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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for CLIP1

check button Gene summary
Gene informationGene symbol

CLIP1

Gene ID

6249

Gene nameCAP-Gly domain containing linker protein 1
SynonymsCLIP|CLIP-170|CLIP170|CYLN1|RSN
Cytomap

12q24.31

Type of geneprotein-coding
DescriptionCAP-Gly domain-containing linker protein 1cytoplasmic linker protein 1cytoplasmic linker protein 170 alpha-2cytoplasmic linker protein CLIP-170restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)
Modification date20180522
UniProtAcc

P30622

ContextPubMed: CLIP1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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Exon skipping events across known transcript of Ensembl for CLIP1 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for CLIP1

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for CLIP1

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_9795212122757380:122757647:122758584:122758690:122762700:122762750122758584:122758690ENSG00000130779.15ENST00000536634.1
exon_skip_9795412122757380:122757647:122758584:122758709:122762700:122762750122758584:122758709ENSG00000130779.15ENST00000302528.7,ENST00000361654.4,ENST00000540338.1,ENST00000538120.1,ENST00000545889.1,ENST00000358808.2,ENST00000537178.1
exon_skip_9795612122758584:122758690:122762700:122762750:122763338:122763489122762700:122762750ENSG00000130779.15ENST00000536634.1
exon_skip_9795712122758584:122758709:122762700:122762750:122763338:122763489122762700:122762750ENSG00000130779.15ENST00000302528.7,ENST00000361654.4,ENST00000540338.1,ENST00000538120.1,ENST00000545889.1,ENST00000358808.2,ENST00000537178.1
exon_skip_9796512122762700:122762750:122763338:122763489:122763574:122763692122763338:122763489ENSG00000130779.15ENST00000302528.7,ENST00000361654.4,ENST00000540338.1,ENST00000538120.1,ENST00000545889.1,ENST00000358808.2,ENST00000536634.1,ENST00000543205.1,ENST00000537178.1
exon_skip_9796812122773035:122773088:122794308:122794429:122801295:122801402122794308:122794429ENSG00000130779.15ENST00000302528.7,ENST00000361654.4,ENST00000540338.1,ENST00000545889.1,ENST00000358808.2,ENST00000537178.1
exon_skip_9796912122794308:122794429:122801295:122801402:122803778:122803895122801295:122801402ENSG00000130779.15ENST00000302528.7,ENST00000361654.4,ENST00000540338.1,ENST00000545889.1,ENST00000358808.2,ENST00000537178.1
exon_skip_9797212122801295:122801402:122803778:122803895:122812493:122812709122803778:122803895ENSG00000130779.15ENST00000302528.7,ENST00000361654.4,ENST00000540338.1,ENST00000545889.1,ENST00000358808.2,ENST00000537178.1
exon_skip_9797912122819194:122819252:122821178:122821295:122825299:122825455122821178:122821295ENSG00000130779.15ENST00000302528.7,ENST00000540338.1,ENST00000358808.2,ENST00000514271.2,ENST00000537178.1
exon_skip_9798112122819194:122819252:122821178:122821295:122825527:122826244122821178:122821295ENSG00000130779.15ENST00000540304.1,ENST00000361654.4
exon_skip_9798612122821178:122821295:122825299:122826244:122837272:122837333122825299:122826244ENSG00000130779.15ENST00000537178.1
exon_skip_9798912122821178:122821295:122825527:122826244:122837272:122837333122825527:122826244ENSG00000130779.15ENST00000361654.4
exon_skip_9799512122825634:122826244:122831921:122832026:122835657:122835690122831921:122832026ENSG00000130779.15ENST00000540338.1
exon_skip_9799612122825634:122826244:122831921:122832026:122837272:122837329122831921:122832026ENSG00000130779.15ENST00000302528.7,ENST00000540304.1,ENST00000545889.1,ENST00000358808.2
exon_skip_9800312122831921:122832026:122835657:122835690:122837272:122837329122835657:122835690ENSG00000130779.15ENST00000540338.1
exon_skip_9800512122837272:122837333:122838999:122839103:122839661:122839859122838999:122839103ENSG00000130779.15ENST00000302528.7,ENST00000361654.4,ENST00000540338.1,ENST00000545889.1,ENST00000358808.2,ENST00000537178.1
exon_skip_9800612122838999:122839103:122839661:122839859:122845505:122845728122839661:122839859ENSG00000130779.15ENST00000302528.7,ENST00000361654.4,ENST00000540338.1,ENST00000545889.1,ENST00000358808.2,ENST00000537178.1
exon_skip_9800812122845505:122845728:122848529:122848654:122861935:122862507122848529:122848654ENSG00000130779.15ENST00000302528.7,ENST00000540304.1,ENST00000541108.1,ENST00000361654.4,ENST00000540338.1,ENST00000537004.1,ENST00000358808.2,ENST00000537178.1
exon_skip_9801112122864914:122865105:122884678:122884790:122907067:122907116122884678:122884790ENSG00000130779.15ENST00000539080.1

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for CLIP1

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_9795212122757380:122757647:122758584:122758690:122762700:122762750122758584:122758690ENSG00000130779.15ENST00000536634.1
exon_skip_9795412122757380:122757647:122758584:122758709:122762700:122762750122758584:122758709ENSG00000130779.15ENST00000361654.4,ENST00000545889.1,ENST00000302528.7,ENST00000358808.2,ENST00000537178.1,ENST00000538120.1,ENST00000540338.1
exon_skip_9795612122758584:122758690:122762700:122762750:122763338:122763489122762700:122762750ENSG00000130779.15ENST00000536634.1
exon_skip_9795712122758584:122758709:122762700:122762750:122763338:122763489122762700:122762750ENSG00000130779.15ENST00000361654.4,ENST00000545889.1,ENST00000302528.7,ENST00000358808.2,ENST00000537178.1,ENST00000538120.1,ENST00000540338.1
exon_skip_9796512122762700:122762750:122763338:122763489:122763574:122763692122763338:122763489ENSG00000130779.15ENST00000361654.4,ENST00000545889.1,ENST00000302528.7,ENST00000358808.2,ENST00000537178.1,ENST00000536634.1,ENST00000538120.1,ENST00000540338.1,ENST00000543205.1
exon_skip_9796812122773035:122773088:122794308:122794429:122801295:122801402122794308:122794429ENSG00000130779.15ENST00000361654.4,ENST00000545889.1,ENST00000302528.7,ENST00000358808.2,ENST00000537178.1,ENST00000540338.1
exon_skip_9796912122794308:122794429:122801295:122801402:122803778:122803895122801295:122801402ENSG00000130779.15ENST00000361654.4,ENST00000545889.1,ENST00000302528.7,ENST00000358808.2,ENST00000537178.1,ENST00000540338.1
exon_skip_9797212122801295:122801402:122803778:122803895:122812493:122812709122803778:122803895ENSG00000130779.15ENST00000361654.4,ENST00000545889.1,ENST00000302528.7,ENST00000358808.2,ENST00000537178.1,ENST00000540338.1
exon_skip_9797912122819194:122819252:122821178:122821295:122825299:122825455122821178:122821295ENSG00000130779.15ENST00000302528.7,ENST00000358808.2,ENST00000537178.1,ENST00000540338.1,ENST00000514271.2
exon_skip_9798112122819194:122819252:122821178:122821295:122825527:122826244122821178:122821295ENSG00000130779.15ENST00000361654.4,ENST00000540304.1
exon_skip_9798612122821178:122821295:122825299:122826244:122837272:122837333122825299:122826244ENSG00000130779.15ENST00000537178.1
exon_skip_9798912122821178:122821295:122825527:122826244:122837272:122837333122825527:122826244ENSG00000130779.15ENST00000361654.4
exon_skip_9799512122825634:122826244:122831921:122832026:122835657:122835690122831921:122832026ENSG00000130779.15ENST00000540338.1
exon_skip_9799612122825634:122826244:122831921:122832026:122837272:122837329122831921:122832026ENSG00000130779.15ENST00000545889.1,ENST00000302528.7,ENST00000358808.2,ENST00000540304.1
exon_skip_9800312122831921:122832026:122835657:122835690:122837272:122837329122835657:122835690ENSG00000130779.15ENST00000540338.1
exon_skip_9800512122837272:122837333:122838999:122839103:122839661:122839859122838999:122839103ENSG00000130779.15ENST00000361654.4,ENST00000545889.1,ENST00000302528.7,ENST00000358808.2,ENST00000537178.1,ENST00000540338.1
exon_skip_9800612122838999:122839103:122839661:122839859:122845505:122845728122839661:122839859ENSG00000130779.15ENST00000361654.4,ENST00000545889.1,ENST00000302528.7,ENST00000358808.2,ENST00000537178.1,ENST00000540338.1
exon_skip_9800812122845505:122845728:122848529:122848654:122861935:122862507122848529:122848654ENSG00000130779.15ENST00000361654.4,ENST00000302528.7,ENST00000358808.2,ENST00000537178.1,ENST00000540338.1,ENST00000540304.1,ENST00000537004.1,ENST00000541108.1
exon_skip_9801112122864914:122865105:122884678:122884790:122907067:122907116122884678:122884790ENSG00000130779.15ENST00000539080.1

