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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for SLC39A10 |
 Gene summary |
| Gene information | Gene symbol | SLC39A10 | Gene ID | 57181 |
| Gene name | solute carrier family 39 member 10 | |
| Synonyms | LZT-Hs2 | |
| Cytomap | 2q32.3 | |
| Type of gene | protein-coding | |
| Description | zinc transporter ZIP10ZIP-10solute carrier family 39 (metal ion transporter), member 10solute carrier family 39 (zinc transporter), member 10zrt- and Irt-like protein 10 | |
| Modification date | 20180523 | |
| UniProtAcc | Q9ULF5 | |
| Context | PubMed: SLC39A10 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for SLC39A10 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for SLC39A10 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for SLC39A10 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_332115 | 2 | 196521958:196522005:196536380:196536444:196544755:196544772 | 196536380:196536444 | ENSG00000196950.9 | ENST00000412905.1 |
| exon_skip_332116 | 2 | 196521958:196522005:196544755:196545774:196548422:196548630 | 196544755:196545774 | ENSG00000196950.9 | ENST00000359634.5 |
| exon_skip_332122 | 2 | 196545616:196545774:196548422:196548630:196571339:196571400 | 196548422:196548630 | ENSG00000196950.9 | ENST00000465851.1,ENST00000444421.1,ENST00000409086.3,ENST00000541054.1,ENST00000430412.1,ENST00000359634.5 |
| exon_skip_332126 | 2 | 196548422:196548630:196571339:196571509:196573379:196573568 | 196571339:196571509 | ENSG00000196950.9 | ENST00000465851.1,ENST00000409086.3,ENST00000541054.1,ENST00000430412.1,ENST00000359634.5 |
| exon_skip_332127 | 2 | 196573379:196573568:196578156:196578277:196581360:196581729 | 196578156:196578277 | ENSG00000196950.9 | ENST00000465851.1,ENST00000409086.3,ENST00000541054.1,ENST00000430412.1,ENST00000359634.5 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for SLC39A10 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_332115 | 2 | 196521958:196522005:196536380:196536444:196544755:196544772 | 196536380:196536444 | ENSG00000196950.9 | ENST00000412905.1 |
| exon_skip_332116 | 2 | 196521958:196522005:196544755:196545774:196548422:196548630 | 196544755:196545774 | ENSG00000196950.9 | ENST00000359634.5 |
| exon_skip_332122 | 2 | 196545616:196545774:196548422:196548630:196571339:196571400 | 196548422:196548630 | ENSG00000196950.9 | ENST00000409086.3,ENST00000444421.1,ENST00000359634.5,ENST00000430412.1,ENST00000541054.1,ENST00000465851.1 |
| exon_skip_332126 | 2 | 196548422:196548630:196571339:196571509:196573379:196573568 | 196571339:196571509 | ENSG00000196950.9 | ENST00000409086.3,ENST00000359634.5,ENST00000430412.1,ENST00000541054.1,ENST00000465851.1 |
| exon_skip_332127 | 2 | 196573379:196573568:196578156:196578277:196581360:196581729 | 196578156:196578277 | ENSG00000196950.9 | ENST00000409086.3,ENST00000359634.5,ENST00000430412.1,ENST00000541054.1,ENST00000465851.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for SLC39A10 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000359634 | 196544755 | 196545774 | 5CDS-5UTR |
| ENST00000359634 | 196548422 | 196548630 | Frame-shift |
| ENST00000409086 | 196548422 | 196548630 | Frame-shift |
| ENST00000359634 | 196571339 | 196571509 | Frame-shift |
| ENST00000409086 | 196571339 | 196571509 | Frame-shift |
| ENST00000359634 | 196578156 | 196578277 | Frame-shift |
| ENST00000409086 | 196578156 | 196578277 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000359634 | 196544755 | 196545774 | 5CDS-5UTR |
| ENST00000359634 | 196548422 | 196548630 | Frame-shift |
| ENST00000409086 | 196548422 | 196548630 | Frame-shift |
| ENST00000359634 | 196571339 | 196571509 | Frame-shift |
| ENST00000409086 | 196571339 | 196571509 | Frame-shift |
| ENST00000359634 | 196578156 | 196578277 | Frame-shift |
