41228573 | 41228675 | 41228587 | 41228587 | Nonsense_Mutation | C | A | p.E223* |
| HNSC | TCGA-CR-6481-01 | exon_skip_369752 | 41240843 | 41240913 | 41240869 | 41240869 | Nonsense_Mutation | G | A | p.Q97* |
| HNSC | TCGA-CV-6441-01 | exon_skip_369752 | 41240843 | 41240913 | 41240914 | 41240914 | Splice_Site | C | T | p.E82_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HEC1A_ENDOMETRIUM | 41226844 | 41226960 | 41226867 | 41226867 | Missense_Mutation | C | T | p.E259K |
| SYO1_SOFT_TISSUE | 41226844 | 41226960 | 41226908 | 41226908 | Missense_Mutation | C | T | p.R245Q |
| L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 41226844 | 41226960 | 41226908 | 41226908 | Missense_Mutation | C | T | p.R245Q |
| SISO_CERVIX | 41231807 | 41231891 | 41231856 | 41231856 | Missense_Mutation | C | T | p.A140T |
| GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 41231807 | 41231891 | 41231856 | 41231856 | Missense_Mutation | C | T | p.A140T |
| SNU175_LARGE_INTESTINE | 41240843 | 41240913 | 41240847 | 41240847 | Missense_Mutation | G | A | p.A104V |
| BE2M17_AUTONOMIC_GANGLIA | 41240843 | 41240913 | 41240868 | 41240868 | Missense_Mutation | T | A | p.Q97L |
| CMK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 41244298 | 41244373 | 41244355 | 41244355 | Missense_Mutation | T | C | p.K63E |
| JHUEM7_ENDOMETRIUM | 41226844 | 41226960 | 41226870 | 41226870 | Nonsense_Mutation | G | A | p.R258* |
| SNU81_LARGE_INTESTINE | 41226844 | 41226960 | 41226870 | 41226870 | Nonsense_Mutation | G | A | p.R258* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ST13 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ST13 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ST13 |
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RelatedDrugs for ST13 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ST13 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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