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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for RAB13 |
 Gene summary |
| Gene information | Gene symbol | RAB13 | Gene ID | 5872 |
| Gene name | RAB13, member RAS oncogene family | |
| Synonyms | GIG4 | |
| Cytomap | 1q21.3 | |
| Type of gene | protein-coding | |
| Description | ras-related protein Rab-13RAS-associated protein RAB13cell growth-inhibiting gene 4 proteingrowth-inhibiting gene 4 protein | |
| Modification date | 20180523 | |
| UniProtAcc | P51153 | |
| Context | PubMed: RAB13 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for RAB13 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for RAB13 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for RAB13 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_31892 | 1 | 153954866:153954920:153955010:153955076:153955194:153955284 | 153955010:153955076 | ENSG00000143545.4 | ENST00000495720.1,ENST00000368575.3 |
| exon_skip_31895 | 1 | 153955010:153955076:153955194:153955284:153955694:153955772 | 153955194:153955284 | ENSG00000143545.4 | ENST00000495720.1,ENST00000368575.3 |
| exon_skip_31898 | 1 | 153955220:153955284:153955694:153955772:153955996:153956057 | 153955694:153955772 | ENSG00000143545.4 | ENST00000484297.1,ENST00000495720.1,ENST00000368575.3 |
| exon_skip_31899 | 1 | 153955996:153956057:153957196:153957257:153958588:153958722 | 153957196:153957257 | ENSG00000143545.4 | ENST00000462680.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for RAB13 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_31892 | 1 | 153954866:153954920:153955010:153955076:153955194:153955284 | 153955010:153955076 | ENSG00000143545.4 | ENST00000368575.3,ENST00000495720.1 |
| exon_skip_31895 | 1 | 153955010:153955076:153955194:153955284:153955694:153955772 | 153955194:153955284 | ENSG00000143545.4 | ENST00000368575.3,ENST00000495720.1 |
| exon_skip_31898 | 1 | 153955220:153955284:153955694:153955772:153955996:153956057 | 153955694:153955772 | ENSG00000143545.4 | ENST00000368575.3,ENST00000495720.1,ENST00000484297.1 |
| exon_skip_31899 | 1 | 153955996:153956057:153957196:153957257:153958588:153958722 | 153957196:153957257 | ENSG00000143545.4 | ENST00000462680.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for RAB13 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000368575 | 153955010 | 153955076 | In-frame |
| ENST00000368575 | 153955194 | 153955284 | In-frame |
| ENST00000368575 | 153955694 | 153955772 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000368575 | 153955010 | 153955076 | In-frame |
| ENST00000368575 | 153955194 | 153955284 | In-frame |
| ENST00000368575 | 153955694 | 153955772 | In-frame |
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Infer the effects of exon skipping event on protein functional features for RAB13 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000368575 | 1193 | 203 | 153955694 | 153955772 | 363 | 440 | 82 | 108 |
| ENST00000368575 | 1193 | 203 | 153955194 | 153955284 | 441 | 530 | 108 | 138 |
| ENST00000368575 | 1193 | 203 | 153955010 | 153955076 | 531 | 596 | 138 | 160 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000368575 | 1193 | 203 | 153955694 | 153955772 | 363 | 440 | 82 | 108 |
| ENST00000368575 | 1193 | 203 | 153955194 | 153955284 | 441 | 530 | 108 | 138 |
| ENST00000368575 | 1193 | 203 | 153955010 | 153955076 | 531 | 596 | 138 | 160 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P51153 | 82 | 108 | 1 | 200 | Chain | ID=PRO_0000121182;Note=Ras-related protein Rab-13 |
| P51153 | 108 | 138 | 1 | 200 | Chain | ID=PRO_0000121182;Note=Ras-related protein Rab-13 |
| P51153 | 108 | 138 | 121 | 124 | Nucleotide binding | Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P51153 | 138 | 160 | 1 | 200 | Chain | ID=PRO_0000121182;Note=Ras-related protein Rab-13 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P51153 | 82 | 108 | 1 | 200 | Chain | ID=PRO_0000121182;Note=Ras-related protein Rab-13 |
| P51153 | 108 | 138 | 1 | 200 | Chain | ID=PRO_0000121182;Note=Ras-related protein Rab-13 |
| P51153 | 108 | 138 | 121 | 124 | Nucleotide binding | Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P51153 | 138 | 160 | 1 | 200 | Chain | ID=PRO_0000121182;Note=Ras-related protein Rab-13 |
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SNVs in the skipped exons for RAB13 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_31892 | 153955011 | 153955076 | 153955048 | 153955048 | Frame_Shift_Del | A | - | p.F148fs |
| UCEC | TCGA-BS-A0U7-01 | exon_skip_31898 | 153955695 | 153955772 | 153955755 | 153955755 | Nonsense_Mutation | G | T | p.Y88* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| ALLSIL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 153955195 | 153955284 | 153955247 | 153955247 | Missense_Mutation | T | C | p.N121S |
| COLO320_LARGE_INTESTINE | 153955195 | 153955284 | 153955268 | 153955268 | Missense_Mutation | A | C | p.V114G |
| BT474_BREAST | 153955695 | 153955772 | 153955721 | 153955721 | Missense_Mutation | G | C | p.Q100E |
| UBLC1_URINARY_TRACT | 153955695 | 153955772 | 153955742 | 153955742 | Missense_Mutation | C | T | p.E93K |
| TUHR14TKB_KIDNEY | 153955695 | 153955772 | 153955760 | 153955760 | Missense_Mutation | C | T | p.V87I |
| SNU1040_LARGE_INTESTINE | 153955695 | 153955772 | 153955765 | 153955765 | Missense_Mutation | A | G | p.I85T |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RAB13 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RAB13 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RAB13 |
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RelatedDrugs for RAB13 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAB13 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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