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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for CORO1B |
 Gene summary |
| Gene information | Gene symbol | CORO1B | Gene ID | 57175 |
| Gene name | coronin 1B | |
| Synonyms | CORONIN-2 | |
| Cytomap | 11q13.2 | |
| Type of gene | protein-coding | |
| Description | coronin-1Bcoronin, actin binding protein, 1B | |
| Modification date | 20180522 | |
| UniProtAcc | Q9BR76 | |
| Context | PubMed: CORO1B [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CORO1B | GO:0016477 | cell migration | 16027158 |
| CORO1B | GO:0030036 | actin cytoskeleton organization | 18775315 |
| CORO1B | GO:0031529 | ruffle organization | 16027158 |
| CORO1B | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation | 17350576|18775315 |
| CORO1B | GO:0035767 | endothelial cell chemotaxis | 23667561 |
| CORO1B | GO:0042060 | wound healing | 23667561 |
| CORO1B | GO:0051017 | actin filament bundle assembly | 17456547 |
| CORO1B | GO:0090135 | actin filament branching | 18775315 |
| CORO1B | GO:1902463 | protein localization to cell leading edge | 17350576 |
| CORO1B | GO:2000394 | positive regulation of lamellipodium morphogenesis | 17350576 |
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Exon skipping events across known transcript of Ensembl for CORO1B from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for CORO1B |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for CORO1B |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_74832 | 11 | 67205753:67205972:67206141:67206420:67207256:67207314 | 67206141:67206420 | ENSG00000172725.9 | ENST00000539724.1,ENST00000393893.1,ENST00000341356.5,ENST00000537042.1 |
| exon_skip_74838 | 11 | 67206141:67206420:67207256:67207314:67207588:67207734 | 67207256:67207314 | ENSG00000172725.9 | ENST00000393893.1,ENST00000341356.5,ENST00000537042.1 |
| exon_skip_74841 | 11 | 67207701:67207734:67207805:67207910:67208595:67208715 | 67207805:67207910 | ENSG00000172725.9 | ENST00000393893.1,ENST00000341356.5 |
| exon_skip_74848 | 11 | 67207805:67207910:67208172:67208307:67208595:67208715 | 67208172:67208307 | ENSG00000172725.9 | ENST00000537042.1 |
| exon_skip_74850 | 11 | 67207805:67207910:67208595:67208715:67208803:67208946 | 67208595:67208715 | ENSG00000172725.9 | ENST00000393893.1,ENST00000341356.5 |
| exon_skip_74855 | 11 | 67209239:67209333:67209436:67209559:67209898:67210101 | 67209436:67209559 | ENSG00000172725.9 | ENST00000545016.1,ENST00000545736.1,ENST00000393893.1,ENST00000453768.2,ENST00000341356.5,ENST00000537042.1 |
| exon_skip_74856 | 11 | 67209898:67210101:67210874:67210936:67211223:67211263 | 67210874:67210936 | ENSG00000172725.9 | ENST00000545736.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for CORO1B |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_74832 | 11 | 67205753:67205972:67206141:67206420:67207256:67207314 | 67206141:67206420 | ENSG00000172725.9 | ENST00000393893.1,ENST00000341356.5,ENST00000537042.1,ENST00000539724.1 |
| exon_skip_74838 | 11 | 67206141:67206420:67207256:67207314:67207588:67207734 | 67207256:67207314 | ENSG00000172725.9 | ENST00000393893.1,ENST00000341356.5,ENST00000537042.1 |
| exon_skip_74841 | 11 | 67207701:67207734:67207805:67207910:67208595:67208715 | 67207805:67207910 | ENSG00000172725.9 | ENST00000393893.1,ENST00000341356.5 |
| exon_skip_74848 | 11 | 67207805:67207910:67208172:67208307:67208595:67208715 | 67208172:67208307 | ENSG00000172725.9 | ENST00000537042.1 |
| exon_skip_74850 | 11 | 67207805:67207910:67208595:67208715:67208803:67208946 | 67208595:67208715 | ENSG00000172725.9 | ENST00000393893.1,ENST00000341356.5 |
| exon_skip_74855 | 11 | 67209239:67209333:67209436:67209559:67209898:67210101 | 67209436:67209559 | ENSG00000172725.9 | ENST00000393893.1,ENST00000341356.5,ENST00000537042.1,ENST00000453768.2,ENST00000545016.1,ENST00000545736.1 |
| exon_skip_74856 | 11 | 67209898:67210101:67210874:67210936:67211223:67211263 | 67210874:67210936 | ENSG00000172725.9 | ENST00000545736.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for CORO1B |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000341356 | 67207256 | 67207314 | Frame-shift |
| ENST00000393893 | 67207256 | 67207314 | Frame-shift |
| ENST00000341356 | 67206141 | 67206420 | In-frame |
| ENST00000393893 | 67206141 | 67206420 | In-frame |
