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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for FAM135A

check button Gene summary
Gene informationGene symbol

FAM135A

Gene ID

57579

Gene namefamily with sequence similarity 135 member A
SynonymsKIAA1411
Cytomap

6q13

Type of geneprotein-coding
Descriptionprotein FAM135A
Modification date20180523
UniProtAcc

Q9P2D6

ContextPubMed: FAM135A [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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Exon skipping events across known transcript of Ensembl for FAM135A from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for FAM135A

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for FAM135A

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_452959671123348:71123405:71124993:71125079:71136141:7113623571124993:71125079ENSG00000082269.12ENST00000418814.2,ENST00000370479.3,ENST00000361499.3
exon_skip_452960671123348:71123405:71124993:71125079:71136272:7113641271124993:71125079ENSG00000082269.12ENST00000515280.1,ENST00000514185.1
exon_skip_452965671124993:71125079:71128077:71128195:71136141:7113623571128077:71128195ENSG00000082269.12ENST00000507085.1
exon_skip_452966671124993:71125079:71128077:71128195:71136272:7113641271128077:71128195ENSG00000082269.12ENST00000508844.1
exon_skip_452967671124993:71125079:71136141:71136235:71138006:7113804771136141:71136235ENSG00000082269.12ENST00000418814.2,ENST00000370479.3,ENST00000361499.3
exon_skip_452969671124993:71125079:71136272:71136412:71138006:7113804771136272:71136412ENSG00000082269.12ENST00000515280.1
exon_skip_452972671124993:71125079:71136272:71136467:71138006:7113804771136272:71136467ENSG00000082269.12ENST00000514185.1
exon_skip_452973671124993:71125079:71138006:71138122:71162194:7116221071138006:71138122ENSG00000082269.12ENST00000505769.1
exon_skip_452974671136230:71136235:71138006:71138122:71162194:7116221071138006:71138122ENSG00000082269.12ENST00000507085.1,ENST00000418814.2,ENST00000515323.1,ENST00000194672.7,ENST00000361499.3
exon_skip_452976671162194:71162274:71185112:71185252:71185365:7118543671185112:71185252ENSG00000082269.12ENST00000418814.2,ENST00000393299.2,ENST00000515323.1,ENST00000194672.7,ENST00000505769.1,ENST00000505868.1,ENST00000361499.3
exon_skip_452979671185365:71185436:71186861:71187035:71190603:7119073071186861:71187035ENSG00000082269.12ENST00000418814.2,ENST00000393299.2,ENST00000370479.3,ENST00000457062.2,ENST00000515323.1,ENST00000505769.1,ENST00000505868.1,ENST00000361499.3
exon_skip_452980671185365:71185436:71186995:71187035:71190603:7119073071186995:71187035ENSG00000082269.12ENST00000194672.7
exon_skip_452981671191835:71191857:71195869:71195947:71200736:7120078671195869:71195947ENSG00000082269.12ENST00000393299.2,ENST00000370479.3,ENST00000457062.2,ENST00000425415.2,ENST00000194672.7
exon_skip_452982671191835:71191857:71200736:71200786:71212338:7121249471200736:71200786ENSG00000082269.12ENST00000418814.2,ENST00000515323.1,ENST00000505769.1,ENST00000505868.1,ENST00000361499.3
exon_skip_452983671232215:71232289:71233669:71233824:71234045:7123430271233669:71233824ENSG00000082269.12ENST00000418814.2,ENST00000515323.1,ENST00000505868.1
exon_skip_452984671232215:71232289:71233669:71233824:71234633:7123489471233669:71233824ENSG00000082269.12ENST00000370479.3,ENST00000457062.2,ENST00000194672.7,ENST00000505769.1,ENST00000361499.3
exon_skip_452986671233669:71233824:71234045:71236401:71237994:7123815571234045:71236401ENSG00000082269.12ENST00000418814.2,ENST00000505868.1
exon_skip_452987671233669:71233824:71234633:71234894:71235566:7123640171234633:71234894ENSG00000082269.12ENST00000505769.1
exon_skip_452988671233669:71233824:71234633:71236401:71237994:7123815571234633:71236401ENSG00000082269.12ENST00000370479.3,ENST00000457062.2,ENST00000194672.7,ENST00000361499.3
exon_skip_452990671245962:71246114:71247993:71248104:71266452:7126656671247993:71248104ENSG00000082269.12ENST00000418814.2,ENST00000370479.3,ENST00000457062.2,ENST00000194672.7,ENST00000505769.1,ENST00000505868.1,ENST00000361499.3
exon_skip_452992671247993:71248104:71266452:71266566:71269418:7127036271266452:71266566ENSG00000082269.12ENST00000418814.2,ENST00000370479.3,ENST00000457062.2,ENST00000194672.7,ENST00000505769.1,ENST00000361499.3

