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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ARHGAP21 |
 Gene summary |
| Gene information | Gene symbol | ARHGAP21 | Gene ID | 57584 |
| Gene name | Rho GTPase activating protein 21 | |
| Synonyms | ARHGAP10 | |
| Cytomap | 10p12.1|10p12.3 | |
| Type of gene | protein-coding | |
| Description | rho GTPase-activating protein 21Rho-GTPase activating protein 10rho GTPase-activating protein 10rho-type GTPase-activating protein 21 | |
| Modification date | 20180523 | |
| UniProtAcc | Q5T5U3 | |
| Context | PubMed: ARHGAP21 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ARHGAP21 | GO:0051683 | establishment of Golgi localization | 20525016 |
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Exon skipping events across known transcript of Ensembl for ARHGAP21 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ARHGAP21 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ARHGAP21 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_48255 | 10 | 24878199:24878231:24879134:24879408:24880153:24880259 | 24879134:24879408 | ENSG00000107863.12 | ENST00000320481.6 |
| exon_skip_48257 | 10 | 24878199:24878231:24880153:24880259:24880570:24880612 | 24880153:24880259 | ENSG00000107863.12 | ENST00000396432.2,ENST00000486374.1 |
| exon_skip_48262 | 10 | 24890906:24891032:24893240:24893277:24896427:24896530 | 24893240:24893277 | ENSG00000107863.12 | ENST00000446003.1,ENST00000493154.1,ENST00000376410.2,ENST00000320481.6,ENST00000396432.2,ENST00000486374.1 |
| exon_skip_48265 | 10 | 24896673:24896832:24908401:24910298:24918924:24918979 | 24908401:24910298 | ENSG00000107863.12 | ENST00000376410.2 |
| exon_skip_48268 | 10 | 24910102:24910298:24911661:24911691:24918924:24918979 | 24911661:24911691 | ENSG00000107863.12 | ENST00000446003.1,ENST00000396432.2 |
| exon_skip_48271 | 10 | 24909807:24910298:24918924:24918979:24922330:24922409 | 24918924:24918979 | ENSG00000107863.12 | ENST00000376410.2 |
| exon_skip_48273 | 10 | 24923939:24924032:24955913:24955938:24959146:24959326 | 24955913:24955938 | ENSG00000107863.12 | ENST00000446003.1,ENST00000376410.2,ENST00000476499.1,ENST00000396432.2,ENST00000416305.1 |
| exon_skip_48275 | 10 | 24959267:24959326:25003225:25003307:25010765:25010795 | 25003225:25003307 | ENSG00000107863.12 | ENST00000472150.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ARHGAP21 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_48255 | 10 | 24878199:24878231:24879134:24879408:24880153:24880259 | 24879134:24879408 | ENSG00000107863.12 | ENST00000320481.6 |
| exon_skip_48257 | 10 | 24878199:24878231:24880153:24880259:24880570:24880612 | 24880153:24880259 | ENSG00000107863.12 | ENST00000396432.2,ENST00000486374.1 |
| exon_skip_48262 | 10 | 24890906:24891032:24893240:24893277:24896427:24896530 | 24893240:24893277 | ENSG00000107863.12 | ENST00000396432.2,ENST00000486374.1,ENST00000320481.6,ENST00000376410.2,ENST00000446003.1,ENST00000493154.1 |
| exon_skip_48265 | 10 | 24896673:24896832:24908401:24910298:24918924:24918979 | 24908401:24910298 | ENSG00000107863.12 | ENST00000376410.2 |
| exon_skip_48268 | 10 | 24910102:24910298:24911661:24911691:24918924:24918979 | 24911661:24911691 | ENSG00000107863.12 | ENST00000396432.2,ENST00000446003.1 |
| exon_skip_48271 | 10 | 24909807:24910298:24918924:24918979:24922330:24922409 | 24918924:24918979 | ENSG00000107863.12 | ENST00000376410.2 |
| exon_skip_48273 | 10 | 24923939:24924032:24955913:24955938:24959146:24959326 | 24955913:24955938 | ENSG00000107863.12 | ENST00000396432.2,ENST00000376410.2,ENST00000446003.1,ENST00000476499.1,ENST00000416305.1 |