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for CLIP1

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST00000302528122758584122758709Frame-shift
ENST00000358808122758584122758709Frame-shift
ENST00000302528122762700122762750Frame-shift
ENST00000358808122762700122762750Frame-shift
ENST00000302528122763338122763489Frame-shift
ENST00000358808122763338122763489Frame-shift
ENST00000302528122794308122794429Frame-shift
ENST00000358808122794308122794429Frame-shift
ENST00000302528122801295122801402Frame-shift
ENST00000358808122801295122801402Frame-shift
ENST00000302528122838999122839103Frame-shift
ENST00000358808122838999122839103Frame-shift
ENST00000302528122848529122848654Frame-shift
ENST00000358808122848529122848654Frame-shift
ENST00000302528122803778122803895In-frame
ENST00000358808122803778122803895In-frame
ENST00000302528122821178122821295In-frame
ENST00000358808122821178122821295In-frame
ENST00000302528122831921122832026In-frame
ENST00000358808122831921122832026In-frame
ENST00000302528122839661122839859In-frame
ENST00000358808122839661122839859In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST00000302528122758584122758709Frame-shift
ENST00000358808122758584122758709Frame-shift
ENST00000302528122762700122762750Frame-shift
ENST00000358808122762700122762750Frame-shift
ENST00000302528122763338122763489Frame-shift
ENST00000358808122763338122763489Frame-shift
ENST00000302528122794308122794429Frame-shift
ENST00000358808122794308122794429Frame-shift
ENST00000302528122801295122801402Frame-shift
ENST00000358808122801295122801402Frame-shift
ENST00000302528122838999122839103Frame-shift
ENST00000358808122838999122839103Frame-shift
ENST00000302528122848529122848654Frame-shift
ENST00000358808122848529122848654Frame-shift
ENST00000302528122803778122803895In-frame
ENST00000358808122803778122803895In-frame
ENST00000302528122821178122821295In-frame
ENST00000358808122821178122821295In-frame
ENST00000302528122831921122832026In-frame
ENST00000358808122831921122832026In-frame
ENST00000302528122839661122839859In-frame
ENST00000358808122839661122839859In-frame

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Infer the effects of exon skipping event on protein functional features for CLIP1

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000003025285850143812283966112283985911141311335401
ENST000003588085897143812283966112283985911611358335401
ENST000003025285850143812283192112283202614771581456491
ENST000003588085897143812283192112283202615241628456491
ENST000003025285850143812282117812282129525272643806845
ENST000003588085897143812282117812282129525742690806845
ENST00000302528585014381228037781228038953325344110721111
ENST00000358808589714381228037781228038953372348810721111

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000003025285850143812283966112283985911141311335401
ENST000003588085897143812283966112283985911611358335401
ENST000003025285850143812283192112283202614771581456491
ENST000003588085897143812283192112283202615241628456491
ENST000003025285850143812282117812282129525272643806845
ENST000003588085897143812282117812282129525742690806845
ENST00000302528585014381228037781228038953325344110721111
ENST00000358808589714381228037781228038953372348810721111

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
P3062233540111438ChainID=PRO_0000083527;Note=CAP-Gly domain-containing linker protein 1
P3062233540111438ChainID=PRO_0000083527;Note=CAP-Gly domain-containing linker protein 1
P306223354013501353Coiled coilOntology_term=ECO:0000255;evidence=ECO:0000255
P306223354013501353Coiled coilOntology_term=ECO:0000255;evidence=ECO:0000255
P30622335401348348Modified residueNote=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JK25
P30622335401348348Modified residueNote=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JK25
P30622456491457502Alternative sequenceID=VSP_000765;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1356075,ECO:0000303|PubMed:15489334;Dbxref=PMID:1356075,PMID:15489334
P30622456491457502Alternative sequenceID=VSP_000765;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1356075,ECO:0000303|PubMed:15489334;Dbxref=PMID:1356075,PMID:15489334
P30622456491457467Alternative sequenceID=VSP_038201;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1600942;Dbxref=PMID:1600942
P30622456491457467Alternative sequenceID=VSP_038201;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1600942;Dbxref=PMID:1600942
P3062245649111438ChainID=PRO_0000083527;Note=CAP-Gly domain-containing linker protein 1
P3062245649111438ChainID=PRO_0000083527;Note=CAP-Gly domain-containing linker protein 1
P306224564913501353Coiled coilOntology_term=ECO:0000255;evidence=ECO:0000255
P306224564913501353Coiled coilOntology_term=ECO:0000255;evidence=ECO:0000255
P3062280684511438ChainID=PRO_0000083527;Note=CAP-Gly domain-containing linker protein 1
P3062280684511438ChainID=PRO_0000083527;Note=CAP-Gly domain-containing linker protein 1
P306228068453501353Coiled coilOntology_term=ECO:0000255;evidence=ECO:0000255
P306228068453501353Coiled coilOntology_term=ECO:0000255;evidence=ECO:0000255
P306221072111111438ChainID=PRO_0000083527;Note=CAP-Gly domain-containing linker protein 1
P306221072111111438ChainID=PRO_0000083527;Note=CAP-Gly domain-containing linker protein 1
P30622107211113501353Coiled coilOntology_term=ECO:0000255;evidence=ECO:0000255
P30622107211113501353Coiled coilOntology_term=ECO:0000255;evidence=ECO:0000255
P306221072111110801080Natural variantID=VAR_020398;Note=D->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1356075,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1129167,PMID:1356075,PMID:15489334
P306221072111110801080Natural variantID=VAR_020398;Note=D->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1356075,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1129167,PMID:1356075,PMID:15489334


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
P3062233540111438ChainID=PRO_0000083527;Note=CAP-Gly domain-containing linker protein 1
P3062233540111438ChainID=PRO_0000083527;Note=CAP-Gly domain-containing linker protein 1
P306223354013501353Coiled coilOntology_term=ECO:0000255;evidence=ECO:0000255
P306223354013501353Coiled coilOntology_term=ECO:0000255;evidence=ECO:0000255
P30622335401348348Modified residueNote=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JK25
P30622335401348348Modified residueNote=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JK25
P30622456491457502Alternative sequenceID=VSP_000765;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1356075,ECO:0000303|PubMed:15489334;Dbxref=PMID:1356075,PMID:15489334
P30622456491457502Alternative sequenceID=VSP_000765;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1356075,ECO:0000303|PubMed:15489334;Dbxref=PMID:1356075,PMID:15489334
P30622456491457467Alternative sequenceID=VSP_038201;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1600942;Dbxref=PMID:1600942
P30622456491457467Alternative sequenceID=VSP_038201;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1600942;Dbxref=PMID:1600942
P3062245649111438ChainID=PRO_0000083527;Note=CAP-Gly domain-containing linker protein 1
P3062245649111438ChainID=PRO_0000083527;Note=CAP-Gly domain-containing linker protein 1
P306224564913501353Coiled coilOntology_term=ECO:0000255;evidence=ECO:0000255
P306224564913501353Coiled coilOntology_term=ECO:0000255;evidence=ECO:0000255
P3062280684511438ChainID=PRO_0000083527;Note=CAP-Gly domain-containing linker protein 1
P3062280684511438ChainID=PRO_0000083527;Note=CAP-Gly domain-containing linker protein 1
P306228068453501353Coiled coilOntology_term=ECO:0000255;evidence=ECO:0000255
P306228068453501353Coiled coilOntology_term=ECO:0000255;evidence=ECO:0000255
P306221072111111438ChainID=PRO_0000083527;Note=CAP-Gly domain-containing linker protein 1
P306221072111111438ChainID=PRO_0000083527;Note=CAP-Gly domain-containing linker protein 1
P30622107211113501353Coiled coilOntology_term=ECO:0000255;evidence=ECO:0000255
P30622107211113501353Coiled coilOntology_term=ECO:0000255;evidence=ECO:0000255
P306221072111110801080Natural variantID=VAR_020398;Note=D->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1356075,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1129167,PMID:1356075,PMID:15489334
P306221072111110801080Natural variantID=VAR_020398;Note=D->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1356075,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1129167,PMID:1356075,PMID:15489334


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SNVs in the skipped exons for CLIP1

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.
CLIP1_LIHC_exon_skip_97986_psi_boxplot.png
boxplot
CLIP1_PRAD_exon_skip_97986_psi_boxplot.png
boxplot

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
BRCATCGA-D8-A1JK-01exon_skip_97968
122794309122794429122794401122794402Frame_Shift_DelTC-p.K1157fs
COADTCGA-F4-6856-01exon_skip_97969
122801296122801402122801318122801318Frame_Shift_DelT-p.M1151fs
LIHCTCGA-DD-A39Y-01exon_skip_97969
122801296122801402122801318122801318Frame_Shift_DelT-p.M1140fs
LIHCTCGA-DD-A3A0-01exon_skip_97969
122801296122801402122801346122801346Frame_Shift_DelT-p.K1130fs
LIHCTCGA-G3-A3CJ-01122825300122826244122825961122825961Frame_Shift_DelT-p.K586fs
LIHCTCGA-G3-A3CJ-01exon_skip_97989
122825528122826244122825961122825961Frame_Shift_DelT-p.K586fs
LIHCTCGA-DD-A1EG-01122825300122826244122826013122826013Frame_Shift_DelG-p.R569fs
LIHCTCGA-DD-A1EG-01exon_skip_97989
122825528122826244122826013122826013Frame_Shift_DelG-p.R569fs
LIHCTCGA-DD-A3A0-01122825300122826244122826043122826043Frame_Shift_DelT-p.I559fs
LIHCTCGA-DD-A3A0-01exon_skip_97989
122825528122826244122826043122826043Frame_Shift_DelT-p.I559fs
LIHCTCGA-G3-A3CJ-01122839000122839103122839040122839040Frame_Shift_DelC-p.E423fs
LIHCTCGA-DD-A3A0-01122839000122839103122839079122839079Frame_Shift_DelT-p.M410fs
LIHCTCGA-DD-A3A0-01exon_skip_98006
122839662122839859122839672122839672Frame_Shift_DelC-p.G398fs
LIHCTCGA-DD-A3A0-01exon_skip_98008
122848530122848654122848615122848615Frame_Shift_DelC-p.E233fs
LIHCTCGA-BC-A112-01exon_skip_97954
122758585122758709122758701122758702Frame_Shift_Ins-Ap.S1314fs
COADTCGA-CM-5861-01122839000122839103122839052122839053Frame_Shift_Ins-Tp.A419fs
CESCTCGA-Q1-A73O-01exon_skip_97965
122763339122763489122763443122763443Nonsense_MutationGCp.S1271*
HNSCTCGA-CR-7368-01exon_skip_97968
122794309122794429122794385122794385Nonsense_MutationGTp.S1162*
HNSCTCGA-CR-7368-01exon_skip_97968
122794309122794429122794385122794385Nonsense_MutationGTp.S1173*
CESCTCGA-DS-A7WH-01exon_skip_97968
122794309122794429122794404122794404Nonsense_MutationGAp.Q1167*
UCECTCGA-BS-A0UV-01exon_skip_97969
122801296122801402122801387122801387Nonsense_MutationCAp.E1117*
PRADTCGA-XK-AAIW-01exon_skip_97972
122803779122803895122803805122803805Nonsense_MutationGAp.Q1103*
LUSCTCGA-66-2785-01exon_skip_97972
122803779122803895122803817122803817Nonsense_MutationCAp.E1110*
COADTCGA-AZ-4315-01122825300122826244122825728122825728Nonsense_MutationCAp.E629X
COADTCGA-AZ-4315-01exon_skip_97989
122825528122826244122825728122825728Nonsense_MutationCAp.E629X
PRADTCGA-CH-5765-01122825300122826244122825728122825728Nonsense_MutationCAp.E664*
PRADTCGA-CH-5765-01122825300122826244122825728122825728Nonsense_MutationCAp.E675X
PRADTCGA-CH-5765-01exon_skip_97989
122825528122826244122825728122825728Nonsense_MutationCAp.E664*
PRADTCGA-CH-5765-01exon_skip_97989
122825528122826244122825728122825728Nonsense_MutationCAp.E675X
UCECTCGA-D1-A17Q-01122825300122826244122825788122825788Nonsense_MutationCAp.E644*
UCECTCGA-D1-A17Q-01exon_skip_97989
122825528122826244122825788122825788Nonsense_MutationCAp.E644*
UCECTCGA-B5-A11N-01122825300122826244122826046122826046Nonsense_MutationCAp.E558*
UCECTCGA-B5-A11N-01exon_skip_97989
122825528122826244122826046122826046Nonsense_MutationCAp.E558*
HNSCTCGA-CN-6989-01122839000122839103122839067122839067Nonsense_MutationGAp.R414*
OVTCGA-24-2254-01122839000122839103122838999122838999Splice_SiteCTp.R436_splice

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description
CLIP1_122821178_122821295_122825299_122826244_122837272_122837333_TCGA-CH-5765-01Sample: TCGA-CH-5765-01
Cancer type: PRAD
ESID:
Skipped exon start: 122825300
Skipped exon end: 122826244
Mutation start: 122825728
Mutation end: 122825728
Mutation type: Nonsense_Mutation
Reference seq: C
Mutation seq: A
AAchange: p.E675X
CLIP1_122821178_122821295_122825299_122826244_122837272_122837333_TCGA-CH-5765-01Sample: TCGA-CH-5765-01
Cancer type: PRAD
ESID: exon_skip_97989
Skipped exon start: 122825528
Skipped exon end: 122826244
Mutation start: 122825728
Mutation end: 122825728
Mutation type: Nonsense_Mutation
Reference seq: C
Mutation seq: A
AAchange: p.E675X
CLIP1_122821178_122821295_122825299_122826244_122837272_122837333_TCGA-CH-5765-01Sample: TCGA-CH-5765-01
Cancer type: PRAD
ESID:
Skipped exon start: 122825300
Skipped exon end: 122826244
Mutation start: 122825728
Mutation end: 122825728
Mutation type: Nonsense_Mutation
Reference seq: C
Mutation seq: A
AAchange: p.E664*
CLIP1_122821178_122821295_122825299_122826244_122837272_122837333_TCGA-CH-5765-01Sample: TCGA-CH-5765-01
Cancer type: PRAD
ESID: exon_skip_97989
Skipped exon start: 122825528
Skipped exon end: 122826244
Mutation start: 122825728
Mutation end: 122825728
Mutation type: Nonsense_Mutation
Reference seq: C
Mutation seq: A
AAchange: p.E664*
exon_skip_97986_PRAD_TCGA-CH-5765-01.png
boxplot

