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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for MICAL3 |
 Gene summary |
| Gene information | Gene symbol | MICAL3 | Gene ID | 57553 |
| Gene name | microtubule associated monooxygenase, calponin and LIM domain containing 3 | |
| Synonyms | MICAL-3 | |
| Cytomap | 22q11.21 | |
| Type of gene | protein-coding | |
| Description | [F-actin]-monooxygenase MICAL3F-actin-monooxygenase MICAL3[F-actin]-methionine sulfoxide oxidase MICAL3flavoprotein oxidoreductase MICAL3molecule interacting with CasL protein 3protein MICAL-3protein-methionine sulfoxide oxidase MICAL3 | |
| Modification date | 20180519 | |
| UniProtAcc | Q7RTP6 | |
| Context | PubMed: MICAL3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MICAL3 | GO:0007010 | cytoskeleton organization | 24440334 |
| MICAL3 | GO:0030042 | actin filament depolymerization | 24440334 |
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Exon skipping events across known transcript of Ensembl for MICAL3 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for MICAL3 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for MICAL3 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_367225 | 22 | 18274029:18274067:18276494:18276560:18291609:18291703 | 18276494:18276560 | ENSG00000243156.3 | ENST00000579997.1 |
| exon_skip_367229 | 22 | 18274029:18274067:18286576:18286627:18291609:18291703 | 18286576:18286627 | ENSG00000243156.3 | ENST00000577821.1 |
| exon_skip_367231 | 22 | 18274029:18274067:18291609:18291703:18293468:18293502 | 18291609:18291703 | ENSG00000243156.3 | ENST00000580469.1,ENST00000441493.2 |
| exon_skip_367234 | 22 | 18293468:18293579:18295272:18295323:18299455:18299550 | 18295272:18295323 | ENSG00000243156.3 | ENST00000577821.1 |
| exon_skip_367235 | 22 | 18299455:18299550:18300076:18301895:18304192:18304275 | 18300076:18301895 | ENSG00000243156.3 | ENST00000441493.2 |
| exon_skip_367236 | 22 | 18304795:18304936:18305712:18305826:18310409:18310547 | 18305712:18305826 | ENSG00000243156.3 | ENST00000441493.2 |
| exon_skip_367237 | 22 | 18304795:18304936:18305712:18305826:18314619:18314693 | 18305712:18305826 | ENSG00000243156.3 | ENST00000498573.1 |
| exon_skip_367247 | 22 | 18305712:18305826:18309219:18309282:18314619:18314693 | 18309219:18309282 | ENSG00000243156.3 | ENST00000578984.1 |
| exon_skip_367248 | 22 | 18305712:18305826:18310409:18310547:18314619:18314693 | 18310409:18310547 | ENSG00000243156.3 | ENST00000441493.2 |
| exon_skip_367254 | 22 | 18314619:18314873:18324587:18324783:18347664:18347752 | 18324587:18324783 | ENSG00000243156.3 | ENST00000441493.2 |
| exon_skip_367259 | 22 | 18354699:18354789:18367040:18367124:18368643:18368759 | 18367040:18367124 | ENSG00000243156.3 | ENST00000414725.2,ENST00000461307.1,ENST00000207726.7 |
| exon_skip_367260 | 22 | 18355512:18355620:18358212:18358320:18362111:18362168 | 18358212:18358320 | ENSG00000243156.3 | ENST00000429452.1,ENST00000585038.1 |
| exon_skip_367264 | 22 | 18362111:18362168:18363970:18364069:18368643:18368817 | 18363970:18364069 | ENSG00000243156.3 | ENST00000429452.1,ENST00000585038.1 |
| exon_skip_367266 | 22 | 18371799:18371996:18374250:18374398:18376573:18376670 | 18374250:18374398 | ENSG00000243156.3 | ENST00000429452.1,ENST00000444520.1,ENST00000400561.2,ENST00000383094.3,ENST00000585038.1,ENST00000414725.2,ENST00000441493.2,ENST00000461307.1,ENST00000207726.7,ENST00000495076.1 |
| exon_skip_367267 | 22 | 18379489:18379747:18382213:18382314:18383607:18383763 | 18382213:18382314 | ENSG00000243156.3 | ENST00000429452.1,ENST00000444520.1,ENST00000400561.2,ENST00000383094.3,ENST00000585038.1,ENST00000414725.2,ENST00000441493.2,ENST00000207726.7 |
| exon_skip_367270 | 22 | 18383607:18383763:18384643:18384745:18385396:18385513 | 18384643:18384745 | ENSG00000243156.3 | ENST00000429452.1,ENST00000444520.1,ENST00000400561.2,ENST00000383094.3,ENST00000585038.1,ENST00000414725.2,ENST00000441493.2,ENST00000207726.7,ENST00000495076.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for MICAL3 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_367225 | 22 | 18274029:18274067:18276494:18276560:18291609:18291703 | 18276494:18276560 | ENSG00000243156.3 | ENST00000579997.1 |
