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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ZSWIM5 |
 Gene summary |
| Gene information | Gene symbol | ZSWIM5 | Gene ID | 57643 |
| Gene name | zinc finger SWIM-type containing 5 | |
| Synonyms | - | |
| Cytomap | 1p34.1 | |
| Type of gene | protein-coding | |
| Description | zinc finger SWIM domain-containing protein 5zinc finger, SWIM domain containing 5 | |
| Modification date | 20180523 | |
| UniProtAcc | Q9P217 | |
| Context | PubMed: ZSWIM5 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for ZSWIM5 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ZSWIM5 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ZSWIM5 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_26080 | 1 | 45486296:45486460:45499983:45500141:45501359:45501495 | 45499983:45500141 | ENSG00000162415.6 | ENST00000359600.5 |
| exon_skip_26081 | 1 | 45504607:45504745:45506063:45506210:45508890:45509067 | 45506063:45506210 | ENSG00000162415.6 | ENST00000359600.5 |
| exon_skip_26084 | 1 | 45506063:45506210:45508890:45509067:45516745:45516925 | 45508890:45509067 | ENSG00000162415.6 | ENST00000359600.5 |
| exon_skip_26085 | 1 | 45508890:45509067:45516745:45516925:45524280:45524431 | 45516745:45516925 | ENSG00000162415.6 | ENST00000359600.5 |
| exon_skip_26086 | 1 | 45516745:45516925:45524280:45524431:45525770:45525919 | 45524280:45524431 | ENSG00000162415.6 | ENST00000359600.5 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ZSWIM5 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_26080 | 1 | 45486296:45486460:45499983:45500141:45501359:45501495 | 45499983:45500141 | ENSG00000162415.6 | ENST00000359600.5 |
| exon_skip_26081 | 1 | 45504607:45504745:45506063:45506210:45508890:45509067 | 45506063:45506210 | ENSG00000162415.6 | ENST00000359600.5 |
| exon_skip_26084 | 1 | 45506063:45506210:45508890:45509067:45516745:45516925 | 45508890:45509067 | ENSG00000162415.6 | ENST00000359600.5 |
| exon_skip_26085 | 1 | 45508890:45509067:45516745:45516925:45524280:45524431 | 45516745:45516925 | ENSG00000162415.6 | ENST00000359600.5 |
| exon_skip_26086 | 1 | 45516745:45516925:45524280:45524431:45525770:45525919 | 45524280:45524431 | ENSG00000162415.6 | ENST00000359600.5 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ZSWIM5 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000359600 | 45499983 | 45500141 | Frame-shift |
| ENST00000359600 | 45524280 | 45524431 | Frame-shift |
| ENST00000359600 | 45506063 | 45506210 | In-frame |
| ENST00000359600 | 45508890 | 45509067 | In-frame |
| ENST00000359600 | 45516745 | 45516925 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000359600 | 45499983 | 45500141 | Frame-shift |
| ENST00000359600 | 45524280 | 45524431 | Frame-shift |
| ENST00000359600 | 45506063 | 45506210 | In-frame |
| ENST00000359600 | 45508890 | 45509067 | In-frame |
| ENST00000359600 | 45516745 | 45516925 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ZSWIM5 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000359600 | 5836 | 1185 | 45516745 | 45516925 | 1459 | 1638 | 417 | 477 |
| ENST00000359600 | 5836 | 1185 | 45508890 | 45509067 | 1639 | 1815 | 477 | 536 |
| ENST00000359600 | 5836 | 1185 | 45506063 | 45506210 | 1816 | 1962 | 536 | 585 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000359600 | 5836 | 1185 | 45516745 | 45516925 | 1459 | 1638 | 417 | 477 |
| ENST00000359600 | 5836 | 1185 | 45508890 | 45509067 | 1639 | 1815 | 477 | 536 |
| ENST00000359600 | 5836 | 1185 | 45506063 | 45506210 | 1816 | 1962 | 536 | 585 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9P217 | 417 | 477 | 1 | 1185 | Chain | ID=PRO_0000223103;Note=Zinc finger SWIM domain-containing protein 5 |
| Q9P217 | 477 | 536 | 1 | 1185 | Chain | ID=PRO_0000223103;Note=Zinc finger SWIM domain-containing protein 5 |
| Q9P217 | 536 | 585 | 1 | 1185 | Chain | ID=PRO_0000223103;Note=Zinc finger SWIM domain-containing protein 5 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9P217 | 417 | 477 | 1 | 1185 | Chain | ID=PRO_0000223103;Note=Zinc finger SWIM domain-containing protein 5 |
