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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for SEMA4G |
 Gene summary |
| Gene information | Gene symbol | SEMA4G | Gene ID | 57715 |
| Gene name | semaphorin 4G | |
| Synonyms | - | |
| Cytomap | 10q24.31 | |
| Type of gene | protein-coding | |
| Description | semaphorin-4Gsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G | |
| Modification date | 20180523 | |
| UniProtAcc | Q9NTN9 | |
| Context | PubMed: SEMA4G [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for SEMA4G from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for SEMA4G |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for SEMA4G |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_44390 | 10 | 102729286:102729348:102729448:102729681:102732285:102732412 | 102729448:102729681 | ENSG00000095539.11 | ENST00000518244.1 |
| exon_skip_44396 | 10 | 102732751:102732793:102732885:102733034:102733303:102733366 | 102732885:102733034 | ENSG00000095539.11 | ENST00000519649.1,ENST00000517724.1,ENST00000521006.1,ENST00000518124.1,ENST00000519756.1,ENST00000210633.3,ENST00000370250.4 |
| exon_skip_44397 | 10 | 102737388:102737487:102738051:102738145:102738283:102738397 | 102738051:102738145 | ENSG00000095539.11 | ENST00000519649.1,ENST00000517724.1,ENST00000521006.1,ENST00000519756.1,ENST00000210633.3,ENST00000370250.4 |
| exon_skip_44399 | 10 | 102738301:102738397:102738605:102738775:102738858:102739025 | 102738605:102738775 | ENSG00000095539.11 | ENST00000519649.1,ENST00000517724.1,ENST00000521006.1,ENST00000210633.3,ENST00000370250.4 |
| exon_skip_44403 | 10 | 102739604:102739749:102739878:102740101:102740334:102740450 | 102739878:102740101 | ENSG00000095539.11 | ENST00000519649.1,ENST00000517724.1,ENST00000521006.1,ENST00000210633.3,ENST00000370250.4 |
| exon_skip_44416 | 10 | 102739878:102740101:102740334:102740450:102740578:102740677 | 102740334:102740450 | ENSG00000095539.11 | ENST00000519649.1,ENST00000517724.1,ENST00000521006.1,ENST00000210633.3,ENST00000370250.4 |
| exon_skip_44424 | 10 | 102740924:102740986:102743061:102744114:102744246:102744547 | 102743061:102744114 | ENSG00000095539.11 | ENST00000521006.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for SEMA4G |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_44390 | 10 | 102729286:102729348:102729448:102729681:102732285:102732412 | 102729448:102729681 | ENSG00000095539.11 | ENST00000518244.1 |
| exon_skip_44396 | 10 | 102732751:102732793:102732885:102733034:102733303:102733366 | 102732885:102733034 | ENSG00000095539.11 | ENST00000519649.1,ENST00000521006.1,ENST00000518124.1,ENST00000370250.4,ENST00000517724.1,ENST00000210633.3,ENST00000519756.1 |
| exon_skip_44397 | 10 | 102737388:102737487:102738051:102738145:102738283:102738397 | 102738051:102738145 | ENSG00000095539.11 | ENST00000519649.1,ENST00000521006.1,ENST00000370250.4,ENST00000517724.1,ENST00000210633.3,ENST00000519756.1 |
| exon_skip_44399 | 10 | 102738301:102738397:102738605:102738775:102738858:102739025 | 102738605:102738775 | ENSG00000095539.11 | ENST00000519649.1,ENST00000521006.1,ENST00000370250.4,ENST00000517724.1,ENST00000210633.3 |
| exon_skip_44403 | 10 | 102739604:102739749:102739878:102740101:102740334:102740450 | 102739878:102740101 | ENSG00000095539.11 | ENST00000519649.1,ENST00000521006.1,ENST00000370250.4,ENST00000517724.1,ENST00000210633.3 |
| exon_skip_44416 | 10 | 102739878:102740101:102740334:102740450:102740578:102740677 | 102740334:102740450 | ENSG00000095539.11 | ENST00000519649.1,ENST00000521006.1,ENST00000370250.4,ENST00000517724.1,ENST00000210633.3 |
| exon_skip_44424 | 10 | 102740924:102740986:102743061:102744114:102744246:102744547 | 102743061:102744114 | ENSG00000095539.11 | ENST00000521006.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for SEMA4G |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370250 | 102732885 | 102733034 | Frame-shift |
