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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for RALB |
 Gene summary |
| Gene information | Gene symbol | RALB | Gene ID | 5899 |
| Gene name | RAS like proto-oncogene B | |
| Synonyms | - | |
| Cytomap | 2q14.2 | |
| Type of gene | protein-coding | |
| Description | ras-related protein Ral-BRALB Ras like proto-oncogene BRAS-like protein Bras related GTP binding protein Bv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) | |
| Modification date | 20180522 | |
| UniProtAcc | P11234 | |
| Context | PubMed: RALB [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| RALB | GO:0009267 | cellular response to starvation | 24056301 |
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Exon skipping events across known transcript of Ensembl for RALB from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for RALB |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for RALB |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_329373 | 2 | 121010450:121010556:121036190:121036354:121043449:121043658 | 121036190:121036354 | ENSG00000144118.9 | ENST00000420510.1 |
| exon_skip_329376 | 2 | 121010450:121010556:121036193:121036354:121043449:121043658 | 121036193:121036354 | ENSG00000144118.9 | ENST00000272519.5 |
| exon_skip_329383 | 2 | 121011026:121011307:121036190:121036354:121043449:121043658 | 121036190:121036354 | ENSG00000144118.9 | ENST00000449649.1 |
| exon_skip_329384 | 2 | 121011026:121011307:121036193:121036354:121043449:121043658 | 121036193:121036354 | ENSG00000144118.9 | ENST00000412383.1 |
| exon_skip_329388 | 2 | 121036193:121036288:121043642:121043658:121047155:121047168 | 121043642:121043658 | ENSG00000144118.9 | ENST00000470417.1 |
| exon_skip_329389 | 2 | 121036193:121036354:121038410:121038483:121043449:121043658 | 121038410:121038483 | ENSG00000144118.9 | ENST00000431732.1 |
| exon_skip_329390 | 2 | 121036193:121036354:121043449:121043658:121047155:121047168 | 121043449:121043658 | ENSG00000144118.9 | ENST00000449649.1,ENST00000447591.1,ENST00000272519.5,ENST00000412383.1,ENST00000420510.1,ENST00000474855.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for RALB |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_329373 | 2 | 121010450:121010556:121036190:121036354:121043449:121043658 | 121036190:121036354 | ENSG00000144118.9 | ENST00000420510.1 |
| exon_skip_329376 | 2 | 121010450:121010556:121036193:121036354:121043449:121043658 | 121036193:121036354 | ENSG00000144118.9 | ENST00000272519.5 |
| exon_skip_329383 | 2 | 121011026:121011307:121036190:121036354:121043449:121043658 | 121036190:121036354 | ENSG00000144118.9 | ENST00000449649.1 |
| exon_skip_329384 | 2 | 121011026:121011307:121036193:121036354:121043449:121043658 | 121036193:121036354 | ENSG00000144118.9 | ENST00000412383.1 |
| exon_skip_329388 | 2 | 121036193:121036288:121043642:121043658:121047155:121047168 | 121043642:121043658 | ENSG00000144118.9 | ENST00000470417.1 |
| exon_skip_329389 | 2 | 121036193:121036354:121038410:121038483:121043449:121043658 | 121038410:121038483 | ENSG00000144118.9 | ENST00000431732.1 |
| exon_skip_329390 | 2 | 121036193:121036354:121043449:121043658:121047155:121047168 | 121043449:121043658 | ENSG00000144118.9 | ENST00000447591.1,ENST00000474855.2,ENST00000272519.5,ENST00000420510.1,ENST00000412383.1,ENST00000449649.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for RALB |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000420510 | 121036190 | 121036354 | 5CDS-5UTR |
| ENST00000272519 | 121036193 | 121036354 | 5CDS-5UTR |
| ENST00000272519 | 121043449 | 121043658 | Frame-shift |
| ENST00000420510 | 121043449 | 121043658 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000420510 | 121036190 | 121036354 | 5CDS-5UTR |
| ENST00000272519 | 121036193 | 121036354 | 5CDS-5UTR |
| ENST00000272519 | 121043449 | 121043658 | Frame-shift |
| ENST00000420510 | 121043449 | 121043658 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for RALB |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for RALB |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LUAD | TCGA-50-5930-01 | exon_skip_329390 | 121043450 | 121043658 | 121043513 | 121043513 | Nonsense_Mutation | G | T | p.E60* |
| UCEC | TCGA-AP-A059-01 | exon_skip_329390 | 121043450 | 121043658 | 121043570 | 121043570 | Nonsense_Mutation | C | T | p.R79* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| JHOC5_OVARY | 121043450 | 121043658 | 121043463 | 121043463 | Missense_Mutation | A | G | p.Y43C |
| SNU1040_LARGE_INTESTINE | 121043450 | 121043658 | 121043561 | 121043561 | Missense_Mutation | G | A | p.A76T |
| RHJT_SOFT_TISSUE | 121043450 | 121043658 | 121043645 | 121043645 | Missense_Mutation | A | G | p.T104A |
| RHJT_SOFT_TISSUE | 121043643 | 121043658 | 121043645 | 121043645 | Missense_Mutation | A | G | p.T104A |
| BDCM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 121043450 | 121043658 | 121043651 | 121043651 | Missense_Mutation | G | A | p.E106K |
| BDCM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 121043643 | 121043658 | 121043651 | 121043651 | Missense_Mutation | G | A | p.E106K |
| SNU81_LARGE_INTESTINE | 121043450 | 121043658 | 121043624 | 121043624 | Nonsense_Mutation | G | T | p.E97* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RALB |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RALB |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RALB |
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RelatedDrugs for RALB |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RALB |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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