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for FAM135A

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_452959671123348:71123405:71124993:71125079:71136141:7113623571124993:71125079ENSG00000082269.12ENST00000418814.2,ENST00000370479.3,ENST00000361499.3
exon_skip_452960671123348:71123405:71124993:71125079:71136272:7113641271124993:71125079ENSG00000082269.12ENST00000514185.1,ENST00000515280.1
exon_skip_452965671124993:71125079:71128077:71128195:71136141:7113623571128077:71128195ENSG00000082269.12ENST00000507085.1
exon_skip_452966671124993:71125079:71128077:71128195:71136272:7113641271128077:71128195ENSG00000082269.12ENST00000508844.1
exon_skip_452967671124993:71125079:71136141:71136235:71138006:7113804771136141:71136235ENSG00000082269.12ENST00000418814.2,ENST00000370479.3,ENST00000361499.3
exon_skip_452969671124993:71125079:71136272:71136412:71138006:7113804771136272:71136412ENSG00000082269.12ENST00000515280.1
exon_skip_452972671124993:71125079:71136272:71136467:71138006:7113804771136272:71136467ENSG00000082269.12ENST00000514185.1
exon_skip_452973671124993:71125079:71138006:71138122:71162194:7116221071138006:71138122ENSG00000082269.12ENST00000505769.1
exon_skip_452974671136230:71136235:71138006:71138122:71162194:7116221071138006:71138122ENSG00000082269.12ENST00000418814.2,ENST00000515323.1,ENST00000507085.1,ENST00000361499.3,ENST00000194672.7
exon_skip_452976671162194:71162274:71185112:71185252:71185365:7118543671185112:71185252ENSG00000082269.12ENST00000418814.2,ENST00000505769.1,ENST00000515323.1,ENST00000361499.3,ENST00000194672.7,ENST00000505868.1,ENST00000393299.2
exon_skip_452979671185365:71185436:71186861:71187035:71190603:7119073071186861:71187035ENSG00000082269.12ENST00000418814.2,ENST00000370479.3,ENST00000505769.1,ENST00000515323.1,ENST00000457062.2,ENST00000361499.3,ENST00000505868.1,ENST00000393299.2
exon_skip_452980671185365:71185436:71186995:71187035:71190603:7119073071186995:71187035ENSG00000082269.12ENST00000194672.7
exon_skip_452981671191835:71191857:71195869:71195947:71200736:7120078671195869:71195947ENSG00000082269.12ENST00000370479.3,ENST00000457062.2,ENST00000194672.7,ENST00000393299.2,ENST00000425415.2
exon_skip_452982671191835:71191857:71200736:71200786:71212338:7121249471200736:71200786ENSG00000082269.12ENST00000418814.2,ENST00000505769.1,ENST00000515323.1,ENST00000361499.3,ENST00000505868.1
exon_skip_452983671232215:71232289:71233669:71233824:71234045:7123430271233669:71233824ENSG00000082269.12ENST00000418814.2,ENST00000515323.1,ENST00000505868.1
exon_skip_452984671232215:71232289:71233669:71233824:71234633:7123489471233669:71233824ENSG00000082269.12ENST00000370479.3,ENST00000505769.1,ENST00000457062.2,ENST00000361499.3,ENST00000194672.7
exon_skip_452986671233669:71233824:71234045:71236401:71237994:7123815571234045:71236401ENSG00000082269.12ENST00000418814.2,ENST00000505868.1
exon_skip_452987671233669:71233824:71234633:71234894:71235566:7123640171234633:71234894ENSG00000082269.12ENST00000505769.1
exon_skip_452988671233669:71233824:71234633:71236401:71237994:7123815571234633:71236401ENSG00000082269.12ENST00000370479.3,ENST00000457062.2,ENST00000361499.3,ENST00000194672.7
exon_skip_452990671245962:71246114:71247993:71248104:71266452:7126656671247993:71248104ENSG00000082269.12ENST00000418814.2,ENST00000370479.3,ENST00000505769.1,ENST00000457062.2,ENST00000361499.3,ENST00000194672.7,ENST00000505868.1
exon_skip_452992671247993:71248104:71266452:71266566:71269418:7127036271266452:71266566ENSG00000082269.12ENST00000418814.2,ENST00000370479.3,ENST00000505769.1,ENST00000457062.2,ENST00000361499.3,ENST00000194672.7