| exon_skip_48275 | 10 | 24959267:24959326:25003225:25003307:25010765:25010795 | 25003225:25003307 | ENSG00000107863.12 | ENST00000472150.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ARHGAP21 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000320481 | 24879134 | 24879408 | 5CDS-5UTR |
| ENST00000396432 | 24880153 | 24880259 | Frame-shift |
| ENST00000320481 | 24893240 | 24893277 | Frame-shift |
| ENST00000396432 | 24893240 | 24893277 | Frame-shift |
| ENST00000396432 | 24955913 | 24955938 | Frame-shift |
| ENST00000396432 | 24911661 | 24911691 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000320481 | 24879134 | 24879408 | 5CDS-5UTR |
| ENST00000396432 | 24880153 | 24880259 | Frame-shift |
| ENST00000320481 | 24893240 | 24893277 | Frame-shift |
| ENST00000396432 | 24893240 | 24893277 | Frame-shift |
| ENST00000396432 | 24955913 | 24955938 | Frame-shift |
| ENST00000396432 | 24911661 | 24911691 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ARHGAP21 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000396432 | 7184 | 1958 | 24911661 | 24911691 | 983 | 1012 | 165 | 175 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000396432 | 7184 | 1958 | 24911661 | 24911691 | 983 | 1012 | 165 | 175 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q5T5U3 | 165 | 175 | 165 | 174 | Alternative sequence | ID=VSP_028298;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q5T5U3 | 165 | 175 | 1 | 1957 | Chain | ID=PRO_0000305245;Note=Rho GTPase-activating protein 21 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q5T5U3 | 165 | 175 | 165 | 174 | Alternative sequence | ID=VSP_028298;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q5T5U3 | 165 | 175 | 1 | 1957 | Chain | ID=PRO_0000305245;Note=Rho GTPase-activating protein 21 |
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SNVs in the skipped exons for ARHGAP21 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
ARHGAP21_CESC_exon_skip_48265_psi_boxplot.png |
ARHGAP21_COAD_exon_skip_48265_psi_boxplot.png |
ARHGAP21_LIHC_exon_skip_48265_psi_boxplot.png |
ARHGAP21_LUAD_exon_skip_48265_psi_boxplot.png |
ARHGAP21_OV_exon_skip_48268_psi_boxplot.png |
ARHGAP21_READ_exon_skip_48265_psi_boxplot.png |
ARHGAP21_SKCM_exon_skip_48265_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| COAD | TCGA-AD-6895-01 | exon_skip_48257 | 24880154 | 24880259 | 24880209 | 24880210 | Frame_Shift_Del | TA | - | p.1365_1366del |
| KIRP | TCGA-DZ-6132-01 | exon_skip_48265 | 24908402 | 24910298 | 24908604 | 24908604 | Frame_Shift_Del | T | - | p.K740fs |
| KIRP | TCGA-DZ-6132-01 | exon_skip_48265 | 24908402 | 24910298 | 24908604 | 24908604 | Frame_Shift_Del | T | - | p.P741fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_48265 | 24908402 | 24910298 | 24908805 | 24908805 | Frame_Shift_Del | G | - | p.P673fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_48265 | 24908402 | 24910298 | 24908895 | 24908895 | Frame_Shift_Del | A | - | p.F643fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_48265 | 24908402 | 24910298 | 24908901 | 24908901 | Frame_Shift_Del | T | - | p.K641fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_48265 | 24908402 | 24910298 | 24909027 | 24909027 | Frame_Shift_Del | A | - | p.F599fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_48265 | 24908402 | 24910298 | 24909255 | 24909255 | Frame_Shift_Del | T | - | p.K523fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_48265 | 24908402 | 24910298 | 24909311 | 24909311 | Frame_Shift_Del | T | - | p.T505fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_48265 | 24908402 | 24910298 | 24909355 | 24909355 | Frame_Shift_Del | T | - | p.N490fs |
| LUAD | TCGA-55-8089-01 | exon_skip_48257 | 24880154 | 24880259 | 24880167 | 24880168 | Frame_Shift_Ins | - | G | p.R1379fs |