| ENST00000341356 | 67207805 | 67207910 | In-frame |
| ENST00000393893 | 67207805 | 67207910 | In-frame |
| ENST00000341356 | 67208595 | 67208715 | In-frame |
| ENST00000393893 | 67208595 | 67208715 | In-frame |
| ENST00000341356 | 67209436 | 67209559 | In-frame |
| ENST00000393893 | 67209436 | 67209559 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000341356 | 67207256 | 67207314 | Frame-shift |
| ENST00000393893 | 67207256 | 67207314 | Frame-shift |
| ENST00000341356 | 67206141 | 67206420 | In-frame |
| ENST00000393893 | 67206141 | 67206420 | In-frame |
| ENST00000341356 | 67207805 | 67207910 | In-frame |
| ENST00000393893 | 67207805 | 67207910 | In-frame |
| ENST00000341356 | 67208595 | 67208715 | In-frame |
| ENST00000393893 | 67208595 | 67208715 | In-frame |
| ENST00000341356 | 67209436 | 67209559 | In-frame |
| ENST00000393893 | 67209436 | 67209559 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CORO1B |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000341356 | 1898 | 489 | 67209436 | 67209559 | 313 | 435 | 67 | 108 |
| ENST00000393893 | 1919 | 489 | 67209436 | 67209559 | 306 | 428 | 67 | 108 |
| ENST00000341356 | 1898 | 489 | 67208595 | 67208715 | 748 | 867 | 212 | 252 |
| ENST00000393893 | 1919 | 489 | 67208595 | 67208715 | 741 | 860 | 212 | 252 |
| ENST00000341356 | 1898 | 489 | 67207805 | 67207910 | 868 | 972 | 252 | 287 |
| ENST00000393893 | 1919 | 489 | 67207805 | 67207910 | 861 | 965 | 252 | 287 |
| ENST00000341356 | 1898 | 489 | 67206141 | 67206420 | 1177 | 1455 | 355 | 448 |
| ENST00000393893 | 1919 | 489 | 67206141 | 67206420 | 1170 | 1448 | 355 | 448 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000341356 | 1898 | 489 | 67209436 | 67209559 | 313 | 435 | 67 | 108 |
| ENST00000393893 | 1919 | 489 | 67209436 | 67209559 | 306 | 428 | 67 | 108 |
| ENST00000341356 | 1898 | 489 | 67208595 | 67208715 | 748 | 867 | 212 | 252 |
| ENST00000393893 | 1919 | 489 | 67208595 | 67208715 | 741 | 860 | 212 | 252 |
| ENST00000341356 | 1898 | 489 | 67207805 | 67207910 | 868 | 972 | 252 | 287 |
| ENST00000393893 | 1919 | 489 | 67207805 | 67207910 | 861 | 965 | 252 | 287 |
| ENST00000341356 | 1898 | 489 | 67206141 | 67206420 | 1177 | 1455 | 355 | 448 |
| ENST00000393893 | 1919 | 489 | 67206141 | 67206420 | 1170 | 1448 | 355 | 448 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9BR76 | 67 | 108 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 67 | 108 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 67 | 108 | 18 | 72 | Repeat | Note=WD 1 |
| Q9BR76 | 67 | 108 | 18 | 72 | Repeat | Note=WD 1 |
| Q9BR76 | 67 | 108 | 73 | 122 | Repeat | Note=WD 2 |
| Q9BR76 | 67 | 108 | 73 | 122 | Repeat | Note=WD 2 |
| Q9BR76 | 212 | 252 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 212 | 252 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 212 | 252 | 211 | 256 | Repeat | Note=WD 5 |
| Q9BR76 | 212 | 252 | 211 | 256 | Repeat | Note=WD 5 |
| Q9BR76 | 252 | 287 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 252 | 287 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 252 | 287 | 211 | 256 | Repeat | Note=WD 5 |
| Q9BR76 | 252 | 287 | 211 | 256 | Repeat | Note=WD 5 |
| Q9BR76 | 252 | 287 | 257 | 296 | Repeat | Note=WD 6 |
| Q9BR76 | 252 | 287 | 257 | 296 | Repeat | Note=WD 6 |
| Q9BR76 | 355 | 448 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 355 | 448 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 355 | 448 | 411 | 411 | Natural variant | ID=VAR_035877;Note=In a colorectal cancer sample%3B somatic mutation. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs756117196,PMID:16959974 |
| Q9BR76 | 355 | 448 | 411 | 411 | Natural variant | ID=VAR_035877;Note=In a colorectal cancer sample%3B somatic mutation. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs756117196,PMID:16959974 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9BR76 | 67 | 108 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 67 | 108 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 67 | 108 | 18 | 72 | Repeat | Note=WD 1 |
| Q9BR76 | 67 | 108 | 18 | 72 | Repeat | Note=WD 1 |
| Q9BR76 | 67 | 108 | 73 | 122 | Repeat | Note=WD 2 |
| Q9BR76 | 67 | 108 | 73 | 122 | Repeat | Note=WD 2 |
| Q9BR76 | 212 | 252 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 212 | 252 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 212 | 252 | 211 | 256 | Repeat | Note=WD 5 |
