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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for RAP2C |
 Gene summary |
| Gene information | Gene symbol | RAP2C | Gene ID | 57826 |
| Gene name | RAP2C, member of RAS oncogene family | |
| Synonyms | - | |
| Cytomap | Xq26.2 | |
| Type of gene | protein-coding | |
| Description | ras-related protein Rap-2csmall GTPase RAP2C | |
| Modification date | 20180522 | |
| UniProtAcc | Q9Y3L5 | |
| Context | PubMed: RAP2C [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for RAP2C from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for RAP2C |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for RAP2C |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_516759 | X | 131348161:131348474:131351023:131351834:131351943:131352040 | 131351023:131351834 | ENSG00000123728.5 | ENST00000370874.1 |
| exon_skip_516765 | X | 131351023:131351184:131351305:131351395:131352259:131352360 | 131351305:131351395 | ENSG00000123728.5 | ENST00000460462.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for RAP2C |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_516759 | X | 131348161:131348474:131351023:131351834:131351943:131352040 | 131351023:131351834 | ENSG00000123728.5 | ENST00000370874.1 |
| exon_skip_516765 | X | 131351023:131351184:131351305:131351395:131352259:131352360 | 131351305:131351395 | ENSG00000123728.5 | ENST00000460462.1 |
| exon_skip_516768 | X | 131351693:131351834:131351943:131352040:131352259:131352360 | 131351943:131352040 | ENSG00000123728.5 | ENST00000370874.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for RAP2C |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370874 | 131351023 | 131351834 | 3UTR-3CDS |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370874 | 131351023 | 131351834 | 3UTR-3CDS |
| ENST00000370874 | 131351943 | 131352040 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for RAP2C |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for RAP2C |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| MDAPCA2B_PROSTATE | 131351024 | 131351834 | 131351049 | 131351049 | Missense_Mutation | C | T | p.S83N |
| MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 131351024 | 131351834 | 131351081 | 131351081 | Missense_Mutation | G | C | p.I72M |
| NCIH1930_LUNG | 131351024 | 131351834 | 131351109 | 131351109 | Missense_Mutation | T | C | p.Q63R |
| 2313287_STOMACH | 131351024 | 131351834 | 131351251 | 131351251 | Missense_Mutation | T | C | p.K16E |
| OCUBM_BREAST | 131351024 | 131351834 | 131351293 | 131351293 | Missense_Mutation | T | C | p.R2G |
| MFE319_ENDOMETRIUM | 131351024 | 131351834 | 131351035 | 131351035 | Nonsense_Mutation | G | A | p.Q88* |
| SNGM_ENDOMETRIUM | 131351024 | 131351834 | 131351025 | 131351025 | Splice_Site | T | C | p.Q91R |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RAP2C |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RAP2C |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RAP2C |
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RelatedDrugs for RAP2C |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAP2C |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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