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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for DPF2 |
 Gene summary |
| Gene information | Gene symbol | DPF2 | Gene ID | 5977 |
| Gene name | double PHD fingers 2 | |
| Synonyms | REQ|UBID4|ubi-d4 | |
| Cytomap | 11q13.1 | |
| Type of gene | protein-coding | |
| Description | zinc finger protein ubi-d4BAF45DBRG1-associated factor 45DD4, zinc and double PHD fingers family 2apoptosis response zinc finger proteinprotein requiemrequiem, apoptosis response zinc finger | |
| Modification date | 20180527 | |
| UniProtAcc | Q92785 | |
| Context | PubMed: DPF2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for DPF2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for DPF2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for DPF2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_60984 | 11 | 65101347:65101389:65107855:65108016:65108436:65108544 | 65107855:65108016 | ENSG00000133884.5 | ENST00000444314.2,ENST00000415073.2,ENST00000252268.4,ENST00000532102.1 |
| exon_skip_60985 | 11 | 65108436:65108544:65108869:65109033:65111215:65111308 | 65108869:65109033 | ENSG00000133884.5 | ENST00000530993.1,ENST00000528416.1,ENST00000532264.1,ENST00000252268.4 |
| exon_skip_60988 | 11 | 65111225:65111308:65111461:65111540:65113136:65113177 | 65111461:65111540 | ENSG00000133884.5 | ENST00000528416.1,ENST00000532264.1,ENST00000530973.1,ENST00000532102.1 |
| exon_skip_60991 | 11 | 65111467:65111540:65112050:65112092:65113136:65113177 | 65112050:65112092 | ENSG00000133884.5 | ENST00000530993.1,ENST00000252268.4 |
| exon_skip_60992 | 11 | 65113211:65113274:65113400:65113529:65113717:65113830 | 65113400:65113529 | ENSG00000133884.5 | ENST00000532052.1,ENST00000528416.1,ENST00000252268.4 |
| exon_skip_60993 | 11 | 65113400:65113529:65113717:65113830:65116320:65116402 | 65113717:65113830 | ENSG00000133884.5 | ENST00000532052.1,ENST00000528416.1,ENST00000252268.4 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for DPF2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_60984 | 11 | 65101347:65101389:65107855:65108016:65108436:65108544 | 65107855:65108016 | ENSG00000133884.5 | ENST00000444314.2,ENST00000415073.2,ENST00000252268.4,ENST00000532102.1 |
| exon_skip_60985 | 11 | 65108436:65108544:65108869:65109033:65111215:65111308 | 65108869:65109033 | ENSG00000133884.5 | ENST00000528416.1,ENST00000530993.1,ENST00000252268.4,ENST00000532264.1 |
| exon_skip_60988 | 11 | 65111225:65111308:65111461:65111540:65113136:65113177 | 65111461:65111540 | ENSG00000133884.5 | ENST00000528416.1,ENST00000532264.1,ENST00000532102.1,ENST00000530973.1 |
| exon_skip_60991 | 11 | 65111467:65111540:65112050:65112092:65113136:65113177 | 65112050:65112092 | ENSG00000133884.5 | ENST00000530993.1,ENST00000252268.4 |
| exon_skip_60992 | 11 | 65113211:65113274:65113400:65113529:65113717:65113830 | 65113400:65113529 | ENSG00000133884.5 | ENST00000528416.1,ENST00000252268.4,ENST00000532052.1 |
| exon_skip_60993 | 11 | 65113400:65113529:65113717:65113830:65116320:65116402 | 65113717:65113830 | ENSG00000133884.5 | ENST00000528416.1,ENST00000252268.4,ENST00000532052.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for DPF2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000528416 | 65108869 | 65109033 | Frame-shift |
| ENST00000528416 | 65111461 | 65111540 | Frame-shift |
| ENST00000528416 | 65113717 | 65113830 | Frame-shift |
| ENST00000528416 | 65113400 | 65113529 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000528416 | 65108869 | 65109033 | Frame-shift |
| ENST00000528416 | 65111461 | 65111540 | Frame-shift |
| ENST00000528416 | 65113717 | 65113830 | Frame-shift |
| ENST00000528416 | 65113400 | 65113529 | In-frame |
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Infer the effects of exon skipping event on protein functional features for DPF2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000528416 | 2816 | 391 | 65113400 | 65113529 | 909 | 1037 | 258 | 301 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000528416 | 2816 | 391 | 65113400 | 65113529 | 909 | 1037 | 258 | 301 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q92785 | 258 | 301 | 156 | 339 | Alternative sequence | ID=VSP_055860;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q92785 | 258 | 301 | 2 | 391 | Chain | ID=PRO_0000168149;Note=Zinc finger protein ubi-d4 |
