ExonSkipDB: functional annotation of exon skipping event in human

Gene summary for SRC

Gene summary

Gene information	Gene symbol	SRC
	Gene ID	6714
	Gene name	SRC proto-oncogene, non-receptor tyrosine kinase
	Synonyms	ASV\|SRC1\|THC6\|c-SRC\|p60-Src
	Cytomap	20q11.23
	Type of gene	protein-coding
	Description	proto-oncogene tyrosine-protein kinase Srcproto-oncogene c-Srcprotooncogene SRC, Rous sarcomatyrosine kinase pp60c-srctyrosine-protein kinase SRC-1v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
	Modification date	20180527
	UniProtAcc	P12931
	Context	PubMed: SRC [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
SRC	GO:0018108	peptidyl-tyrosine phosphorylation	12051764\|22732588
SRC	GO:0035556	intracellular signal transduction	15248232
SRC	GO:0046777	protein autophosphorylation	16441665
SRC	GO:0071902	positive regulation of protein serine/threonine kinase activity	19059439

Top

Exon skipping events across known transcript of Ensembl for SRC from UCSC genome browser

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Gene isoform structures and expression levels for SRC

Expression levels of gene isoforms across TCGA.

Expression levels of gene isoforms across GTEx.

Top

Exon skipping events with PSIs in TCGA for SRC

Information of exkip skipping event in TCGA.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_351599	20	35993606:35993680:36011021:36011190:36012552:36012806	36011021:36011190	ENSG00000197122.7	ENST00000373578.2
exon_skip_351610	20	36011091:36011189:36012552:36012806:36014477:36014577	36012552:36012806	ENSG00000197122.7	ENST00000360723.4,ENST00000445403.1,ENST00000358208.4
exon_skip_351615	20	36014477:36014577:36014862:36014880:36022297:36022396	36014862:36014880	ENSG00000197122.7	ENST00000360723.4,ENST00000373558.2
exon_skip_351616	20	36014477:36014577:36022297:36022396:36022576:36022680	36022297:36022396	ENSG00000197122.7	ENST00000445403.1,ENST00000373567.2,ENST00000373578.2,ENST00000358208.4
exon_skip_351619	20	36024564:36024714:36026101:36026257:36028517:36028697	36026101:36026257	ENSG00000197122.7	ENST00000360723.4,ENST00000445403.1,ENST00000373567.2,ENST00000373558.2,ENST00000373578.2,ENST00000358208.4
exon_skip_351622	20	36028653:36028697:36030004:36030081:36030837:36030991	36030004:36030081	ENSG00000197122.7	ENST00000477066.1,ENST00000360723.4,ENST00000445403.1,ENST00000373567.2,ENST00000373558.2,ENST00000373578.2,ENST00000358208.4

PSI values of skipped exons in TCGA.

Top

Exon skipping events with PSIs in GTEx for SRC

Information of exkip skipping event in GTEx

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_351599	20	35993606:35993680:36011021:36011190:36012552:36012806	36011021:36011190	ENSG00000197122.7	ENST00000373578.2
exon_skip_351610	20	36011091:36011189:36012552:36012806:36014477:36014577	36012552:36012806	ENSG00000197122.7	ENST00000445403.1,ENST00000360723.4,ENST00000358208.4
exon_skip_351615	20	36014477:36014577:36014862:36014880:36022297:36022396	36014862:36014880	ENSG00000197122.7	ENST00000360723.4,ENST00000373558.2
exon_skip_351619	20	36024564:36024714:36026101:36026257:36028517:36028697	36026101:36026257	ENSG00000197122.7	ENST00000445403.1,ENST00000373578.2,ENST00000360723.4,ENST00000358208.4,ENST00000373567.2,ENST00000373558.2
exon_skip_351622	20	36028653:36028697:36030004:36030081:36030837:36030991	36030004:36030081	ENSG00000197122.7	ENST00000445403.1,ENST00000373578.2,ENST00000360723.4,ENST00000358208.4,ENST00000373567.2,ENST00000373558.2,ENST00000477066.1

PSI values of skipped exons in GTEx.

* Skipped exon sequences.

Top

Open reading frame (ORF) annotation in the exon skipping event for SRC

Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000358208	36012552	36012806	5CDS-5UTR
ENST00000373578	36011021	36011190	5UTR-5UTR
ENST00000358208	36030004	36030081	Frame-shift
ENST00000373567	36030004	36030081	Frame-shift
ENST00000373578	36030004	36030081	Frame-shift
ENST00000358208	36022297	36022396	In-frame
ENST00000373567	36022297	36022396	In-frame
ENST00000373578	36022297	36022396	In-frame
ENST00000358208	36026101	36026257	In-frame
ENST00000373567	36026101	36026257	In-frame
ENST00000373578	36026101	36026257	In-frame

Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000358208	36012552	36012806	5CDS-5UTR
ENST00000373578	36011021	36011190	5UTR-5UTR
ENST00000358208	36030004	36030081	Frame-shift
ENST00000373567	36030004	36030081	Frame-shift
ENST00000373578	36030004	36030081	Frame-shift
ENST00000358208	36026101	36026257	In-frame
ENST00000373567	36026101	36026257	In-frame
ENST00000373578	36026101	36026257	In-frame

Top

Infer the effects of exon skipping event on protein functional features for SRC

Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.

Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000358208	3765	536	36022297	36022396	453	551	117	149
ENST00000373567	4338	536	36022297	36022396	390	488	117	149
ENST00000373578	4648	536	36022297	36022396	700	798	117	149
ENST00000358208	3765	536	36026101	36026257	806	961	234	286
ENST00000373567	4338	536	36026101	36026257	743	898	234	286
ENST00000373578	4648	536	36026101	36026257	1053	1208	234	286

Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000358208	3765	536	36026101	36026257	806	961	234	286
ENST00000373567	4338	536	36026101	36026257	743	898	234	286
ENST00000373578	4648	536	36026101	36026257	1053	1208	234	286

Lost protein functional features of individual exon skipping events in TCGA.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P12931	117	149	117	117	Alternative sequence	ID=VSP_012134;Note=In isoform 2. T->TRKVDVR;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:2681803;Dbxref=PMID:2681803
P12931	117	149	117	117	Alternative sequence	ID=VSP_012134;Note=In isoform 2. T->TRKVDVR;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:2681803;Dbxref=PMID:2681803
P12931	117	149	117	117	Alternative sequence	ID=VSP_012134;Note=In isoform 2. T->TRKVDVR;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:2681803;Dbxref=PMID:2681803
P12931	117	149	118	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	117	149	118	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	117	149	118	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	117	149	132	136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	117	149	132	136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	117	149	132	136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	117	149	140	142	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	117	149	140	142	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	117	149	140	142	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	117	149	2	536	Chain	ID=PRO_0000088141;Note=Proto-oncogene tyrosine-protein kinase Src
P12931	117	149	2	536	Chain	ID=PRO_0000088141;Note=Proto-oncogene tyrosine-protein kinase Src
P12931	117	149	2	536	Chain	ID=PRO_0000088141;Note=Proto-oncogene tyrosine-protein kinase Src
P12931	117	149	84	145	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00192
P12931	117	149	84	145	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00192
P12931	117	149	84	145	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00192
P12931	117	149	137	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	117	149	137	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	117	149	137	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	117	149	146	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	117	149	146	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	117	149	146	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	117	149	127	129	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	117	149	127	129	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	117	149	127	129	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	240	242	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	240	242	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	240	242	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	256	259	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	256	259	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	256	259	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	270	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	270	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	270	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	283	289	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	283	289	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	283	289	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	2	536	Chain	ID=PRO_0000088141;Note=Proto-oncogene tyrosine-protein kinase Src
P12931	234	286	2	536	Chain	ID=PRO_0000088141;Note=Proto-oncogene tyrosine-protein kinase Src
P12931	234	286	2	536	Chain	ID=PRO_0000088141;Note=Proto-oncogene tyrosine-protein kinase Src
P12931	234	286	151	248	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00191
P12931	234	286	151	248	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00191
P12931	234	286	151	248	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00191
P12931	234	286	270	523	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P12931	234	286	270	523	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P12931	234	286	270	523	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P12931	234	286	267	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	267	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	267	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	237	237	Natural variant	ID=VAR_041830;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs34881773,PMID:17344846
P12931	234	286	237	237	Natural variant	ID=VAR_041830;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs34881773,PMID:17344846
P12931	234	286	237	237	Natural variant	ID=VAR_041830;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs34881773,PMID:17344846
P12931	234	286	276	284	Nucleotide binding	Note=ATP
P12931	234	286	276	284	Nucleotide binding	Note=ATP
P12931	234	286	276	284	Nucleotide binding	Note=ATP

Lost protein functional features of individual exon skipping events in GTEx.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P12931	234	286	240	242	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	240	242	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	240	242	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	256	259	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	256	259	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	256	259	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	270	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	270	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	270	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	283	289	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	283	289	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	283	289	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	2	536	Chain	ID=PRO_0000088141;Note=Proto-oncogene tyrosine-protein kinase Src
P12931	234	286	2	536	Chain	ID=PRO_0000088141;Note=Proto-oncogene tyrosine-protein kinase Src
P12931	234	286	2	536	Chain	ID=PRO_0000088141;Note=Proto-oncogene tyrosine-protein kinase Src
P12931	234	286	151	248	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00191
P12931	234	286	151	248	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00191
P12931	234	286	151	248	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00191
P12931	234	286	270	523	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P12931	234	286	270	523	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P12931	234	286	270	523	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P12931	234	286	267	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	267	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	267	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FMK
P12931	234	286	237	237	Natural variant	ID=VAR_041830;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs34881773,PMID:17344846
P12931	234	286	237	237	Natural variant	ID=VAR_041830;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs34881773,PMID:17344846
P12931	234	286	237	237	Natural variant	ID=VAR_041830;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs34881773,PMID:17344846
P12931	234	286	276	284	Nucleotide binding	Note=ATP
P12931	234	286	276	284	Nucleotide binding	Note=ATP
P12931	234	286	276	284	Nucleotide binding	Note=ATP

Top

SNVs in the skipped exons for SRC

- Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.

