ExonSkipDB: functional annotation of exon skipping event in human

Gene summary for STK33

Gene summary

Gene information	Gene symbol	STK33
	Gene ID	65975
	Gene name	serine/threonine kinase 33
	Synonyms	-
	Cytomap	11p15.4
	Type of gene	protein-coding
	Description	serine/threonine-protein kinase 33
	Modification date	20180523
	UniProtAcc	Q9BYT3
	Context	PubMed: STK33 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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Exon skipping events across known transcript of Ensembl for STK33 from UCSC genome browser

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Gene isoform structures and expression levels for STK33

Expression levels of gene isoforms across TCGA.

Expression levels of gene isoforms across GTEx.

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Exon skipping events with PSIs in TCGA for STK33

Information of exkip skipping event in TCGA.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_68601	11	8413733:8414257:8435041:8435239:8457040:8457126	8435041:8435239	ENSG00000130413.11	ENST00000396672.1,ENST00000315204.1,ENST00000534493.1,ENST00000447869.1,ENST00000473980.1,ENST00000358872.3,ENST00000486305.2
exon_skip_68602	11	8457573:8457686:8462224:8462300:8474368:8474453	8462224:8462300	ENSG00000130413.11	ENST00000396672.1,ENST00000315204.1,ENST00000396673.1,ENST00000534493.1,ENST00000447869.1,ENST00000526517.1,ENST00000358872.3,ENST00000486305.2,ENST00000444064.2
exon_skip_68604	11	8483351:8483456:8486255:8486369:8494709:8494823	8486255:8486369	ENSG00000130413.11	ENST00000396672.1,ENST00000315204.1,ENST00000396673.1,ENST00000457885.2,ENST00000534493.1,ENST00000447869.1,ENST00000418597.1,ENST00000422559.2
exon_skip_68605	11	8486255:8486369:8494709:8494823:8496227:8496302	8494709:8494823	ENSG00000130413.11	ENST00000396672.1,ENST00000315204.1,ENST00000396673.1,ENST00000457885.2,ENST00000534493.1,ENST00000447869.1,ENST00000418597.1,ENST00000422559.2
exon_skip_68616	11	8496227:8496363:8502080:8502161:8615629:8615702	8502080:8502161	ENSG00000130413.11	ENST00000422559.2
exon_skip_68618	11	8496365:8496613:8498233:8498298:8498796:8498830	8498233:8498298	ENSG00000130413.11	ENST00000431279.2
exon_skip_68632	11	8496365:8496613:8502080:8502161:8615629:8615702	8502080:8502161	ENSG00000130413.11	ENST00000454443.2
exon_skip_68633	11	8496365:8496613:8554894:8555043:8615290:8615503	8554894:8555043	ENSG00000130413.11	ENST00000315204.1,ENST00000396673.1
exon_skip_68635	11	8496194:8496613:8602360:8602507:8615290:8615532	8602360:8602507	ENSG00000130413.11	ENST00000532336.1

PSI values of skipped exons in TCGA.

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Exon skipping events with PSIs in GTEx for STK33

Information of exkip skipping event in GTEx

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_68601	11	8413733:8414257:8435041:8435239:8457040:8457126	8435041:8435239	ENSG00000130413.11	ENST00000473980.1,ENST00000486305.2,ENST00000447869.1,ENST00000315204.1,ENST00000396672.1,ENST00000358872.3,ENST00000534493.1
exon_skip_68602	11	8457573:8457686:8462224:8462300:8474368:8474453	8462224:8462300	ENSG00000130413.11	ENST00000486305.2,ENST00000447869.1,ENST00000315204.1,ENST00000396672.1,ENST00000358872.3,ENST00000396673.1,ENST00000444064.2,ENST00000534493.1,ENST00000526517.1
exon_skip_68605	11	8486255:8486369:8494709:8494823:8496227:8496302	8494709:8494823	ENSG00000130413.11	ENST00000447869.1,ENST00000315204.1,ENST00000396672.1,ENST00000396673.1,ENST00000534493.1,ENST00000418597.1,ENST00000422559.2,ENST00000457885.2
exon_skip_68616	11	8496227:8496363:8502080:8502161:8615629:8615702	8502080:8502161	ENSG00000130413.11	ENST00000422559.2
exon_skip_68618	11	8496365:8496613:8498233:8498298:8498796:8498830	8498233:8498298	ENSG00000130413.11	ENST00000431279.2
exon_skip_68632	11	8496365:8496613:8502080:8502161:8615629:8615702	8502080:8502161	ENSG00000130413.11	ENST00000454443.2
exon_skip_68633	11	8496365:8496613:8554894:8555043:8615290:8615503	8554894:8555043	ENSG00000130413.11	ENST00000315204.1,ENST00000396673.1
exon_skip_68635	11	8496194:8496613:8602360:8602507:8615290:8615532	8602360:8602507	ENSG00000130413.11	ENST00000532336.1
exon_skip_68639	11	8498796:8498830:8502080:8502161:8615290:8615503	8502080:8502161	ENSG00000130413.11	ENST00000431279.2

