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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for PTPRK |
 Gene summary |
| Gene information | Gene symbol | PTPRK | Gene ID | 5796 |
| Gene name | protein tyrosine phosphatase, receptor type K | |
| Synonyms | R-PTP-kappa | |
| Cytomap | 6q22.33 | |
| Type of gene | protein-coding | |
| Description | receptor-type tyrosine-protein phosphatase kappadJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappaprotein-tyrosine phosphatase kappaprotein-tyrosine phospha | |
| Modification date | 20180519 | |
| UniProtAcc | Q15262 | |
| Context | PubMed: PTPRK [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PTPRK | GO:0006470 | protein dephosphorylation | 16263724 |
| PTPRK | GO:0007165 | signal transduction | 16849327 |
| PTPRK | GO:0007179 | transforming growth factor beta receptor signaling pathway | 15899872 |
| PTPRK | GO:0008285 | negative regulation of cell proliferation | 15899872|18276111 |
| PTPRK | GO:0010839 | negative regulation of keratinocyte proliferation | 16263724 |
| PTPRK | GO:0030336 | negative regulation of cell migration | 18276111 |
| PTPRK | GO:0034394 | protein localization to cell surface | 18276111 |
| PTPRK | GO:0034614 | cellular response to reactive oxygen species | 16849327 |
| PTPRK | GO:0034644 | cellular response to UV | 16849327 |
| PTPRK | GO:0045786 | negative regulation of cell cycle | 15899872 |
| PTPRK | GO:0045892 | negative regulation of transcription, DNA-templated | 18276111 |
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Exon skipping events across known transcript of Ensembl for PTPRK from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for PTPRK |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for PTPRK |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_462190 | 6 | 128294166:128294302:128294808:128294972:128297801:128297927 | 128294808:128294972 | ENSG00000152894.10 | ENST00000368227.3,ENST00000368226.4,ENST00000368210.3,ENST00000368213.5,ENST00000368215.3,ENST00000368207.3,ENST00000532331.1 |
| exon_skip_462193 | 6 | 128302260:128302434:128303975:128304125:128304386:128304522 | 128303975:128304125 | ENSG00000152894.10 | ENST00000368227.3,ENST00000368226.4,ENST00000368210.3,ENST00000368213.5,ENST00000368215.3,ENST00000368207.3,ENST00000532331.1 |
| exon_skip_462194 | 6 | 128313817:128313854:128316393:128316411:128316606:128316683 | 128316393:128316411 | ENSG00000152894.10 | ENST00000368210.3,ENST00000368213.5,ENST00000368207.3,ENST00000532331.1 |
| exon_skip_462195 | 6 | 128319864:128320049:128322340:128322352:128324341:128324377 | 128322340:128322352 | ENSG00000152894.10 | ENST00000415055.2,ENST00000368207.3,ENST00000532331.1 |
| exon_skip_462197 | 6 | 128319864:128320049:128324341:128324377:128326228:128326389 | 128324341:128324377 | ENSG00000152894.10 | ENST00000368227.3,ENST00000368210.3,ENST00000415046.2 |
| exon_skip_462198 | 6 | 128321131:128321475:128322340:128322352:128324341:128324377 | 128322340:128322352 | ENSG00000152894.10 | ENST00000531050.1,ENST00000524481.1 |
| exon_skip_462201 | 6 | 128322340:128322352:128324341:128324377:128326228:128326389 | 128324341:128324377 | ENSG00000152894.10 | ENST00000531050.1,ENST00000415055.2,ENST00000524481.1,ENST00000368207.3,ENST00000532331.1 |
| exon_skip_462202 | 6 | 128326228:128326389:128327170:128327200:128329190:128329222 | 128327170:128327200 | ENSG00000152894.10 | ENST00000531050.1,ENST00000415055.2 |
| exon_skip_462203 | 6 | 128326228:128326389:128327170:128327200:128330274:128330317 | 128327170:128327200 | ENSG00000152894.10 | ENST00000524481.1,ENST00000415046.2,ENST00000368207.3 |
| exon_skip_462205 | 6 | 128327170:128327200:128329190:128329232:128330274:128330317 | 128329190:128329232 | ENSG00000152894.10 | ENST00000531050.1 |
