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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for METTL14 |
 Gene summary |
| Gene information | Gene symbol | METTL14 | Gene ID | 57721 |
| Gene name | methyltransferase like 14 | |
| Synonyms | hMETTL14 | |
| Cytomap | 4q26 | |
| Type of gene | protein-coding | |
| Description | N6-adenosine-methyltransferase non-catalytic subunitN6-adenosine-methyltransferase subunit METTL14methyltransferase-like protein 14 | |
| Modification date | 20180522 | |
| UniProtAcc | Q9HCE5 | |
| Context | PubMed: METTL14 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| METTL14 | GO:0080009 | mRNA methylation | 27281194|27373337|27627798 |
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Exon skipping events across known transcript of Ensembl for METTL14 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for METTL14 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for METTL14 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_425897 | 4 | 119606569:119606755:119607704:119607854:119609077:119609166 | 119607704:119607854 | ENSG00000145388.10 | ENST00000508801.1 |
| exon_skip_425898 | 4 | 119606569:119606755:119609077:119609166:119610524:119610584 | 119609077:119609166 | ENSG00000145388.10 | ENST00000506780.1 |
| exon_skip_425899 | 4 | 119615590:119615681:119618336:119618478:119621704:119621797 | 119618336:119618478 | ENSG00000145388.10 | ENST00000506780.1,ENST00000502564.1,ENST00000388822.5 |
| exon_skip_425902 | 4 | 119618336:119618478:119621704:119621797:119625089:119625206 | 119621704:119621797 | ENSG00000145388.10 | ENST00000506780.1,ENST00000502564.1,ENST00000388822.5 |
| exon_skip_425904 | 4 | 119625089:119625206:119626765:119626976:119631152:119631401 | 119626765:119626976 | ENSG00000145388.10 | ENST00000506780.1,ENST00000388822.5 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for METTL14 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_425897 | 4 | 119606569:119606755:119607704:119607854:119609077:119609166 | 119607704:119607854 | ENSG00000145388.10 | ENST00000508801.1 |
| exon_skip_425898 | 4 | 119606569:119606755:119609077:119609166:119610524:119610584 | 119609077:119609166 | ENSG00000145388.10 | ENST00000506780.1 |
| exon_skip_425899 | 4 | 119615590:119615681:119618336:119618478:119621704:119621797 | 119618336:119618478 | ENSG00000145388.10 | ENST00000388822.5,ENST00000506780.1,ENST00000502564.1 |
| exon_skip_425902 | 4 | 119618336:119618478:119621704:119621797:119625089:119625206 | 119621704:119621797 | ENSG00000145388.10 | ENST00000388822.5,ENST00000506780.1,ENST00000502564.1 |
| exon_skip_425904 | 4 | 119625089:119625206:119626765:119626976:119631152:119631401 | 119626765:119626976 | ENSG00000145388.10 | ENST00000388822.5,ENST00000506780.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for METTL14 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000388822 | 119618336 | 119618478 | Frame-shift |
| ENST00000388822 | 119626765 | 119626976 | Frame-shift |
| ENST00000388822 | 119621704 | 119621797 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000388822 | 119618336 | 119618478 | Frame-shift |
| ENST00000388822 | 119626765 | 119626976 | Frame-shift |
| ENST00000388822 | 119621704 | 119621797 | In-frame |
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Infer the effects of exon skipping event on protein functional features for METTL14 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000388822 | 6686 | 456 | 119621704 | 119621797 | 813 | 905 | 215 | 246 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000388822 | 6686 | 456 | 119621704 | 119621797 | 813 | 905 | 215 | 246 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9HCE5 | 215 | 246 | 225 | 234 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IL2 |
| Q9HCE5 | 215 | 246 | 242 | 242 | Binding site | Note=Interaction with METTL3;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5IL0,ECO:0000244|PDB:5IL1,ECO:0000244|PDB:5IL2,ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194 |
| Q9HCE5 | 215 | 246 | 245 | 245 | Binding site | Note=Interaction with METTL3;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5IL0,ECO:0000244|PDB:5IL1,ECO:0000244|PDB:5IL2,ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194 |
| Q9HCE5 | 215 | 246 | 1 | 456 | Chain | ID=PRO_0000325790;Note=N6-adenosine-methyltransferase non-catalytic subunit |
| Q9HCE5 | 215 | 246 | 213 | 217 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IL2 |
