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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for SENP7 |
 Gene summary |
| Gene information | Gene symbol | SENP7 | Gene ID | 57337 |
| Gene name | SUMO specific peptidase 7 | |
| Synonyms | - | |
| Cytomap | 3q12.3 | |
| Type of gene | protein-coding | |
| Description | sentrin-specific protease 7SUMO-1-specific protease 2SUMO1/sentrin specific peptidase 7sentrin/SUMO-specific protease SENP7 | |
| Modification date | 20180523 | |
| UniProtAcc | Q9BQF6 | |
| Context | PubMed: SENP7 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for SENP7 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for SENP7 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for SENP7 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_386172 | 3 | 101047321:101047390:101047489:101047533:101049177:101049230 | 101047489:101047533 | ENSG00000138468.11 | ENST00000394091.1,ENST00000314261.7,ENST00000348610.3,ENST00000394085.3,ENST00000394094.2,ENST00000358203.3,ENST00000394095.2 |
| exon_skip_386176 | 3 | 101051613:101051706:101056352:101056475:101058938:101059055 | 101056352:101056475 | ENSG00000138468.11 | ENST00000394091.1,ENST00000314261.7,ENST00000348610.3,ENST00000394094.2,ENST00000358203.3,ENST00000394095.2 |
| exon_skip_386178 | 3 | 101060489:101060623:101062529:101062798:101066715:101066757 | 101062529:101062798 | ENSG00000138468.11 | ENST00000394091.1,ENST00000314261.7,ENST00000348610.3,ENST00000394094.2,ENST00000358203.3,ENST00000394095.2 |
| exon_skip_386183 | 3 | 101085273:101085613:101086673:101086855:101090851:101090970 | 101086673:101086855 | ENSG00000138468.11 | ENST00000394091.1,ENST00000314261.7,ENST00000348610.3,ENST00000394094.2,ENST00000358203.3,ENST00000394095.2 |
| exon_skip_386185 | 3 | 101090851:101090970:101117704:101117899:101136436:101136634 | 101117704:101117899 | ENSG00000138468.11 | ENST00000348610.3,ENST00000394095.2 |
| exon_skip_386186 | 3 | 101090851:101090970:101117704:101117899:101177798:101177896 | 101117704:101117899 | ENSG00000138468.11 | ENST00000314261.7 |
| exon_skip_386188 | 3 | 101090851:101090970:101136436:101136634:101177798:101177896 | 101136436:101136634 | ENSG00000138468.11 | ENST00000394094.2 |
| exon_skip_386190 | 3 | 101117704:101117899:101136436:101136634:101177798:101177896 | 101136436:101136634 | ENSG00000138468.11 | ENST00000348610.3,ENST00000394095.2 |
| exon_skip_386192 | 3 | 101177798:101177896:101212716:101212812:101231934:101232028 | 101212716:101212812 | ENSG00000138468.11 | ENST00000394091.1,ENST00000348610.3 |
| exon_skip_386195 | 3 | 101212716:101212812:101219913:101219963:101231934:101232028 | 101219913:101219963 | ENSG00000138468.11 | ENST00000314261.7,ENST00000394094.2,ENST00000358203.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for SENP7 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_386172 | 3 | 101047321:101047390:101047489:101047533:101049177:101049230 | 101047489:101047533 | ENSG00000138468.11 | ENST00000394095.2,ENST00000394091.1,ENST00000394094.2,ENST00000314261.7,ENST00000358203.3,ENST00000394085.3,ENST00000348610.3 |
| exon_skip_386176 | 3 | 101051613:101051706:101056352:101056475:101058938:101059055 | 101056352:101056475 | ENSG00000138468.11 | ENST00000394095.2,ENST00000394091.1,ENST00000394094.2,ENST00000314261.7,ENST00000358203.3,ENST00000348610.3 |
| exon_skip_386178 | 3 | 101060489:101060623:101062529:101062798:101066715:101066757 | 101062529:101062798 | ENSG00000138468.11 | ENST00000394095.2,ENST00000394091.1,ENST00000394094.2,ENST00000314261.7,ENST00000358203.3,ENST00000348610.3 |