PSI values of skipped exons in GTEx.

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for STK33

Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000315204	8554894	8555043	3UTR-3UTR
ENST00000315204	8462224	8462300	Frame-shift
ENST00000396672	8462224	8462300	Frame-shift
ENST00000447869	8462224	8462300	Frame-shift
ENST00000315204	8435041	8435239	In-frame
ENST00000396672	8435041	8435239	In-frame
ENST00000447869	8435041	8435239	In-frame
ENST00000315204	8486255	8486369	In-frame
ENST00000396672	8486255	8486369	In-frame
ENST00000447869	8486255	8486369	In-frame
ENST00000315204	8494709	8494823	In-frame
ENST00000396672	8494709	8494823	In-frame
ENST00000447869	8494709	8494823	In-frame

Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000315204	8554894	8555043	3UTR-3UTR
ENST00000315204	8462224	8462300	Frame-shift
ENST00000396672	8462224	8462300	Frame-shift
ENST00000447869	8462224	8462300	Frame-shift
ENST00000315204	8435041	8435239	In-frame
ENST00000396672	8435041	8435239	In-frame
ENST00000447869	8435041	8435239	In-frame
ENST00000315204	8494709	8494823	In-frame
ENST00000396672	8494709	8494823	In-frame
ENST00000447869	8494709	8494823	In-frame

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Infer the effects of exon skipping event on protein functional features for STK33

Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.

Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000315204	2724	514	8494709	8494823	749	862	75	113
ENST00000396672	2575	514	8494709	8494823	600	713	75	113
ENST00000447869	3120	514	8494709	8494823	1145	1258	75	113
ENST00000315204	2724	514	8486255	8486369	863	976	113	151
ENST00000396672	2575	514	8486255	8486369	714	827	113	151
ENST00000447869	3120	514	8486255	8486369	1259	1372	113	151
ENST00000315204	2724	514	8435041	8435239	1670	1867	382	448
ENST00000396672	2575	514	8435041	8435239	1521	1718	382	448
ENST00000447869	3120	514	8435041	8435239	2066	2263	382	448

Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000315204	2724	514	8494709	8494823	749	862	75	113
ENST00000396672	2575	514	8494709	8494823	600	713	75	113
ENST00000447869	3120	514	8494709	8494823	1145	1258	75	113
ENST00000315204	2724	514	8435041	8435239	1670	1867	382	448
ENST00000396672	2575	514	8435041	8435239	1521	1718	382	448
ENST00000447869	3120	514	8435041	8435239	2066	2263	382	448

