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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for INTS3 |
 Gene summary |
| Gene information | Gene symbol | INTS3 | Gene ID | 65123 |
| Gene name | integrator complex subunit 3 | |
| Synonyms | C1orf193|C1orf60|INT3|SOSS-A|SOSSA | |
| Cytomap | 1q21.3 | |
| Type of gene | protein-coding | |
| Description | integrator complex subunit 3SOSS complex subunit Asensor of single-strand DNA complex subunit Asensor of ssDNA subunit A | |
| Modification date | 20180519 | |
| UniProtAcc | Q68E01 | |
| Context | PubMed: INTS3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| INTS3 | GO:0016180 | snRNA processing | 16239144 |
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Exon skipping events across known transcript of Ensembl for INTS3 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for INTS3 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for INTS3 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_10615 | 1 | 153719432:153719546:153719754:153719839:153721164:153721231 | 153719754:153719839 | ENSG00000143624.9 | ENST00000456435.1,ENST00000435409.2,ENST00000318967.2 |
| exon_skip_10618 | 1 | 153723610:153723715:153724754:153724884:153726176:153726294 | 153724754:153724884 | ENSG00000143624.9 | ENST00000481797.1 |
| exon_skip_10619 | 1 | 153723610:153723715:153724754:153724884:153727117:153727215 | 153724754:153724884 | ENSG00000143624.9 | ENST00000476843.1,ENST00000456435.1,ENST00000435409.2,ENST00000318967.2,ENST00000512605.1 |
| exon_skip_10630 | 1 | 153724754:153724884:153726176:153726294:153727117:153727215 | 153726176:153726294 | ENSG00000143624.9 | ENST00000481797.1 |
| exon_skip_10632 | 1 | 153724754:153724884:153727117:153727215:153730047:153730239 | 153727117:153727215 | ENSG00000143624.9 | ENST00000476843.1,ENST00000456435.1,ENST00000435409.2,ENST00000318967.2,ENST00000480659.1,ENST00000512605.1 |
| exon_skip_10634 | 1 | 153727117:153727215:153730047:153730239:153732001:153732089 | 153730047:153730239 | ENSG00000143624.9 | ENST00000476843.1,ENST00000456435.1,ENST00000435409.2,ENST00000318967.2,ENST00000480659.1,ENST00000512605.1,ENST00000481797.1 |
| exon_skip_10635 | 1 | 153730112:153730239:153732001:153732089:153732786:153732866 | 153732001:153732089 | ENSG00000143624.9 | ENST00000476843.1,ENST00000456435.1,ENST00000435409.2,ENST00000318967.2,ENST00000480659.1,ENST00000512605.1,ENST00000481797.1 |
| exon_skip_10638 | 1 | 153730112:153730239:153734045:153734152:153735203:153735316 | 153734045:153734152 | ENSG00000143624.9 | ENST00000503133.1 |
| exon_skip_10639 | 1 | 153732786:153732866:153733302:153733394:153734045:153734152 | 153733302:153733394 | ENSG00000143624.9 | ENST00000456435.1,ENST00000435409.2,ENST00000318967.2,ENST00000512605.1,ENST00000481797.1 |
| exon_skip_10644 | 1 | 153733302:153733394:153733495:153733585:153734045:153734152 | 153733495:153733585 | ENSG00000143624.9 | ENST00000476843.1 |
| exon_skip_10645 | 1 | 153735203:153735323:153735708:153735838:153736307:153736362 | 153735708:153735838 | ENSG00000143624.9 | ENST00000476843.1,ENST00000456435.1,ENST00000435409.2,ENST00000318967.2,ENST00000512605.1,ENST00000481797.1,ENST00000503133.1 |
| exon_skip_10647 | 1 | 153735708:153735838:153736307:153736362:153736593:153736697 | 153736307:153736362 | ENSG00000143624.9 | ENST00000476843.1,ENST00000456435.1,ENST00000435409.2,ENST00000318967.2,ENST00000512605.1,ENST00000481797.1,ENST00000503133.1 |
| exon_skip_10654 | 1 | 153736307:153736362:153736593:153736697:153737165:153737210 | 153736593:153736697 | ENSG00000143624.9 | ENST00000476843.1,ENST00000456435.1,ENST00000435409.2,ENST00000318967.2,ENST00000512605.1,ENST00000481797.1,ENST00000503133.1 |
| exon_skip_10660 | 1 | 153740149:153740303:153741368:153741437:153742244:153742320 | 153741368:153741437 | ENSG00000143624.9 | ENST00000476843.1,ENST00000368669.1,ENST00000456435.1,ENST00000435409.2,ENST00000318967.2,ENST00000368670.1,ENST00000512605.1,ENST00000481797.1,ENST00000503133.1 |
| exon_skip_10665 | 1 | 153741368:153741437:153742244:153742320:153742673:153742787 | 153742244:153742320 | ENSG00000143624.9 | ENST00000476843.1,ENST00000368669.1,ENST00000456435.1,ENST00000435409.2,ENST00000318967.2,ENST00000368670.1,ENST00000512605.1,ENST00000481797.1,ENST00000503133.1 |
| exon_skip_10669 | 1 | 153742673:153742787:153743160:153743209:153744271:153744439 | 153743160:153743209 | ENSG00000143624.9 | ENST00000476843.1,ENST00000368669.1,ENST00000456435.1,ENST00000435409.2,ENST00000318967.2,ENST00000368670.1,ENST00000512605.1,ENST00000481797.1,ENST00000503133.1 |
| exon_skip_10672 | 1 | 153744271:153744439:153744815:153744916:153745114:153745187 | 153744815:153744916 | ENSG00000143624.9 | ENST00000476843.1,ENST00000435409.2,ENST00000318967.2,ENST00000368670.1,ENST00000481797.1,ENST00000503133.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for INTS3 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_10615 | 1 | 153719432:153719546:153719754:153719839:153721164:153721231 | 153719754:153719839 | ENSG00000143624.9 | ENST00000318967.2,ENST00000456435.1,ENST00000435409.2 |
| exon_skip_10618 | 1 | 153723610:153723715:153724754:153724884:153726176:153726294 | 153724754:153724884 | ENSG00000143624.9 | ENST00000481797.1 |
| exon_skip_10619 | 1 | 153723610:153723715:153724754:153724884:153727117:153727215 | 153724754:153724884 | ENSG00000143624.9 | ENST00000318967.2,ENST00000456435.1,ENST00000435409.2,ENST00000512605.1,ENST00000476843.1 |
| exon_skip_10630 | 1 | 153724754:153724884:153726176:153726294:153727117:153727215 | 153726176:153726294 | ENSG00000143624.9 | ENST00000481797.1 |
| exon_skip_10632 | 1 | 153724754:153724884:153727117:153727215:153730047:153730239 | 153727117:153727215 | ENSG00000143624.9 | ENST00000318967.2,ENST00000456435.1,ENST00000435409.2,ENST00000512605.1,ENST00000476843.1,ENST00000480659.1 |
| exon_skip_10634 | 1 | 153727117:153727215:153730047:153730239:153732001:153732089 | 153730047:153730239 | ENSG00000143624.9 | ENST00000318967.2,ENST00000456435.1,ENST00000435409.2,ENST00000481797.1,ENST00000512605.1,ENST00000476843.1,ENST00000480659.1 |
| exon_skip_10635 | 1 | 153730112:153730239:153732001:153732089:153732786:153732866 | 153732001:153732089 | ENSG00000143624.9 | ENST00000318967.2,ENST00000456435.1,ENST00000435409.2,ENST00000481797.1,ENST00000512605.1,ENST00000476843.1,ENST00000480659.1 |
| exon_skip_10638 | 1 | 153730112:153730239:153734045:153734152:153735203:153735316 | 153734045:153734152 | ENSG00000143624.9 | ENST00000503133.1 |
| exon_skip_10639 | 1 | 153732786:153732866:153733302:153733394:153734045:153734152 | 153733302:153733394 | ENSG00000143624.9 | ENST00000318967.2,ENST00000456435.1,ENST00000435409.2,ENST00000481797.1,ENST00000512605.1 |
| exon_skip_10644 | 1 | 153733302:153733394:153733495:153733585:153734045:153734152 | 153733495:153733585 | ENSG00000143624.9 | ENST00000476843.1 |
| exon_skip_10645 | 1 | 153735203:153735323:153735708:153735838:153736307:153736362 | 153735708:153735838 | ENSG00000143624.9 | ENST00000318967.2,ENST00000456435.1,ENST00000435409.2,ENST00000481797.1,ENST00000512605.1,ENST00000476843.1,ENST00000503133.1 |
| exon_skip_10647 | 1 | 153735708:153735838:153736307:153736362:153736593:153736697 | 153736307:153736362 | ENSG00000143624.9 | ENST00000318967.2,ENST00000456435.1,ENST00000435409.2,ENST00000481797.1,ENST00000512605.1,ENST00000476843.1,ENST00000503133.1 |
| exon_skip_10654 | 1 | 153736307:153736362:153736593:153736697:153737165:153737210 | 153736593:153736697 | ENSG00000143624.9 | ENST00000318967.2,ENST00000456435.1,ENST00000435409.2,ENST00000481797.1,ENST00000512605.1,ENST00000476843.1,ENST00000503133.1 |
| exon_skip_10660 | 1 | 153740149:153740303:153741368:153741437:153742244:153742320 | 153741368:153741437 | ENSG00000143624.9 | ENST00000318967.2,ENST00000456435.1,ENST00000435409.2,ENST00000481797.1,ENST00000512605.1,ENST00000476843.1,ENST00000503133.1,ENST00000368670.1,ENST00000368669.1 |
| exon_skip_10665 | 1 | 153741368:153741437:153742244:153742320:153742673:153742787 | 153742244:153742320 | ENSG00000143624.9 | ENST00000318967.2,ENST00000456435.1,ENST00000435409.2,ENST00000481797.1,ENST00000512605.1,ENST00000476843.1,ENST00000503133.1,ENST00000368670.1,ENST00000368669.1 |
| exon_skip_10669 | 1 | 153742673:153742787:153743160:153743209:153744271:153744439 | 153743160:153743209 | ENSG00000143624.9 | ENST00000318967.2,ENST00000456435.1,ENST00000435409.2,ENST00000481797.1,ENST00000512605.1,ENST00000476843.1,ENST00000503133.1,ENST00000368670.1,ENST00000368669.1 |
| exon_skip_10672 | 1 | 153744271:153744439:153744815:153744916:153745114:153745187 | 153744815:153744916 | ENSG00000143624.9 | ENST00000318967.2,ENST00000435409.2,ENST00000481797.1,ENST00000476843.1,ENST00000503133.1,ENST00000368670.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for INTS3 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for INTS3 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for INTS3 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_10634 | 153730048 | 153730239 | 153730064 | 153730064 | Frame_Shift_Del | A | - | p.Q119fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_10638 | 153734046 | 153734152 | 153734056 | 153734056 | Frame_Shift_Del | C | - | p.P268fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_10638 | 153734046 | 153734152 | 153734056 | 153734056 | Frame_Shift_Del | C | - | p.P268fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_10645 | 153735709 | 153735838 | 153735775 | 153735775 | Frame_Shift_Del | C | - | p.T362fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_10660 | 153741369 | 153741437 | 153741379 | 153741379 | Frame_Shift_Del | A | - | p.E546fs |
| STAD | TCGA-BR-6566-01 | exon_skip_10634 | 153730048 | 153730239 | 153730152 | 153730153 | Frame_Shift_Ins | - | G | p.C354fs |
| STAD | TCGA-BR-6566-01 | exon_skip_10634 | 153730048 | 153730239 | 153730153 | 153730154 | Frame_Shift_Ins | - | G | p.C354fs |
| BLCA | TCGA-CF-A1HS-01 | exon_skip_10618 exon_skip_10619 | 153724755 | 153724884 | 153724860 | 153724860 | Nonsense_Mutation | C | T | p.Q279* |
| UCEC | TCGA-AX-A06H-01 | exon_skip_10665 | 153742245 | 153742320 | 153742293 | 153742293 | Nonsense_Mutation | C | T | p.R788* |
| STAD | TCGA-BR-8591-01 | exon_skip_10645 | 153735709 | 153735838 | 153735839 | 153735839 | Splice_Site | G | A | . |
| STAD | TCGA-BR-8591-01 | exon_skip_10645 | 153735709 | 153735838 | 153735839 | 153735839 | Splice_Site | G | A | p.S589_splice |
| STAD | TCGA-BR-4370-01 | exon_skip_10672 | 153744816 | 153744916 | 153744815 | 153744815 | Splice_Site | G | A | . |
| STAD | TCGA-BR-4370-01 | exon_skip_10672 | 153744816 | 153744916 | 153744815 | 153744815 | Splice_Site | G | A | p.S907_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| L33_PANCREAS | 153741369 | 153741437 | 153741428 | 153741429 | Frame_Shift_Del | CT | - | p.S769fs |
| SW1417_LARGE_INTESTINE | 153719755 | 153719839 | 153719770 | 153719770 | Missense_Mutation | C | T | p.R150W |
| HEC1B_ENDOMETRIUM | 153724755 | 153724884 | 153724854 | 153724854 | Missense_Mutation | A | G | p.N277D |
| NCIH2066_LUNG | 153724755 | 153724884 | 153724863 | 153724863 | Missense_Mutation | G | T | p.A280S |
| OVK18_OVARY | 153727118 | 153727215 | 153727169 | 153727169 | Missense_Mutation | G | A | p.R304H |
| SKUT1_SOFT_TISSUE | 153730048 | 153730239 | 153730126 | 153730126 | Missense_Mutation | C | T | p.R346C |
| HEC1A_ENDOMETRIUM | 153730048 | 153730239 | 153730127 | 153730127 | Missense_Mutation | G | A | p.R346H |
| DV90_LUNG | 153730048 | 153730239 | 153730142 | 153730142 | Missense_Mutation | G | A | p.R351H |
| DJM1_SKIN | 153732002 | 153732089 | 153732018 | 153732018 | Missense_Mutation | C | G | p.S389C |
| SNU1040_LARGE_INTESTINE | 153733303 | 153733394 | 153733317 | 153733317 | Missense_Mutation | C | A | p.F444L |
| NCIH1770_LUNG | 153733303 | 153733394 | 153733336 | 153733336 | Missense_Mutation | C | T | p.H451Y |
| NCIH2106_LUNG | 153733303 | 153733394 | 153733336 | 153733336 | Missense_Mutation | C | T | p.H451Y |
| SNU1033_LARGE_INTESTINE | 153733303 | 153733394 | 153733339 | 153733339 | Missense_Mutation | G | A | p.V452M |
| KASUMI2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 153735709 | 153735838 | 153735721 | 153735721 | Missense_Mutation | A | G | p.E550G |
| NCIH727_LUNG | 153735709 | 153735838 | 153735726 | 153735726 | Missense_Mutation | C | A | p.R552S |
| MZ7MEL_SKIN | 153735709 | 153735838 | 153735783 | 153735783 | Missense_Mutation | C | T | p.L571F |
| HEC59_ENDOMETRIUM | 153735709 | 153735838 | 153735804 | 153735804 | Missense_Mutation | C | A | p.L578M |
| MOLT3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 153736308 | 153736362 | 153736345 | 153736345 | Missense_Mutation | G | A | p.V602M |
| DOTC24510_CERVIX | 153736594 | 153736697 | 153736600 | 153736600 | Missense_Mutation | T | C | p.F610L |
| DMS454_LUNG | 153741369 | 153741437 | 153741375 | 153741375 | Missense_Mutation | G | A | p.D751N |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for INTS3 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for INTS3 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for INTS3 |
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RelatedDrugs for INTS3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for INTS3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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