| exon_skip_367229 | 22 | 18274029:18274067:18286576:18286627:18291609:18291703 | 18286576:18286627 | ENSG00000243156.3 | ENST00000577821.1 |
| exon_skip_367231 | 22 | 18274029:18274067:18291609:18291703:18293468:18293502 | 18291609:18291703 | ENSG00000243156.3 | ENST00000441493.2,ENST00000580469.1 |
| exon_skip_367234 | 22 | 18293468:18293579:18295272:18295323:18299455:18299550 | 18295272:18295323 | ENSG00000243156.3 | ENST00000577821.1 |
| exon_skip_367235 | 22 | 18299455:18299550:18300076:18301895:18304192:18304275 | 18300076:18301895 | ENSG00000243156.3 | ENST00000441493.2 |
| exon_skip_367236 | 22 | 18304795:18304936:18305712:18305826:18310409:18310547 | 18305712:18305826 | ENSG00000243156.3 | ENST00000441493.2 |
| exon_skip_367237 | 22 | 18304795:18304936:18305712:18305826:18314619:18314693 | 18305712:18305826 | ENSG00000243156.3 | ENST00000498573.1 |
| exon_skip_367247 | 22 | 18305712:18305826:18309219:18309282:18314619:18314693 | 18309219:18309282 | ENSG00000243156.3 | ENST00000578984.1 |
| exon_skip_367248 | 22 | 18305712:18305826:18310409:18310547:18314619:18314693 | 18310409:18310547 | ENSG00000243156.3 | ENST00000441493.2 |
| exon_skip_367254 | 22 | 18314619:18314873:18324587:18324783:18347664:18347752 | 18324587:18324783 | ENSG00000243156.3 | ENST00000441493.2 |
| exon_skip_367259 | 22 | 18354699:18354789:18367040:18367124:18368643:18368759 | 18367040:18367124 | ENSG00000243156.3 | ENST00000414725.2,ENST00000207726.7,ENST00000461307.1 |
| exon_skip_367260 | 22 | 18355512:18355620:18358212:18358320:18362111:18362168 | 18358212:18358320 | ENSG00000243156.3 | ENST00000429452.1,ENST00000585038.1 |
| exon_skip_367264 | 22 | 18362111:18362168:18363970:18364069:18368643:18368817 | 18363970:18364069 | ENSG00000243156.3 | ENST00000429452.1,ENST00000585038.1 |
| exon_skip_367266 | 22 | 18371799:18371996:18374250:18374398:18376573:18376670 | 18374250:18374398 | ENSG00000243156.3 | ENST00000441493.2,ENST00000400561.2,ENST00000444520.1,ENST00000495076.1,ENST00000414725.2,ENST00000383094.3,ENST00000207726.7,ENST00000429452.1,ENST00000461307.1,ENST00000585038.1 |
| exon_skip_367267 | 22 | 18379489:18379747:18382213:18382314:18383607:18383763 | 18382213:18382314 | ENSG00000243156.3 | ENST00000441493.2,ENST00000400561.2,ENST00000444520.1,ENST00000414725.2,ENST00000383094.3,ENST00000207726.7,ENST00000429452.1,ENST00000585038.1 |
| exon_skip_367270 | 22 | 18383607:18383763:18384643:18384745:18385396:18385513 | 18384643:18384745 | ENSG00000243156.3 | ENST00000441493.2,ENST00000400561.2,ENST00000444520.1,ENST00000495076.1,ENST00000414725.2,ENST00000383094.3,ENST00000207726.7,ENST00000429452.1,ENST00000585038.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for MICAL3 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000441493 | 18291609 | 18291703 | Frame-shift |
| ENST00000441493 | 18300076 | 18301895 | Frame-shift |
| ENST00000441493 | 18324587 | 18324783 | Frame-shift |
| ENST00000441493 | 18374250 | 18374398 | Frame-shift |
| ENST00000441493 | 18382213 | 18382314 | Frame-shift |
| ENST00000441493 | 18305712 | 18305826 | In-frame |
| ENST00000441493 | 18310409 | 18310547 | In-frame |
| ENST00000441493 | 18384643 | 18384745 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000441493 | 18291609 | 18291703 | Frame-shift |
| ENST00000441493 | 18300076 | 18301895 | Frame-shift |
| ENST00000441493 | 18324587 | 18324783 | Frame-shift |
| ENST00000441493 | 18374250 | 18374398 | Frame-shift |
| ENST00000441493 | 18382213 | 18382314 | Frame-shift |
| ENST00000441493 | 18305712 | 18305826 | In-frame |
| ENST00000441493 | 18310409 | 18310547 | In-frame |
