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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for DPP10 |
 Gene summary |
| Gene information | Gene symbol | DPP10 | Gene ID | 57628 |
| Gene name | dipeptidyl peptidase like 10 | |
| Synonyms | DPL2|DPPY|DPRP-3|DPRP3 | |
| Cytomap | 2q14.1 | |
| Type of gene | protein-coding | |
| Description | inactive dipeptidyl peptidase 10DPP Xdipeptidyl peptidase 10dipeptidyl peptidase IV-related protein 3dipeptidyl peptidase Xdipeptidyl peptidase-like protein 2dipeptidyl-peptidase 10 (inactive)dipeptidyl-peptidase 10 (non-functional) | |
| Modification date | 20180519 | |
| UniProtAcc | Q8N608 | |
| Context | PubMed: DPP10 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| DPP10 | GO:1903078 | positive regulation of protein localization to plasma membrane | 15671030 |
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Exon skipping events across known transcript of Ensembl for DPP10 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for DPP10 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for DPP10 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_329136 | 2 | 115220971:115221003:115464693:115464751:116066814:116066929 | 115464693:115464751 | ENSG00000175497.12 | ENST00000461250.1 |
| exon_skip_329139 | 2 | 115919178:115919605:116066814:116066929:116101392:116101488 | 116066814:116066929 | ENSG00000175497.12 | ENST00000393147.2 |
| exon_skip_329140 | 2 | 115919810:115919849:116066814:116066929:116101392:116101488 | 116066814:116066929 | ENSG00000175497.12 | ENST00000486885.1,ENST00000310323.8 |
| exon_skip_329141 | 2 | 116101392:116101488:116257085:116257180:116283473:116283548 | 116257085:116257180 | ENSG00000175497.12 | ENST00000429914.1,ENST00000486885.1,ENST00000393147.2,ENST00000409163.1,ENST00000393146.2,ENST00000410059.1,ENST00000310323.8,ENST00000461250.1,ENST00000419287.1 |
| exon_skip_329142 | 2 | 116283473:116283548:116336689:116336842:116447262:116447315 | 116336689:116336842 | ENSG00000175497.12 | ENST00000429914.1 |
| exon_skip_329143 | 2 | 116510749:116510873:116520147:116520186:116525872:116525980 | 116520147:116520186 | ENSG00000175497.12 | ENST00000393147.2,ENST00000409163.1,ENST00000410059.1,ENST00000310323.8 |
| exon_skip_329144 | 2 | 116548656:116548755:116548862:116548932:116572368:116572563 | 116548862:116548932 | ENSG00000175497.12 | ENST00000393147.2,ENST00000409163.1,ENST00000410059.1,ENST00000310323.8 |
| exon_skip_329146 | 2 | 116593732:116593832:116594082:116594141:116594249:116594258 | 116594082:116594141 | ENSG00000175497.12 | ENST00000393147.2,ENST00000473362.1,ENST00000409163.1,ENST00000410059.1,ENST00000310323.8 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for DPP10 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_329136 | 2 | 115220971:115221003:115464693:115464751:116066814:116066929 | 115464693:115464751 | ENSG00000175497.12 | ENST00000461250.1 |
| exon_skip_329139 | 2 | 115919178:115919605:116066814:116066929:116101392:116101488 | 116066814:116066929 | ENSG00000175497.12 | ENST00000393147.2 |
| exon_skip_329140 | 2 | 115919810:115919849:116066814:116066929:116101392:116101488 | 116066814:116066929 | ENSG00000175497.12 | ENST00000310323.8,ENST00000486885.1 |
| exon_skip_329141 | 2 | 116101392:116101488:116257085:116257180:116283473:116283548 | 116257085:116257180 | ENSG00000175497.12 | ENST00000410059.1,ENST00000461250.1,ENST00000409163.1,ENST00000393146.2,ENST00000393147.2,ENST00000310323.8,ENST00000486885.1,ENST00000429914.1,ENST00000419287.1 |
| exon_skip_329142 | 2 | 116283473:116283548:116336689:116336842:116447262:116447315 | 116336689:116336842 | ENSG00000175497.12 | ENST00000429914.1 |
| exon_skip_329143 | 2 | 116510749:116510873:116520147:116520186:116525872:116525980 | 116520147:116520186 | ENSG00000175497.12 | ENST00000410059.1,ENST00000409163.1,ENST00000393147.2,ENST00000310323.8 |
| exon_skip_329144 | 2 | 116548656:116548755:116548862:116548932:116572368:116572563 | 116548862:116548932 | ENSG00000175497.12 | ENST00000410059.1,ENST00000409163.1,ENST00000393147.2,ENST00000310323.8 |
| exon_skip_329146 | 2 | 116593732:116593832:116594082:116594141:116594249:116594258 | 116594082:116594141 | ENSG00000175497.12 | ENST00000410059.1,ENST00000409163.1,ENST00000393147.2,ENST00000310323.8,ENST00000473362.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for DPP10 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000410059 | 116257085 | 116257180 | Frame-shift |