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for FAM135A

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000041881471138006711381225CDS-5UTR
ENST0000037047971124993711250795UTR-5UTR
ENST0000041881471124993711250795UTR-5UTR
ENST0000037047971136141711362355UTR-5UTR
ENST0000041881471136141711362355UTR-5UTR
ENST000004188147118511271185252Frame-shift
ENST000004188147120073671200786Frame-shift
ENST000003704797123366971233824Frame-shift
ENST000004188147123366971233824Frame-shift
ENST000004188147123404571236401Frame-shift
ENST000003704797123463371236401Frame-shift
ENST000003704797118686171187035In-frame
ENST000004188147118686171187035In-frame
ENST000003704797119586971195947In-frame
ENST000003704797124799371248104In-frame
ENST000004188147124799371248104In-frame
ENST000003704797126645271266566In-frame
ENST000004188147126645271266566In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000041881471138006711381225CDS-5UTR
ENST0000037047971124993711250795UTR-5UTR
ENST0000041881471124993711250795UTR-5UTR
ENST0000037047971136141711362355UTR-5UTR
ENST0000041881471136141711362355UTR-5UTR
ENST000004188147118511271185252Frame-shift
ENST000004188147120073671200786Frame-shift
ENST000003704797123366971233824Frame-shift
ENST000004188147123366971233824Frame-shift
ENST000004188147123404571236401Frame-shift
ENST000003704797123463371236401Frame-shift
ENST000003704797118686171187035In-frame
ENST000004188147118686171187035In-frame
ENST000003704797119586971195947In-frame
ENST000003704797124799371248104In-frame
ENST000004188147124799371248104In-frame
ENST000003704797126645271266566In-frame
ENST000004188147126645271266566In-frame

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Infer the effects of exon skipping event on protein functional features for FAM135A

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000037047956931515711868617118703575893180137
ENST000004188146432151571186861711870359831156123180
ENST0000037047956931515711958697119594712131290231257
ENST000003704795693151571247993712481043997410711591196
ENST000003704795693151571266452712665664108422111961234
ENST000004188146432151571247993712481044732484213721409
ENST000004188146432151571266452712665664843495614091447

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000037047956931515711868617118703575893180137
ENST000004188146432151571186861711870359831156123180
ENST0000037047956931515711958697119594712131290231257
ENST000003704795693151571247993712481043997410711591196
ENST000003704795693151571266452712665664108422111961234
ENST000004188146432151571247993712481044732484213721409
ENST000004188146432151571266452712665664843495614091447

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature


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SNVs in the skipped exons for FAM135A