| ENST00000441493 | 18384643 | 18384745 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MICAL3 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000441493 | 9462 | 2002 | 18384643 | 18384745 | 943 | 1044 | 196 | 230 |
| ENST00000441493 | 9462 | 2002 | 18310409 | 18310547 | 3409 | 3546 | 1018 | 1064 |
| ENST00000441493 | 9462 | 2002 | 18305712 | 18305826 | 3547 | 3660 | 1064 | 1102 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000441493 | 9462 | 2002 | 18384643 | 18384745 | 943 | 1044 | 196 | 230 |
| ENST00000441493 | 9462 | 2002 | 18310409 | 18310547 | 3409 | 3546 | 1018 | 1064 |
| ENST00000441493 | 9462 | 2002 | 18305712 | 18305826 | 3547 | 3660 | 1064 | 1102 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q7RTP6 | 196 | 230 | 1 | 2002 | Chain | ID=PRO_0000075846;Note=[F-actin]-monooxygenase MICAL3 |
| Q7RTP6 | 196 | 230 | 2 | 494 | Region | Note=Monooxygenase domain;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VDP3 |
| Q7RTP6 | 1018 | 1064 | 949 | 2002 | Alternative sequence | ID=VSP_039488;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10718198,ECO:0000303|PubMed:15461802;Dbxref=PMID:10718198,PMID:15461802 |
| Q7RTP6 | 1018 | 1064 | 950 | 2002 | Alternative sequence | ID=VSP_042602;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q7RTP6 | 1018 | 1064 | 967 | 2002 | Alternative sequence | ID=VSP_039489;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 |
| Q7RTP6 | 1018 | 1064 | 1 | 2002 | Chain | ID=PRO_0000075846;Note=[F-actin]-monooxygenase MICAL3 |
| Q7RTP6 | 1018 | 1064 | 889 | 1138 | Compositional bias | Note=Glu-rich |
| Q7RTP6 | 1064 | 1102 | 949 | 2002 | Alternative sequence | ID=VSP_039488;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10718198,ECO:0000303|PubMed:15461802;Dbxref=PMID:10718198,PMID:15461802 |
| Q7RTP6 | 1064 | 1102 | 950 | 2002 | Alternative sequence | ID=VSP_042602;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q7RTP6 | 1064 | 1102 | 967 | 2002 | Alternative sequence | ID=VSP_039489;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 |
| Q7RTP6 | 1064 | 1102 | 1 | 2002 | Chain | ID=PRO_0000075846;Note=[F-actin]-monooxygenase MICAL3 |
| Q7RTP6 | 1064 | 1102 | 889 | 1138 | Compositional bias | Note=Glu-rich |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q7RTP6 | 196 | 230 | 1 | 2002 | Chain | ID=PRO_0000075846;Note=[F-actin]-monooxygenase MICAL3 |
| Q7RTP6 | 196 | 230 | 2 | 494 | Region | Note=Monooxygenase domain;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VDP3 |
| Q7RTP6 | 1018 | 1064 | 949 | 2002 | Alternative sequence | ID=VSP_039488;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10718198,ECO:0000303|PubMed:15461802;Dbxref=PMID:10718198,PMID:15461802 |
| Q7RTP6 | 1018 | 1064 | 950 | 2002 | Alternative sequence | ID=VSP_042602;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q7RTP6 | 1018 | 1064 | 967 | 2002 | Alternative sequence | ID=VSP_039489;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 |
| Q7RTP6 | 1018 | 1064 | 1 | 2002 | Chain | ID=PRO_0000075846;Note=[F-actin]-monooxygenase MICAL3 |
| Q7RTP6 | 1018 | 1064 | 889 | 1138 | Compositional bias | Note=Glu-rich |
| Q7RTP6 | 1064 | 1102 | 949 | 2002 | Alternative sequence | ID=VSP_039488;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10718198,ECO:0000303|PubMed:15461802;Dbxref=PMID:10718198,PMID:15461802 |
| Q7RTP6 | 1064 | 1102 | 950 | 2002 | Alternative sequence | ID=VSP_042602;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q7RTP6 | 1064 | 1102 | 967 | 2002 | Alternative sequence | ID=VSP_039489;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 |
| Q7RTP6 | 1064 | 1102 | 1 | 2002 | Chain | ID=PRO_0000075846;Note=[F-actin]-monooxygenase MICAL3 |
| Q7RTP6 | 1064 | 1102 | 889 | 1138 | Compositional bias | Note=Glu-rich |
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SNVs in the skipped exons for MICAL3 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
MICAL3_COAD_exon_skip_367235_psi_boxplot.png |
MICAL3_ESCA_exon_skip_367235_psi_boxplot.png |
MICAL3_GBM_exon_skip_367235_psi_boxplot.png |