| ENST00000410059 | 116548862 | 116548932 | Frame-shift |
| ENST00000410059 | 116594082 | 116594141 | Frame-shift |
| ENST00000410059 | 116520147 | 116520186 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000410059 | 116257085 | 116257180 | Frame-shift |
| ENST00000410059 | 116548862 | 116548932 | Frame-shift |
| ENST00000410059 | 116594082 | 116594141 | Frame-shift |
| ENST00000410059 | 116520147 | 116520186 | In-frame |
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Infer the effects of exon skipping event on protein functional features for DPP10 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000410059 | 6295 | 796 | 116520147 | 116520186 | 1555 | 1593 | 358 | 371 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000410059 | 6295 | 796 | 116520147 | 116520186 | 1555 | 1593 | 358 | 371 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for DPP10 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_329140 exon_skip_329139 | 116066815 | 116066929 | 116066853 | 116066853 | Frame_Shift_Del | G | - | p.K33fs |
| SKCM | TCGA-EE-A2MS-06 | exon_skip_329140 exon_skip_329139 | 116066815 | 116066929 | 116066879 | 116066879 | Frame_Shift_Del | T | - | p.I42fs |
| SKCM | TCGA-EE-A2MS-06 | exon_skip_329140 exon_skip_329139 | 116066815 | 116066929 | 116066879 | 116066879 | Frame_Shift_Del | T | - | p.I46fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_329141 | 116257086 | 116257180 | 116257177 | 116257177 | Frame_Shift_Del | T | - | p.T121fs |
| COAD | TCGA-AA-3525-01 | exon_skip_329143 | 116520148 | 116520186 | 116520174 | 116520175 | Frame_Shift_Ins | - | CT | p.W317fs |
| PRAD | TCGA-EJ-A8FN-01 | exon_skip_329140 exon_skip_329139 | 116066815 | 116066929 | 116066821 | 116066821 | Nonsense_Mutation | G | T | p.G23* |
| BLCA | TCGA-ZF-A9R4-01 | exon_skip_329141 | 116257086 | 116257180 | 116257166 | 116257166 | Nonsense_Mutation | G | T | p.E118* |
| GBM | TCGA-19-4068-01 | exon_skip_329144 | 116548863 | 116548932 | 116548904 | 116548904 | Nonsense_Mutation | C | T | p.R562* |
| UCEC | TCGA-D1-A17Q-01 | exon_skip_329140 exon_skip_329139 | 116066815 | 116066929 | 116066930 | 116066930 | Splice_Site | G | A | e2+1 |
| HNSC | TCGA-CR-7374-01 | exon_skip_329141 | 116257086 | 116257180 | 116257182 | 116257182 | Splice_Site | T | A | p.F122_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| MZ7MEL_SKIN | 116066815 | 116066929 | 116066855 | 116066855 | Missense_Mutation | G | A | p.G34E |
| NCIH226_LUNG | 116066815 | 116066929 | 116066885 | 116066885 | Missense_Mutation | T | C | p.V44A |
| CORL32_LUNG | 116066815 | 116066929 | 116066896 | 116066896 | Missense_Mutation | C | T | p.L48F |
| RKO_LARGE_INTESTINE | 116066815 | 116066929 | 116066911 | 116066911 | Missense_Mutation | G | T | p.V53F |
| SNU1040_LARGE_INTESTINE | 116257086 | 116257180 | 116257107 | 116257107 | Missense_Mutation | G | A | p.S98N |
| KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 116257086 | 116257180 | 116257160 | 116257160 | Missense_Mutation | T | A | p.L116I |
| NCIH1299_LUNG | 116257086 | 116257180 | 116257166 | 116257166 | Missense_Mutation | G | C | p.E118Q |
| NCIH1355_LUNG | 116520148 | 116520186 | 116520174 | 116520174 | Missense_Mutation | G | T | p.W367C |
| RERFLCSQ1_LUNG | 116594083 | 116594141 | 116594092 | 116594092 | Missense_Mutation | T | G | p.F687C |
| CAL12T_LUNG | 116066815 | 116066929 | 116066821 | 116066821 | Nonsense_Mutation | G | T | p.G23* |
| NCIH460_LUNG | 116066815 | 116066929 | 116066851 | 116066851 | Nonsense_Mutation | A | T | p.K33* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DPP10 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DPP10 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DPP10 |
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RelatedDrugs for DPP10 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DPP10 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| DPP10 | C0023903 | Liver neoplasms | 1 | CTD_human |
| DPP10 | C0032927 | Precancerous Conditions | 1 | CTD_human |
| DPP10 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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