| ENST00000370250 | 102738051 | 102738145 | Frame-shift |
| ENST00000370250 | 102738605 | 102738775 | Frame-shift |
| ENST00000370250 | 102739878 | 102740101 | Frame-shift |
| ENST00000370250 | 102740334 | 102740450 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370250 | 102732885 | 102733034 | Frame-shift |
| ENST00000370250 | 102738051 | 102738145 | Frame-shift |
| ENST00000370250 | 102738605 | 102738775 | Frame-shift |
| ENST00000370250 | 102739878 | 102740101 | Frame-shift |
| ENST00000370250 | 102740334 | 102740450 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for SEMA4G |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for SEMA4G |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
SEMA4G_CHOL_exon_skip_44424_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_44397 | 102738052 | 102738145 | 102738119 | 102738119 | Frame_Shift_Del | C | - | p.A168fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_44403 | 102739879 | 102740101 | 102739948 | 102739948 | Frame_Shift_Del | T | - | p.F400fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_44416 | 102740335 | 102740450 | 102740407 | 102740407 | Frame_Shift_Del | G | - | p.R475fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_44416 | 102740335 | 102740450 | 102740425 | 102740425 | Frame_Shift_Del | A | - | p.E481fs |
| STAD | TCGA-CD-A4MJ-01 | exon_skip_44424 | 102743062 | 102744114 | 102743278 | 102743278 | Frame_Shift_Del | A | - | p.E641fs |
| THYM | TCGA-XM-A8RG-01 | exon_skip_44424 | 102743062 | 102744114 | 102743633 | 102743633 | Frame_Shift_Del | C | - | p.L759fs |
| CHOL | TCGA-W5-AA2Q-01 | exon_skip_44424 | 102743062 | 102744114 | 102743836 | 102743836 | Frame_Shift_Del | A | - | p.E827fs |
| SKCM | TCGA-EE-A2MU-06 | exon_skip_44416 | 102740335 | 102740450 | 102740344 | 102740344 | Nonsense_Mutation | G | A | p.W454* |
| SKCM | TCGA-EE-A2MU-06 | exon_skip_44416 | 102740335 | 102740450 | 102740344 | 102740344 | Nonsense_Mutation | G | A | p.W454X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-W5-AA2Q-01 |
| Cancer type: CHOL | |
| ESID: exon_skip_44424 | |
| Skipped exon start: 102743062 | |
| Skipped exon end: 102744114 | |
| Mutation start: 102743836 | |
| Mutation end: 102743836 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: A | |
| Mutation seq: - | |
| AAchange: p.E827fs | |
exon_skip_44424_CHOL_TCGA-W5-AA2Q-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| IM95_STOMACH | 102743062 | 102744114 | 102743603 | 102743603 | Frame_Shift_Del | G | - | p.E744fs |
| SNU1040_LARGE_INTESTINE | 102743062 | 102744114 | 102743662 | 102743662 | Frame_Shift_Del | C | - | p.A764fs |
| SNGM_ENDOMETRIUM | 102743062 | 102744114 | 102743679 | 102743679 | Frame_Shift_Del | C | - | p.P774fs |
| NCIH1092_LUNG | 102732886 | 102733034 | 102732892 | 102732892 | Missense_Mutation | C | A | p.S44Y |
| C80_LARGE_INTESTINE | 102732886 | 102733034 | 102732901 | 102732901 | Missense_Mutation | G | A | p.R47Q |
| CROAP2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 102738052 | 102738145 | 102738058 | 102738058 | Missense_Mutation | G | A | p.E148K |
| CTB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 102738052 | 102738145 | 102738094 | 102738094 | Missense_Mutation | A | G | p.K160E |
| NBSUSSR_AUTONOMIC_GANGLIA | 102738052 | 102738145 | 102738107 | 102738107 | Missense_Mutation | C | T | p.P164L |
| GP2D_LARGE_INTESTINE | 102738052 | 102738145 | 102738130 | 102738130 | Missense_Mutation | A | T | p.T172S |
| GP5D_LARGE_INTESTINE | 102738052 | 102738145 | 102738130 | 102738130 | Missense_Mutation | A | T | p.T172S |
| T173_FIBROBLAST | 102738606 | 102738775 | 102738656 | 102738656 | Missense_Mutation | G | A | p.V232M |
| NCIH1155_LUNG | 102738606 | 102738775 | 102738690 | 102738690 | Missense_Mutation | C | T | p.T243M |
| NCIH2342_LUNG | 102738606 | 102738775 | 102738692 | 102738692 | Missense_Mutation | G | C | p.E244Q |