- Differential PSIs between mutated versus non-mutated samples.

- Non-synonymous mutations located in the skipped exons in TCGA.

Cancer type	Sample	ESID	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
STAD	TCGA-FP-A4BE-01	exon_skip_351610	36012553	36012806	36012784	36012784	Frame_Shift_Del	G	-	p.P76fs

- Depth of coverage in the three exons composing exon skipping event

Depth of coverage in three exons

Mutation description

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
KM12_LARGE_INTESTINE	36026102	36026257	36026165	36026166	Frame_Shift_Del	AG	-	p.Q256fs
BICR18_UPPER_AERODIGESTIVE_TRACT	36012553	36012806	36012728	36012730	In_Frame_Del	GCC	-	p.A59del
BFTC905_URINARY_TRACT	36012553	36012806	36012609	36012609	Missense_Mutation	T	G	p.L18R
CAOV4_OVARY	36012553	36012806	36012609	36012609	Missense_Mutation	T	G	p.L18R
HSC3_UPPER_AERODIGESTIVE_TRACT	36012553	36012806	36012609	36012609	Missense_Mutation	T	G	p.L18R
CHP126_AUTONOMIC_GANGLIA	36012553	36012806	36012629	36012629	Missense_Mutation	C	G	p.H25D
KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	36012553	36012806	36012629	36012629	Missense_Mutation	C	T	p.H25Y
ALLSIL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	36012553	36012806	36012651	36012651	Missense_Mutation	T	C	p.F32S
CORL303_LUNG	36012553	36012806	36012651	36012651	Missense_Mutation	T	C	p.F32S
CROAP2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	36012553	36012806	36012651	36012651	Missense_Mutation	T	C	p.F32S
TYKNU_OVARY	36012553	36012806	36012651	36012651	Missense_Mutation	T	C	p.F32S
HSC2_UPPER_AERODIGESTIVE_TRACT	36012553	36012806	36012665	36012665	Missense_Mutation	A	C	p.T37P
TYKNU_OVARY	36012553	36012806	36012665	36012665	Missense_Mutation	A	C	p.T37P
MFE296_ENDOMETRIUM	36012553	36012806	36012798	36012798	Missense_Mutation	C	A	p.P81Q
HT115_LARGE_INTESTINE	36012553	36012806	36012803	36012803	Missense_Mutation	G	T	p.A83S
RCHACV_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	36022298	36022396	36022365	36022365	Missense_Mutation	G	A	p.V140M
MOLT16_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	36026102	36026257	36026147	36026147	Missense_Mutation	C	T	p.T250M
HCC2450_LUNG	36026102	36026257	36026164	36026164	Missense_Mutation	C	G	p.Q256E
MFE319_ENDOMETRIUM	36026102	36026257	36026165	36026165	Missense_Mutation	A	G	p.Q256R
BICR18_UPPER_AERODIGESTIVE_TRACT	36012553	36012806	36012805	36012805	Splice_Site	C	A	p.A83A

Top

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SRC

sQTL information located at the skipped exons.

Exon skip ID

Chromosome

Three exons

Skippped exon

ENST

Cancer type

SNP id

Location

DNA change (ref/var)

P-value

Top

Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SRC

Top

Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SRC

Top

RelatedDrugs for SRC

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
	P12931	DB06616	Bosutinib	Proto-oncogene tyrosine-protein kinase Src	small molecule	approved
	P12931	DB09079	Nintedanib	Proto-oncogene tyrosine-protein kinase Src	small molecule	approved
	P12931	DB01254	Dasatinib	Proto-oncogene tyrosine-protein kinase Src	small molecule	approved\|investigational
	P12931	DB08901	Ponatinib	Proto-oncogene tyrosine-protein kinase Src	small molecule	approved\|investigational
	P12931	DB12010	Fostamatinib	Proto-oncogene tyrosine-protein kinase Src	small molecule	approved\|investigational
	P12931	DB04272	Citric Acid	Proto-oncogene tyrosine-protein kinase Src	small molecule	approved\|nutraceutical\|vet_approved

Top

RelatedDiseases for SRC

Diseases associated with this gene.
(DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
SRC	C0005695	Bladder Neoplasm	2	CTD_human
SRC	C0027626	Neoplasm Invasiveness	2	CTD_human
SRC	C0009319	Colitis	1	CTD_human
SRC	C0009375	Colonic Neoplasms	1	CTD_human
SRC	C0018800	Cardiomegaly	1	CTD_human
SRC	C0038220	Status Epilepticus	1	CTD_human
SRC	C0085548	Autosomal Recessive Polycystic Kidney Disease	1	CTD_human
SRC	C1458155	Mammary Neoplasms	1	CTD_human

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in TCGA
	Exon skipping events with PSIs in GTEx
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	SNVs in the skipped exons with depth of coverage
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Splicing Quantitative Trait Methylation (sQTM) in the skipped exon
	Related drugs with this gene
	Related diseases with this gene

Home

Download

Statistics

Landscape

Help

Contact