MICAL3_HNSC_exon_skip_367235_psi_boxplot.png |
MICAL3_LGG_exon_skip_367235_psi_boxplot.png |
MICAL3_LIHC_exon_skip_367235_psi_boxplot.png |
MICAL3_LUAD_exon_skip_367235_psi_boxplot.png |
MICAL3_LUSC_exon_skip_367235_psi_boxplot.png |
MICAL3_READ_exon_skip_367235_psi_boxplot.png |
MICAL3_SKCM_exon_skip_367235_psi_boxplot.png |
MICAL3_STAD_exon_skip_367235_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_367235 | 18300077 | 18301895 | 18300090 | 18300090 | Frame_Shift_Del | G | - | p.P1779fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_367235 | 18300077 | 18301895 | 18300125 | 18300125 | Frame_Shift_Del | C | - | p.A1768fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_367235 | 18300077 | 18301895 | 18300311 | 18300311 | Frame_Shift_Del | G | - | p.R1707fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_367235 | 18300077 | 18301895 | 18300311 | 18300311 | Frame_Shift_Del | G | - | p.R1707fs |
| STAD | TCGA-HU-A4G9-01 | exon_skip_367235 | 18300077 | 18301895 | 18300311 | 18300311 | Frame_Shift_Del | G | - | p.R1706fs |
| UCEC | TCGA-B5-A0JV-01 | exon_skip_367235 | 18300077 | 18301895 | 18300311 | 18300311 | Frame_Shift_Del | G | - | p.R1706fs |
| KIRP | TCGA-P4-A5E6-01 | exon_skip_367235 | 18300077 | 18301895 | 18300505 | 18300505 | Frame_Shift_Del | T | - | p.Q1641fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_367235 | 18300077 | 18301895 | 18300684 | 18300684 | Frame_Shift_Del | C | - | p.G1581fs |
| HNSC | TCGA-CR-7370-01 | exon_skip_367235 | 18300077 | 18301895 | 18300912 | 18300912 | Frame_Shift_Del | G | - | p.P1505fs |
| COAD | TCGA-AD-5900-01 | exon_skip_367235 | 18300077 | 18301895 | 18300932 | 18300932 | Frame_Shift_Del | G | - | p.R1499fs |
| COAD | TCGA-AZ-4615-01 | exon_skip_367235 | 18300077 | 18301895 | 18300932 | 18300932 | Frame_Shift_Del | G | - | p.R1499fs |
| COAD | TCGA-CM-5861-01 | exon_skip_367235 | 18300077 | 18301895 | 18300932 | 18300932 | Frame_Shift_Del | G | - | p.R1499fs |
| COAD | TCGA-G4-6628-01 | exon_skip_367235 | 18300077 | 18301895 | 18300932 | 18300932 | Frame_Shift_Del | G | - | p.R1499fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_367235 | 18300077 | 18301895 | 18300932 | 18300932 | Frame_Shift_Del | G | - | p.R1499fs |
| READ | TCGA-EI-6507-01 | exon_skip_367235 | 18300077 | 18301895 | 18300932 | 18300932 | Frame_Shift_Del | G | - | p.R1499fs |
| STAD | TCGA-VQ-A8P2-01 | exon_skip_367235 | 18300077 | 18301895 | 18300932 | 18300932 | Frame_Shift_Del | G | - | p.R1499fs |
| UCEC | TCGA-BG-A0VZ-01 | exon_skip_367235 | 18300077 | 18301895 | 18300932 | 18300932 | Frame_Shift_Del | G | - | p.R1499fs |
| ESCA | TCGA-R6-A8WC-01 | exon_skip_367235 | 18300077 | 18301895 | 18301005 | 18301005 | Frame_Shift_Del | C | - | p.K1475fs |
| ESCA | TCGA-R6-A8WC-01 | exon_skip_367235 | 18300077 | 18301895 | 18301005 | 18301005 | Frame_Shift_Del | C | - | p.R1474fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_367235 | 18300077 | 18301895 | 18301214 | 18301214 | Frame_Shift_Del | G | - | p.R1405fs |
| LUAD | TCGA-86-8054-01 | exon_skip_367235 | 18300077 | 18301895 | 18301310 | 18301310 | Frame_Shift_Del | G | - | p.Q1373fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_367235 | 18300077 | 18301895 | 18301475 | 18301475 | Frame_Shift_Del | G | - | p.L1318fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_367235 | 18300077 | 18301895 | 18301475 | 18301475 | Frame_Shift_Del | G | - | p.L1318fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_367235 | 18300077 | 18301895 | 18301788 | 18301788 | Frame_Shift_Del | G | - | p.P1213fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_367235 | 18300077 | 18301895 | 18301788 | 18301788 | Frame_Shift_Del | G | - | p.P1213fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_367235 | 18300077 | 18301895 | 18301788 | 18301788 | Frame_Shift_Del | G | - | p.P1213fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_367235 | 18300077 | 18301895 | 18301834 | 18301834 | Frame_Shift_Del | A | - | p.F1198fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_367264 | 18363971 | 18364069 | 18364031 | 18364031 | Frame_Shift_Del | T | - | p.K760fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_367264 | 18363971 | 18364069 | 18364031 | 18364031 | Frame_Shift_Del | T | - | p.K760fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_367264 | 18363971 | 18364069 | 18364031 | 18364031 | Frame_Shift_Del | T | - | p.K760fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_367264 | 18363971 | 18364069 | 18364031 | 18364031 | Frame_Shift_Del | T | - | p.V761X |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_367266 | 18374251 | 18374398 | 18374376 | 18374376 | Frame_Shift_Del | T | - | p.K523fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_367267 | 18382214 | 18382314 | 18382248 | 18382248 | Frame_Shift_Del | T | - | p.K305fs |
| PRAD | TCGA-XJ-A9DX-01 | exon_skip_367235 | 18300077 | 18301895 | 18300931 | 18300932 | Frame_Shift_Ins | - | G | p.G1499fs |
| GBM | TCGA-06-0174-01 | exon_skip_367235 | 18300077 | 18301895 | 18301237 | 18301238 | Frame_Shift_Ins | - | C | p.E1397fs |
| BRCA | TCGA-BH-A1FD-01 | exon_skip_367236 exon_skip_367237 | 18305713 | 18305826 | 18305741 | 18305742 | Frame_Shift_Ins | - | G | p.G1094fs |
| LUAD | TCGA-MP-A4SY-01 | exon_skip_367235 | 18300077 | 18301895 | 18300359 | 18300359 | Nonsense_Mutation | C | A | p.E1690* |
| STAD | TCGA-HU-A4GC-01 | exon_skip_367235 | 18300077 | 18301895 | 18300777 | 18300777 | Nonsense_Mutation | C | T | p.W1550* |
| STAD | TCGA-HU-A4GC-01 | exon_skip_367235 | 18300077 | 18301895 | 18300777 | 18300777 | Nonsense_Mutation | C | T | p.W1550X |
| LGG | TCGA-DU-6392-01 | exon_skip_367235 | 18300077 | 18301895 | 18300809 | 18300809 | Nonsense_Mutation | G | A | p.Q1540* |
| LUSC | TCGA-85-6561-01 | exon_skip_367235 | 18300077 | 18301895 | 18300884 | 18300884 | Nonsense_Mutation | C | A | p.E1515* |
| SKCM | TCGA-EB-A6QY-01 | exon_skip_367235 | 18300077 | 18301895 | 18301532 | 18301532 | Nonsense_Mutation | G | A | p.Q1299* |
| SKCM | TCGA-D3-A5GN-06 | exon_skip_367236 exon_skip_367237 | 18305713 | 18305826 | 18305764 | 18305764 | Nonsense_Mutation | C | A | p.E1086* |
| SKCM | TCGA-D3-A5GN-06 | exon_skip_367236 exon_skip_367237 | 18305713 | 18305826 | 18305764 | 18305764 | Nonsense_Mutation | C | A | p.E1086X |
| LUSC | TCGA-39-5031-01 | exon_skip_367266 | 18374251 | 18374398 | 18374399 | 18374399 | Splice_Site | C | G | p.E516_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-DU-6392-01 |
| Cancer type: LGG | |
| ESID: exon_skip_367235 | |
| Skipped exon start: 18300077 | |
| Skipped exon end: 18301895 | |
| Mutation start: 18300809 | |
| Mutation end: 18300809 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.Q1540* | |
exon_skip_106946_LGG_TCGA-DU-6392-01.png | |
exon_skip_114879_LGG_TCGA-DU-6392-01.png | |
exon_skip_120606_LGG_TCGA-DU-6392-01.png | |
exon_skip_130417_LGG_TCGA-DU-6392-01.png | |
exon_skip_138304_LGG_TCGA-DU-6392-01.png | |
exon_skip_143841_LGG_TCGA-DU-6392-01.png | |
exon_skip_143843_LGG_TCGA-DU-6392-01.png | |
exon_skip_145922_LGG_TCGA-DU-6392-01.png | |
exon_skip_155098_LGG_TCGA-DU-6392-01.png | |
exon_skip_26359_LGG_TCGA-DU-6392-01.png | |
exon_skip_290929_LGG_TCGA-DU-6392-01.png | |
exon_skip_297109_LGG_TCGA-DU-6392-01.png | |
exon_skip_33957_LGG_TCGA-DU-6392-01.png | |
exon_skip_343170_LGG_TCGA-DU-6392-01.png | |
exon_skip_354191_LGG_TCGA-DU-6392-01.png | |
exon_skip_367235_LGG_TCGA-DU-6392-01.png | |
exon_skip_423495_LGG_TCGA-DU-6392-01.png | |
exon_skip_423582_LGG_TCGA-DU-6392-01.png | |
exon_skip_430528_LGG_TCGA-DU-6392-01.png | |
exon_skip_432953_LGG_TCGA-DU-6392-01.png | |
exon_skip_436589_LGG_TCGA-DU-6392-01.png | |
exon_skip_438105_LGG_TCGA-DU-6392-01.png | |
exon_skip_438310_LGG_TCGA-DU-6392-01.png | |
exon_skip_442085_LGG_TCGA-DU-6392-01.png | |
exon_skip_481046_LGG_TCGA-DU-6392-01.png | |
exon_skip_484517_LGG_TCGA-DU-6392-01.png | |
exon_skip_502736_LGG_TCGA-DU-6392-01.png | |
exon_skip_512614_LGG_TCGA-DU-6392-01.png | |
exon_skip_7508_LGG_TCGA-DU-6392-01.png | |
exon_skip_7509_LGG_TCGA-DU-6392-01.png | |
exon_skip_79467_LGG_TCGA-DU-6392-01.png | |
exon_skip_85050_LGG_TCGA-DU-6392-01.png | |
exon_skip_95050_LGG_TCGA-DU-6392-01.png | |
exon_skip_95053_LGG_TCGA-DU-6392-01.png | |
 | Sample: TCGA-85-6561-01 |
| Cancer type: LUSC | |
| ESID: exon_skip_367235 | |
| Skipped exon start: 18300077 | |
| Skipped exon end: 18301895 | |
| Mutation start: 18300884 | |
| Mutation end: 18300884 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: C | |
| Mutation seq: A | |
| AAchange: p.E1515* | |
exon_skip_104683_LUSC_TCGA-85-6561-01.png | |
exon_skip_315479_LUSC_TCGA-85-6561-01.png | |
exon_skip_344069_LUSC_TCGA-85-6561-01.png | |
exon_skip_354387_LUSC_TCGA-85-6561-01.png | |
exon_skip_367235_LUSC_TCGA-85-6561-01.png | |
exon_skip_371719_LUSC_TCGA-85-6561-01.png | |
exon_skip_91283_LUSC_TCGA-85-6561-01.png | |
 | Sample: TCGA-AD-5900-01 |
| Cancer type: COAD | |
| ESID: exon_skip_367235 | |
| Skipped exon start: 18300077 | |
| Skipped exon end: 18301895 | |
| Mutation start: 18300932 | |
| Mutation end: 18300932 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: G | |
| Mutation seq: - | |
| AAchange: p.R1499fs | |
exon_skip_123601_COAD_TCGA-AD-5900-01.png | |
exon_skip_135806_COAD_TCGA-AD-5900-01.png | |
exon_skip_146733_COAD_TCGA-AD-5900-01.png | |
exon_skip_291928_COAD_TCGA-AD-5900-01.png | |
exon_skip_303809_COAD_TCGA-AD-5900-01.png | |
exon_skip_315782_COAD_TCGA-AD-5900-01.png | |
exon_skip_367235_COAD_TCGA-AD-5900-01.png | |
exon_skip_376149_COAD_TCGA-AD-5900-01.png | |
exon_skip_457524_COAD_TCGA-AD-5900-01.png | |
exon_skip_459148_COAD_TCGA-AD-5900-01.png | |
exon_skip_68768_COAD_TCGA-AD-5900-01.png | |
 | Sample: TCGA-G4-6628-01 |
| Cancer type: COAD | |
| ESID: exon_skip_367235 | |
| Skipped exon start: 18300077 | |
| Skipped exon end: 18301895 | |
| Mutation start: 18300932 | |
| Mutation end: 18300932 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: G | |
| Mutation seq: - | |
| AAchange: p.R1499fs | |
exon_skip_142268_COAD_TCGA-G4-6628-01.png | |
exon_skip_306804_COAD_TCGA-G4-6628-01.png | |
exon_skip_331095_COAD_TCGA-G4-6628-01.png | |
exon_skip_367235_COAD_TCGA-G4-6628-01.png | |
 | Sample: TCGA-R6-A8WC-01 |
| Cancer type: ESCA | |
| ESID: exon_skip_367235 | |
| Skipped exon start: 18300077 | |
| Skipped exon end: 18301895 | |
| Mutation start: 18301005 | |
| Mutation end: 18301005 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: C | |
| Mutation seq: - | |
| AAchange: p.R1474fs | |
| Sample: TCGA-R6-A8WC-01 |
| Cancer type: ESCA | |
| ESID: exon_skip_367235 | |
| Skipped exon start: 18300077 | |
| Skipped exon end: 18301895 | |
| Mutation start: 18301005 | |
| Mutation end: 18301005 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: C | |
| Mutation seq: - | |
| AAchange: p.K1475fs | |
exon_skip_286384_ESCA_TCGA-R6-A8WC-01.png | |
exon_skip_288276_ESCA_TCGA-R6-A8WC-01.png | |
exon_skip_367235_ESCA_TCGA-R6-A8WC-01.png | |
 | Sample: TCGA-06-0174-01 |
| Cancer type: GBM | |
| ESID: exon_skip_367235 | |
| Skipped exon start: 18300077 | |
| Skipped exon end: 18301895 | |
| Mutation start: 18301237 | |
| Mutation end: 18301238 | |
| Mutation type: Frame_Shift_Ins | |
| Reference seq: - | |
| Mutation seq: C | |
| AAchange: p.E1397fs | |
exon_skip_367235_GBM_TCGA-06-0174-01.png | |
exon_skip_465262_GBM_TCGA-06-0174-01.png | |
 | Sample: TCGA-CR-7370-01 |
| Cancer type: HNSC | |
| ESID: exon_skip_367235 | |
| Skipped exon start: 18300077 | |
| Skipped exon end: 18301895 | |
| Mutation start: 18300912 | |
| Mutation end: 18300912 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: G | |
| Mutation seq: - | |
| AAchange: p.P1505fs | |
exon_skip_344274_HNSC_TCGA-CR-7370-01.png | |
exon_skip_367235_HNSC_TCGA-CR-7370-01.png | |
exon_skip_389215_HNSC_TCGA-CR-7370-01.png | |
 | Sample: TCGA-86-8054-01 |
| Cancer type: LUAD | |
| ESID: exon_skip_367235 | |
| Skipped exon start: 18300077 | |
| Skipped exon end: 18301895 | |
| Mutation start: 18301310 | |
| Mutation end: 18301310 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: G | |
| Mutation seq: - | |
| AAchange: p.Q1373fs | |
exon_skip_367235_LUAD_TCGA-86-8054-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| CW2_LARGE_INTESTINE | 18300077 | 18301895 | 18300311 | 18300311 | Frame_Shift_Del | G | - | p.R1707fs |
| HCT116_LARGE_INTESTINE | 18300077 | 18301895 | 18301310 | 18301310 | Frame_Shift_Del | G | - | p.Q1373fs |
| SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 18300077 | 18301895 | 18301493 | 18301493 | Frame_Shift_Del | G | - | p.L1312fs |
| SNU407_LARGE_INTESTINE | 18300077 | 18301895 | 18300911 | 18300912 | Frame_Shift_Ins | - | G | p.R1506fs |
| HCET_UPPER_AERODIGESTIVE_TRACT | 18300077 | 18301895 | 18300297 | 18300299 | In_Frame_Del | CTT | - | p.K1710del |
| MM415_SKIN | 18291610 | 18291703 | 18291643 | 18291643 | Missense_Mutation | C | T | p.V1873M |
| DOHH2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 18291610 | 18291703 | 18291649 | 18291649 | Missense_Mutation | T | C | p.R1871G |
| KMH2_THYROID | 18300077 | 18301895 | 18300133 | 18300133 | Missense_Mutation | G | A | p.S1765F |
| HEC1_ENDOMETRIUM | 18300077 | 18301895 | 18300265 | 18300265 | Missense_Mutation | G | T | p.P1721Q |
| MOLT3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 18300077 | 18301895 | 18300296 | 18300296 | Missense_Mutation | C | T | p.E1711K |
| SCH_STOMACH | 18300077 | 18301895 | 18300296 | 18300296 | Missense_Mutation | C | T | p.E1711K |
| HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 18300077 | 18301895 | 18300329 | 18300329 | Missense_Mutation | A | G | p.S1700P |
| VMRCLCD_LUNG | 18300077 | 18301895 | 18300395 | 18300395 | Missense_Mutation | C | A | p.D1678Y |
| MEWO_SKIN | 18300077 | 18301895 | 18300423 | 18300424 | Missense_Mutation | GG | AA | p.T1668I |
| MEWO_SKIN | 18300077 | 18301895 | 18300424 | 18300424 | Missense_Mutation | G | A | p.T1668I |
| ABC1_LUNG | 18300077 | 18301895 | 18300458 | 18300458 | Missense_Mutation | C | T | p.G1657S |
| MOLT16_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 18300077 | 18301895 | 18300458 | 18300458 | Missense_Mutation | C | T | p.G1657S |
| DKMG_CENTRAL_NERVOUS_SYSTEM | 18300077 | 18301895 | 18300530 | 18300530 | Missense_Mutation | G | A | p.R1633C |
| EPLC272H_LUNG | 18300077 | 18301895 | 18300535 | 18300535 | Missense_Mutation | C | A | p.R1631M |
| JEKO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 18300077 | 18301895 | 18300617 | 18300617 | Missense_Mutation | C | T | p.V1604M |
| MYLA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 18300077 | 18301895 | 18300638 | 18300638 | Missense_Mutation | T | C | p.M1597V |
| HEC59_ENDOMETRIUM | 18300077 | 18301895 | 18300728 | 18300728 | Missense_Mutation | T | C | p.R1567G |
| SNUC5_LARGE_INTESTINE | 18300077 | 18301895 | 18300754 | 18300754 | Missense_Mutation | T | G | p.H1558P |
| NCIH1155_LUNG | 18300077 | 18301895 | 18300781 | 18300781 | Missense_Mutation | C | T | p.C1549Y |
| IGR1_SKIN | 18300077 | 18301895 | 18300913 | 18300913 | Missense_Mutation | G | T | p.P1505H |
| CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 18300077 | 18301895 | 18300923 | 18300923 | Missense_Mutation | C | A | p.A1502S |
| SARC9371_BONE | 18300077 | 18301895 | 18300934 | 18300934 | Missense_Mutation | G | A | p.P1498L |
| HEC59_ENDOMETRIUM | 18300077 | 18301895 | 18300944 | 18300944 | Missense_Mutation | T | C | p.M1495V |
| NUGC4_STOMACH | 18300077 | 18301895 | 18300982 | 18300982 | Missense_Mutation | T | A | p.N1482I |
| NCIH513_PLEURA | 18300077 | 18301895 | 18301046 | 18301046 | Missense_Mutation | G | T | p.P1461T |
| NCIH1155_LUNG | 18300077 | 18301895 | 18301049 | 18301049 | Missense_Mutation | G | A | p.P1460S |
| UMUC16_URINARY_TRACT | 18300077 | 18301895 | 18301055 | 18301055 | Missense_Mutation | T | G | p.S1458R |