| exon_skip_386183 | 3 | 101085273:101085613:101086673:101086855:101090851:101090970 | 101086673:101086855 | ENSG00000138468.11 | ENST00000394095.2,ENST00000394091.1,ENST00000394094.2,ENST00000314261.7,ENST00000358203.3,ENST00000348610.3 |
| exon_skip_386185 | 3 | 101090851:101090970:101117704:101117899:101136436:101136634 | 101117704:101117899 | ENSG00000138468.11 | ENST00000394095.2,ENST00000348610.3 |
| exon_skip_386186 | 3 | 101090851:101090970:101117704:101117899:101177798:101177896 | 101117704:101117899 | ENSG00000138468.11 | ENST00000314261.7 |
| exon_skip_386188 | 3 | 101090851:101090970:101136436:101136634:101177798:101177896 | 101136436:101136634 | ENSG00000138468.11 | ENST00000394094.2 |
| exon_skip_386190 | 3 | 101117704:101117899:101136436:101136634:101177798:101177896 | 101136436:101136634 | ENSG00000138468.11 | ENST00000394095.2,ENST00000348610.3 |
| exon_skip_386192 | 3 | 101177798:101177896:101212716:101212812:101231934:101232028 | 101212716:101212812 | ENSG00000138468.11 | ENST00000394091.1,ENST00000348610.3 |
| exon_skip_386195 | 3 | 101212716:101212812:101219913:101219963:101231934:101232028 | 101219913:101219963 | ENSG00000138468.11 | ENST00000394094.2,ENST00000314261.7,ENST00000358203.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for SENP7 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000394095 | 101047489 | 101047533 | Frame-shift |
| ENST00000394095 | 101062529 | 101062798 | Frame-shift |
| ENST00000394095 | 101086673 | 101086855 | Frame-shift |
| ENST00000394095 | 101056352 | 101056475 | In-frame |
| ENST00000394095 | 101117704 | 101117899 | In-frame |
| ENST00000394095 | 101136436 | 101136634 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000394095 | 101047489 | 101047533 | Frame-shift |
| ENST00000394095 | 101062529 | 101062798 | Frame-shift |
| ENST00000394095 | 101086673 | 101086855 | Frame-shift |
| ENST00000394095 | 101056352 | 101056475 | In-frame |
| ENST00000394095 | 101117704 | 101117899 | In-frame |
| ENST00000394095 | 101136436 | 101136634 | In-frame |
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Infer the effects of exon skipping event on protein functional features for SENP7 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000394095 | 4962 | 1050 | 101136436 | 101136634 | 339 | 536 | 95 | 160 |
| ENST00000394095 | 4962 | 1050 | 101117704 | 101117899 | 537 | 731 | 161 | 225 |
| ENST00000394095 | 4962 | 1050 | 101056352 | 101056475 | 2412 | 2534 | 786 | 826 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000394095 | 4962 | 1050 | 101136436 | 101136634 | 339 | 536 | 95 | 160 |
| ENST00000394095 | 4962 | 1050 | 101117704 | 101117899 | 537 | 731 | 161 | 225 |
| ENST00000394095 | 4962 | 1050 | 101056352 | 101056475 | 2412 | 2534 | 786 | 826 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9BQF6 | 95 | 160 | 1 | 812 | Alternative sequence | ID=VSP_039498;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| Q9BQF6 | 95 | 160 | 95 | 225 | Alternative sequence | ID=VSP_039501;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q9BQF6 | 95 | 160 | 95 | 160 | Alternative sequence | ID=VSP_039500;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11230166;Dbxref=PMID:11230166 |
| Q9BQF6 | 95 | 160 | 1 | 1050 | Chain | ID=PRO_0000101726;Note=Sentrin-specific protease 7 |
| Q9BQF6 | 161 | 225 | 1 | 812 | Alternative sequence | ID=VSP_039498;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| Q9BQF6 | 161 | 225 | 95 | 225 | Alternative sequence | ID=VSP_039501;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q9BQF6 | 161 | 225 | 1 | 1050 | Chain | ID=PRO_0000101726;Note=Sentrin-specific protease 7 |