| exon_skip_462206 | 6 | 128404859:128404969:128410834:128411137:128505576:128505870 | 128410834:128411137 | ENSG00000152894.10 | ENST00000368227.3,ENST00000368226.4,ENST00000368210.3,ENST00000531050.1,ENST00000524534.1,ENST00000368213.5,ENST00000524481.1,ENST00000368215.3,ENST00000368207.3,ENST00000532331.1 |
| exon_skip_462207 | 6 | 128410834:128411137:128505576:128505870:128540066:128540241 | 128505576:128505870 | ENSG00000152894.10 | ENST00000368227.3,ENST00000368226.4,ENST00000368210.3,ENST00000531050.1,ENST00000524534.1,ENST00000368213.5,ENST00000524481.1,ENST00000368215.3,ENST00000368207.3,ENST00000532331.1 |
| exon_skip_462213 | 6 | 128561179:128561295:128563665:128563747:128643183:128643318 | 128563665:128563747 | ENSG00000152894.10 | ENST00000368227.3,ENST00000368226.4,ENST00000368210.3,ENST00000429595.1,ENST00000524534.1,ENST00000368213.5,ENST00000524481.1,ENST00000368215.3,ENST00000495748.1,ENST00000368207.3,ENST00000532331.1 |
| exon_skip_462216 | 6 | 128563665:128563747:128643183:128643455:128718710:128718762 | 128643183:128643455 | ENSG00000152894.10 | ENST00000368227.3,ENST00000368226.4,ENST00000368210.3,ENST00000524534.1,ENST00000368213.5,ENST00000524481.1,ENST00000368215.3,ENST00000495748.1,ENST00000368207.3,ENST00000532331.1 |
| exon_skip_462219 | 6 | 128643395:128643455:128718710:128718833:128841403:128841503 | 128718710:128718833 | ENSG00000152894.10 | ENST00000368227.3,ENST00000368210.3,ENST00000525459.1,ENST00000524534.1,ENST00000368213.5,ENST00000524481.1,ENST00000368215.3,ENST00000368207.3,ENST00000532331.1 |
| exon_skip_462221 | 6 | 128718710:128718833:128730438:128730477:128841403:128841503 | 128730438:128730477 | ENSG00000152894.10 | ENST00000532751.1 |
| exon_skip_462222 | 6 | 128718710:128718833:128812876:128812994:128841403:128841503 | 128812876:128812994 | ENSG00000152894.10 | ENST00000392449.4 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for PTPRK |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_462190 | 6 | 128294166:128294302:128294808:128294972:128297801:128297927 | 128294808:128294972 | ENSG00000152894.10 | ENST00000368226.4,ENST00000368227.3,ENST00000532331.1,ENST00000368213.5,ENST00000368210.3,ENST00000368215.3,ENST00000368207.3 |
| exon_skip_462193 | 6 | 128302260:128302434:128303975:128304125:128304386:128304522 | 128303975:128304125 | ENSG00000152894.10 | ENST00000368226.4,ENST00000368227.3,ENST00000532331.1,ENST00000368213.5,ENST00000368210.3,ENST00000368215.3,ENST00000368207.3 |
| exon_skip_462194 | 6 | 128313817:128313854:128316393:128316411:128316606:128316683 | 128316393:128316411 | ENSG00000152894.10 | ENST00000532331.1,ENST00000368213.5,ENST00000368210.3,ENST00000368207.3 |
| exon_skip_462195 | 6 | 128319864:128320049:128322340:128322352:128324341:128324377 | 128322340:128322352 | ENSG00000152894.10 | ENST00000532331.1,ENST00000368207.3,ENST00000415055.2 |
| exon_skip_462197 | 6 | 128319864:128320049:128324341:128324377:128326228:128326389 | 128324341:128324377 | ENSG00000152894.10 | ENST00000368227.3,ENST00000368210.3,ENST00000415046.2 |
| exon_skip_462198 | 6 | 128321131:128321475:128322340:128322352:128324341:128324377 | 128322340:128322352 | ENSG00000152894.10 | ENST00000531050.1,ENST00000524481.1 |
| exon_skip_462201 | 6 | 128322340:128322352:128324341:128324377:128326228:128326389 | 128324341:128324377 | ENSG00000152894.10 | ENST00000532331.1,ENST00000368207.3,ENST00000415055.2,ENST00000531050.1,ENST00000524481.1 |
| exon_skip_462202 | 6 | 128326228:128326389:128327170:128327200:128329190:128329222 | 128327170:128327200 | ENSG00000152894.10 | ENST00000415055.2,ENST00000531050.1 |
| exon_skip_462203 | 6 | 128326228:128326389:128327170:128327200:128330274:128330317 | 128327170:128327200 | ENSG00000152894.10 | ENST00000368207.3,ENST00000415046.2,ENST00000524481.1 |
| exon_skip_462205 | 6 | 128327170:128327200:128329190:128329232:128330274:128330317 | 128329190:128329232 | ENSG00000152894.10 | ENST00000531050.1 |
| exon_skip_462213 | 6 | 128561179:128561295:128563665:128563747:128643183:128643318 | 128563665:128563747 | ENSG00000152894.10 | ENST00000368226.4,ENST00000368227.3,ENST00000532331.1,ENST00000368213.5,ENST00000368210.3,ENST00000368215.3,ENST00000368207.3,ENST00000524481.1,ENST00000524534.1,ENST00000495748.1,ENST00000429595.1 |
| exon_skip_462216 | 6 | 128563665:128563747:128643183:128643455:128718710:128718762 | 128643183:128643455 | ENSG00000152894.10 | ENST00000368226.4,ENST00000368227.3,ENST00000532331.1,ENST00000368213.5,ENST00000368210.3,ENST00000368215.3,ENST00000368207.3,ENST00000524481.1,ENST00000524534.1,ENST00000495748.1 |
| exon_skip_462219 | 6 | 128643395:128643455:128718710:128718833:128841403:128841503 | 128718710:128718833 | ENSG00000152894.10 | ENST00000368227.3,ENST00000532331.1,ENST00000368213.5,ENST00000368210.3,ENST00000368215.3,ENST00000368207.3,ENST00000524481.1,ENST00000524534.1,ENST00000525459.1 |
| exon_skip_462221 | 6 | 128718710:128718833:128730438:128730477:128841403:128841503 | 128730438:128730477 | ENSG00000152894.10 | ENST00000532751.1 |
| exon_skip_462222 | 6 | 128718710:128718833:128812876:128812994:128841403:128841503 | 128812876:128812994 | ENSG00000152894.10 | ENST00000392449.4 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for PTPRK |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for PTPRK |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for PTPRK |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_462206 | 128410835 | 128411137 | 128410951 | 128410951 | Frame_Shift_Del | G | - | p.P450fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_462207 | 128505577 | 128505870 | 128505849 | 128505849 | Frame_Shift_Del | G | - | p.P298fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_462216 | 128643184 | 128643455 | 128643201 | 128643201 | Frame_Shift_Del | A | - | p.W160fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_462216 | 128643184 | 128643455 | 128643242 | 128643242 | Frame_Shift_Del | C | - | p.G146fs |
| STAD | TCGA-BR-7851-01 | exon_skip_462206 | 128410835 | 128411137 | 128411121 | 128411122 | Frame_Shift_Ins | - | G | p.P393fs |
| STAD | TCGA-BR-7851-01 | exon_skip_462206 | 128410835 | 128411137 | 128411122 | 128411123 | Frame_Shift_Ins | - | G | p.P393fs |
| BLCA | TCGA-DK-A2I4-01 | exon_skip_462206 | 128410835 | 128411137 | 128410865 | 128410865 | Nonsense_Mutation | C | A | p.E479* |
| BRCA | TCGA-A2-A0YK-01 | exon_skip_462206 | 128410835 | 128411137 | 128410949 | 128410949 | Nonsense_Mutation | G | A | p.Q451* |
| SKCM | TCGA-D3-A8GI-06 | exon_skip_462206 | 128410835 | 128411137 | 128411070 | 128411070 | Nonsense_Mutation | C | T | p.W410* |
| OV | TCGA-13-0726-01 | exon_skip_462207 | 128505577 | 128505870 | 128505586 | 128505586 | Nonsense_Mutation | T | T | p.K385* |
| STAD | TCGA-VQ-A91V-01 | exon_skip_462207 | 128505577 | 128505870 | 128505687 | 128505687 | Nonsense_Mutation | C | T | p.W351* |
| STAD | TCGA-VQ-A91V-01 | exon_skip_462207 | 128505577 | 128505870 | 128505687 | 128505687 | Nonsense_Mutation | C | T | p.W351X |
| UCEC | TCGA-EO-A1Y5-01 | exon_skip_462207 | 128505577 | 128505870 | 128505748 | 128505748 | Nonsense_Mutation | G | A | p.R331* |
| HNSC | TCGA-BB-8596-01 | exon_skip_462213 | 128563666 | 128563747 | 128563725 | 128563725 | Nonsense_Mutation | G | C | p.S173* |
| UCEC | TCGA-AX-A0J0-01 | exon_skip_462216 | 128643184 | 128643455 | 128643330 | 128643330 | Nonsense_Mutation | C | A | p.G117* |
| ESCA | TCGA-LN-A49R-01 | exon_skip_462219 | 128718711 | 128718833 | 128718824 | 128718824 | Nonsense_Mutation | G | T | p.Y76* |
| LUSC | TCGA-22-5491-01 | exon_skip_462206 | 128410835 | 128411137 | 128411138 | 128411138 | Splice_Site | C | T | p.E388_splice |
| UCEC | TCGA-B5-A0K6-01 | exon_skip_462219 | 128718711 | 128718833 | 128718710 | 128718710 | Splice_Site | C | T | p.G75_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LS411N_LARGE_INTESTINE | 128294809 | 128294972 | 128294860 | 128294860 | Frame_Shift_Del | T | - | p.K1360fs |
| U937_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 128505577 | 128505870 | 128505668 | 128505668 | Frame_Shift_Del | G | - | p.T357fs |
| SW48_LARGE_INTESTINE | 128505577 | 128505870 | 128505583 | 128505584 | Frame_Shift_Ins | - | T | p.C386fs |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 128294809 | 128294972 | 128294824 | 128294824 | Missense_Mutation | G | A | p.T1372M |
| HEC1A_ENDOMETRIUM | 128294809 | 128294972 | 128294843 | 128294843 | Missense_Mutation | C | T | p.E1366K |
| HEC1_ENDOMETRIUM | 128294809 | 128294972 | 128294843 | 128294843 | Missense_Mutation | C | T | p.E1366K |
| OVK18_OVARY | 128303976 | 128304125 | 128304038 | 128304038 | Missense_Mutation | A | T | p.Y1158N |
| EVSAT_BREAST | 128410835 | 128411137 | 128410860 | 128410860 | Missense_Mutation | C | G | p.E480D |
| KMRC20_KIDNEY | 128410835 | 128411137 | 128410891 | 128410891 | Missense_Mutation | G | A | p.T470I |
| NCIH524_LUNG | 128410835 | 128411137 | 128410955 | 128410955 | Missense_Mutation | C | A | p.A449S |
| LN443_CENTRAL_NERVOUS_SYSTEM | 128410835 | 128411137 | 128410975 | 128410975 | Missense_Mutation | C | A | p.C442F |
| LN443_CENTRAL_NERVOUS_SYSTEM | 128410835 | 128411137 | 128410977 | 128410977 | Missense_Mutation | G | T | p.D441E |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 128410835 | 128411137 | 128410984 | 128410984 | Missense_Mutation | T | C | p.K439R |
| SW684_SOFT_TISSUE | 128410835 | 128411137 | 128411069 | 128411069 | Missense_Mutation | C | T | p.E411K |
| NCC010_KIDNEY | 128410835 | 128411137 | 128411114 | 128411114 | Missense_Mutation | A | C | p.L396V |
| ISHIKAWAHERAKLIO02ER_ENDOMETRIUM | 128410835 | 128411137 | 128411126 | 128411126 | Missense_Mutation | T | C | p.T392A |
| HCC2998_LARGE_INTESTINE | 128505577 | 128505870 | 128505667 | 128505667 | Missense_Mutation | C | T | p.E358K |
| SW684_SOFT_TISSUE | 128505577 | 128505870 | 128505667 | 128505667 | Missense_Mutation | C | T | p.E358K |
| BECKER_CENTRAL_NERVOUS_SYSTEM | 128505577 | 128505870 | 128505772 | 128505772 | Missense_Mutation | T | C | p.I323V |
| LU134A_LUNG | 128563666 | 128563747 | 128563707 | 128563707 | Missense_Mutation | T | A | p.Y179F |
| NCIH2444_LUNG | 128563666 | 128563747 | 128563737 | 128563737 | Missense_Mutation | T | G | p.E169A |
| IGR1_SKIN | 128643184 | 128643455 | 128643224 | 128643224 | Missense_Mutation | G | A | p.A152V |
| SNU1040_LARGE_INTESTINE | 128643184 | 128643455 | 128643227 | 128643227 | Missense_Mutation | C | T | p.R151Q |
| HS695T_SKIN | 128643184 | 128643455 | 128643246 | 128643246 | Missense_Mutation | T | A | p.T145S |
| ES2_OVARY | 128643184 | 128643455 | 128643270 | 128643270 | Missense_Mutation | G | A | p.P137S |
| KYAE1_OESOPHAGUS | 128643184 | 128643455 | 128643301 | 128643301 | Missense_Mutation | T | G | p.L126F |
| SNU81_LARGE_INTESTINE | 128643184 | 128643455 | 128643385 | 128643385 | Missense_Mutation | C | A | p.M98I |
| COLO792_SKIN | 128643184 | 128643455 | 128643453 | 128643453 | Missense_Mutation | A | C | p.S76A |
| SNU1040_LARGE_INTESTINE | 128718711 | 128718833 | 128718755 | 128718755 | Missense_Mutation | A | G | p.V60A |
| CORL24_LUNG | 128718711 | 128718833 | 128718790 | 128718790 | Missense_Mutation | G | C | p.H48Q |
| KYSE140_OESOPHAGUS | 128303976 | 128304125 | 128303978 | 128303978 | Nonsense_Mutation | G | A | p.Q1178* |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 128563666 | 128563747 | 128563667 | 128563667 | Splice_Site | A | G | p.C192C |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PTPRK |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PTPRK |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PTPRK |
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RelatedDrugs for PTPRK |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PTPRK |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| PTPRK | C0025202 | melanoma | 2 | CTD_human |
| PTPRK | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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