Lost protein functional features of individual exon skipping events in TCGA.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q9BYT3	75	113	1	514	Chain	ID=PRO_0000232644;Note=Serine/threonine-protein kinase 33
Q9BYT3	75	113	1	514	Chain	ID=PRO_0000232644;Note=Serine/threonine-protein kinase 33
Q9BYT3	75	113	1	514	Chain	ID=PRO_0000232644;Note=Serine/threonine-protein kinase 33
Q9BYT3	75	113	98	98	Natural variant	ID=VAR_041172;Note=E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs34525052,PMID:17344846
Q9BYT3	75	113	98	98	Natural variant	ID=VAR_041172;Note=E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs34525052,PMID:17344846
Q9BYT3	75	113	98	98	Natural variant	ID=VAR_041172;Note=E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs34525052,PMID:17344846
Q9BYT3	113	151	145	145	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9BYT3	113	151	145	145	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9BYT3	113	151	145	145	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9BYT3	113	151	1	514	Chain	ID=PRO_0000232644;Note=Serine/threonine-protein kinase 33
Q9BYT3	113	151	1	514	Chain	ID=PRO_0000232644;Note=Serine/threonine-protein kinase 33
Q9BYT3	113	151	1	514	Chain	ID=PRO_0000232644;Note=Serine/threonine-protein kinase 33
Q9BYT3	113	151	116	381	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9BYT3	113	151	116	381	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9BYT3	113	151	116	381	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9BYT3	113	151	122	130	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9BYT3	113	151	122	130	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9BYT3	113	151	122	130	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9BYT3	382	448	383	448	Alternative sequence	ID=VSP_017939;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q9BYT3	382	448	383	448	Alternative sequence	ID=VSP_017939;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q9BYT3	382	448	383	448	Alternative sequence	ID=VSP_017939;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q9BYT3	382	448	1	514	Chain	ID=PRO_0000232644;Note=Serine/threonine-protein kinase 33
Q9BYT3	382	448	1	514	Chain	ID=PRO_0000232644;Note=Serine/threonine-protein kinase 33
Q9BYT3	382	448	1	514	Chain	ID=PRO_0000232644;Note=Serine/threonine-protein kinase 33
Q9BYT3	382	448	443	446	Compositional bias	Note=Poly-Glu
Q9BYT3	382	448	443	446	Compositional bias	Note=Poly-Glu
Q9BYT3	382	448	443	446	Compositional bias	Note=Poly-Glu
Q9BYT3	382	448	407	407	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q924X7
Q9BYT3	382	448	407	407	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q924X7
Q9BYT3	382	448	407	407	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q924X7
Q9BYT3	382	448	436	436	Natural variant	ID=VAR_041174;Note=D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs3751096,PMID:17344846
Q9BYT3	382	448	436	436	Natural variant	ID=VAR_041174;Note=D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs3751096,PMID:17344846
Q9BYT3	382	448	436	436	Natural variant	ID=VAR_041174;Note=D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs3751096,PMID:17344846
Q9BYT3	382	448	437	437	Natural variant	ID=VAR_041175;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs3751095,PMID:17344846
Q9BYT3	382	448	437	437	Natural variant	ID=VAR_041175;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs3751095,PMID:17344846
Q9BYT3	382	448	437	437	Natural variant	ID=VAR_041175;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs3751095,PMID:17344846
Q9BYT3	382	448	436	437	Sequence conflict	Note=DA->ET;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BYT3	382	448	436	437	Sequence conflict	Note=DA->ET;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BYT3	382	448	436	437	Sequence conflict	Note=DA->ET;Ontology_term=ECO:0000305;evidence=ECO:0000305

