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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for PSMD10 |
 Gene summary |
| Gene information | Gene symbol | PSMD10 | Gene ID | 5716 |
| Gene name | proteasome 26S subunit, non-ATPase 10 | |
| Synonyms | dJ889N15.2|p28|p28(GANK) | |
| Cytomap | Xq22.3 | |
| Type of gene | protein-coding | |
| Description | 26S proteasome non-ATPase regulatory subunit 1026S proteasome regulatory subunit p28ankyrin repeat proteingankyrinhepatocellular carcinoma-associated protein p28-IIproteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | |
| Modification date | 20180522 | |
| UniProtAcc | O75832 | |
| Context | PubMed: PSMD10 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PSMD10 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 16023600 |
| PSMD10 | GO:0007253 | cytoplasmic sequestering of NF-kappaB | 18040287 |
| PSMD10 | GO:0030307 | positive regulation of cell growth | 10613832 |
| PSMD10 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 18040287 |
| PSMD10 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 16023600 |
| PSMD10 | GO:0043066 | negative regulation of apoptotic process | 16023600 |
| PSMD10 | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator | 16023600 |
| PSMD10 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity | 11900540 |
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Exon skipping events across known transcript of Ensembl for PSMD10 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for PSMD10 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for PSMD10 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_516356 | X | 107330274:107331082:107331182:107331329:107331981:107332080 | 107331182:107331329 | ENSG00000101843.14 | ENST00000361815.5,ENST00000217958.3 |
| exon_skip_516357 | X | 107331325:107331329:107331981:107332080:107334636:107334750 | 107331981:107332080 | ENSG00000101843.14 | ENST00000361815.5,ENST00000372296.1,ENST00000372295.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for PSMD10 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_516356 | X | 107330274:107331082:107331182:107331329:107331981:107332080 | 107331182:107331329 | ENSG00000101843.14 | ENST00000217958.3,ENST00000361815.5 |
| exon_skip_516357 | X | 107331325:107331329:107331981:107332080:107334636:107334750 | 107331981:107332080 | ENSG00000101843.14 | ENST00000372296.1,ENST00000372295.1,ENST00000361815.5 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for PSMD10 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000217958 | 107331182 | 107331329 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000217958 | 107331182 | 107331329 | In-frame |
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Infer the effects of exon skipping event on protein functional features for PSMD10 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000217958 | 1563 | 226 | 107331182 | 107331329 | 312 | 458 | 71 | 120 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000217958 | 1563 | 226 | 107331182 | 107331329 | 312 | 458 | 71 | 120 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O75832 | 71 | 120 | 71 | 73 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TR4 |
| O75832 | 71 | 120 | 1 | 226 | Chain | ID=PRO_0000067045;Note=26S proteasome non-ATPase regulatory subunit 10 |
| O75832 | 71 | 120 | 76 | 83 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UOH |
| O75832 | 71 | 120 | 86 | 94 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UOH |
| O75832 | 71 | 120 | 109 | 115 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UOH |
| O75832 | 71 | 120 | 119 | 127 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UOH |
| O75832 | 71 | 120 | 1 | 71 | Region | Note=Interaction with RB1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10613832;Dbxref=PMID:10613832 |
| O75832 | 71 | 120 | 39 | 226 | Region | Note=Interaction with RELA |
| O75832 | 71 | 120 | 70 | 102 | Repeat | Note=ANK 3 |
| O75832 | 71 | 120 | 103 | 135 | Repeat | Note=ANK 4 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O75832 | 71 | 120 | 71 | 73 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TR4 |
| O75832 | 71 | 120 | 1 | 226 | Chain | ID=PRO_0000067045;Note=26S proteasome non-ATPase regulatory subunit 10 |
| O75832 | 71 | 120 | 76 | 83 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UOH |
| O75832 | 71 | 120 | 86 | 94 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UOH |
| O75832 | 71 | 120 | 109 | 115 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UOH |
| O75832 | 71 | 120 | 119 | 127 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UOH |
| O75832 | 71 | 120 | 1 | 71 | Region | Note=Interaction with RB1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10613832;Dbxref=PMID:10613832 |
| O75832 | 71 | 120 | 39 | 226 | Region | Note=Interaction with RELA |
| O75832 | 71 | 120 | 70 | 102 | Repeat | Note=ANK 3 |
| O75832 | 71 | 120 | 103 | 135 | Repeat | Note=ANK 4 |
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SNVs in the skipped exons for PSMD10 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_516356 | 107331183 | 107331329 | 107331262 | 107331262 | Frame_Shift_Del | C | - | p.G94fs |
| SKCM | TCGA-D3-A2J7-06 | exon_skip_516356 | 107331183 | 107331329 | 107331269 | 107331269 | Frame_Shift_Del | G | - | p.L92fs |
| SKCM | TCGA-D3-A2J7-06 | exon_skip_516356 | 107331183 | 107331329 | 107331269 | 107331269 | Frame_Shift_Del | G | - | p.L93fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| DV90_LUNG | 107331982 | 107332080 | 107332019 | 107332019 | Frame_Shift_Del | A | - | p.L60fs |
| HT115_LARGE_INTESTINE | 107331183 | 107331329 | 107331304 | 107331304 | Missense_Mutation | G | A | p.A80V |
| JHU011_UPPER_AERODIGESTIVE_TRACT | 107331982 | 107332080 | 107332077 | 107332077 | Missense_Mutation | T | A | p.S40C |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PSMD10 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PSMD10 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PSMD10 |
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RelatedDrugs for PSMD10 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PSMD10 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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