| Y79_AUTONOMIC_GANGLIA | 18300077 | 18301895 | 18301058 | 18301058 | Missense_Mutation | A | G | p.S1457P |
| TOV21G_OVARY | 18300077 | 18301895 | 18301207 | 18301207 | Missense_Mutation | G | A | p.P1407L |
| NCIH727_LUNG | 18300077 | 18301895 | 18301207 | 18301207 | Missense_Mutation | G | A | p.P1407L |
| MDAMB435S_SKIN | 18300077 | 18301895 | 18301234 | 18301234 | Missense_Mutation | G | A | p.P1398L |
| KYSE180_OESOPHAGUS | 18300077 | 18301895 | 18301292 | 18301292 | Missense_Mutation | G | A | p.L1379F |
| KYSE180_OESOPHAGUS | 18300077 | 18301895 | 18301292 | 18301293 | Missense_Mutation | GG | AT | p.1378_1379HL>QF |
| KYSE180_OESOPHAGUS | 18300077 | 18301895 | 18301293 | 18301293 | Missense_Mutation | G | T | p.H1378Q |
| OC316_OVARY | 18300077 | 18301895 | 18301358 | 18301358 | Missense_Mutation | C | T | p.A1357T |
| OC314_OVARY | 18300077 | 18301895 | 18301358 | 18301358 | Missense_Mutation | C | T | p.A1357T |
| NCIH650_LUNG | 18300077 | 18301895 | 18301433 | 18301433 | Missense_Mutation | C | A | p.A1332S |
| SNGM_ENDOMETRIUM | 18300077 | 18301895 | 18301516 | 18301516 | Missense_Mutation | G | T | p.T1304N |
| NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 18300077 | 18301895 | 18301522 | 18301522 | Missense_Mutation | C | T | p.S1302N |
| SNU1076_UPPER_AERODIGESTIVE_TRACT | 18300077 | 18301895 | 18301585 | 18301585 | Missense_Mutation | C | T | p.R1281H |
| NCIH1623_LUNG | 18300077 | 18301895 | 18301586 | 18301586 | Missense_Mutation | G | T | p.R1281S |
| CESS_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 18300077 | 18301895 | 18301601 | 18301601 | Missense_Mutation | T | G | p.T1276P |
| CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 18300077 | 18301895 | 18301645 | 18301645 | Missense_Mutation | C | T | p.C1261Y |
| SKMEL2_SKIN | 18300077 | 18301895 | 18301831 | 18301831 | Missense_Mutation | G | A | p.P1199L |
| HEC108_ENDOMETRIUM | 18300077 | 18301895 | 18301841 | 18301841 | Missense_Mutation | G | A | p.R1196C |
| HPBALL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 18305713 | 18305826 | 18305743 | 18305743 | Missense_Mutation | G | T | p.P1093T |
| NCIH23_LUNG | 18310410 | 18310547 | 18310412 | 18310412 | Missense_Mutation | C | A | p.G1064V |
| RCHACV_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 18310410 | 18310547 | 18310467 | 18310467 | Missense_Mutation | G | A | p.R1046C |
| MKN45_STOMACH | 18310410 | 18310547 | 18310473 | 18310473 | Missense_Mutation | G | A | p.H1044Y |
| IGROV1_OVARY | 18324588 | 18324783 | 18324720 | 18324720 | Missense_Mutation | C | T | p.R890Q |
| NCIH1734_LUNG | 18374251 | 18374398 | 18374318 | 18374318 | Missense_Mutation | G | T | p.L543I |
| SW948_LARGE_INTESTINE | 18374251 | 18374398 | 18374350 | 18374350 | Missense_Mutation | G | A | p.T532I |
| DMS153_LUNG | 18384644 | 18384745 | 18384647 | 18384647 | Missense_Mutation | C | G | p.E230Q |
| NCIH2172_LUNG | 18384644 | 18384745 | 18384670 | 18384670 | Missense_Mutation | C | A | p.G222V |
| 22RV1_PROSTATE | 18300077 | 18301895 | 18300635 | 18300635 | Nonsense_Mutation | G | A | p.R1598* |
| SNU1040_LARGE_INTESTINE | 18300077 | 18301895 | 18300635 | 18300635 | Nonsense_Mutation | G | A | p.R1598* |
| DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 18300077 | 18301895 | 18301310 | 18301310 | Nonsense_Mutation | G | A | p.Q1373* |
| HCC2450_LUNG | 18300077 | 18301895 | 18301379 | 18301379 | Nonsense_Mutation | C | A | p.E1350* |
| NCIH23_LUNG | 18310410 | 18310547 | 18310413 | 18310413 | Nonsense_Mutation | C | A | p.G1064* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MICAL3 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
Top |
Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MICAL3 |
Top |
Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MICAL3 |
Top |
RelatedDrugs for MICAL3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MICAL3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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