| Q92785 | 258 | 301 | 281 | 281 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
| Q92785 | 258 | 301 | 280 | 280 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
| Q92785 | 258 | 301 | 274 | 276 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VDC |
| Q92785 | 258 | 301 | 284 | 286 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VDC |
| Q92785 | 258 | 301 | 296 | 298 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VDC |
| Q92785 | 258 | 301 | 270 | 330 | Zinc finger | Note=PHD-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00146 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q92785 | 258 | 301 | 156 | 339 | Alternative sequence | ID=VSP_055860;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q92785 | 258 | 301 | 2 | 391 | Chain | ID=PRO_0000168149;Note=Zinc finger protein ubi-d4 |
| Q92785 | 258 | 301 | 281 | 281 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
| Q92785 | 258 | 301 | 280 | 280 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
| Q92785 | 258 | 301 | 274 | 276 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VDC |
| Q92785 | 258 | 301 | 284 | 286 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VDC |
| Q92785 | 258 | 301 | 296 | 298 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VDC |
| Q92785 | 258 | 301 | 270 | 330 | Zinc finger | Note=PHD-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00146 |
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SNVs in the skipped exons for DPF2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_60984 | 65107856 | 65108016 | 65107860 | 65107860 | Frame_Shift_Del | G | - | p.G13fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_60984 | 65107856 | 65108016 | 65107860 | 65107860 | Frame_Shift_Del | G | - | p.G13fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_60985 | 65108870 | 65109033 | 65108946 | 65108946 | Frame_Shift_Del | C | - | p.D126fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_60985 | 65108870 | 65109033 | 65108974 | 65108974 | Frame_Shift_Del | C | - | p.P136fs |
| LIHC | TCGA-BC-A3KG-01 | exon_skip_60992 | 65113401 | 65113529 | 65113456 | 65113456 | Frame_Shift_Del | G | - | p.L277fs |
| COAD | TCGA-G4-6588-01 | exon_skip_60992 | 65113401 | 65113529 | 65113517 | 65113518 | Frame_Shift_Del | TG | - | p.297_298del |
| HNSC | TCGA-CV-7242-01 | exon_skip_60993 | 65113718 | 65113830 | 65113793 | 65113793 | Frame_Shift_Del | G | - | p.C327fs |
| UCEC | TCGA-AP-A059-01 | exon_skip_60985 | 65108870 | 65109033 | 65108959 | 65108959 | Nonsense_Mutation | C | T | p.R131* |
| SARC | TCGA-QC-A7B5-01 | exon_skip_60985 | 65108870 | 65109033 | 65108977 | 65108977 | Nonsense_Mutation | C | T | p.R137* |
| STAD | TCGA-BR-8680-01 | exon_skip_60985 | 65108870 | 65109033 | 65109022 | 65109022 | Nonsense_Mutation | C | T | p.R152* |
| LUAD | TCGA-78-7536-01 | exon_skip_60988 | 65111462 | 65111540 | 65111510 | 65111510 | Nonsense_Mutation | G | T | p.E203* |
| LUAD | TCGA-86-A4JF-01 | exon_skip_60992 | 65113401 | 65113529 | 65113496 | 65113496 | Nonsense_Mutation | G | T | p.E291* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| NUGC3_STOMACH | 65108870 | 65109033 | 65108946 | 65108946 | Frame_Shift_Del | C | - | p.D126fs |
| SNU175_LARGE_INTESTINE | 65107856 | 65108016 | 65107975 | 65107975 | Missense_Mutation | G | T | p.S51I |
| KM12_LARGE_INTESTINE | 65107856 | 65108016 | 65108007 | 65108007 | Missense_Mutation | C | T | p.R62W |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 65111462 | 65111540 | 65111474 | 65111474 | Missense_Mutation | G | A | p.G191S |
| SW156_KIDNEY | 65113401 | 65113529 | 65113443 | 65113443 | Missense_Mutation | G | A | p.C273Y |
| FTC238_THYROID | 65113401 | 65113529 | 65113482 | 65113482 | Missense_Mutation | C | T | p.T286M |
| FTC133_THYROID | 65113401 | 65113529 | 65113482 | 65113482 | Missense_Mutation | C | T | p.T286M |
| 2313287_STOMACH | 65113401 | 65113529 | 65113529 | 65113529 | Splice_Site | G | T | p.G302W |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DPF2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DPF2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DPF2 |
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RelatedDrugs for DPF2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DPF2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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