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-G3-A3CJ-01exon_skip_452981
71195870711959477119591371195913Frame_Shift_DelA-p.R246fs
LIHCTCGA-DD-A1EG-01exon_skip_452983
exon_skip_452984
71233670712338247123370471233704Frame_Shift_DelA-p.K380fs
LIHCTCGA-DD-A1EG-01exon_skip_452986
71234046712364017123416871234168Frame_Shift_DelC-p.P461fs
LIHCTCGA-DD-A3A1-01exon_skip_452986
71234046712364017123510571235105Frame_Shift_DelA-p.E773fs
LIHCTCGA-DD-A3A1-01exon_skip_452988
71234634712364017123510571235105Frame_Shift_DelA-p.E773fs
LIHCTCGA-DD-A39Y-01exon_skip_452986
71234046712364017123577671235776Frame_Shift_DelA-p.K998fs
LIHCTCGA-DD-A39Y-01exon_skip_452988
71234634712364017123577671235776Frame_Shift_DelA-p.K998fs
READTCGA-EI-6507-01exon_skip_452986
71234046712364017123577671235776Frame_Shift_DelA-p.M800fs
READTCGA-EI-6507-01exon_skip_452988
71234634712364017123577671235776Frame_Shift_DelA-p.M800fs
LIHCTCGA-DD-A39Y-01exon_skip_452986
71234046712364017123586571235865Frame_Shift_DelT-p.P1026fs
LIHCTCGA-DD-A39Y-01exon_skip_452988
71234634712364017123586571235865Frame_Shift_DelT-p.P1026fs
LIHCTCGA-DD-A1EG-01exon_skip_452990
71247994712481047124801771248017Frame_Shift_DelA-p.K1382fs
LIHCTCGA-DD-A39Y-01exon_skip_452990
71247994712481047124801771248017Frame_Shift_DelA-p.K1382fs
LIHCTCGA-DD-A3A0-01exon_skip_452990
71247994712481047124801771248017Frame_Shift_DelA-p.K1382fs
LIHCTCGA-G3-A3CJ-01exon_skip_452990
71247994712481047124801771248017Frame_Shift_DelA-p.K1382fs
LIHCTCGA-DD-A1EG-01exon_skip_452990
71247994712481047124807671248076Frame_Shift_DelT-p.T1400fs
STADTCGA-CG-5726-01exon_skip_452986
71234046712364017123555771235558Frame_Shift_Ins-Tp.V924fs
STADTCGA-CG-5726-01exon_skip_452988
71234634712364017123555771235558Frame_Shift_Ins-Tp.V924fs
STADTCGA-CG-5726-01exon_skip_452986
71234046712364017123555871235559Frame_Shift_Ins-Tp.V924fs
STADTCGA-CG-5726-01exon_skip_452988
71234634712364017123555871235559Frame_Shift_Ins-Tp.V924fs
UCECTCGA-B5-A11N-01exon_skip_452983
exon_skip_452984
71233670712338247123377771233777Nonsense_MutationCAp.S404*
UCSTCGA-ND-A4WC-01exon_skip_452983
exon_skip_452984
71233670712338247123377771233777Nonsense_MutationCAp.S404*
UCSTCGA-ND-A4WC-01exon_skip_452983
exon_skip_452984
71233670712338247123377771233777Nonsense_MutationCAp.S404X
BLCATCGA-GV-A3JV-01exon_skip_452986
71234046712364017123483471234834Nonsense_MutationCTp.R683*
BLCATCGA-GV-A3JV-01exon_skip_452987
71234634712348947123483471234834Nonsense_MutationCTp.R683*
BLCATCGA-GV-A3JV-01exon_skip_452988
71234634712364017123483471234834Nonsense_MutationCTp.R683*
UCECTCGA-AP-A051-01exon_skip_452986
71234046712364017123498471234984Nonsense_MutationCTp.R537*
UCECTCGA-AP-A051-01exon_skip_452988
71234634712364017123498471234984Nonsense_MutationCTp.R537*
HNSCTCGA-D6-A4ZB-01exon_skip_452986
71234046712364017123524071235240Nonsense_MutationCGp.S818*
HNSCTCGA-D6-A4ZB-01exon_skip_452988
71234634712364017123524071235240Nonsense_MutationCGp.S818*
COADTCGA-CA-6718-01exon_skip_452992
71266453712665667126653071266530Nonsense_MutationGTp.E1436X