| Q9BQF6 | 786 | 826 | 1 | 812 | Alternative sequence | ID=VSP_039498;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| Q9BQF6 | 786 | 826 | 813 | 827 | Alternative sequence | ID=VSP_039502;Note=In isoform 3. TRKENNLTEDNPNLS->MKKFLYIKSVFHTLR;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| Q9BQF6 | 786 | 826 | 801 | 803 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EAY |
| Q9BQF6 | 786 | 826 | 1 | 1050 | Chain | ID=PRO_0000101726;Note=Sentrin-specific protease 7 |
| Q9BQF6 | 786 | 826 | 778 | 791 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EAY |
| Q9BQF6 | 786 | 826 | 795 | 799 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EAY |
| Q9BQF6 | 786 | 826 | 807 | 812 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EAY |
| Q9BQF6 | 786 | 826 | 760 | 1050 | Region | Note=Protease |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9BQF6 | 95 | 160 | 1 | 812 | Alternative sequence | ID=VSP_039498;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| Q9BQF6 | 95 | 160 | 95 | 225 | Alternative sequence | ID=VSP_039501;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q9BQF6 | 95 | 160 | 95 | 160 | Alternative sequence | ID=VSP_039500;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11230166;Dbxref=PMID:11230166 |
| Q9BQF6 | 95 | 160 | 1 | 1050 | Chain | ID=PRO_0000101726;Note=Sentrin-specific protease 7 |
| Q9BQF6 | 161 | 225 | 1 | 812 | Alternative sequence | ID=VSP_039498;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| Q9BQF6 | 161 | 225 | 95 | 225 | Alternative sequence | ID=VSP_039501;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q9BQF6 | 161 | 225 | 1 | 1050 | Chain | ID=PRO_0000101726;Note=Sentrin-specific protease 7 |
| Q9BQF6 | 786 | 826 | 1 | 812 | Alternative sequence | ID=VSP_039498;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| Q9BQF6 | 786 | 826 | 813 | 827 | Alternative sequence | ID=VSP_039502;Note=In isoform 3. TRKENNLTEDNPNLS->MKKFLYIKSVFHTLR;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| Q9BQF6 | 786 | 826 | 801 | 803 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EAY |
| Q9BQF6 | 786 | 826 | 1 | 1050 | Chain | ID=PRO_0000101726;Note=Sentrin-specific protease 7 |
| Q9BQF6 | 786 | 826 | 778 | 791 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EAY |
| Q9BQF6 | 786 | 826 | 795 | 799 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EAY |
| Q9BQF6 | 786 | 826 | 807 | 812 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EAY |
| Q9BQF6 | 786 | 826 | 760 | 1050 | Region | Note=Protease |
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SNVs in the skipped exons for SENP7 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_386176 | 101056353 | 101056475 | 101056383 | 101056383 | Frame_Shift_Del | T | - | p.N818fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_386178 | 101062530 | 101062798 | 101062542 | 101062542 | Frame_Shift_Del | T | - | p.K698fs |
| BLCA | TCGA-2F-A9KP-01 | exon_skip_386178 | 101062530 | 101062798 | 101062549 | 101062549 | Frame_Shift_Del | T | - | p.K696fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_386178 | 101062530 | 101062798 | 101062553 | 101062553 | Frame_Shift_Del | T | - | p.M695fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_386178 | 101062530 | 101062798 | 101062553 | 101062553 | Frame_Shift_Del | T | - | p.M695fs |
| PRAD | TCGA-VP-A87D-01 | exon_skip_386183 | 101086674 | 101086855 | 101086791 | 101086800 | Frame_Shift_Del | TTTAACATCC | - | p.KDVK284fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_386195 | 101219914 | 101219963 | 101219943 | 101219943 | Frame_Shift_Del | T | - | p.R21fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_386195 | 101219914 | 101219963 | 101219943 | 101219943 | Frame_Shift_Del | T | - | p.R21fs |
| SKCM | TCGA-W3-AA1R-06 | exon_skip_386186 exon_skip_386185 | 101117705 | 101117899 | 101117716 | 101117716 | Nonsense_Mutation | A | T | p.Y222* |
| COAD | TCGA-AZ-6601-01 | exon_skip_386188 exon_skip_386190 | 101136437 | 101136634 | 101136588 | 101136588 | Nonsense_Mutation | G | A | p.R111X |
| BLCA | TCGA-ZF-A9R7-01 | exon_skip_386192 | 101212717 | 101212812 | 101212742 | 101212742 | Nonsense_Mutation | G | C | p.S54* |
| ESCA | TCGA-L5-A4OF-01 | exon_skip_386176 | 101056353 | 101056475 | 101056352 | 101056352 | Splice_Site | C | T | . |
| ESCA | TCGA-L5-A4OF-01 | exon_skip_386176 | 101056353 | 101056475 | 101056352 | 101056352 | Splice_Site | C | T | e17+1 |
| LUSC | TCGA-66-2756-01 | exon_skip_386178 | 101062530 | 101062798 | 101062529 | 101062529 | Splice_Site | C | A | p.Q702_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| MDAPCA2B_PROSTATE | 101056353 | 101056475 | 101056410 | 101056410 | Frame_Shift_Del | A | - | p.F808fs |
| HCC2998_LARGE_INTESTINE | 101056353 | 101056475 | 101056357 | 101056357 | Missense_Mutation | G | T | p.L826I |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 101056353 | 101056475 | 101056360 | 101056360 | Missense_Mutation | T | C | p.N825D |
| SNUC5_LARGE_INTESTINE | 101056353 | 101056475 | 101056365 | 101056365 | Missense_Mutation | T | C | p.N823S |
| MZ7MEL_SKIN | 101056353 | 101056475 | 101056387 | 101056387 | Missense_Mutation | C | T | p.E816K |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 101056353 | 101056475 | 101056468 | 101056468 | Missense_Mutation | T | G | p.I789L |
| DMS454_LUNG | 101062530 | 101062798 | 101062571 | 101062571 | Missense_Mutation | C | A | p.V689F |
| MDAMB361_BREAST | 101062530 | 101062798 | 101062633 | 101062633 | Missense_Mutation | G | C | p.S668C |
| HEC6_ENDOMETRIUM | 101062530 | 101062798 | 101062675 | 101062675 | Missense_Mutation | G | A | p.P654L |
| UMC11_LUNG | 101062530 | 101062798 | 101062729 | 101062729 | Missense_Mutation | T | G | p.K636T |
| EN_ENDOMETRIUM | 101062530 | 101062798 | 101062736 | 101062736 | Missense_Mutation | T | G | p.K634Q |
| CW2_LARGE_INTESTINE | 101086674 | 101086855 | 101086703 | 101086703 | Missense_Mutation | T | A | p.T317S |
| NCIH2291_LUNG | 101117705 | 101117899 | 101117821 | 101117821 | Missense_Mutation | C | A | p.E187D |
| SUM229PE_BREAST | 101136437 | 101136634 | 101136614 | 101136614 | Missense_Mutation | G | A | p.T102M |
| HSC1_SKIN | 101136437 | 101136634 | 101136632 | 101136632 | Missense_Mutation | T | G | p.Q96P |
| CALU3_LUNG | 101212717 | 101212812 | 101212768 | 101212768 | Missense_Mutation | T | G | p.Q45H |
| CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 101212717 | 101212812 | 101212779 | 101212779 | Missense_Mutation | C | T | p.V42I |
| IGR39_SKIN | 101219914 | 101219963 | 101219918 | 101219918 | Missense_Mutation | G | A | p.S29L |
| IGR37_SKIN | 101219914 | 101219963 | 101219918 | 101219918 | Missense_Mutation | G | A | p.S29L |
| A253_SALIVARY_GLAND | 101219914 | 101219963 | 101219954 | 101219954 | Missense_Mutation | G | C | p.T17R |
| HT55_LARGE_INTESTINE | 101056353 | 101056475 | 101056372 | 101056372 | Nonsense_Mutation | C | A | p.E821* |
| SNU81_LARGE_INTESTINE | 101219914 | 101219963 | 101219962 | 101219962 | Splice_Site | T | C | p.E14E |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SENP7 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SENP7 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SENP7 |
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RelatedDrugs for SENP7 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SENP7 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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