| LIHC | TCGA-BC-A112-01 | exon_skip_48265 | 24908402 | 24910298 | 24908804 | 24908805 | Frame_Shift_Ins | - | G | p.S674fs |
| COAD | TCGA-G4-6628-01 | exon_skip_48265 | 24908402 | 24910298 | 24909254 | 24909255 | Frame_Shift_Ins | - | T | p.Q524fs |
| DLBC | TCGA-GS-A9TT-01 | exon_skip_48265 | 24908402 | 24910298 | 24909678 | 24909679 | Frame_Shift_Ins | - | G | p.Q382fs |
| CESC | TCGA-C5-A1BJ-01 | exon_skip_48265 | 24908402 | 24910298 | 24909044 | 24909044 | Nonsense_Mutation | G | A | p.Q594* |
| LGG | TCGA-E1-A7YH-01 | exon_skip_48265 | 24908402 | 24910298 | 24909113 | 24909113 | Nonsense_Mutation | G | A | p.R571* |
| READ | TCGA-EI-6917-01 | exon_skip_48265 | 24908402 | 24910298 | 24909164 | 24909164 | Nonsense_Mutation | G | A | p.R554X |
| UCEC | TCGA-D1-A16X-01 | exon_skip_48265 | 24908402 | 24910298 | 24909164 | 24909164 | Nonsense_Mutation | G | A | p.R554* |
| SKCM | TCGA-FS-A1ZA-06 | exon_skip_48265 | 24908402 | 24910298 | 24909488 | 24909488 | Nonsense_Mutation | G | A | p.R446* |
| LUAD | TCGA-NJ-A4YP-01 | exon_skip_48265 | 24908402 | 24910298 | 24910189 | 24910189 | Nonsense_Mutation | G | T | p.S212* |
| GBM | TCGA-76-4926-01 | exon_skip_48262 | 24893241 | 24893277 | 24893240 | 24893240 | Splice_Site | C | T | p.K907_splice |
| OV | TCGA-61-2012-01 | exon_skip_48268 | 24911662 | 24911691 | 24911660 | 24911660 | Splice_Site | A | T | p.L175_splice |
| HNSC | TCGA-CV-5439-01 | exon_skip_48273 | 24955914 | 24955938 | 24955940 | 24955940 | Splice_Site | T | A | p.D82_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-61-2012-01 |
| Cancer type: OV | |
| ESID: exon_skip_48268 | |
| Skipped exon start: 24911662 | |
| Skipped exon end: 24911691 | |
| Mutation start: 24911660 | |
| Mutation end: 24911660 | |
| Mutation type: Splice_Site | |
| Reference seq: A | |
| Mutation seq: T | |
| AAchange: p.L175_splice | |
exon_skip_48268_OV_TCGA-61-2012-01.png | |
 | Sample: TCGA-FS-A1ZA-06 |
| Cancer type: SKCM | |
| ESID: exon_skip_48265 | |
| Skipped exon start: 24908402 | |
| Skipped exon end: 24910298 | |
| Mutation start: 24909488 | |
| Mutation end: 24909488 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.R446* | |
exon_skip_322247_SKCM_TCGA-FS-A1ZA-06.png | |
exon_skip_48265_SKCM_TCGA-FS-A1ZA-06.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 24880154 | 24880259 | 24880167 | 24880167 | Frame_Shift_Del | T | - | p.P1379fs |
| EW22_BONE | 24908402 | 24910298 | 24909602 | 24909605 | Frame_Shift_Del | TTGT | - | p.TI407fs |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 24880154 | 24880259 | 24880173 | 24880174 | Frame_Shift_Ins | - | C | p.V1377fs |
| SNU119_OVARY | 24880154 | 24880259 | 24880232 | 24880232 | Missense_Mutation | C | G | p.D1358H |
| DV90_LUNG | 24880154 | 24880259 | 24880246 | 24880246 | Missense_Mutation | T | C | p.E1353G |
| NCIH630_LARGE_INTESTINE | 24908402 | 24910298 | 24908590 | 24908590 | Missense_Mutation | C | T | p.R745H |
| RCK8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 24908402 | 24910298 | 24908603 | 24908603 | Missense_Mutation | G | A | p.P741S |
| EVSAT_BREAST | 24908402 | 24910298 | 24908608 | 24908608 | Missense_Mutation | T | C | p.E739G |
| A2780_OVARY | 24908402 | 24910298 | 24908714 | 24908714 | Missense_Mutation | C | A | p.D704Y |
| HUO3N1_BONE | 24908402 | 24910298 | 24908726 | 24908726 | Missense_Mutation | C | A | p.A700S |
| OCIMY5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 24908402 | 24910298 | 24908867 | 24908867 | Missense_Mutation | T | C | p.N653D |
| CMLT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 24908402 | 24910298 | 24908927 | 24908927 | Missense_Mutation | C | T | p.V633I |