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LOVO_LARGE_INTESTINE71234046712364017123430571234305Frame_Shift_DelA-p.T506fs
HEC6_ENDOMETRIUM71234046712364017123430571234305Frame_Shift_DelA-p.T506fs
OC316_OVARY71234046712364017123452771234528Frame_Shift_DelAG-p.E581fs
OC314_OVARY71234046712364017123452771234528Frame_Shift_DelAG-p.E581fs
CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE71234046712364017123430471234305Frame_Shift_Ins-Ap.TK506fs
COLO320_LARGE_INTESTINE71234046712364017123430471234305Frame_Shift_Ins-Ap.TK506fs
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE71234046712364017123430471234305Frame_Shift_Ins-Ap.TK506fs
HCC2814_LUNG71234046712364017123430471234305Frame_Shift_Ins-Ap.TK506fs
JHUEM1_ENDOMETRIUM71234046712364017123430471234305Frame_Shift_Ins-Ap.TK506fs
KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE71234046712364017123430471234305Frame_Shift_Ins-Ap.TK506fs
KYSE70_OESOPHAGUS71234046712364017123430471234305Frame_Shift_Ins-Ap.TK506fs
NCIH647_LUNG71234046712364017123430471234305Frame_Shift_Ins-Ap.TK506fs
NCO2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE71234046712364017123430471234305Frame_Shift_Ins-Ap.TK506fs
OV56_OVARY71234046712364017123430471234305Frame_Shift_Ins-Ap.TK506fs
P31FUJ_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE71234046712364017123430471234305Frame_Shift_Ins-Ap.TK506fs
SKNDZ_AUTONOMIC_GANGLIA71234046712364017123430471234305Frame_Shift_Ins-Ap.TK506fs
SNU601_STOMACH71234046712364017123430471234305Frame_Shift_Ins-Ap.TK506fs
NUGC3_STOMACH71234046712364017123577571235776Frame_Shift_Ins-Ap.K997fs
NUGC3_STOMACH71234634712364017123577571235776Frame_Shift_Ins-Ap.K997fs
EFO21_OVARY71138007711381227113805271138052Missense_MutationGAp.E3K
SNU1272_KIDNEY71138007711381227113807371138073Missense_MutationTAp.F10I
SW1271_LUNG71185113711852527118522071185220Missense_MutationTAp.F89I
SBC1_LUNG71186862711870357118688471186884Missense_MutationCAp.Q131K
JHUEM7_ENDOMETRIUM71186862711870357118690071186900Missense_MutationGAp.R136Q
HT115_LARGE_INTESTINE71186862711870357118690071186900Missense_MutationGAp.R136Q
HCC2998_LARGE_INTESTINE71233670712338247123369871233698Missense_MutationGAp.A378T
HT115_LARGE_INTESTINE71233670712338247123376771233767Missense_MutationGTp.D401Y
BICR18_UPPER_AERODIGESTIVE_TRACT71233670712338247123381971233819Missense_MutationCTp.T418I
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE71233670712338247123381971233819Missense_MutationCTp.T418I
HS294T_SKIN71234046712364017123410671234106Missense_MutationACp.D440A
EMCBAC2_LUNG71234046712364017123410671234106Missense_MutationACp.D440A
SUPB8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE71234046712364017123411871234118Missense_MutationCAp.T444N
SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE71234046712364017123417171234171Missense_MutationGTp.A462S
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE71234046712364017123418771234187Missense_MutationTAp.I467N
BICR18_UPPER_AERODIGESTIVE_TRACT71234046712364017123418771234187Missense_MutationTAp.I467N
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE71234046712364017123419171234191Missense_MutationGCp.W468C
BICR18_UPPER_AERODIGESTIVE_TRACT71234046712364017123419171234191Missense_MutationGCp.W468C
OE21_OESOPHAGUS71234046712364017123431271234312Missense_MutationTAp.L509I
KMS18_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE71234046712364017123437071234370Missense_MutationGTp.S528I
SNUC5_LARGE_INTESTINE71234046712364017123437271234372Missense_MutationAGp.T529A
HEC108_ENDOMETRIUM71234046712364017123437271234372Missense_MutationAGp.T529A
NUGC4_STOMACH71234046712364017123454771234547Missense_MutationCAp.S587Y
SNU1040_LARGE_INTESTINE71234634712348947123465771234657Missense_MutationGAp.D624N
SNU1040_LARGE_INTESTINE71234046712364017123465771234657Missense_MutationGAp.D624N
SNU1040_LARGE_INTESTINE71234634712364017123465771234657Missense_MutationGAp.D624N
LS180_LARGE_INTESTINE71234634712348947123487471234874Missense_MutationTCp.F696S
LS180_LARGE_INTESTINE71234046712364017123487471234874Missense_MutationTCp.F696S