| Q9HCE5 | 215 | 246 | 221 | 223 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IL2 |
| Q9HCE5 | 215 | 246 | 240 | 251 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IL2 |
| Q9HCE5 | 215 | 246 | 245 | 245 | Mutagenesis | Note=Reduced RNA-binding. Reduced RNA-binding%3B when associated with E-255. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194 |
| Q9HCE5 | 215 | 246 | 237 | 238 | Region | Note=Interaction with METTL3;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5IL0,ECO:0000244|PDB:5IL1,ECO:0000244|PDB:5IL2,ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194 |
| Q9HCE5 | 215 | 246 | 245 | 254 | Region | Note=Positively charged region required for RNA-binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9HCE5 | 215 | 246 | 225 | 234 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IL2 |
| Q9HCE5 | 215 | 246 | 242 | 242 | Binding site | Note=Interaction with METTL3;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5IL0,ECO:0000244|PDB:5IL1,ECO:0000244|PDB:5IL2,ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194 |
| Q9HCE5 | 215 | 246 | 245 | 245 | Binding site | Note=Interaction with METTL3;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5IL0,ECO:0000244|PDB:5IL1,ECO:0000244|PDB:5IL2,ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194 |
| Q9HCE5 | 215 | 246 | 1 | 456 | Chain | ID=PRO_0000325790;Note=N6-adenosine-methyltransferase non-catalytic subunit |
| Q9HCE5 | 215 | 246 | 213 | 217 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IL2 |
| Q9HCE5 | 215 | 246 | 221 | 223 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IL2 |
| Q9HCE5 | 215 | 246 | 240 | 251 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IL2 |
| Q9HCE5 | 215 | 246 | 245 | 245 | Mutagenesis | Note=Reduced RNA-binding. Reduced RNA-binding%3B when associated with E-255. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194 |
| Q9HCE5 | 215 | 246 | 237 | 238 | Region | Note=Interaction with METTL3;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5IL0,ECO:0000244|PDB:5IL1,ECO:0000244|PDB:5IL2,ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194 |
| Q9HCE5 | 215 | 246 | 245 | 254 | Region | Note=Positively charged region required for RNA-binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194 |
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SNVs in the skipped exons for METTL14 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_425904 | 119626766 | 119626976 | 119626780 | 119626780 | Frame_Shift_Del | G | - | p.M290fs |
| UCS | TCGA-NA-A4R1-01 | exon_skip_425902 | 119621705 | 119621797 | 119621741 | 119621741 | Nonsense_Mutation | C | T | p.R228* |
| UCS | TCGA-NA-A4R1-01 | exon_skip_425902 | 119621705 | 119621797 | 119621741 | 119621741 | Nonsense_Mutation | C | T | p.R228X |
| BLCA | TCGA-KQ-A41N-01 | exon_skip_425902 | 119621705 | 119621797 | 119621745 | 119621745 | Nonsense_Mutation | C | G | p.S229* |
| UCEC | TCGA-AX-A0J1-01 | exon_skip_425904 | 119626766 | 119626976 | 119626970 | 119626970 | Nonsense_Mutation | C | T | p.R354* |
| PAAD | TCGA-F2-A44G-01 | exon_skip_425898 | 119609078 | 119609166 | 119609076 | 119609076 | Splice_Site | A | G | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| KM12_LARGE_INTESTINE | 119609078 | 119609166 | 119609082 | 119609082 | Missense_Mutation | G | A | p.G24E |
| HCT116_LARGE_INTESTINE | 119618337 | 119618478 | 119618383 | 119618383 | Missense_Mutation | C | G | p.P184A |
| OUMS23_LARGE_INTESTINE | 119621705 | 119621797 | 119621711 | 119621711 | Missense_Mutation | A | G | p.K218E |
| SMZ1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 119626766 | 119626976 | 119626814 | 119626814 | Missense_Mutation | G | A | p.G302R |
| SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 119626766 | 119626976 | 119626893 | 119626893 | Missense_Mutation | T | C | p.V328A |
| HCC2998_LARGE_INTESTINE | 119626766 | 119626976 | 119626970 | 119626970 | Nonsense_Mutation | C | T | p.R354* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for METTL14 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for METTL14 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for METTL14 |
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RelatedDrugs for METTL14 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for METTL14 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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