Lost protein functional features of individual exon skipping events in GTEx.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q9BYT3	75	113	1	514	Chain	ID=PRO_0000232644;Note=Serine/threonine-protein kinase 33
Q9BYT3	75	113	1	514	Chain	ID=PRO_0000232644;Note=Serine/threonine-protein kinase 33
Q9BYT3	75	113	1	514	Chain	ID=PRO_0000232644;Note=Serine/threonine-protein kinase 33
Q9BYT3	75	113	98	98	Natural variant	ID=VAR_041172;Note=E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs34525052,PMID:17344846
Q9BYT3	75	113	98	98	Natural variant	ID=VAR_041172;Note=E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs34525052,PMID:17344846
Q9BYT3	75	113	98	98	Natural variant	ID=VAR_041172;Note=E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs34525052,PMID:17344846
Q9BYT3	382	448	383	448	Alternative sequence	ID=VSP_017939;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q9BYT3	382	448	383	448	Alternative sequence	ID=VSP_017939;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q9BYT3	382	448	383	448	Alternative sequence	ID=VSP_017939;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q9BYT3	382	448	1	514	Chain	ID=PRO_0000232644;Note=Serine/threonine-protein kinase 33
Q9BYT3	382	448	1	514	Chain	ID=PRO_0000232644;Note=Serine/threonine-protein kinase 33
Q9BYT3	382	448	1	514	Chain	ID=PRO_0000232644;Note=Serine/threonine-protein kinase 33
Q9BYT3	382	448	443	446	Compositional bias	Note=Poly-Glu
Q9BYT3	382	448	443	446	Compositional bias	Note=Poly-Glu
Q9BYT3	382	448	443	446	Compositional bias	Note=Poly-Glu
Q9BYT3	382	448	407	407	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q924X7
Q9BYT3	382	448	407	407	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q924X7
Q9BYT3	382	448	407	407	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q924X7
Q9BYT3	382	448	436	436	Natural variant	ID=VAR_041174;Note=D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs3751096,PMID:17344846
Q9BYT3	382	448	436	436	Natural variant	ID=VAR_041174;Note=D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs3751096,PMID:17344846
Q9BYT3	382	448	436	436	Natural variant	ID=VAR_041174;Note=D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs3751096,PMID:17344846
Q9BYT3	382	448	437	437	Natural variant	ID=VAR_041175;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs3751095,PMID:17344846
Q9BYT3	382	448	437	437	Natural variant	ID=VAR_041175;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs3751095,PMID:17344846
Q9BYT3	382	448	437	437	Natural variant	ID=VAR_041175;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs3751095,PMID:17344846
Q9BYT3	382	448	436	437	Sequence conflict	Note=DA->ET;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BYT3	382	448	436	437	Sequence conflict	Note=DA->ET;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BYT3	382	448	436	437	Sequence conflict	Note=DA->ET;Ontology_term=ECO:0000305;evidence=ECO:0000305

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SNVs in the skipped exons for STK33

- Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.

- Differential PSIs between mutated versus non-mutated samples.

- Non-synonymous mutations located in the skipped exons in TCGA.

Cancer type	Sample	ESID	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
LIHC	TCGA-DD-A39Y-01	exon_skip_68605	8494710	8494823	8494774	8494774	Frame_Shift_Del	C	-	p.G92fs
SKCM	TCGA-EE-A183-06	exon_skip_68601	8435042	8435239	8435184	8435184	Nonsense_Mutation	C	T	p.W401*
THYM	TCGA-4V-A9QL-01	exon_skip_68602	8462225	8462300	8462251	8462251	Nonsense_Mutation	C	T	p.W307*
COAD	TCGA-AU-6004-01	exon_skip_68604	8486256	8486369	8486271	8486271	Nonsense_Mutation	T	-	p.V147X
UCEC	TCGA-B5-A11R-01	exon_skip_68605	8494710	8494823	8494810	8494810	Nonsense_Mutation	G	C	p.S80*
STAD	TCGA-VQ-A8P3-01	exon_skip_68605	8494710	8494823	8494817	8494817	Nonsense_Mutation	T	A	p.R78*
HNSC	TCGA-CQ-7069-01	exon_skip_68605	8494710	8494823	8494819	8494819	Nonsense_Mutation	G	C	p.S77*