LS180_LARGE_INTESTINE71234634712364017123487471234874Missense_MutationTCp.F696S
AN3CA_ENDOMETRIUM71234046712364017123490571234905Missense_MutationATp.K706N
AN3CA_ENDOMETRIUM71234634712364017123490571234905Missense_MutationATp.K706N
MCAS_OVARY71234046712364017123490971234909Missense_MutationAGp.I708V
MCAS_OVARY71234634712364017123490971234909Missense_MutationAGp.I708V
MFE319_ENDOMETRIUM71234046712364017123495171234951Missense_MutationTGp.C722G
MFE319_ENDOMETRIUM71234634712364017123495171234951Missense_MutationTGp.C722G
NCIH716_LARGE_INTESTINE71234046712364017123500871235008Missense_MutationAGp.T741A
NCIH716_LARGE_INTESTINE71234634712364017123500871235008Missense_MutationAGp.T741A
COGE352_BONE71234046712364017123504471235044Missense_MutationAGp.I753V
COGE352_BONE71234634712364017123504471235044Missense_MutationAGp.I753V
HS695T_SKIN71234046712364017123532171235321Missense_MutationCTp.S845F
HS695T_SKIN71234634712364017123532171235321Missense_MutationCTp.S845F
MEWO_SKIN71234046712364017123532171235321Missense_MutationCTp.S845F
MEWO_SKIN71234634712364017123532171235321Missense_MutationCTp.S845F
CW2_LARGE_INTESTINE71234046712364017123533971235339Missense_MutationCTp.P851L
CW2_LARGE_INTESTINE71234634712364017123533971235339Missense_MutationCTp.P851L
OAW42_OVARY71234046712364017123536271235362Missense_MutationGAp.V859I
OAW42_OVARY71234634712364017123536271235362Missense_MutationGAp.V859I
KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE71234046712364017123539671235396Missense_MutationCTp.T870I
KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE71234634712364017123539671235396Missense_MutationCTp.T870I
CAL12T_LUNG71234046712364017123539871235398Missense_MutationGCp.V871L
CAL12T_LUNG71234634712364017123539871235398Missense_MutationGCp.V871L
SNU1040_LARGE_INTESTINE71234046712364017123539971235399Missense_MutationTCp.V871A
SNU1040_LARGE_INTESTINE71234634712364017123539971235399Missense_MutationTCp.V871A
ML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE71234046712364017123543571235435Missense_MutationAGp.D883G
ML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE71234634712364017123543571235435Missense_MutationAGp.D883G
CAL148_BREAST71234046712364017123545271235452Missense_MutationAGp.S889G
CAL148_BREAST71234634712364017123545271235452Missense_MutationAGp.S889G
AN3CA_ENDOMETRIUM71234046712364017123545571235455Missense_MutationAGp.I890V
AN3CA_ENDOMETRIUM71234634712364017123545571235455Missense_MutationAGp.I890V
RCK8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE71234046712364017123546771235467Missense_MutationCGp.Q894E
RCK8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE71234634712364017123546771235467Missense_MutationCGp.Q894E
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE71234046712364017123549571235495Missense_MutationTCp.L903S
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE71234634712364017123549571235495Missense_MutationTCp.L903S
EW18_BONE71234046712364017123551971235519Missense_MutationAGp.H911R
EW18_BONE71234634712364017123551971235519Missense_MutationAGp.H911R
LNCAPCLONEFGC_PROSTATE71234046712364017123557471235574Missense_MutationGTp.E929D
LNCAPCLONEFGC_PROSTATE71234634712364017123557471235574Missense_MutationGTp.E929D
JHUEM1_ENDOMETRIUM71234046712364017123559671235596Missense_MutationAGp.S937G
JHUEM1_ENDOMETRIUM71234634712364017123559671235596Missense_MutationAGp.S937G
EKVX_LUNG71234046712364017123567571235675Missense_MutationCGp.T963R
EKVX_LUNG71234634712364017123567571235675Missense_MutationCGp.T963R
SW1990_PANCREAS71234046712364017123583771235837Missense_MutationGTp.S1017I
SW1990_PANCREAS71234634712364017123583771235837Missense_MutationGTp.S1017I
HEC251_ENDOMETRIUM71234046712364017123590971235909Missense_MutationACp.N1041T
HEC251_ENDOMETRIUM71234634712364017123590971235909Missense_MutationACp.N1041T
OC316_OVARY71234046712364017123593371235933Missense_MutationCTp.T1049M
OC316_OVARY71234634712364017123593371235933Missense_MutationCTp.T1049M
JHUEM2_ENDOMETRIUM71234046712364017123593371235933Missense_MutationCTp.T1049M