| Q9BR76 | 212 | 252 | 211 | 256 | Repeat | Note=WD 5 |
| Q9BR76 | 252 | 287 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 252 | 287 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 252 | 287 | 211 | 256 | Repeat | Note=WD 5 |
| Q9BR76 | 252 | 287 | 211 | 256 | Repeat | Note=WD 5 |
| Q9BR76 | 252 | 287 | 257 | 296 | Repeat | Note=WD 6 |
| Q9BR76 | 252 | 287 | 257 | 296 | Repeat | Note=WD 6 |
| Q9BR76 | 355 | 448 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 355 | 448 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 355 | 448 | 411 | 411 | Natural variant | ID=VAR_035877;Note=In a colorectal cancer sample%3B somatic mutation. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs756117196,PMID:16959974 |
| Q9BR76 | 355 | 448 | 411 | 411 | Natural variant | ID=VAR_035877;Note=In a colorectal cancer sample%3B somatic mutation. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs756117196,PMID:16959974 |
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SNVs in the skipped exons for CORO1B |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_74841 | 67207806 | 67207910 | 67207859 | 67207859 | Frame_Shift_Del | C | - | p.A270fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_74841 | 67207806 | 67207910 | 67207859 | 67207859 | Frame_Shift_Del | C | - | p.A270fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_74841 | 67207806 | 67207910 | 67207886 | 67207886 | Frame_Shift_Del | G | - | p.L261fs |
| KIRC | TCGA-CZ-5989-01 | exon_skip_74832 | 67206142 | 67206420 | 67206198 | 67206199 | Frame_Shift_Ins | - | G | p.L430fs |
| THCA | TCGA-DJ-A1QD-01 | exon_skip_74832 | 67206142 | 67206420 | 67206198 | 67206199 | Frame_Shift_Ins | - | G | p.L430fs |
| THCA | TCGA-DJ-A1QE-01 | exon_skip_74832 | 67206142 | 67206420 | 67206198 | 67206199 | Frame_Shift_Ins | - | G | p.L430fs |
| BLCA | TCGA-XF-AAN5-01 | exon_skip_74850 | 67208596 | 67208715 | 67208697 | 67208697 | Nonsense_Mutation | C | A | p.E219* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SNU503_LARGE_INTESTINE | 67209437 | 67209559 | 67209453 | 67209453 | Frame_Shift_Del | T | - | p.E103fs |
| SNU175_LARGE_INTESTINE | 67206142 | 67206420 | 67206260 | 67206260 | Missense_Mutation | C | T | p.R409H |
| SNU1040_LARGE_INTESTINE | 67206142 | 67206420 | 67206260 | 67206260 | Missense_Mutation | C | T | p.R409H |
| HCT15_LARGE_INTESTINE | 67206142 | 67206420 | 67206266 | 67206266 | Missense_Mutation | C | T | p.S407N |
| KYSE140_OESOPHAGUS | 67206142 | 67206420 | 67206282 | 67206282 | Missense_Mutation | G | A | p.R402W |
| HEC1B_ENDOMETRIUM | 67206142 | 67206420 | 67206308 | 67206308 | Missense_Mutation | C | T | p.R393Q |
| AU565_BREAST | 67206142 | 67206420 | 67206332 | 67206332 | Missense_Mutation | G | A | p.A385V |
| HEC151_ENDOMETRIUM | 67206142 | 67206420 | 67206342 | 67206342 | Missense_Mutation | C | T | p.G382R |
| HS633T_SOFT_TISSUE | 67206142 | 67206420 | 67206342 | 67206342 | Missense_Mutation | C | A | p.G382W |
| DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 67207806 | 67207910 | 67207828 | 67207828 | Missense_Mutation | C | T | p.S280N |
| HS600T_FIBROBLAST | 67207806 | 67207910 | 67207881 | 67207881 | Missense_Mutation | C | G | p.Q262H |
| NCIH1304_LUNG | 67207806 | 67207910 | 67207881 | 67207881 | Missense_Mutation | C | G | p.Q262H |
| RXF393_KIDNEY | 67208596 | 67208715 | 67208619 | 67208619 | Missense_Mutation | G | A | p.R245W |
| SNU1040_LARGE_INTESTINE | 67209437 | 67209559 | 67209552 | 67209552 | Missense_Mutation | C | T | p.R70H |
| CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 67206142 | 67206420 | 67206408 | 67206408 | Nonsense_Mutation | G | A | p.Q360* |
| EN_ENDOMETRIUM | 67208596 | 67208715 | 67208631 | 67208631 | Nonsense_Mutation | G | A | p.R241* |
| REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 67209437 | 67209559 | 67209514 | 67209514 | Nonsense_Mutation | C | A | p.G83* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CORO1B |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CORO1B |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CORO1B |
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RelatedDrugs for CORO1B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CORO1B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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