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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ROS1 |
 Gene summary |
| Gene information | Gene symbol | ROS1 | Gene ID | 6098 |
| Gene name | ROS proto-oncogene 1, receptor tyrosine kinase | |
| Synonyms | MCF3|ROS|c-ros-1 | |
| Cytomap | 6q22.1 | |
| Type of gene | protein-coding | |
| Description | proto-oncogene tyrosine-protein kinase ROSROS proto-oncogene 1 , receptor tyrosine kinasec-ros oncogene 1 , receptor tyrosine kinaseproto-oncogene c-Ros-1transmembrane tyrosine-specific protein kinasev-ros avian UR2 sarcoma virus oncogene homolog 1 | |
| Modification date | 20180523 | |
| UniProtAcc | P08922 | |
| Context | PubMed: ROS1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ROS1 | GO:0001558 | regulation of cell growth | 16885344 |
| ROS1 | GO:0006468 | protein phosphorylation | 16885344 |
| ROS1 | GO:0032006 | regulation of TOR signaling | 16885344 |
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Exon skipping events across known transcript of Ensembl for ROS1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ROS1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ROS1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_462005 | 6 | 117609462:117609965:117622136:117622300:117629956:117630091 | 117622136:117622300 | ENSG00000047936.6 | ENST00000368507.3,ENST00000368508.3 |
| exon_skip_462007 | 6 | 117730744:117730805:117735681:117735708:117737420:117737480 | 117735681:117735708 | ENSG00000047936.6 | ENST00000368507.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ROS1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_462005 | 6 | 117609462:117609965:117622136:117622300:117629956:117630091 | 117622136:117622300 | ENSG00000047936.6 | ENST00000368508.3,ENST00000368507.3 |
| exon_skip_462007 | 6 | 117730744:117730805:117735681:117735708:117737420:117737480 | 117735681:117735708 | ENSG00000047936.6 | ENST00000368507.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ROS1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000368508 | 117622136 | 117622300 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000368508 | 117622136 | 117622300 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for ROS1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for ROS1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| STAD | TCGA-CD-8536-01 | exon_skip_462005 | 117622137 | 117622300 | 117622204 | 117622205 | Frame_Shift_Ins | - | A | p.F2222fs |
| STAD | TCGA-CD-8536-01 | exon_skip_462005 | 117622137 | 117622300 | 117622205 | 117622206 | Frame_Shift_Ins | - | A | p.F2222fs |
| CESC | TCGA-IR-A3LA-01 | exon_skip_462005 | 117622137 | 117622300 | 117622176 | 117622176 | Nonsense_Mutation | C | A | p.E2232* |
| SKCM | TCGA-WE-AAA0-06 | exon_skip_462005 | 117622137 | 117622300 | 117622224 | 117622224 | Nonsense_Mutation | G | A | p.Q2216* |
| LUSC | TCGA-22-5472-01 | exon_skip_462005 | 117622137 | 117622300 | 117622242 | 117622242 | Nonsense_Mutation | T | A | p.R2210* |
| COAD | TCGA-CA-6717-01 | exon_skip_462005 | 117622137 | 117622300 | 117622269 | 117622269 | Nonsense_Mutation | C | A | p.E2201X |
| ACC | TCGA-OR-A5LK-01 | exon_skip_462005 | 117622137 | 117622300 | 117622297 | 117622297 | Nonsense_Mutation | C | T | p.W2191* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| JHUEM7_ENDOMETRIUM | 117622137 | 117622300 | 117622152 | 117622152 | Missense_Mutation | T | G | p.N2240H |
| TC106_BONE | 117622137 | 117622300 | 117622173 | 117622173 | Missense_Mutation | C | A | p.A2233S |
| NK92MI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 117622137 | 117622300 | 117622226 | 117622226 | Missense_Mutation | A | G | p.L2215P |
| NCIH513_PLEURA | 117622137 | 117622300 | 117622250 | 117622250 | Missense_Mutation | G | C | p.T2207S |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ROS1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ROS1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ROS1 |
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RelatedDrugs for ROS1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P08922 | DB12010 | Fostamatinib | Proto-oncogene tyrosine-protein kinase ROS | small molecule | approved|investigational |
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RelatedDiseases for ROS1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| ROS1 | C0007131 | Non-Small Cell Lung Carcinoma | 4 | CTD_human |
| ROS1 | C0017638 | Glioma | 1 | CTD_human |
| ROS1 | C0025202 | melanoma | 1 | CTD_human |
| ROS1 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
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