| HUNS1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 24908402 | 24910298 | 24909025 | 24909025 | Missense_Mutation | T | A | p.Q600L |
| HT55_LARGE_INTESTINE | 24908402 | 24910298 | 24909106 | 24909106 | Missense_Mutation | C | T | p.S573N |
| KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 24908402 | 24910298 | 24909114 | 24909114 | Missense_Mutation | C | A | p.R570S |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 24908402 | 24910298 | 24909134 | 24909134 | Missense_Mutation | C | T | p.V564I |
| IGROV1_OVARY | 24908402 | 24910298 | 24909152 | 24909152 | Missense_Mutation | A | G | p.F558L |
| JHUEM1_ENDOMETRIUM | 24908402 | 24910298 | 24909153 | 24909153 | Missense_Mutation | A | C | p.N557K |
| BT474_BREAST | 24908402 | 24910298 | 24909163 | 24909163 | Missense_Mutation | C | G | p.R554P |
| OE19_OESOPHAGUS | 24908402 | 24910298 | 24909193 | 24909193 | Missense_Mutation | G | A | p.P544L |
| SNU489_CENTRAL_NERVOUS_SYSTEM | 24908402 | 24910298 | 24909305 | 24909305 | Missense_Mutation | C | T | p.E507K |
| HCC2450_LUNG | 24908402 | 24910298 | 24909569 | 24909569 | Missense_Mutation | A | G | p.S419P |
| KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 24908402 | 24910298 | 24909634 | 24909634 | Missense_Mutation | T | C | p.D397G |
| STM9101_SOFT_TISSUE | 24908402 | 24910298 | 24909683 | 24909683 | Missense_Mutation | G | A | p.H381Y |
| STM9101_SOFT_TISSUE | 24908402 | 24910298 | 24909687 | 24909687 | Missense_Mutation | A | T | p.N379K |
| LB771HNC_UPPER_AERODIGESTIVE_TRACT | 24908402 | 24910298 | 24909817 | 24909817 | Missense_Mutation | G | A | p.S336F |
| LB771PBL_MATCHED_NORMAL_TISSUE | 24908402 | 24910298 | 24909817 | 24909817 | Missense_Mutation | G | A | p.S336F |
| HEC251_ENDOMETRIUM | 24908402 | 24910298 | 24909833 | 24909833 | Missense_Mutation | G | T | p.H331N |
| KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 24908402 | 24910298 | 24909857 | 24909857 | Missense_Mutation | A | G | p.S323P |
| ABC1_LUNG | 24908402 | 24910298 | 24909857 | 24909857 | Missense_Mutation | A | G | p.S323P |
| KASUMI2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 24908402 | 24910298 | 24909917 | 24909917 | Missense_Mutation | A | G | p.Y303H |
| MRKNU1_BREAST | 24908402 | 24910298 | 24909925 | 24909925 | Missense_Mutation | T | A | p.E300V |
| NO11_CENTRAL_NERVOUS_SYSTEM | 24908402 | 24910298 | 24910028 | 24910028 | Missense_Mutation | C | G | p.V266L |
| NKL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 24908402 | 24910298 | 24910082 | 24910082 | Missense_Mutation | T | C | p.I248V |
| LNCAPCLONEFGC_PROSTATE | 24908402 | 24910298 | 24910132 | 24910132 | Missense_Mutation | T | C | p.Q231R |
| HCC1143_BREAST | 24908402 | 24910298 | 24910138 | 24910138 | Missense_Mutation | T | C | p.K229R |
| NCIH526_LUNG | 24908402 | 24910298 | 24910152 | 24910152 | Missense_Mutation | G | C | p.D224E |
| SNU1040_LARGE_INTESTINE | 24908402 | 24910298 | 24910175 | 24910175 | Missense_Mutation | G | A | p.P217S |
| SKMEL2_SKIN | 24908402 | 24910298 | 24910228 | 24910228 | Missense_Mutation | G | A | p.P199L |
| BCP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 24908402 | 24910298 | 24909026 | 24909026 | Nonsense_Mutation | G | A | p.Q600* |
| HEC251_ENDOMETRIUM | 24908402 | 24910298 | 24909164 | 24909164 | Nonsense_Mutation | G | A | p.R554* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ARHGAP21 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ARHGAP21 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ARHGAP21 |
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RelatedDrugs for ARHGAP21 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARHGAP21 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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