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
HEC59_ENDOMETRIUM122825300122826244122825950122825951Frame_Shift_Ins-Tp.E601fs
HEC59_ENDOMETRIUM122825528122826244122825950122825951Frame_Shift_Ins-Tp.E601fs
ES5_BONE122825300122826244122825803122825805In_Frame_DelCAA-p.649_650LG>R
ES5_BONE122825528122826244122825803122825805In_Frame_DelCAA-p.649_650LG>R
NCIH1385_LUNG122758585122758690122758630122758630Missense_MutationTGp.E1349A
NCIH1385_LUNG122758585122758709122758630122758630Missense_MutationTGp.E1349A
HCT15_LARGE_INTESTINE122758585122758690122758669122758669Missense_MutationTGp.K1336T
HCT15_LARGE_INTESTINE122758585122758709122758669122758669Missense_MutationTGp.K1336T
A388_SKIN122763339122763489122763461122763461Missense_MutationGCp.S1265C
SMSCTR_SOFT_TISSUE122794309122794429122794322122794322Missense_MutationGTp.T1194K
PEO1_OVARY122794309122794429122794322122794322Missense_MutationGCp.T1194R
SNU1079_BILIARY_TRACT122794309122794429122794329122794329Missense_MutationCTp.E1192K
SARC9371_BONE122794309122794429122794329122794329Missense_MutationCTp.E1192K
TOV21G_OVARY122794309122794429122794382122794382Missense_MutationGAp.A1174V
BICR18_UPPER_AERODIGESTIVE_TRACT122803779122803895122803792122803792Missense_MutationTCp.K1118R
FARAGE_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE122825300122826244122825402122825402Missense_MutationACp.S783R
HS746T_STOMACH122825300122826244122825458122825458Missense_MutationGTp.Q765K
GCT_SOFT_TISSUE122825300122826244122825515122825515Missense_MutationCTp.E746K
JHH1_LIVER122825300122826244122825661122825661Missense_MutationGAp.A697V
JHH1_LIVER122825528122826244122825661122825661Missense_MutationGAp.A697V
NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE122825300122826244122825734122825734Missense_MutationCTp.E673K
NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE122825528122826244122825734122825734Missense_MutationCTp.E673K
VMRCMELG_SKIN122825300122826244122825734122825734Missense_MutationCTp.E673K
VMRCMELG_SKIN122825528122826244122825734122825734Missense_MutationCTp.E673K
HCC1359_LUNG122825300122826244122825754122825754Missense_MutationACp.M666R
HCC1359_LUNG122825528122826244122825754122825754Missense_MutationACp.M666R
HCC2998_LARGE_INTESTINE122825300122826244122825906122825906Missense_MutationCAp.E615D
HCC2998_LARGE_INTESTINE122825528122826244122825906122825906Missense_MutationCAp.E615D
IPC298_SKIN122825300122826244122825940122825940Missense_MutationGAp.S604L
IPC298_SKIN122825528122826244122825940122825940Missense_MutationGAp.S604L
NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE122825300122826244122825971122825971Missense_MutationCAp.A594S
NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE122825528122826244122825971122825971Missense_MutationCAp.A594S
HARA_LUNG122825300122826244122826012122826012Missense_MutationCAp.R580L
HARA_LUNG122825528122826244122826012122826012Missense_MutationCAp.R580L
SNGM_ENDOMETRIUM122825300122826244122826029122826029Missense_MutationCAp.K574N
SNGM_ENDOMETRIUM122825528122826244122826029122826029Missense_MutationCAp.K574N
HUG1N_STOMACH122825300122826244122826055122826055Missense_MutationGAp.H566Y
HUG1N_STOMACH122825528122826244122826055122826055Missense_MutationGAp.H566Y
NCIH2228_LUNG122825300122826244122826064122826064Missense_MutationGAp.R563C
NCIH2228_LUNG122825528122826244122826064122826064Missense_MutationGAp.R563C
HCT116_LARGE_INTESTINE122825300122826244122826105122826105Missense_MutationAGp.L549S
HCT116_LARGE_INTESTINE122825528122826244122826105122826105Missense_MutationAGp.L549S
CL34_LARGE_INTESTINE122825300122826244122826153122826153Missense_MutationAGp.L533P
CL34_LARGE_INTESTINE122825528122826244122826153122826153Missense_MutationAGp.L533P
FARAGE_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE122825300122826244122826238122826238Missense_MutationTCp.T505A
FARAGE_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE122825528122826244122826238122826238Missense_MutationTCp.T505A
NCIBL128_MATCHED_NORMAL_TISSUE122831922122832026122831927122831927Missense_MutationTCp.T501A
BICR18_UPPER_AERODIGESTIVE_TRACT122831922122832026122831998122831998Missense_MutationAGp.I477T
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE122831922122832026122831998122831998Missense_MutationAGp.I477T
OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE122831922122832026122831998122831998Missense_MutationAGp.I477T
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE122835658122835690122835680122835680Missense_MutationTGp.Q460P
MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE122839662122839859122839827122839827Missense_MutationCAp.K346N
HEC59_ENDOMETRIUM122839662122839859122839840122839840Missense_MutationCTp.R342H
IM9_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE122848530122848654122848533122848533Missense_MutationGAp.T260I
LXF289_LUNG122848530122848654122848570122848570Missense_MutationCTp.E248K
MDAMB361_BREAST122762701122762750122762736122762736Nonsense_MutationGAp.Q1311*
HCC1954_BREAST122825300122826244122826085122826085Nonsense_MutationGAp.Q556*
HCC1954_BREAST122825528122826244122826085122826085Nonsense_MutationGAp.Q556*
RERFLCAD1_LUNG122758585122758690122758586122758586Splice_SiteTAp.S1364C
RERFLCAD1_LUNG122758585122758709122758586122758586Splice_SiteTAp.S1364C
SNU503_LARGE_INTESTINE122835658122835690122835689122835689Splice_SiteTAp.Q457L
CAKI1_KIDNEY122835658122835690122835690122835690Splice_SiteGTp.Q457K

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CLIP1

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CLIP1


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CLIP1


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RelatedDrugs for CLIP1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CLIP1

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource