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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for PTK2

check button Gene summary
Gene informationGene symbol

PTK2

Gene ID

5747

Gene nameprotein tyrosine kinase 2
SynonymsFADK|FAK|FAK1|FRNK|PPP1R71|p125FAK|pp125FAK
Cytomap

8q24.3

Type of geneprotein-coding
Descriptionfocal adhesion kinase 1FADK 1FAK-related non-kinase polypeptidePTK2 protein tyrosine kinase 2focal adhesion kinase isoform FAK-Del33focal adhesion kinase-related nonkinaseprotein phosphatase 1 regulatory subunit 71
Modification date20180527
UniProtAcc

Q05397

ContextPubMed: PTK2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
PTK2

GO:0007179

transforming growth factor beta receptor signaling pathway

24036928

PTK2

GO:0007229

integrin-mediated signaling pathway

24036928

PTK2

GO:0018108

peptidyl-tyrosine phosphorylation

10655584|11331870

PTK2

GO:0022408

negative regulation of cell-cell adhesion

21703394

PTK2

GO:0030335

positive regulation of cell migration

11331870|21703394

PTK2

GO:0033628

regulation of cell adhesion mediated by integrin

10655584

PTK2

GO:0046777

protein autophosphorylation

10655584|11331870

PTK2

GO:0048013

ephrin receptor signaling pathway

10655584

PTK2

GO:0060396

growth hormone receptor signaling pathway

10925297


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Exon skipping events across known transcript of Ensembl for PTK2 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for PTK2

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for PTK2

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_4928158141669718:141669777:141675015:141675096:141678367:141678517141675015:141675096ENSG00000169398.15ENST00000538769.1,ENST00000519654.1,ENST00000517887.1,ENST00000519419.1,ENST00000524202.1,ENST00000521059.1,ENST00000517712.1,ENST00000340930.3,ENST00000395218.2,ENST00000519465.1,ENST00000430260.2,ENST00000522684.1,ENST00000523539.1,ENST00000519993.1,ENS
exon_skip_4928218141675015:141675096:141678367:141678523:141684396:141684503141678367:141678523ENSG00000169398.15ENST00000538769.1,ENST00000519654.1,ENST00000517887.1,ENST00000519419.1,ENST00000524202.1,ENST00000521059.1,ENST00000519465.1,ENST00000430260.2,ENST00000522684.1,ENST00000523539.1,ENST00000535192.1
exon_skip_4928268141678387:141678523:141679825:141679834:141684396:141684503141679825:141679834ENSG00000169398.15ENST00000520460.1,ENST00000340930.3,ENST00000519993.1,ENST00000521986.1
exon_skip_4928278141678387:141678523:141684396:141684503:141685558:141685598141684396:141684503ENSG00000169398.15ENST00000538769.1,ENST00000523805.1,ENST00000519654.1,ENST00000517887.1,ENST00000519419.1,ENST00000524202.1,ENST00000521059.1,ENST00000519465.1,ENST00000430260.2,ENST00000522684.1,ENST00000523539.1,ENST00000535192.1
exon_skip_4928338141684396:141684503:141685528:141685598:141696730:141696793141685528:141685598ENSG00000169398.15ENST00000340930.3,ENST00000395218.2
exon_skip_4928368141684396:141684503:141685558:141685598:141696730:141696793141685558:141685598ENSG00000169398.15ENST00000538769.1,ENST00000523805.1,ENST00000519654.1,ENST00000517887.1,ENST00000519419.1,ENST00000521059.1,ENST00000519465.1,ENST00000430260.2,ENST00000522684.1,ENST00000523539.1,ENST00000519993.1,ENST00000521986.1,ENST00000535192.1
exon_skip_4928378141684396:141684503:141685558:141685598:141710989:141711121141685558:141685598ENSG00000169398.15ENST00000524202.1
exon_skip_4928418141685558:141685598:141696730:141696793:141710989:141711121141696730:141696793ENSG00000169398.15ENST00000538769.1,ENST00000519654.1,ENST00000517887.1,ENST00000519419.1,ENST00000521059.1,ENST00000340930.3,ENST00000395218.2,ENST00000519465.1,ENST00000430260.2,ENST00000522684.1,ENST00000523539.1,ENST00000519993.1,ENST00000521986.1,ENST00000535192.1
exon_skip_4928448141696730:141696793:141710989:141711121:141712668:141712806141710989:141711121ENSG00000169398.15ENST00000538769.1,ENST00000517887.1,ENST00000519419.1,ENST00000521059.1,ENST00000340930.3,ENST00000395218.2,ENST00000519465.1,ENST00000430260.2,ENST00000522684.1,ENST00000523539.1,ENST00000519993.1,ENST00000521986.1
exon_skip_4928468141711041:141711121:141712668:141712806:141716217:141716267141712668:141712806ENSG00000169398.15ENST00000538769.1,ENST00000517887.1,ENST00000519419.1,ENST00000524202.1,ENST00000521059.1,ENST00000340930.3,ENST00000518173.1,ENST00000521250.1,ENST00000395218.2,ENST00000522424.1,ENST00000519465.1,ENST00000521562.1,ENST00000430260.2,ENST00000522684.1,ENS
exon_skip_4928488141711041:141711121:141716217:141716304:141727696:141727808141716217:141716304ENSG00000169398.15ENST00000519654.1,ENST00000535192.1
exon_skip_4928508141716255:141716304:141727696:141727808:141728415:141728454141727696:141727808ENSG00000169398.15ENST00000430260.2
exon_skip_4928518141716255:141716304:141727696:141727808:141745349:141745385141727696:141727808ENSG00000169398.15ENST00000538769.1,ENST00000519654.1,ENST00000517887.1,ENST00000519419.1,ENST00000521981.1,ENST00000524202.1,ENST00000521059.1,ENST00000340930.3,ENST00000395218.2,ENST00000519465.1,ENST00000522684.1,ENST00000523539.1,ENST00000519993.1,ENST00000521986.1,ENS
exon_skip_4928558141727787:141727808:141728107:141728310:141728415:141728454141728107:141728310ENSG00000169398.15ENST00000521562.1
exon_skip_4928578141727787:141727808:141745349:141745554:141749116:141749206141745349:141745554ENSG00000169398.15ENST00000538769.1,ENST00000519654.1,ENST00000517887.1,ENST00000519419.1,ENST00000524202.1,ENST00000521059.1,ENST00000518509.1,ENST00000340930.3,ENST00000395218.2,ENST00000519465.1,ENST00000522684.1,ENST00000523539.1,ENST00000519993.1,ENST00000521986.1,ENS
exon_skip_4928598141745349:141745554:141749116:141749206:141753328:141753429141749116:141749206ENSG00000169398.15ENST00000538769.1,ENST00000519654.1,ENST00000520917.1,ENST00000517887.1,ENST00000519419.1,ENST00000524202.1,ENST00000521059.1,ENST00000518509.1,ENST00000340930.3,ENST00000395218.2,ENST00000519465.1,ENST00000522684.1,ENST00000523539.1,ENST00000519993.1,ENS
exon_skip_4928618141753388:141753429:141754750:141754866:141756858:141756959141754750:141754866ENSG00000169398.15ENST00000538769.1,ENST00000519654.1,ENST00000517887.1,ENST00000519419.1,ENST00000524202.1,ENST00000521059.1,ENST00000340930.3,ENST00000395218.2,ENST00000519465.1,ENST00000522684.1,ENST00000523539.1,ENST00000519993.1,ENST00000521986.1,ENST00000523670.1,ENS
exon_skip_4928648141754845:141754866:141756858:141756959:141762330:141762415141756858:141756959ENSG00000169398.15ENST00000538769.1,ENST00000519654.1,ENST00000523746.1,ENST00000519024.1,ENST00000517887.1,ENST00000519419.1,ENST00000521059.1,ENST00000340930.3,ENST00000395218.2,ENST00000519465.1,ENST00000522684.1,ENST00000523539.1,ENST00000519993.1,ENST00000521986.1,ENS
exon_skip_4928668141756932:141756959:141762001:141762086:141762330:141762412141762001:141762086ENSG00000169398.15ENST00000524202.1
exon_skip_4928698141756932:141756959:141762330:141762415:141771263:141771361141762330:141762415ENSG00000169398.15ENST00000538769.1,ENST00000519899.1,ENST00000519654.1,ENST00000523746.1,ENST00000519024.1,ENST00000517887.1,ENST00000519419.1,ENST00000521059.1,ENST00000340930.3,ENST00000395218.2,ENST00000519361.1,ENST00000519465.1,ENST00000522684.1,ENST00000523539.1,ENS
exon_skip_4928718141762330:141762415:141771263:141771361:141774332:141774359141771263:141771361ENSG00000169398.15ENST00000519899.1,ENST00000519654.1,ENST00000523746.1,ENST00000517887.1,ENST00000519419.1,ENST00000524202.1,ENST00000521059.1,ENST00000520151.1,ENST00000340930.3,ENST00000521172.1,ENST00000395218.2,ENST00000519465.1,ENST00000522684.1,ENST00000521986.1,ENS
exon_skip_4928728141771280:141771361:141772466:141772487:141774332:141774359141772466:141772487ENSG00000169398.15ENST00000538769.1,ENST00000523474.1,ENST00000519024.1,ENST00000519361.1,ENST00000520843.1,ENST00000523539.1,ENST00000519993.1
exon_skip_4928748141774332:141774389:141779673:141779691:141799572:141799625141779673:141779691ENSG00000169398.15ENST00000519993.1
exon_skip_4928768141774332:141774389:141799572:141799625:141803452:141803483141799572:141799625ENSG00000169398.15ENST00000538769.1,ENST00000519654.1,ENST00000523746.1,ENST00000517887.1,ENST00000519419.1,ENST00000521981.1,ENST00000524202.1,ENST00000521059.1,ENST00000340930.3,ENST00000395218.2,ENST00000522684.1,ENST00000523539.1,ENST00000535192.1
exon_skip_4928788141779673:141779691:141780814:141780898:141799572:141799625141780814:141780898ENSG00000169398.15ENST00000521986.1
exon_skip_4928798141810557:141810675:141813641:141813749:141828375:141828448141813641:141813749ENSG00000169398.15ENST00000519654.1,ENST00000517887.1,ENST00000519419.1,ENST00000524202.1,ENST00000521059.1,ENST00000340930.3,ENST00000395218.2,ENST00000522684.1,ENST00000519993.1,ENST00000535192.1
exon_skip_4928818141813641:141813749:141828375:141828453:141828978:141829119141828375:141828453ENSG00000169398.15ENST00000519654.1,ENST00000517887.1,ENST00000519419.1,ENST00000524202.1,ENST00000521059.1,ENST00000340930.3,ENST00000395218.2,ENST00000522684.1,ENST00000519993.1,ENST00000535192.1
exon_skip_4928848141829082:141829119:141840570:141840625:141856358:141856389141840570:141840625ENSG00000169398.15ENST00000519654.1,ENST00000517887.1,ENST00000519419.1,ENST00000524202.1,ENST00000521059.1,ENST00000340930.3,ENST00000395218.2,ENST00000522684.1,ENST00000519993.1,ENST00000535192.1
exon_skip_4928858141829082:141829119:141840570:141840625:141856697:141856777141840570:141840625ENSG00000169398.15ENST00000524357.1
exon_skip_4928888141840574:141840625:141856358:141856421:141856697:141856777141856358:141856421ENSG00000169398.15ENST00000519654.1,ENST00000517887.1,ENST00000519419.1,ENST00000521059.1,ENST00000340930.3,ENST00000395218.2,ENST00000522684.1,ENST00000521791.1,ENST00000519993.1,ENST00000535192.1
exon_skip_4928908141856757:141856777:141874410:141874498:141889569:141889736141874410:141874498ENSG00000169398.15ENST00000519654.1,ENST00000517887.1,ENST00000519419.1,ENST00000521059.1,ENST00000520828.1,ENST00000340930.3,ENST00000395218.2,ENST00000522684.1,ENST00000520475.1,ENST00000535192.1
exon_skip_4928918141856757:141856777:141874410:141874498:141900641:141900702141874410:141874498ENSG00000169398.15ENST00000523067.1,ENST00000521791.1,ENST00000519993.1
exon_skip_4929028141856757:141856777:141900641:141900868:142011223:142011257141900641:141900868ENSG00000169398.15ENST00000524357.1
exon_skip_4929068141874410:141874498:141889569:141889736:141900641:141900702141889569:141889736ENSG00000169398.15ENST00000519654.1,ENST00000517887.1,ENST00000519419.1,ENST00000521059.1,ENST00000520828.1,ENST00000340930.3,ENST00000395218.2,ENST00000522684.1,ENST00000520475.1,ENST00000535192.1
exon_skip_4929188141874410:141874498:141900641:141900868:141958764:141958822141900641:141900868ENSG00000169398.15ENST00000523067.1
exon_skip_4929198141874410:141874498:141900641:141900868:142011223:142011257141900641:141900868ENSG00000169398.15ENST00000519993.1
exon_skip_4929308141889610:141889736:141900641:141900868:141935759:141935848141900641:141900868ENSG00000169398.15ENST00000521395.1,ENST00000523803.1,ENST00000340930.3,ENST00000520892.1,ENST00000395218.2,ENST00000517453.1,ENST00000522684.1
exon_skip_4929328141889610:141889736:141900641:141900868:141958764:141958822141900641:141900868ENSG00000169398.15ENST00000520045.1
exon_skip_4929338141889610:141889736:141900641:141900868:142011223:142011257141900641:141900868ENSG00000169398.15ENST00000519881.1
exon_skip_4929398141900682:141900868:141919647:141919720:141935660:141935848141919647:141919720ENSG00000169398.15ENST00000521332.1
exon_skip_4929528141900682:141900868:141935759:141935848:141958764:141958822141935759:141935848ENSG00000169398.15ENST00000524040.1
exon_skip_4929568141900682:141900868:141935759:141935848:142010978:142011025141935759:141935848ENSG00000169398.15ENST00000520892.1
exon_skip_4929578141900763:141900868:141935759:141935848:142011223:142011257141935759:141935848ENSG00000169398.15ENST00000340930.3,ENST00000395218.2
exon_skip_4929588141900682:141900868:141935759:141935848:142012112:142012209141935759:141935848ENSG00000169398.15ENST00000517453.1
exon_skip_4929678141900682:141900868:141958764:141958822:142011223:142011257141958764:141958822ENSG00000169398.15ENST00000523067.1,ENST00000520045.1
exon_skip_4929758141900682:141900868:141994176:141994254:142011223:142011257141994176:141994254ENSG00000169398.15ENST00000521059.1
exon_skip_4929818141930988:141931231:141935759:141935848:141958764:141958822141935759:141935848ENSG00000169398.15ENST00000524257.1
exon_skip_4929958141935787:141935848:141958764:141958822:142011223:142011257141958764:141958822ENSG00000169398.15ENST00000524257.1,ENST00000524040.1
exon_skip_4929998141935787:141935848:141993940:141994254:142012112:142012315141993940:141994254ENSG00000169398.15ENST00000519635.1

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for PTK2

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_4928128141669718:141669777:141670699:141670747:141672746:141673187141670699:141670747ENSG00000169398.15ENST00000522950.1
exon_skip_4928158141669718:141669777:141675015:141675096:141678367:141678517141675015:141675096ENSG00000169398.15ENST00000522684.1,ENST00000519654.1,ENST00000535192.1,ENST00000519465.1,ENST00000517887.1,ENST00000521059.1,ENST00000395218.2,ENST00000517712.1,ENST00000523539.1,ENST00000340930.3,ENST00000519993.1,ENST00000538769.1,ENST00000519419.1,ENST00000524202.1,ENS
exon_skip_4928218141675015:141675096:141678367:141678523:141684396:141684503141678367:141678523ENSG00000169398.15ENST00000522684.1,ENST00000519654.1,ENST00000535192.1,ENST00000519465.1,ENST00000517887.1,ENST00000521059.1,ENST00000523539.1,ENST00000538769.1,ENST00000519419.1,ENST00000524202.1,ENST00000430260.2
exon_skip_4928268141678387:141678523:141679825:141679834:141684396:141684503141679825:141679834ENSG00000169398.15ENST00000340930.3,ENST00000519993.1,ENST00000521986.1,ENST00000520460.1
exon_skip_4928278141678387:141678523:141684396:141684503:141685558:141685598141684396:141684503ENSG00000169398.15ENST00000522684.1,ENST00000519654.1,ENST00000535192.1,ENST00000519465.1,ENST00000517887.1,ENST00000521059.1,ENST00000523539.1,ENST00000538769.1,ENST00000519419.1,ENST00000524202.1,ENST00000430260.2,ENST00000523805.1
exon_skip_4928338141684396:141684503:141685528:141685598:141696730:141696793141685528:141685598ENSG00000169398.15ENST00000395218.2,ENST00000340930.3
exon_skip_4928368141684396:141684503:141685558:141685598:141696730:141696793141685558:141685598ENSG00000169398.15ENST00000522684.1,ENST00000519654.1,ENST00000535192.1,ENST00000519465.1,ENST00000517887.1,ENST00000521059.1,ENST00000523539.1,ENST00000519993.1,ENST00000538769.1,ENST00000519419.1,ENST00000430260.2,ENST00000521986.1,ENST00000523805.1
exon_skip_4928378141684396:141684503:141685558:141685598:141710989:141711121141685558:141685598ENSG00000169398.15ENST00000524202.1
exon_skip_4928418141685558:141685598:141696730:141696793:141710989:141711121141696730:141696793ENSG00000169398.15ENST00000522684.1,ENST00000519654.1,ENST00000535192.1,ENST00000519465.1,ENST00000517887.1,ENST00000521059.1,ENST00000395218.2,ENST00000523539.1,ENST00000340930.3,ENST00000519993.1,ENST00000538769.1,ENST00000519419.1,ENST00000430260.2,ENST00000521986.1
exon_skip_4928448141696730:141696793:141710989:141711121:141712668:141712806141710989:141711121ENSG00000169398.15ENST00000522684.1,ENST00000519465.1,ENST00000517887.1,ENST00000521059.1,ENST00000395218.2,ENST00000523539.1,ENST00000340930.3,ENST00000519993.1,ENST00000538769.1,ENST00000519419.1,ENST00000430260.2,ENST00000521986.1
exon_skip_4928468141711041:141711121:141712668:141712806:141716217:141716267141712668:141712806ENSG00000169398.15ENST00000522684.1,ENST00000519465.1,ENST00000517887.1,ENST00000521059.1,ENST00000395218.2,ENST00000523539.1,ENST00000340930.3,ENST00000519993.1,ENST00000538769.1,ENST00000519419.1,ENST00000524202.1,ENST00000430260.2,ENST00000521986.1,ENST00000518173.1,ENS
exon_skip_4928488141711041:141711121:141716217:141716304:141727696:141727808141716217:141716304ENSG00000169398.15ENST00000519654.1,ENST00000535192.1
exon_skip_4928508141716255:141716304:141727696:141727808:141728415:141728454141727696:141727808ENSG00000169398.15ENST00000430260.2
exon_skip_4928518141716255:141716304:141727696:141727808:141745349:141745385141727696:141727808ENSG00000169398.15ENST00000522684.1,ENST00000519654.1,ENST00000535192.1,ENST00000519465.1,ENST00000517887.1,ENST00000521059.1,ENST00000395218.2,ENST00000523539.1,ENST00000340930.3,ENST00000519993.1,ENST00000538769.1,ENST00000519419.1,ENST00000524202.1,ENST00000521986.1,ENS
exon_skip_4928578141727787:141727808:141745349:141745554:141749116:141749206141745349:141745554ENSG00000169398.15ENST00000522684.1,ENST00000519654.1,ENST00000535192.1,ENST00000519465.1,ENST00000517887.1,ENST00000521059.1,ENST00000395218.2,ENST00000523539.1,ENST00000340930.3,ENST00000519993.1,ENST00000538769.1,ENST00000519419.1,ENST00000524202.1,ENST00000521986.1,ENS
exon_skip_4928588141727787:141727808:141745349:141745554:141771263:141771361141745349:141745554ENSG00000169398.15ENST00000521029.1
exon_skip_4928598141745349:141745554:141749116:141749206:141753328:141753429141749116:141749206ENSG00000169398.15ENST00000522684.1,ENST00000519654.1,ENST00000535192.1,ENST00000519465.1,ENST00000517887.1,ENST00000521059.1,ENST00000395218.2,ENST00000523539.1,ENST00000340930.3,ENST00000519993.1,ENST00000538769.1,ENST00000519419.1,ENST00000524202.1,ENST00000521986.1,ENS
exon_skip_4928618141753388:141753429:141754750:141754866:141756858:141756959141754750:141754866ENSG00000169398.15ENST00000522684.1,ENST00000519654.1,ENST00000535192.1,ENST00000519465.1,ENST00000517887.1,ENST00000521059.1,ENST00000395218.2,ENST00000523539.1,ENST00000340930.3,ENST00000519993.1,ENST00000538769.1,ENST00000519419.1,ENST00000524202.1,ENST00000521986.1,ENS
exon_skip_4928648141754845:141754866:141756858:141756959:141762330:141762415141756858:141756959ENSG00000169398.15ENST00000522684.1,ENST00000519654.1,ENST00000535192.1,ENST00000519465.1,ENST00000517887.1,ENST00000521059.1,ENST00000395218.2,ENST00000523539.1,ENST00000340930.3,ENST00000519993.1,ENST00000538769.1,ENST00000519419.1,ENST00000521986.1,ENST00000519024.1,ENS
exon_skip_4928668141756932:141756959:141762001:141762086:141762330:141762412141762001:141762086ENSG00000169398.15ENST00000524202.1
exon_skip_4928698141756932:141756959:141762330:141762415:141771263:141771361141762330:141762415ENSG00000169398.15ENST00000522684.1,ENST00000519654.1,ENST00000535192.1,ENST00000519465.1,ENST00000517887.1,ENST00000521059.1,ENST00000395218.2,ENST00000523539.1,ENST00000340930.3,ENST00000519993.1,ENST00000538769.1,ENST00000519419.1,ENST00000521986.1,ENST00000519024.1,ENS
exon_skip_4928718141762330:141762415:141771263:141771361:141774332:141774359141771263:141771361ENSG00000169398.15ENST00000522684.1,ENST00000519654.1,ENST00000535192.1,ENST00000519465.1,ENST00000517887.1,ENST00000521059.1,ENST00000395218.2,ENST00000340930.3,ENST00000519419.1,ENST00000524202.1,ENST00000521986.1,ENST00000520151.1,ENST00000523746.1,ENST00000519899.1,ENS
exon_skip_4928728141771280:141771361:141772466:141772487:141774332:141774359141772466:141772487ENSG00000169398.15ENST00000523539.1,ENST00000519993.1,ENST00000538769.1,ENST00000519024.1,ENST00000523474.1,ENST00000519361.1,ENST00000520843.1
exon_skip_4928748141774332:141774389:141779673:141779691:141799572:141799625141779673:141779691ENSG00000169398.15ENST00000519993.1
exon_skip_4928768141774332:141774389:141799572:141799625:141803452:141803483141799572:141799625ENSG00000169398.15ENST00000522684.1,ENST00000519654.1,ENST00000535192.1,ENST00000517887.1,ENST00000521059.1,ENST00000395218.2,ENST00000523539.1,ENST00000340930.3,ENST00000538769.1,ENST00000519419.1,ENST00000524202.1,ENST00000521981.1,ENST00000523746.1
exon_skip_4928788141779673:141779691:141780814:141780898:141799572:141799625141780814:141780898ENSG00000169398.15ENST00000521986.1
exon_skip_4928798141810557:141810675:141813641:141813749:141828375:141828448141813641:141813749ENSG00000169398.15ENST00000522684.1,ENST00000519654.1,ENST00000535192.1,ENST00000517887.1,ENST00000521059.1,ENST00000395218.2,ENST00000340930.3,ENST00000519993.1,ENST00000519419.1,ENST00000524202.1
exon_skip_4928818141813641:141813749:141828375:141828453:141828978:141829119141828375:141828453ENSG00000169398.15ENST00000522684.1,ENST00000519654.1,ENST00000535192.1,ENST00000517887.1,ENST00000521059.1,ENST00000395218.2,ENST00000340930.3,ENST00000519993.1,ENST00000519419.1,ENST00000524202.1
exon_skip_4928848141829082:141829119:141840570:141840625:141856358:141856389141840570:141840625ENSG00000169398.15ENST00000522684.1,ENST00000519654.1,ENST00000535192.1,ENST00000517887.1,ENST00000521059.1,ENST00000395218.2,ENST00000340930.3,ENST00000519993.1,ENST00000519419.1,ENST00000524202.1
exon_skip_4928858141829082:141829119:141840570:141840625:141856697:141856777141840570:141840625ENSG00000169398.15ENST00000524357.1
exon_skip_4928888141840574:141840625:141856358:141856421:141856697:141856777141856358:141856421ENSG00000169398.15ENST00000522684.1,ENST00000519654.1,ENST00000535192.1,ENST00000517887.1,ENST00000521059.1,ENST00000395218.2,ENST00000340930.3,ENST00000519993.1,ENST00000519419.1,ENST00000521791.1
exon_skip_4928908141856757:141856777:141874410:141874498:141889569:141889736141874410:141874498ENSG00000169398.15ENST00000522684.1,ENST00000519654.1,ENST00000535192.1,ENST00000517887.1,ENST00000521059.1,ENST00000395218.2,ENST00000340930.3,ENST00000519419.1,ENST00000520828.1,ENST00000520475.1
exon_skip_4928918141856757:141856777:141874410:141874498:141900641:141900702141874410:141874498ENSG00000169398.15ENST00000519993.1,ENST00000521791.1,ENST00000523067.1
exon_skip_4929028141856757:141856777:141900641:141900868:142011223:142011257141900641:141900868ENSG00000169398.15ENST00000524357.1
exon_skip_4929068141874410:141874498:141889569:141889736:141900641:141900702141889569:141889736ENSG00000169398.15ENST00000522684.1,ENST00000519654.1,ENST00000535192.1,ENST00000517887.1,ENST00000521059.1,ENST00000395218.2,ENST00000340930.3,ENST00000519419.1,ENST00000520828.1,ENST00000520475.1
exon_skip_4929198141874410:141874498:141900641:141900868:142011223:142011257141900641:141900868ENSG00000169398.15ENST00000519993.1
exon_skip_4929308141889610:141889736:141900641:141900868:141935759:141935848141900641:141900868ENSG00000169398.15ENST00000522684.1,ENST00000395218.2,ENST00000340930.3,ENST00000520892.1,ENST00000523803.1,ENST00000517453.1,ENST00000521395.1
exon_skip_4929328141889610:141889736:141900641:141900868:141958764:141958822141900641:141900868ENSG00000169398.15ENST00000520045.1
exon_skip_4929338141889610:141889736:141900641:141900868:142011223:142011257141900641:141900868ENSG00000169398.15ENST00000519881.1
exon_skip_4929528141900682:141900868:141935759:141935848:141958764:141958822141935759:141935848ENSG00000169398.15ENST00000524040.1
exon_skip_4929568141900682:141900868:141935759:141935848:142010978:142011025141935759:141935848ENSG00000169398.15ENST00000520892.1
exon_skip_4929578141900763:141900868:141935759:141935848:142011223:142011257141935759:141935848ENSG00000169398.15ENST00000395218.2,ENST00000340930.3
exon_skip_4929588141900682:141900868:141935759:141935848:142012112:142012209141935759:141935848ENSG00000169398.15ENST00000517453.1
exon_skip_4929678141900682:141900868:141958764:141958822:142011223:142011257141958764:141958822ENSG00000169398.15ENST00000523067.1,ENST00000520045.1
exon_skip_4929758141900682:141900868:141994176:141994254:142011223:142011257141994176:141994254ENSG00000169398.15ENST00000521059.1
exon_skip_4929808141930988:141931231:141935660:141935848:142011223:142011257141935660:141935848ENSG00000169398.15ENST00000523679.1
exon_skip_4929818141930988:141931231:141935759:141935848:141958764:141958822141935759:141935848ENSG00000169398.15ENST00000524257.1
exon_skip_4929958141935787:141935848:141958764:141958822:142011223:142011257141958764:141958822ENSG00000169398.15ENST00000524040.1,ENST00000524257.1
exon_skip_4929998141935787:141935848:141993940:141994254:142012112:142012315141993940:141994254ENSG00000169398.15ENST00000519635.1

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for PTK2

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000005226841419006411419008683UTR-3CDS
ENST000005210591419941761419942543UTR-3UTR
ENST00000521059141684396141684503Frame-shift
ENST00000522684141684396141684503Frame-shift
ENST00000521059141685558141685598Frame-shift
ENST00000522684141685558141685598Frame-shift
ENST00000521059141727696141727808Frame-shift
ENST00000522684141727696141727808Frame-shift
ENST00000521059141745349141745554Frame-shift
ENST00000522684141745349141745554Frame-shift
ENST00000521059141754750141754866Frame-shift
ENST00000522684141754750141754866Frame-shift
ENST00000521059141756858141756959Frame-shift
ENST00000522684141756858141756959Frame-shift
ENST00000521059141762330141762415Frame-shift
ENST00000522684141762330141762415Frame-shift
ENST00000521059141771263141771361Frame-shift
ENST00000522684141771263141771361Frame-shift
ENST00000521059141799572141799625Frame-shift
ENST00000522684141799572141799625Frame-shift
ENST00000521059141840570141840625Frame-shift
ENST00000522684141840570141840625Frame-shift
ENST00000521059141874410141874498Frame-shift
ENST00000522684141874410141874498Frame-shift
ENST00000521059141889569141889736Frame-shift
ENST00000522684141889569141889736Frame-shift
ENST00000521059141675015141675096In-frame
ENST00000522684141675015141675096In-frame
ENST00000521059141678367141678523In-frame
ENST00000522684141678367141678523In-frame
ENST00000521059141696730141696793In-frame
ENST00000522684141696730141696793In-frame
ENST00000521059141710989141711121In-frame
ENST00000522684141710989141711121In-frame
ENST00000521059141712668141712806In-frame
ENST00000522684141712668141712806In-frame
ENST00000521059141749116141749206In-frame
ENST00000522684141749116141749206In-frame
ENST00000521059141813641141813749In-frame
ENST00000522684141813641141813749In-frame
ENST00000521059141828375141828453In-frame
ENST00000522684141828375141828453In-frame
ENST00000521059141856358141856421In-frame
ENST00000522684141856358141856421In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000005226841419006411419008683UTR-3CDS
ENST000005210591419941761419942543UTR-3UTR
ENST00000521059141684396141684503Frame-shift
ENST00000522684141684396141684503Frame-shift
ENST00000521059141685558141685598Frame-shift
ENST00000522684141685558141685598Frame-shift
ENST00000521059141727696141727808Frame-shift
ENST00000522684141727696141727808Frame-shift
ENST00000521059141745349141745554Frame-shift
ENST00000522684141745349141745554Frame-shift
ENST00000521059141754750141754866Frame-shift
ENST00000522684141754750141754866Frame-shift
ENST00000521059141756858141756959Frame-shift
ENST00000522684141756858141756959Frame-shift
ENST00000521059141762330141762415Frame-shift
ENST00000522684141762330141762415Frame-shift
ENST00000521059141771263141771361Frame-shift
ENST00000522684141771263141771361Frame-shift
ENST00000521059141799572141799625Frame-shift
ENST00000522684141799572141799625Frame-shift
ENST00000521059141840570141840625Frame-shift
ENST00000522684141840570141840625Frame-shift
ENST00000521059141874410141874498Frame-shift
ENST00000522684141874410141874498Frame-shift
ENST00000521059141889569141889736Frame-shift
ENST00000522684141889569141889736Frame-shift
ENST00000521059141675015141675096In-frame
ENST00000522684141675015141675096In-frame
ENST00000521059141678367141678523In-frame
ENST00000522684141678367141678523In-frame
ENST00000521059141696730141696793In-frame
ENST00000522684141696730141696793In-frame
ENST00000521059141710989141711121In-frame
ENST00000522684141710989141711121In-frame
ENST00000521059141712668141712806In-frame
ENST00000522684141712668141712806In-frame
ENST00000521059141749116141749206In-frame
ENST00000522684141749116141749206In-frame
ENST00000521059141813641141813749In-frame
ENST00000522684141813641141813749In-frame
ENST00000521059141828375141828453In-frame
ENST00000522684141828375141828453In-frame
ENST00000521059141856358141856421In-frame
ENST00000522684141856358141856421In-frame

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Infer the effects of exon skipping event on protein functional features for PTK2

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000052105944221052141856358141856421713775177197
ENST0000052268449721052141856358141856421761823177197
ENST00000521059442210521418283751418284539721049263289
ENST000005226844972105214182837514182845310201097263289
ENST000005210594422105214181364114181374910501157289325
ENST000005226844972105214181364114181374910981205289325
ENST000005210594422105214174911614174920619182007578608
ENST000005226844972105214174911614174920619662055578608
ENST000005210594422105214171266814171280624122549743789
ENST000005226844972105214171266814171280624602597743789
ENST000005210594422105214171098914171112125502681789833
ENST000005226844972105214171098914171112125982729789833
ENST000005210594422105214169673014169679326822744833854
ENST000005226844972105214169673014169679327302792833854
ENST000005210594422105214167836714167852328923047903955
ENST000005226844972105214167836714167852329403095903955
ENST000005210594422105214167501514167509630483128955982
ENST000005226844972105214167501514167509630963176955982

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000052105944221052141856358141856421713775177197
ENST0000052268449721052141856358141856421761823177197
ENST00000521059442210521418283751418284539721049263289
ENST000005226844972105214182837514182845310201097263289
ENST000005210594422105214181364114181374910501157289325
ENST000005226844972105214181364114181374910981205289325
ENST000005210594422105214174911614174920619182007578608
ENST000005226844972105214174911614174920619662055578608
ENST000005210594422105214171266814171280624122549743789
ENST000005226844972105214171266814171280624602597743789
ENST000005210594422105214171098914171112125502681789833
ENST000005226844972105214171098914171112125982729789833
ENST000005210594422105214169673014169679326822744833854
ENST000005226844972105214169673014169679327302792833854
ENST000005210594422105214167836714167852328923047903955
ENST000005226844972105214167836714167852329403095903955
ENST000005210594422105214167501514167509630483128955982
ENST000005226844972105214167501514167509630963176955982

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q053971771971692Alternative sequenceID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q053971771971692Alternative sequenceID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q053971771971181Alternative sequenceID=VSP_004967;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053971771971181Alternative sequenceID=VSP_004967;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q05397177197182189Alternative sequenceID=VSP_004968;Note=In isoform 2%2C isoform 3 and isoform 4. EMRGNALE->MSDYWVVG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q05397177197182189Alternative sequenceID=VSP_004968;Note=In isoform 2%2C isoform 3 and isoform 4. EMRGNALE->MSDYWVVG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q05397177197188190Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397177197188190Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q0539717719721052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q0539717719721052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q0539717719735355DomainNote=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
Q0539717719735355DomainNote=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
Q05397177197165179HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397177197165179HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397177197185187HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397177197185187HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397177197191194HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397177197191194HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397177197197201HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397177197197201HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397177197184184Sequence conflictNote=R->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397177197184184Sequence conflictNote=R->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q053972632891692Alternative sequenceID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q053972632891692Alternative sequenceID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397263289264266Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397263289264266Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397263289268275Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397263289268275Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397263289279283Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397263289279283Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q0539726328921052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q0539726328921052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q0539726328935355DomainNote=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
Q0539726328935355DomainNote=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
Q05397263289276278TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397263289276278TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q053972893251692Alternative sequenceID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q053972893251692Alternative sequenceID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397289325290294Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397289325290294Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397289325299306Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397289325299306Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397289325308311Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397289325308311Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397289325314320Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397289325314320Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q0539728932521052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q0539728932521052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q0539728932535355DomainNote=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
Q0539728932535355DomainNote=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
Q05397289325296298HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397289325296298HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397289325292292Natural variantID=VAR_041682;Note=H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
Q05397289325292292Natural variantID=VAR_041682;Note=H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
Q05397289325292292Natural variantID=VAR_041683;Note=H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
Q05397289325292292Natural variantID=VAR_041683;Note=H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
Q053975786081692Alternative sequenceID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q053975786081692Alternative sequenceID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397578608579583Alternative sequenceID=VSP_004971;Note=In isoform 4. ASKGK->GKKSG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q05397578608579583Alternative sequenceID=VSP_004971;Note=In isoform 4. ASKGK->GKKSG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053975786085841052Alternative sequenceID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053975786085841052Alternative sequenceID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q0539757860821052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q0539757860821052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397578608422680DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q05397578608422680DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q05397578608586588HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I4E
Q05397578608586588HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I4E
Q05397578608591596HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I4E
Q05397578608591596HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I4E
Q05397578608601616HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I4E
Q05397578608601616HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I4E
Q05397578608580580Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
Q05397578608580580Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
Q053977437895841052Alternative sequenceID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053977437895841052Alternative sequenceID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053977437897071052Alternative sequenceID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053977437897071052Alternative sequenceID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q05397743789744789Alternative sequenceID=VSP_057268;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q05397743789744789Alternative sequenceID=VSP_057268;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q0539774378921052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q0539774378921052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q053977437897071052RegionNote=Interaction with TGFB1I1
Q053977437897071052RegionNote=Interaction with TGFB1I1
Q05397743789778778Sequence conflictNote=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397743789778778Sequence conflictNote=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q053977898335841052Alternative sequenceID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053977898335841052Alternative sequenceID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053977898337071052Alternative sequenceID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053977898337071052Alternative sequenceID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q05397789833744789Alternative sequenceID=VSP_057268;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q05397789833744789Alternative sequenceID=VSP_057268;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q0539778983321052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q0539778983321052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397789833793793Natural variantID=VAR_041684;Note=In a glioblastoma multiforme sample%3B somatic mutation. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
Q05397789833793793Natural variantID=VAR_041684;Note=In a glioblastoma multiforme sample%3B somatic mutation. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
Q053977898337071052RegionNote=Interaction with TGFB1I1
Q053977898337071052RegionNote=Interaction with TGFB1I1
Q053978338545841052Alternative sequenceID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053978338545841052Alternative sequenceID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053978338547071052Alternative sequenceID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053978338547071052Alternative sequenceID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q05397833854834854Alternative sequenceID=VSP_004970;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q05397833854834854Alternative sequenceID=VSP_004970;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q0539783385421052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q0539783385421052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397833854843843Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q05397833854843843Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q053978338547071052RegionNote=Interaction with TGFB1I1
Q053978338547071052RegionNote=Interaction with TGFB1I1
Q053979039555841052Alternative sequenceID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053979039555841052Alternative sequenceID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053979039557071052Alternative sequenceID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053979039557071052Alternative sequenceID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q05397903955903903Alternative sequenceID=VSP_042170;Note=In isoform 5. K->KPWR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q05397903955903903Alternative sequenceID=VSP_042170;Note=In isoform 5. K->KPWR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q05397903955915917Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q05397903955915917Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q0539790395521052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q0539790395521052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397903955863913Compositional biasNote=Pro-rich
Q05397903955863913Compositional biasNote=Pro-rich
Q05397903955923942HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q05397903955923942HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q05397903955947949HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q05397903955947949HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q05397903955950971HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q05397903955950971HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q05397903955910910Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:1
Q05397903955910910Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:1
Q05397903955914914Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
Q05397903955914914Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
Q05397903955925925Modified residueNote=Phosphotyrosine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12387730,ECO:0000269|PubMed:19339212;Dbxref=PMID:12387730,PMID:19339212
Q05397903955925925Modified residueNote=Phosphotyrosine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12387730,ECO:0000269|PubMed:19339212;Dbxref=PMID:12387730,PMID:19339212
Q05397903955928928MutagenesisNote=Loss of interaction with TGFB1I1. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9756887;Dbxref=PMID:9756887
Q05397903955928928MutagenesisNote=Loss of interaction with TGFB1I1. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9756887;Dbxref=PMID:9756887
Q053979039557071052RegionNote=Interaction with TGFB1I1
Q053979039557071052RegionNote=Interaction with TGFB1I1
Q053979039559121052RegionNote=Interaction with ARHGEF28;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q053979039559121052RegionNote=Interaction with ARHGEF28;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q053979559825841052Alternative sequenceID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053979559825841052Alternative sequenceID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053979559827071052Alternative sequenceID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053979559827071052Alternative sequenceID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q0539795598221052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q0539795598221052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397955982950971HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q05397955982950971HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q05397955982972974HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q05397955982972974HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q05397955982977979HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q05397955982977979HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q053979559829801006HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q053979559829801006HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q053979559827071052RegionNote=Interaction with TGFB1I1
Q053979559827071052RegionNote=Interaction with TGFB1I1
Q053979559829121052RegionNote=Interaction with ARHGEF28;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q053979559829121052RegionNote=Interaction with ARHGEF28;Ontology_term=ECO:0000250;evidence=ECO:0000250


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q053971771971692Alternative sequenceID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q053971771971692Alternative sequenceID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q053971771971181Alternative sequenceID=VSP_004967;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053971771971181Alternative sequenceID=VSP_004967;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q05397177197182189Alternative sequenceID=VSP_004968;Note=In isoform 2%2C isoform 3 and isoform 4. EMRGNALE->MSDYWVVG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q05397177197182189Alternative sequenceID=VSP_004968;Note=In isoform 2%2C isoform 3 and isoform 4. EMRGNALE->MSDYWVVG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q05397177197188190Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397177197188190Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q0539717719721052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q0539717719721052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q0539717719735355DomainNote=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
Q0539717719735355DomainNote=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
Q05397177197165179HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397177197165179HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397177197185187HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397177197185187HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397177197191194HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397177197191194HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397177197197201HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397177197197201HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397177197184184Sequence conflictNote=R->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397177197184184Sequence conflictNote=R->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q053972632891692Alternative sequenceID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q053972632891692Alternative sequenceID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397263289264266Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397263289264266Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397263289268275Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397263289268275Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397263289279283Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397263289279283Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q0539726328921052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q0539726328921052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q0539726328935355DomainNote=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
Q0539726328935355DomainNote=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
Q05397263289276278TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397263289276278TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q053972893251692Alternative sequenceID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q053972893251692Alternative sequenceID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397289325290294Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397289325290294Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397289325299306Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397289325299306Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397289325308311Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397289325308311Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397289325314320Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397289325314320Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q0539728932521052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q0539728932521052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q0539728932535355DomainNote=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
Q0539728932535355DomainNote=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
Q05397289325296298HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397289325296298HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
Q05397289325292292Natural variantID=VAR_041682;Note=H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
Q05397289325292292Natural variantID=VAR_041682;Note=H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
Q05397289325292292Natural variantID=VAR_041683;Note=H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
Q05397289325292292Natural variantID=VAR_041683;Note=H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
Q053975786081692Alternative sequenceID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q053975786081692Alternative sequenceID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397578608579583Alternative sequenceID=VSP_004971;Note=In isoform 4. ASKGK->GKKSG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q05397578608579583Alternative sequenceID=VSP_004971;Note=In isoform 4. ASKGK->GKKSG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053975786085841052Alternative sequenceID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053975786085841052Alternative sequenceID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q0539757860821052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q0539757860821052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397578608422680DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q05397578608422680DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q05397578608586588HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I4E
Q05397578608586588HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I4E
Q05397578608591596HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I4E
Q05397578608591596HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I4E
Q05397578608601616HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I4E
Q05397578608601616HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I4E
Q05397578608580580Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
Q05397578608580580Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
Q053977437895841052Alternative sequenceID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053977437895841052Alternative sequenceID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053977437897071052Alternative sequenceID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053977437897071052Alternative sequenceID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q05397743789744789Alternative sequenceID=VSP_057268;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q05397743789744789Alternative sequenceID=VSP_057268;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q0539774378921052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q0539774378921052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q053977437897071052RegionNote=Interaction with TGFB1I1
Q053977437897071052RegionNote=Interaction with TGFB1I1
Q05397743789778778Sequence conflictNote=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397743789778778Sequence conflictNote=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q053977898335841052Alternative sequenceID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053977898335841052Alternative sequenceID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053977898337071052Alternative sequenceID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053977898337071052Alternative sequenceID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q05397789833744789Alternative sequenceID=VSP_057268;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q05397789833744789Alternative sequenceID=VSP_057268;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q0539778983321052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q0539778983321052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397789833793793Natural variantID=VAR_041684;Note=In a glioblastoma multiforme sample%3B somatic mutation. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
Q05397789833793793Natural variantID=VAR_041684;Note=In a glioblastoma multiforme sample%3B somatic mutation. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
Q053977898337071052RegionNote=Interaction with TGFB1I1
Q053977898337071052RegionNote=Interaction with TGFB1I1
Q053978338545841052Alternative sequenceID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053978338545841052Alternative sequenceID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053978338547071052Alternative sequenceID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053978338547071052Alternative sequenceID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q05397833854834854Alternative sequenceID=VSP_004970;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q05397833854834854Alternative sequenceID=VSP_004970;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q0539783385421052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q0539783385421052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397833854843843Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q05397833854843843Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q053978338547071052RegionNote=Interaction with TGFB1I1
Q053978338547071052RegionNote=Interaction with TGFB1I1
Q053979039555841052Alternative sequenceID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053979039555841052Alternative sequenceID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053979039557071052Alternative sequenceID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053979039557071052Alternative sequenceID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q05397903955903903Alternative sequenceID=VSP_042170;Note=In isoform 5. K->KPWR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q05397903955903903Alternative sequenceID=VSP_042170;Note=In isoform 5. K->KPWR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q05397903955915917Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q05397903955915917Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q0539790395521052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q0539790395521052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397903955863913Compositional biasNote=Pro-rich
Q05397903955863913Compositional biasNote=Pro-rich
Q05397903955923942HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q05397903955923942HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q05397903955947949HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q05397903955947949HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q05397903955950971HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q05397903955950971HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q05397903955910910Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:1
Q05397903955910910Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:1
Q05397903955914914Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
Q05397903955914914Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
Q05397903955925925Modified residueNote=Phosphotyrosine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12387730,ECO:0000269|PubMed:19339212;Dbxref=PMID:12387730,PMID:19339212
Q05397903955925925Modified residueNote=Phosphotyrosine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12387730,ECO:0000269|PubMed:19339212;Dbxref=PMID:12387730,PMID:19339212
Q05397903955928928MutagenesisNote=Loss of interaction with TGFB1I1. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9756887;Dbxref=PMID:9756887
Q05397903955928928MutagenesisNote=Loss of interaction with TGFB1I1. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9756887;Dbxref=PMID:9756887
Q053979039557071052RegionNote=Interaction with TGFB1I1
Q053979039557071052RegionNote=Interaction with TGFB1I1
Q053979039559121052RegionNote=Interaction with ARHGEF28;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q053979039559121052RegionNote=Interaction with ARHGEF28;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q053979559825841052Alternative sequenceID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053979559825841052Alternative sequenceID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053979559827071052Alternative sequenceID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q053979559827071052Alternative sequenceID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
Q0539795598221052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q0539795598221052ChainID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397955982950971HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q05397955982950971HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q05397955982972974HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q05397955982972974HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q05397955982977979HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q05397955982977979HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q053979559829801006HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q053979559829801006HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
Q053979559827071052RegionNote=Interaction with TGFB1I1
Q053979559827071052RegionNote=Interaction with TGFB1I1
Q053979559829121052RegionNote=Interaction with ARHGEF28;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q053979559829121052RegionNote=Interaction with ARHGEF28;Ontology_term=ECO:0000250;evidence=ECO:0000250


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SNVs in the skipped exons for PTK2

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.
PTK2_HNSC_exon_skip_492888_psi_boxplot.png
boxplot

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-DD-A1EG-01exon_skip_492821
141678368141678523141678498141678498Frame_Shift_DelG-p.P913fs
LIHCTCGA-DD-A3A0-01exon_skip_492821
141678368141678523141678498141678498Frame_Shift_DelG-p.P913fs
LIHCTCGA-G3-A3CJ-01exon_skip_492821
141678368141678523141678498141678498Frame_Shift_DelG-p.P913fs
LIHCTCGA-DD-A3A0-01exon_skip_492833
exon_skip_492837
exon_skip_492836
141685529141685598141685532141685532Frame_Shift_DelT-p.R877fs
LIHCTCGA-DD-A3A1-01exon_skip_492833
exon_skip_492837
exon_skip_492836
141685529141685598141685538141685538Frame_Shift_DelC-p.A875fs
LIHCTCGA-G3-A3CJ-01exon_skip_492857
141745350141745554141745361141745361Frame_Shift_DelT-p.K673fs
LIHCTCGA-DD-A3A0-01exon_skip_492857
141745350141745554141745465141745465Frame_Shift_DelC-p.E639fs
LIHCTCGA-DD-A39Y-01exon_skip_492859
141749117141749206141749145141749145Frame_Shift_DelA-p.F599fs
LIHCTCGA-DD-A1EG-01exon_skip_492869
141762331141762415141762375141762375Frame_Shift_DelT-p.N458fs
LIHCTCGA-DD-A3A0-01exon_skip_492879
141813642141813749141813659141813659Frame_Shift_DelT-p.I320fs
STADTCGA-B7-5816-01exon_skip_492879
141813642141813749141813659141813659Frame_Shift_DelT-p.I342fs
LIHCTCGA-DD-A1EG-01exon_skip_492884
exon_skip_492885
141840571141840625141840598141840598Frame_Shift_DelA-p.F207fs
LIHCTCGA-DD-A3A0-01exon_skip_492888
141856359141856421141856383141856383Frame_Shift_DelT-p.K191fs
LIHCTCGA-DD-A1EG-01exon_skip_492902
exon_skip_492919
exon_skip_492918
exon_skip_492932
exon_skip_492933
exon_skip_492930
141900642141900868141900839141900839Frame_Shift_DelT-p.I44fs
LIHCTCGA-DD-A3A0-01exon_skip_492902
exon_skip_492919
exon_skip_492918
exon_skip_492932
exon_skip_492933
exon_skip_492930
141900642141900868141900839141900839Frame_Shift_DelT-p.I44fs
COADTCGA-AZ-6601-01exon_skip_492841
141696731141696793141696772141696772Nonsense_MutationGAp.R841X
LUADTCGA-44-2668-01exon_skip_492846
141712669141712806141712746141712746Nonsense_MutationGAp.Q764*
ESCATCGA-L5-A4OI-01exon_skip_492857
141745350141745554141745480141745480Nonsense_MutationGAp.R634*
ESCATCGA-L5-A4OI-01exon_skip_492857
141745350141745554141745480141745480Nonsense_MutationGAp.R656X
UCECTCGA-D1-A17Q-01exon_skip_492857
141745350141745554141745480141745480Nonsense_MutationGAp.R656*
STADTCGA-BR-8680-01exon_skip_492859
141749117141749206141749153141749153Nonsense_MutationGAp.R597*
ESCATCGA-VR-AA4G-01exon_skip_492871
141771264141771361141771320141771320Nonsense_MutationGAp.R448X
OVTCGA-24-2035-01exon_skip_492871
141771264141771361141771320141771320Nonsense_MutationGAp.R426*
HNSCTCGA-CV-5430-01exon_skip_492891
exon_skip_492890
141874411141874498141874416141874416Nonsense_MutationGAp.Q149*
SARCTCGA-DX-AB2P-01exon_skip_492906
141889570141889736141889657141889657Nonsense_MutationGTp.S92*
UCECTCGA-AX-A05Z-01exon_skip_492902
exon_skip_492919
exon_skip_492918
exon_skip_492932
exon_skip_492933
exon_skip_492930
141900642141900868141900822141900822Nonsense_MutationGTp.Y27*
HNSCTCGA-CN-4726-01exon_skip_492888
141856359141856421141856357141856357Splice_SiteAGp.E198_splice

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description
PTK2_141856757_141856777_141874410_141874498_141900641_141900702_TCGA-CV-5430-01Sample: TCGA-CV-5430-01
Cancer type: HNSC
ESID: exon_skip_492890
Skipped exon start: 141874411
Skipped exon end: 141874498
Mutation start: 141874416
Mutation end: 141874416
Mutation type: Nonsense_Mutation
Reference seq: G
Mutation seq: A
AAchange: p.Q149*
exon_skip_286384_HNSC_TCGA-CV-5430-01.png
boxplot
exon_skip_492891_HNSC_TCGA-CV-5430-01.png
boxplot
exon_skip_78884_HNSC_TCGA-CV-5430-01.png
boxplot
PTK2_141840574_141840625_141856358_141856421_141856697_141856777_TCGA-CN-4726-01Sample: TCGA-CN-4726-01
Cancer type: HNSC
ESID: exon_skip_492888
Skipped exon start: 141856359
Skipped exon end: 141856421
Mutation start: 141856357
Mutation end: 141856357
Mutation type: Splice_Site
Reference seq: A
Mutation seq: G
AAchange: p.E198_splice
exon_skip_492888_HNSC_TCGA-CN-4726-01.png
boxplot

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
DV90_LUNG141678368141678523141678498141678498Frame_Shift_DelG-p.P913fs
A431_SKIN141712669141712806141712801141712804Frame_Shift_DelAGAA-p.VS744fs
A431_SKIN141900642141900868141900740141900740Frame_Shift_DelT-p.M33fs
CAPAN1_PANCREAS141710990141711121141711043141711057In_Frame_DelGCTGTCGGATTAGAC-p.RLIRQ811del
FUOV1_OVARY141675016141675096141675026141675026Missense_MutationGCp.T979S
HEC1A_ENDOMETRIUM141684397141684503141684446141684446Missense_MutationCTp.S887N
HEC1_ENDOMETRIUM141684397141684503141684446141684446Missense_MutationCTp.S887N
HEC1B_ENDOMETRIUM141684397141684503141684446141684446Missense_MutationCTp.S887N
CL34_LARGE_INTESTINE141710990141711121141710997141710997Missense_MutationCAp.R831I
LS411N_LARGE_INTESTINE141710990141711121141711057141711057Missense_MutationCTp.R811H
MZ7MEL_SKIN141710990141711121141711064141711064Missense_MutationCTp.E809K
MCC13_SKIN141710990141711121141711117141711117Missense_MutationGAp.S791F
NCIH510_LUNG141716218141716304141716250141716250Missense_MutationGTp.P733T
RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE141716218141716304141716256141716256Missense_MutationGAp.P731S
MDAMB361_BREAST141745350141745554141745375141745375Missense_MutationAGp.F669L
ZR7530_BREAST141745350141745554141745438141745438Missense_MutationGAp.P648S
KASUMI2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE141745350141745554141745483141745483Missense_MutationCTp.G633S
OCILY7_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE141749117141749206141749188141749188Missense_MutationGCp.P585R
H290_PLEURA141754751141754866141754788141754788Missense_MutationCAp.A533S
HOP62_LUNG141754751141754866141754820141754820Missense_MutationGCp.S522C
EB3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE141754751141754866141754836141754836Missense_MutationTAp.S517C
PFEIFFER_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE141762331141762415141762345141762345Missense_MutationACp.F468C
SW684_SOFT_TISSUE141762331141762415141762373141762373Missense_MutationACp.C459G
HEC108_ENDOMETRIUM141799573141799625141799621141799621Missense_MutationCTp.A377T
C33A_CERVIX141813642141813749141813697141813697Missense_MutationCAp.S307I
KM12_LARGE_INTESTINE141889570141889736141889586141889586Missense_MutationGAp.P116S
HEC1B_ENDOMETRIUM141889570141889736141889618141889618Missense_MutationGTp.S105Y
HEC59_ENDOMETRIUM141889570141889736141889676141889676Missense_MutationGAp.R86C
BICR18_UPPER_AERODIGESTIVE_TRACT141900642141900868141900700141900700Missense_MutationTCp.N46S
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE141900642141900868141900700141900700Missense_MutationTCp.N46S
DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE141900642141900868141900700141900700Missense_MutationTCp.N46S
L542_MATCHED_NORMAL_TISSUE141900642141900868141900733141900733Missense_MutationCTp.R35Q
ESS1_ENDOMETRIUM141900642141900868141900790141900790Missense_MutationGAp.S16L
K029AX_SKIN141900642141900868141900815141900815Missense_MutationGAp.P8S
HC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE141745350141745554141745541141745541Nonsense_MutationCTp.W613*
HT115_LARGE_INTESTINE141749117141749206141749153141749153Nonsense_MutationGAp.R597*
A2780_OVARY141745350141745554141745351141745351Splice_SiteTCp.S677G
SNU1040_LARGE_INTESTINE141856359141856421141856420141856420Splice_SiteGAp.R178*
HS688AT_FIBROBLAST141856359141856421141856420141856420Splice_SiteGAp.R178*

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PTK2

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value
exon_skip_4928788141779673:141779691:141780814:141780898:141799572:141799625141780814:141780898ENST00000521986.1ESCArs79812711chr8:141780818T/C6.97e-04
exon_skip_4929758141900682:141900868:141994176:141994254:142011223:142011257141994176:141994254ENST00000521059.1ESCArs13258775chr8:141994240T/C3.11e-07
exon_skip_4929758141900682:141900868:141994176:141994254:142011223:142011257141994176:141994254ENST00000521059.1ESCArs13258775chr8:141994240T/C6.86e-04
exon_skip_4929758141900682:141900868:141994176:141994254:142011223:142011257141994176:141994254ENST00000521059.1ESCArs13258775chr8:141994240T/C7.63e-04
exon_skip_4929758141900682:141900868:141994176:141994254:142011223:142011257141994176:141994254ENST00000521059.1OVrs13258775chr8:141994240T/C4.52e-04
exon_skip_4929758141900682:141900868:141994176:141994254:142011223:142011257141994176:141994254ENST00000521059.1STADrs13258775chr8:141994240T/C3.45e-07
exon_skip_4929758141900682:141900868:141994176:141994254:142011223:142011257141994176:141994254ENST00000521059.1STADrs13258775chr8:141994240T/C2.10e-04
exon_skip_4929998141935787:141935848:141993940:141994254:142012112:142012315141993940:141994254ENST00000519635.1ESCArs13258775chr8:141994240T/C3.11e-07
exon_skip_4929998141935787:141935848:141993940:141994254:142012112:142012315141993940:141994254ENST00000519635.1ESCArs13258775chr8:141994240T/C6.86e-04
exon_skip_4929998141935787:141935848:141993940:141994254:142012112:142012315141993940:141994254ENST00000519635.1ESCArs13258775chr8:141994240T/C7.63e-04
exon_skip_4929998141935787:141935848:141993940:141994254:142012112:142012315141993940:141994254ENST00000519635.1OVrs13258775chr8:141994240T/C4.52e-04
exon_skip_4929998141935787:141935848:141993940:141994254:142012112:142012315141993940:141994254ENST00000519635.1STADrs13258775chr8:141994240T/C3.45e-07
exon_skip_4929998141935787:141935848:141993940:141994254:142012112:142012315141993940:141994254ENST00000519635.1STADrs13258775chr8:141994240T/C2.10e-04

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PTK2


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PTK2


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RelatedDrugs for PTK2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
Q05397DB12010FostamatinibFocal adhesion kinase 1small moleculeapproved|investigational

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RelatedDiseases for PTK2

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
PTK2C0007137Squamous cell carcinoma2CTD_human
PTK2C0027626Neoplasm Invasiveness2CTD_human
PTK2C0003873Rheumatoid Arthritis1CTD_human
PTK2C0007621Neoplastic Cell Transformation1CTD_human
PTK2C0017636Glioblastoma1CTD_human
PTK2C0024668Mammary Neoplasms, Experimental1CTD_human
PTK2C0026640Mouth Neoplasms1CTD_human
PTK2C2239176Liver carcinoma1CTD_human