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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for KIAA0895L |
 Gene summary |
| Gene information | Gene symbol | KIAA0895L | Gene ID | 653319 |
| Gene name | KIAA0895 like | |
| Synonyms | - | |
| Cytomap | 16q22.1 | |
| Type of gene | protein-coding | |
| Description | uncharacterized protein KIAA0895-like | |
| Modification date | 20180329 | |
| UniProtAcc | Q68EN5 | |
| Context | PubMed: KIAA0895L [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for KIAA0895L from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for KIAA0895L |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for KIAA0895L |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_145207 | 16 | 67210673:67210878:67211912:67212000:67212101:67212407 | 67211912:67212000 | ENSG00000196123.8 | ENST00000561621.1 |
| exon_skip_145209 | 16 | 67210673:67210878:67211912:67212010:67212101:67212407 | 67211912:67212010 | ENSG00000196123.8 | ENST00000290881.7,ENST00000569349.1,ENST00000563918.1,ENST00000563902.1,ENST00000561679.1 |
| exon_skip_145211 | 16 | 67212347:67212407:67213304:67213465:67213717:67213857 | 67213304:67213465 | ENSG00000196123.8 | ENST00000570009.1 |
| exon_skip_145212 | 16 | 67212347:67212407:67213332:67213465:67213717:67213857 | 67213332:67213465 | ENSG00000196123.8 | ENST00000290881.7,ENST00000569349.1,ENST00000563902.1,ENST00000561621.1,ENST00000568563.1 |
| exon_skip_145217 | 16 | 67214477:67214569:67215460:67215600:67217164:67217352 | 67215460:67215600 | ENSG00000196123.8 | ENST00000561621.1 |
| exon_skip_145220 | 16 | 67214477:67214569:67215508:67215600:67217164:67217352 | 67215508:67215600 | ENSG00000196123.8 | ENST00000290881.7 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for KIAA0895L |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_145207 | 16 | 67210673:67210878:67211912:67212000:67212101:67212407 | 67211912:67212000 | ENSG00000196123.8 | ENST00000561621.1 |
| exon_skip_145209 | 16 | 67210673:67210878:67211912:67212010:67212101:67212407 | 67211912:67212010 | ENSG00000196123.8 | ENST00000561679.1,ENST00000569349.1,ENST00000290881.7,ENST00000563918.1,ENST00000563902.1 |
| exon_skip_145211 | 16 | 67212347:67212407:67213304:67213465:67213717:67213857 | 67213304:67213465 | ENSG00000196123.8 | ENST00000570009.1 |
| exon_skip_145212 | 16 | 67212347:67212407:67213332:67213465:67213717:67213857 | 67213332:67213465 | ENSG00000196123.8 | ENST00000568563.1,ENST00000569349.1,ENST00000561621.1,ENST00000290881.7,ENST00000563902.1 |
| exon_skip_145217 | 16 | 67214477:67214569:67215460:67215600:67217164:67217352 | 67215460:67215600 | ENSG00000196123.8 | ENST00000561621.1 |
| exon_skip_145220 | 16 | 67214477:67214569:67215508:67215600:67217164:67217352 | 67215508:67215600 | ENSG00000196123.8 | ENST00000290881.7 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for KIAA0895L |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000290881 | 67215508 | 67215600 | 3UTR-3UTR |
| ENST00000290881 | 67211912 | 67212010 | Frame-shift |
| ENST00000563902 | 67211912 | 67212010 | Frame-shift |
| ENST00000290881 | 67213332 | 67213465 | Frame-shift |
| ENST00000563902 | 67213332 | 67213465 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000290881 | 67215508 | 67215600 | 3UTR-3UTR |
| ENST00000290881 | 67211912 | 67212010 | Frame-shift |
| ENST00000563902 | 67211912 | 67212010 | Frame-shift |
| ENST00000290881 | 67213332 | 67213465 | Frame-shift |
| ENST00000563902 | 67213332 | 67213465 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for KIAA0895L |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for KIAA0895L |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_145207 | 67211913 | 67212000 | 67211925 | 67211925 | Frame_Shift_Del | G | - | p.T413fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_145209 | 67211913 | 67212010 | 67211925 | 67211925 | Frame_Shift_Del | G | - | p.T413fs |
| BLCA | TCGA-K4-A3WU-01 | exon_skip_145212 exon_skip_145211 | 67213305 | 67213465 | 67213339 | 67213339 | Nonsense_Mutation | C | A | p.E281* |
| BLCA | TCGA-K4-A3WU-01 | exon_skip_145212 exon_skip_145211 | 67213333 | 67213465 | 67213339 | 67213339 | Nonsense_Mutation | C | A | p.E281* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SNUC2A_LARGE_INTESTINE | 67213333 | 67213465 | 67213348 | 67213348 | Missense_Mutation | G | C | p.L278V |
| SNUC2A_LARGE_INTESTINE | 67213305 | 67213465 | 67213348 | 67213348 | Missense_Mutation | G | C | p.L278V |
| SNUC2B_LARGE_INTESTINE | 67213333 | 67213465 | 67213348 | 67213348 | Missense_Mutation | G | C | p.L278V |
| SNUC2B_LARGE_INTESTINE | 67213305 | 67213465 | 67213348 | 67213348 | Missense_Mutation | G | C | p.L278V |
| HEC59_ENDOMETRIUM | 67213333 | 67213465 | 67213405 | 67213405 | Missense_Mutation | G | A | p.R259W |
| HEC59_ENDOMETRIUM | 67213305 | 67213465 | 67213405 | 67213405 | Missense_Mutation | G | A | p.R259W |
| KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 67213333 | 67213465 | 67213421 | 67213421 | Missense_Mutation | C | T | p.M253I |
| KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 67213305 | 67213465 | 67213421 | 67213421 | Missense_Mutation | C | T | p.M253I |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 67213333 | 67213465 | 67213462 | 67213462 | Missense_Mutation | C | G | p.V240L |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 67213305 | 67213465 | 67213462 | 67213462 | Missense_Mutation | C | G | p.V240L |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for KIAA0895L |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for KIAA0895L |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for KIAA0895L |
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RelatedDrugs for KIAA0895L |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KIAA0895L |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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