- Depth of coverage in the three exons composing exon skipping event

Depth of coverage in three exons

Mutation description

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
MEWO_SKIN	8435042	8435239	8435050	8435050	Missense_Mutation	C	T	p.E446K
OSC20_UPPER_AERODIGESTIVE_TRACT	8435042	8435239	8435093	8435093	Missense_Mutation	C	A	p.W431C
HLFA_FIBROBLAST	8435042	8435239	8435214	8435214	Missense_Mutation	G	A	p.P391L
SNU81_LARGE_INTESTINE	8435042	8435239	8435226	8435226	Missense_Mutation	G	T	p.S387Y
SNU175_LARGE_INTESTINE	8462225	8462300	8462238	8462238	Missense_Mutation	C	T	p.V312I
LS411N_LARGE_INTESTINE	8462225	8462300	8462283	8462283	Missense_Mutation	C	T	p.A297T
MFE319_ENDOMETRIUM	8486256	8486369	8486281	8486281	Missense_Mutation	G	A	p.A143V
HEC251_ENDOMETRIUM	8486256	8486369	8486306	8486306	Missense_Mutation	C	A	p.D135Y
KMRC2_KIDNEY	8494710	8494823	8494748	8494748	Missense_Mutation	C	G	p.V101L
DMS153_LUNG	8494710	8494823	8494771	8494771	Missense_Mutation	C	T	p.R93Q
KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	8494710	8494823	8494771	8494771	Missense_Mutation	C	T	p.R93Q
KMRC2_KIDNEY	8494710	8494823	8494816	8494816	Missense_Mutation	C	T	p.R78K
NCIH2135_LUNG	8494710	8494823	8494819	8494819	Missense_Mutation	G	A	p.S77L
HCC2998_LARGE_INTESTINE	8494710	8494823	8494757	8494757	Nonsense_Mutation	C	A	p.E98*
NCIH1435_LUNG	8494710	8494823	8494802	8494802	Nonsense_Mutation	C	A	p.E83*
MFE319_ENDOMETRIUM	8435042	8435239	8435042	8435042	Splice_Site	C	T	p.Q448Q

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for STK33

sQTL information located at the skipped exons.