| Q9P217 | 477 | 536 | 1 | 1185 | Chain | ID=PRO_0000223103;Note=Zinc finger SWIM domain-containing protein 5 |
| Q9P217 | 536 | 585 | 1 | 1185 | Chain | ID=PRO_0000223103;Note=Zinc finger SWIM domain-containing protein 5 |
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SNVs in the skipped exons for ZSWIM5 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
ZSWIM5_LUAD_exon_skip_26084_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_26085 | 45516746 | 45516925 | 45516821 | 45516821 | Frame_Shift_Del | G | - | p.L453fs |
| STAD | TCGA-D7-8575-01 | exon_skip_26080 | 45499984 | 45500141 | 45500007 | 45500008 | Frame_Shift_Ins | - | A | p.S809fs |
| STAD | TCGA-D7-8575-01 | exon_skip_26080 | 45499984 | 45500141 | 45500008 | 45500009 | Frame_Shift_Ins | - | A | p.S809fs |
| LUAD | TCGA-91-6829-01 | exon_skip_26081 | 45506064 | 45506210 | 45506070 | 45506070 | Nonsense_Mutation | T | A | p.K584* |
| BLCA | TCGA-ZF-A9RF-01 | exon_skip_26084 | 45508891 | 45509067 | 45508984 | 45508984 | Nonsense_Mutation | G | A | p.R506* |
| SKCM | TCGA-FR-A726-01 | exon_skip_26085 | 45516746 | 45516925 | 45516916 | 45516916 | Nonsense_Mutation | C | T | p.W421* |
| UCEC | TCGA-BK-A0C9-01 | exon_skip_26086 | 45524281 | 45524431 | 45524299 | 45524299 | Nonsense_Mutation | G | A | p.Q412* |
| SKCM | TCGA-EE-A3AC-06 | exon_skip_26086 | 45524281 | 45524431 | 45524428 | 45524428 | Nonsense_Mutation | G | A | p.R369* |
| SKCM | TCGA-EE-A3AC-06 | exon_skip_26086 | 45524281 | 45524431 | 45524428 | 45524428 | Nonsense_Mutation | G | A | p.R369X |
| LUAD | TCGA-05-4249-01 | exon_skip_26084 | 45508891 | 45509067 | 45508890 | 45508890 | Splice_Site | C | - | p.E537_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-05-4249-01 |
| Cancer type: LUAD | |
| ESID: exon_skip_26084 | |
| Skipped exon start: 45508891 | |
| Skipped exon end: 45509067 | |
| Mutation start: 45508890 | |
| Mutation end: 45508890 | |
| Mutation type: Splice_Site | |
| Reference seq: C | |
| Mutation seq: - | |
| AAchange: p.E537_splice | |
exon_skip_26084_LUAD_TCGA-05-4249-01.png | |
exon_skip_347230_LUAD_TCGA-05-4249-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| COV362_OVARY | 45499984 | 45500141 | 45500070 | 45500070 | Missense_Mutation | G | A | p.P788L |
| ISTSL1_LUNG | 45499984 | 45500141 | 45500094 | 45500094 | Missense_Mutation | G | A | p.P780L |
| LNCAPCLONEFGC_PROSTATE | 45499984 | 45500141 | 45500112 | 45500112 | Missense_Mutation | G | A | p.A774V |
| AN3CA_ENDOMETRIUM | 45499984 | 45500141 | 45500113 | 45500113 | Missense_Mutation | C | T | p.A774T |
| RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 45506064 | 45506210 | 45506097 | 45506097 | Missense_Mutation | G | A | p.R575W |
| LS180_LARGE_INTESTINE | 45506064 | 45506210 | 45506148 | 45506148 | Missense_Mutation | C | T | p.A558T |
| NCIH1155_LUNG | 45516746 | 45516925 | 45516751 | 45516751 | Missense_Mutation | C | T | p.S476N |
| MEWO_SKIN | 45516746 | 45516925 | 45516802 | 45516802 | Missense_Mutation | C | T | p.G459E |
| SNU1_STOMACH | 45516746 | 45516925 | 45516833 | 45516833 | Missense_Mutation | C | T | p.D449N |
| SNUC4_LARGE_INTESTINE | 45516746 | 45516925 | 45516910 | 45516910 | Missense_Mutation | C | T | p.C423Y |
| HCC1395_BREAST | 45524281 | 45524431 | 45524347 | 45524347 | Missense_Mutation | G | A | p.L396F |
| HCC44_LUNG | 45524281 | 45524431 | 45524397 | 45524397 | Missense_Mutation | C | G | p.G379A |
| MHHES1_BONE | 45516746 | 45516925 | 45516746 | 45516746 | Splice_Site | C | A | p.D478Y |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZSWIM5 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZSWIM5 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZSWIM5 |
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RelatedDrugs for ZSWIM5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZSWIM5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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