| VMCUB1_URINARY_TRACT | 102738606 | 102738775 | 102738704 | 102738704 | Missense_Mutation | G | A | p.E248K |
| SNUC4_LARGE_INTESTINE | 102738606 | 102738775 | 102738717 | 102738717 | Missense_Mutation | G | A | p.G252D |
| HS936T_SKIN | 102738606 | 102738775 | 102738726 | 102738726 | Missense_Mutation | C | T | p.T255I |
| MDAPCA2B_PROSTATE | 102739879 | 102740101 | 102739885 | 102739885 | Missense_Mutation | A | G | p.T379A |
| OC316_OVARY | 102739879 | 102740101 | 102739897 | 102739897 | Missense_Mutation | C | T | p.R383C |
| OC314_OVARY | 102739879 | 102740101 | 102739897 | 102739897 | Missense_Mutation | C | T | p.R383C |
| CCK81_LARGE_INTESTINE | 102739879 | 102740101 | 102739898 | 102739898 | Missense_Mutation | G | A | p.R383H |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 102739879 | 102740101 | 102739904 | 102739904 | Missense_Mutation | A | G | p.Q385R |
| HCC1143_BREAST | 102739879 | 102740101 | 102739916 | 102739916 | Missense_Mutation | C | T | p.S389L |
| U937_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 102739879 | 102740101 | 102739966 | 102739966 | Missense_Mutation | C | A | p.L406M |
| TUR_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 102739879 | 102740101 | 102739966 | 102739966 | Missense_Mutation | C | A | p.L406M |
| SNU175_LARGE_INTESTINE | 102739879 | 102740101 | 102739973 | 102739973 | Missense_Mutation | C | T | p.A408V |
| RKO_LARGE_INTESTINE | 102739879 | 102740101 | 102740081 | 102740081 | Missense_Mutation | A | G | p.D444G |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 102740335 | 102740450 | 102740395 | 102740395 | Missense_Mutation | C | T | p.T471I |
| 2313287_STOMACH | 102743062 | 102744114 | 102743164 | 102743164 | Missense_Mutation | A | G | p.N598S |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 102743062 | 102744114 | 102743203 | 102743203 | Missense_Mutation | G | A | p.R611H |
| HEC6_ENDOMETRIUM | 102743062 | 102744114 | 102743209 | 102743209 | Missense_Mutation | G | A | p.G613D |
| MS1_SKIN | 102743062 | 102744114 | 102743234 | 102743234 | Missense_Mutation | T | G | p.D621E |
| MS1_LUNG | 102743062 | 102744114 | 102743234 | 102743234 | Missense_Mutation | T | G | p.D621E |
| COLO201_LARGE_INTESTINE | 102743062 | 102744114 | 102743263 | 102743263 | Missense_Mutation | G | T | p.G631V |
| COLO205_LARGE_INTESTINE | 102743062 | 102744114 | 102743263 | 102743263 | Missense_Mutation | G | T | p.G631V |
| KYSE150_OESOPHAGUS | 102743062 | 102744114 | 102743295 | 102743295 | Missense_Mutation | C | G | p.L642V |
| C33A_CERVIX | 102743062 | 102744114 | 102743322 | 102743322 | Missense_Mutation | C | T | p.R651W |
| CCRFCEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 102743062 | 102744114 | 102743476 | 102743476 | Missense_Mutation | G | A | p.R702Q |
| OVSAHO_OVARY | 102743062 | 102744114 | 102743505 | 102743505 | Missense_Mutation | T | C | p.Y712H |
| ESS1_ENDOMETRIUM | 102743062 | 102744114 | 102743591 | 102743591 | Missense_Mutation | G | C | p.E740D |
| TE9_OESOPHAGUS | 102743062 | 102744114 | 102743730 | 102743730 | Missense_Mutation | C | T | p.R787W |
| HS172T_FIBROBLAST | 102743062 | 102744114 | 102743731 | 102743731 | Missense_Mutation | G | A | p.R787Q |
| T98G_CENTRAL_NERVOUS_SYSTEM | 102743062 | 102744114 | 102743731 | 102743731 | Missense_Mutation | G | A | p.R787Q |
| SNU1040_LARGE_INTESTINE | 102743062 | 102744114 | 102743851 | 102743851 | Missense_Mutation | C | T | p.T827M |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SEMA4G |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SEMA4G |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SEMA4G |
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RelatedDrugs for SEMA4G |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SEMA4G |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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