Exon skip ID	Chromosome	Three exons	Skippped exon	ENST	Cancer type	SNP id	Location	DNA change (ref/var)	P-value
exon_skip_68635	11	8496194:8496613:8602360:8602507:8615290:8615532	8602360:8602507	ENST00000532336.1	LGG	rs4131072	chr11:8602452	T/C	3.05e-04
exon_skip_68635	11	8496194:8496613:8602360:8602507:8615290:8615532	8602360:8602507	ENST00000532336.1	THCA	rs4131072	chr11:8602452	T/C	5.57e-05
exon_skip_68601	11	8413733:8414257:8435041:8435239:8457040:8457126	8435041:8435239	ENST00000396672.1,ENST00000315204.1,ENST00000534493.1,ENST00000447869.1,ENST00000473980.1,ENST00000358872.3,ENST00000486305.2	GBM	rs3751095	chr11:8435077	C/T	3.37e-05
exon_skip_68601	11	8413733:8414257:8435041:8435239:8457040:8457126	8435041:8435239	ENST00000396672.1,ENST00000315204.1,ENST00000534493.1,ENST00000447869.1,ENST00000473980.1,ENST00000358872.3,ENST00000486305.2	GBM	rs3751096	chr11:8435078	A/C	3.37e-05
exon_skip_68601	11	8413733:8414257:8435041:8435239:8457040:8457126	8435041:8435239	ENST00000396672.1,ENST00000315204.1,ENST00000534493.1,ENST00000447869.1,ENST00000473980.1,ENST00000358872.3,ENST00000486305.2	KIRP	rs3751095	chr11:8435077	C/T	2.22e-04
exon_skip_68601	11	8413733:8414257:8435041:8435239:8457040:8457126	8435041:8435239	ENST00000396672.1,ENST00000315204.1,ENST00000534493.1,ENST00000447869.1,ENST00000473980.1,ENST00000358872.3,ENST00000486305.2	KIRP	rs3751096	chr11:8435078	A/C	2.22e-04
exon_skip_68601	11	8413733:8414257:8435041:8435239:8457040:8457126	8435041:8435239	ENST00000396672.1,ENST00000315204.1,ENST00000534493.1,ENST00000447869.1,ENST00000473980.1,ENST00000358872.3,ENST00000486305.2	LGG	rs3751095	chr11:8435077	C/T	4.76e-12
exon_skip_68601	11	8413733:8414257:8435041:8435239:8457040:8457126	8435041:8435239	ENST00000396672.1,ENST00000315204.1,ENST00000534493.1,ENST00000447869.1,ENST00000473980.1,ENST00000358872.3,ENST00000486305.2	LGG	rs3751096	chr11:8435078	A/C	4.76e-12
exon_skip_68601	11	8413733:8414257:8435041:8435239:8457040:8457126	8435041:8435239	ENST00000396672.1,ENST00000315204.1,ENST00000534493.1,ENST00000447869.1,ENST00000473980.1,ENST00000358872.3,ENST00000486305.2	LGG	rs3751095	chr11:8435077	C/T	1.24e-06
exon_skip_68601	11	8413733:8414257:8435041:8435239:8457040:8457126	8435041:8435239	ENST00000396672.1,ENST00000315204.1,ENST00000534493.1,ENST00000447869.1,ENST00000473980.1,ENST00000358872.3,ENST00000486305.2	LGG	rs3751096	chr11:8435078	A/C	1.24e-06
exon_skip_68601	11	8413733:8414257:8435041:8435239:8457040:8457126	8435041:8435239	ENST00000396672.1,ENST00000315204.1,ENST00000534493.1,ENST00000447869.1,ENST00000473980.1,ENST00000358872.3,ENST00000486305.2	THCA	rs3751095	chr11:8435077	C/T	5.56e-15
exon_skip_68601	11	8413733:8414257:8435041:8435239:8457040:8457126	8435041:8435239	ENST00000396672.1,ENST00000315204.1,ENST00000534493.1,ENST00000447869.1,ENST00000473980.1,ENST00000358872.3,ENST00000486305.2	THCA	rs3751096	chr11:8435078	A/C	5.56e-15
exon_skip_68601	11	8413733:8414257:8435041:8435239:8457040:8457126	8435041:8435239	ENST00000396672.1,ENST00000315204.1,ENST00000534493.1,ENST00000447869.1,ENST00000473980.1,ENST00000358872.3,ENST00000486305.2	THCA	rs3751095	chr11:8435077	C/T	1.14e-04
exon_skip_68601	11	8413733:8414257:8435041:8435239:8457040:8457126	8435041:8435239	ENST00000396672.1,ENST00000315204.1,ENST00000534493.1,ENST00000447869.1,ENST00000473980.1,ENST00000358872.3,ENST00000486305.2	THCA	rs3751096	chr11:8435078	A/C	1.14e-04
exon_skip_68604	11	8483351:8483456:8486255:8486369:8494709:8494823	8486255:8486369	ENST00000396672.1,ENST00000315204.1,ENST00000396673.1,ENST00000457885.2,ENST00000534493.1,ENST00000447869.1,ENST00000418597.1,ENST00000422559.2	LGG	rs1446464	chr11:8486310	C/A	2.02e-04
exon_skip_68604	11	8483351:8483456:8486255:8486369:8494709:8494823	8486255:8486369	ENST00000396672.1,ENST00000315204.1,ENST00000396673.1,ENST00000457885.2,ENST00000534493.1,ENST00000447869.1,ENST00000418597.1,ENST00000422559.2	THCA	rs1446464	chr11:8486310	C/A	1.36e-03
exon_skip_68618	11	8496365:8496613:8498233:8498298:8498796:8498830	8498233:8498298	ENST00000431279.2	GBM	rs10840057	chr11:8498228	C/A	1.24e-06
exon_skip_68618	11	8496365:8496613:8498233:8498298:8498796:8498830	8498233:8498298	ENST00000431279.2	LGG	rs10840057	chr11:8498228	C/A	5.33e-19
exon_skip_68618	11	8496365:8496613:8498233:8498298:8498796:8498830	8498233:8498298	ENST00000431279.2	LGG	rs10840057	chr11:8498228	C/A	2.84e-06
exon_skip_68618	11	8496365:8496613:8498233:8498298:8498796:8498830	8498233:8498298	ENST00000431279.2	THCA	rs10840057	chr11:8498228	C/A	5.35e-18
exon_skip_68618	11	8496365:8496613:8498233:8498298:8498796:8498830	8498233:8498298	ENST00000431279.2	THCA	rs10840057	chr11:8498228	C/A	8.89e-04

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STK33

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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STK33

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RelatedDrugs for STK33

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
	Q9BYT3	DB12010	Fostamatinib	Serine/threonine-protein kinase 33	small molecule	approved\|investigational

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RelatedDiseases for STK33

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in TCGA
	Exon skipping events with PSIs in GTEx
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	SNVs in the skipped exons with depth of coverage
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Splicing Quantitative Trait Methylation (sQTM) in the skipped exon
	Related drugs with this gene
	Related diseases with this gene

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