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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for TMEM159 |
 Gene summary |
| Gene information | Gene symbol | TMEM159 | Gene ID | 57146 |
| Gene name | transmembrane protein 159 | |
| Synonyms | - | |
| Cytomap | 16p12.3 | |
| Type of gene | protein-coding | |
| Description | promethin | |
| Modification date | 20180522 | |
| UniProtAcc | Q96B96 | |
| Context | PubMed: TMEM159 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for TMEM159 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for TMEM159 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for TMEM159 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_134429 | 16 | 21170030:21170067:21172298:21172329:21172405:21172461 | 21172298:21172329 | ENSG00000011638.6 | ENST00000577162.1,ENST00000572599.1 |
| exon_skip_134430 | 16 | 21170030:21170067:21172298:21172599:21181757:21181926 | 21172298:21172599 | ENSG00000011638.6 | ENST00000261388.3,ENST00000574092.1 |
| exon_skip_134432 | 16 | 21170030:21170067:21172405:21172599:21181757:21181926 | 21172405:21172599 | ENSG00000011638.6 | ENST00000233047.4,ENST00000572258.1 |
| exon_skip_134438 | 16 | 21172405:21172599:21178160:21178232:21181757:21181926 | 21178160:21178232 | ENSG00000011638.6 | ENST00000573487.1,ENST00000451578.2 |
| exon_skip_134442 | 16 | 21181792:21181926:21185330:21185469:21190117:21190253 | 21185330:21185469 | ENSG00000011638.6 | ENST00000573487.1 |
| exon_skip_134443 | 16 | 21181792:21181926:21185330:21185469:21190795:21190930 | 21185330:21185469 | ENSG00000011638.6 | ENST00000261388.3,ENST00000233047.4,ENST00000572599.1,ENST00000451578.2 |
| exon_skip_134450 | 16 | 21185330:21185469:21188457:21188648:21190795:21190930 | 21188457:21188648 | ENSG00000011638.6 | ENST00000573688.1 |
| exon_skip_134453 | 16 | 21185330:21185469:21190117:21190253:21190795:21190930 | 21190117:21190253 | ENSG00000011638.6 | ENST00000573487.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for TMEM159 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_134429 | 16 | 21170030:21170067:21172298:21172329:21172405:21172461 | 21172298:21172329 | ENSG00000011638.6 | ENST00000572599.1,ENST00000577162.1 |
| exon_skip_134430 | 16 | 21170030:21170067:21172298:21172599:21181757:21181926 | 21172298:21172599 | ENSG00000011638.6 | ENST00000574092.1,ENST00000261388.3 |
| exon_skip_134432 | 16 | 21170030:21170067:21172405:21172599:21181757:21181926 | 21172405:21172599 | ENSG00000011638.6 | ENST00000233047.4,ENST00000572258.1 |
| exon_skip_134438 | 16 | 21172405:21172599:21178160:21178232:21181757:21181926 | 21178160:21178232 | ENSG00000011638.6 | ENST00000573487.1,ENST00000451578.2 |
| exon_skip_134442 | 16 | 21181792:21181926:21185330:21185469:21190117:21190253 | 21185330:21185469 | ENSG00000011638.6 | ENST00000573487.1 |
| exon_skip_134443 | 16 | 21181792:21181926:21185330:21185469:21190795:21190930 | 21185330:21185469 | ENSG00000011638.6 | ENST00000233047.4,ENST00000261388.3,ENST00000451578.2,ENST00000572599.1 |
| exon_skip_134450 | 16 | 21185330:21185469:21188457:21188648:21190795:21190930 | 21188457:21188648 | ENSG00000011638.6 | ENST00000573688.1 |
| exon_skip_134453 | 16 | 21185330:21185469:21190117:21190253:21190795:21190930 | 21190117:21190253 | ENSG00000011638.6 | ENST00000573487.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for TMEM159 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for TMEM159 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for TMEM159 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| BLCA | TCGA-BT-A3PH-01 | exon_skip_134430 | 21172299 | 21172599 | 21172532 | 21172532 | Nonsense_Mutation | C | G | p.S10* |
| BLCA | TCGA-BT-A3PH-01 | exon_skip_134432 | 21172406 | 21172599 | 21172532 | 21172532 | Nonsense_Mutation | C | G | p.S10* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| ETK1_BILIARY_TRACT | 21185331 | 21185469 | 21185342 | 21185342 | Missense_Mutation | T | A | p.S93T |
| COLO320_LARGE_INTESTINE | 21185331 | 21185469 | 21185438 | 21185438 | Missense_Mutation | T | C | p.S125P |
| HCT116_LARGE_INTESTINE | 21185331 | 21185469 | 21185438 | 21185438 | Missense_Mutation | T | C | p.S125P |
| NCIH2052_PLEURA | 21185331 | 21185469 | 21185438 | 21185438 | Missense_Mutation | T | C | p.S125P |
| NCIH378_LUNG | 21185331 | 21185469 | 21185438 | 21185438 | Missense_Mutation | T | C | p.S125P |
| HEC251_ENDOMETRIUM | 21185331 | 21185469 | 21185394 | 21185394 | Nonsense_Mutation | C | A | p.S110* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TMEM159 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_134450 | 16 | 21185330:21185469:21188457:21188648:21190795:21190930 | 21188457:21188648 | ENST00000573688.1 | KIRP | rs2204997 | chr16:21188649 | G/A | 2.41e-04 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TMEM159 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TMEM159 |
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RelatedDrugs for TMEM159 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM159 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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