| ENST00000409086 | 196578156 | 196578277 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for SLC39A10 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for SLC39A10 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| KIRC | TCGA-CZ-4863-01 | exon_skip_332116 | 196544756 | 196545774 | 196545001 | 196545001 | Frame_Shift_Del | T | - | p.S78fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_332116 | 196544756 | 196545774 | 196545001 | 196545001 | Frame_Shift_Del | T | - | p.F80fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_332116 | 196544756 | 196545774 | 196545001 | 196545001 | Frame_Shift_Del | T | - | p.F80fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_332116 | 196544756 | 196545774 | 196545048 | 196545048 | Frame_Shift_Del | A | - | p.R94fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_332116 | 196544756 | 196545774 | 196545126 | 196545126 | Frame_Shift_Del | A | - | p.G120fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_332116 | 196544756 | 196545774 | 196545416 | 196545416 | Frame_Shift_Del | C | - | p.T217fs |
| BLCA | TCGA-DK-AA6S-01 | exon_skip_332116 | 196544756 | 196545774 | 196545734 | 196545734 | Frame_Shift_Del | C | - | p.S323fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_332122 | 196548423 | 196548630 | 196548492 | 196548492 | Frame_Shift_Del | T | - | p.F360fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_332122 | 196548423 | 196548630 | 196548551 | 196548551 | Frame_Shift_Del | T | - | p.H379fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_332126 | 196571340 | 196571509 | 196571358 | 196571358 | Frame_Shift_Del | T | - | p.I412fs |
| STAD | TCGA-BR-8361-01 | exon_skip_332116 | 196544756 | 196545774 | 196544941 | 196544942 | Frame_Shift_Ins | - | A | p.E59fs |
| STAD | TCGA-BR-8361-01 | exon_skip_332116 | 196544756 | 196545774 | 196544942 | 196544943 | Frame_Shift_Ins | - | A | p.E59fs |
| STAD | TCGA-HU-A4GX-01 | exon_skip_332116 | 196544756 | 196545774 | 196544942 | 196544943 | Frame_Shift_Ins | - | A | p.E59fs |
| HNSC | TCGA-F7-A61S-01 | exon_skip_332116 | 196544756 | 196545774 | 196545000 | 196545001 | Frame_Shift_Ins | - | T | p.SF78fs |
| KIRC | TCGA-B0-5096-01 | exon_skip_332116 | 196544756 | 196545774 | 196545178 | 196545178 | Nonsense_Mutation | G | T | p.E138* |
| KIRC | TCGA-B0-5096-01 | exon_skip_332116 | 196544756 | 196545774 | 196545178 | 196545178 | Nonsense_Mutation | G | T | p.E138X |
| READ | TCGA-EI-6917-01 | exon_skip_332116 | 196544756 | 196545774 | 196545400 | 196545400 | Nonsense_Mutation | G | T | p.E212X |
| ESCA | TCGA-IC-A6RE-01 | exon_skip_332116 | 196544756 | 196545774 | 196545499 | 196545499 | Nonsense_Mutation | G | T | p.E245X |
| SKCM | TCGA-EE-A29M-06 | exon_skip_332116 | 196544756 | 196545774 | 196545682 | 196545682 | Nonsense_Mutation | C | T | p.R306* |
| SKCM | TCGA-EE-A29M-06 | exon_skip_332116 | 196544756 | 196545774 | 196545682 | 196545682 | Nonsense_Mutation | C | T | p.R306X |
| COAD | TCGA-AZ-4315-01 | exon_skip_332116 | 196544756 | 196545774 | 196545754 | 196545754 | Nonsense_Mutation | G | T | p.E330X |
| SKCM | TCGA-EE-A29E-06 | exon_skip_332122 | 196548423 | 196548630 | 196548522 | 196548522 | Nonsense_Mutation | C | T | p.Q370* |
| READ | TCGA-F5-6814-01 | exon_skip_332127 | 196578157 | 196578277 | 196578193 | 196578193 | Nonsense_Mutation | G | T | p.E538X |
| HNSC | TCGA-F7-7848-01 | exon_skip_332127 | 196578157 | 196578277 | 196578254 | 196578254 | Nonsense_Mutation | G | A | p.W558* |
| UCEC | TCGA-D1-A174-01 | exon_skip_332127 | 196578157 | 196578277 | 196578278 | 196578278 | Splice_Site | G | T | p.G566_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SISO_CERVIX | 196544756 | 196545774 | 196544942 | 196544942 | Frame_Shift_Del | A | - | p.E59fs |
| SNU1_STOMACH | 196544756 | 196545774 | 196544942 | 196544942 | Frame_Shift_Del | A | - | p.E59fs |
| MFE319_ENDOMETRIUM | 196544756 | 196545774 | 196544942 | 196544942 | Frame_Shift_Del | A | - | p.E59fs |
| GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 196544756 | 196545774 | 196544942 | 196544942 | Frame_Shift_Del | A | - | p.E59fs |
| C33A_CERVIX | 196544756 | 196545774 | 196544966 | 196544967 | Frame_Shift_Del | TT | - | p.L67fs |
| 22RV1_PROSTATE | 196544756 | 196545774 | 196544953 | 196544953 | Missense_Mutation | T | C | p.Y63H |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 196544756 | 196545774 | 196544973 | 196544973 | Missense_Mutation | G | C | p.E69D |
| NCIH2347_LUNG | 196544756 | 196545774 | 196544975 | 196544975 | Missense_Mutation | G | A | p.R70H |
| NCIH2882_LUNG | 196544756 | 196545774 | 196545007 | 196545007 | Missense_Mutation | G | T | p.G81C |
| MFE319_ENDOMETRIUM | 196544756 | 196545774 | 196545196 | 196545196 | Missense_Mutation | A | G | p.S144G |
| PANC0504_PANCREAS | 196544756 | 196545774 | 196545216 | 196545216 | Missense_Mutation | C | A | p.N150K |
| SW1116_LARGE_INTESTINE | 196544756 | 196545774 | 196545233 | 196545233 | Missense_Mutation | A | G | p.E156G |
| ISTSL2_LUNG | 196544756 | 196545774 | 196545367 | 196545367 | Missense_Mutation | A | G | p.I201V |
| JHUEM1_ENDOMETRIUM | 196544756 | 196545774 | 196545374 | 196545374 | Missense_Mutation | C | A | p.P203H |
| VMRCLCD_LUNG | 196544756 | 196545774 | 196545383 | 196545383 | Missense_Mutation | G | C | p.R206P |
| KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 196544756 | 196545774 | 196545404 | 196545404 | Missense_Mutation | C | T | p.P213L |
| BCPAP_THYROID | 196544756 | 196545774 | 196545419 | 196545419 | Missense_Mutation | A | G | p.N218S |
| CMLT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 196544756 | 196545774 | 196545605 | 196545605 | Missense_Mutation | T | C | p.V280A |
| HCC461_LUNG | 196544756 | 196545774 | 196545620 | 196545620 | Missense_Mutation | G | A | p.R285H |
| TC205_BONE | 196544756 | 196545774 | 196545620 | 196545620 | Missense_Mutation | G | A | p.R285H |
| NCIH748_LUNG | 196544756 | 196545774 | 196545623 | 196545623 | Missense_Mutation | A | G | p.N286S |
| QIMRWIL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 196544756 | 196545774 | 196545637 | 196545637 | Missense_Mutation | G | T | p.G291C |
| JHUEM7_ENDOMETRIUM | 196544756 | 196545774 | 196545651 | 196545651 | Missense_Mutation | A | C | p.Q295H |
| SNU81_LARGE_INTESTINE | 196544756 | 196545774 | 196545683 | 196545683 | Missense_Mutation | G | A | p.R306Q |
| MKN74_STOMACH | 196544756 | 196545774 | 196545752 | 196545752 | Missense_Mutation | A | C | p.N329T |
| SNU81_LARGE_INTESTINE | 196548423 | 196548630 | 196548447 | 196548447 | Missense_Mutation | A | C | p.K345Q |
| NCIH211_LUNG | 196548423 | 196548630 | 196548522 | 196548522 | Missense_Mutation | C | G | p.Q370E |
| TGBC1TKB_BILIARY_TRACT | 196548423 | 196548630 | 196548579 | 196548579 | Missense_Mutation | A | C | p.N389H |
| RKO_LARGE_INTESTINE | 196571340 | 196571509 | 196571361 | 196571361 | Missense_Mutation | C | G | p.S413C |
| CALU6_LUNG | 196571340 | 196571509 | 196571396 | 196571396 | Missense_Mutation | G | T | p.V425L |
| IGR1_SKIN | 196571340 | 196571509 | 196571396 | 196571396 | Missense_Mutation | G | A | p.V425M |
| 2313287_STOMACH | 196571340 | 196571509 | 196571486 | 196571486 | Missense_Mutation | G | A | p.A455T |
| HT29_LARGE_INTESTINE | 196571340 | 196571509 | 196571505 | 196571505 | Missense_Mutation | C | T | p.P461L |
| SH10TC_STOMACH | 196578157 | 196578277 | 196578186 | 196578186 | Missense_Mutation | C | A | p.N535K |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SLC39A10 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SLC39A10 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SLC39A10 |
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RelatedDrugs for SLC39A10 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC39A10 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| SLC39A10 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
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