JHUEM2_ENDOMETRIUM71234634712364017123593371235933Missense_MutationCTp.T1049M
OC314_OVARY71234046712364017123593371235933Missense_MutationCTp.T1049M
OC314_OVARY71234634712364017123593371235933Missense_MutationCTp.T1049M
SNU1040_LARGE_INTESTINE71234046712364017123596671235966Missense_MutationGAp.S1060N
SNU1040_LARGE_INTESTINE71234634712364017123596671235966Missense_MutationGAp.S1060N
EN_ENDOMETRIUM71234046712364017123600571236005Missense_MutationAGp.E1073G
EN_ENDOMETRIUM71234634712364017123600571236005Missense_MutationAGp.E1073G
EKVX_LUNG71234046712364017123611971236119Missense_MutationCAp.T1111K
EKVX_LUNG71234634712364017123611971236119Missense_MutationCAp.T1111K
HCC461_LUNG71234046712364017123614871236148Missense_MutationGCp.E1121Q
HCC461_LUNG71234634712364017123614871236148Missense_MutationGCp.E1121Q
H2369_PLEURA71234046712364017123622371236223Missense_MutationAGp.T1146A
H2369_PLEURA71234634712364017123622371236223Missense_MutationAGp.T1146A
LNZTA3WT4_CENTRAL_NERVOUS_SYSTEM71234046712364017123625471236254Missense_MutationCGp.P1156R
LNZTA3WT4_CENTRAL_NERVOUS_SYSTEM71234634712364017123625471236254Missense_MutationCGp.P1156R
LNZ308_CENTRAL_NERVOUS_SYSTEM71234046712364017123625471236254Missense_MutationCGp.P1156R
LNZ308_CENTRAL_NERVOUS_SYSTEM71234634712364017123625471236254Missense_MutationCGp.P1156R
GEO_LARGE_INTESTINE71234046712364017123626671236266Missense_MutationGAp.R1160Q
GEO_LARGE_INTESTINE71234634712364017123626671236266Missense_MutationGAp.R1160Q
SW756_CERVIX71234046712364017123629371236293Missense_MutationCGp.S1169C
SW756_CERVIX71234634712364017123629371236293Missense_MutationCGp.S1169C
TUHR10TKB_KIDNEY71234046712364017123631371236313Missense_MutationGTp.A1176S
TUHR10TKB_KIDNEY71234634712364017123631371236313Missense_MutationGTp.A1176S
ECGI10_OESOPHAGUS71234046712364017123631371236313Missense_MutationGTp.A1176S
ECGI10_OESOPHAGUS71234634712364017123631371236313Missense_MutationGTp.A1176S
CORL23_LUNG71247994712481047124809271248092Missense_MutationATp.S1406C
SCS214_SOFT_TISSUE71266453712665667126645571266455Missense_MutationCTp.L1411F
SKOV3_OVARY71266453712665667126645571266455Missense_MutationCTp.L1411F
SLVL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE71266453712665667126650371266503Missense_MutationTCp.Y1427H
HS936T_SKIN71266453712665667126650771266507Missense_MutationTCp.V1428A
HCC56_LARGE_INTESTINE71266453712665667126655271266552Missense_MutationAGp.K1443R
HEC108_ENDOMETRIUM71200737712007867120075771200757Nonsense_MutationCTp.R282*
SW684_SOFT_TISSUE71234634712348947123483471234834Nonsense_MutationCTp.R683*
SW684_SOFT_TISSUE71234046712364017123483471234834Nonsense_MutationCTp.R683*
SW684_SOFT_TISSUE71234634712364017123483471234834Nonsense_MutationCTp.R683*
HCT116_LARGE_INTESTINE71234046712364017123626571236265Nonsense_MutationCTp.R1160*
HCT116_LARGE_INTESTINE71234634712364017123626571236265Nonsense_MutationCTp.R1160*

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FAM135A

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value
exon_skip_452986671233669:71233824:71234045:71236401:71237994:7123815571234045:71236401ENST00000418814.2,ENST00000505868.1PRADrs7740873chr6:71236216C/T9.34e-04
exon_skip_452986671233669:71233824:71234045:71236401:71237994:7123815571234045:71236401ENST00000418814.2,ENST00000505868.1PRADrs7740873chr6:71236216C/T9.34e-04
exon_skip_452988671233669:71233824:71234633:71236401:71237994:7123815571234633:71236401ENST00000370479.3,ENST00000457062.2,ENST00000194672.7,ENST00000361499.3PRADrs7740873chr6:71236216C/T9.34e-04
exon_skip_452988671233669:71233824:71234633:71236401:71237994:7123815571234633:71236401ENST00000370479.3,ENST00000457062.2,ENST00000194672.7,ENST00000361499.3PRADrs7740873chr6:71236216C/T9.34e-04

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FAM135A


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FAM135A


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RelatedDrugs for FAM135A

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM135A

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource