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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for RAB25 |
 Gene summary |
| Gene information | Gene symbol | RAB25 | Gene ID | 57111 |
| Gene name | RAB25, member RAS oncogene family | |
| Synonyms | CATX-8|RAB11C | |
| Cytomap | 1q22 | |
| Type of gene | protein-coding | |
| Description | ras-related protein Rab-25 | |
| Modification date | 20180523 | |
| UniProtAcc | P57735 | |
| Context | PubMed: RAB25 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| RAB25 | GO:0008284 | positive regulation of cell proliferation | 15502842 |
| RAB25 | GO:0031268 | pseudopodium organization | 17925226 |
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Exon skipping events across known transcript of Ensembl for RAB25 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for RAB25 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for RAB25 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_11876 | 1 | 156031173:156031234:156038060:156038254:156039461:156039542 | 156038060:156038254 | ENSG00000132698.9 | ENST00000473336.1,ENST00000487325.1 |
| exon_skip_11884 | 1 | 156035701:156035897:156038060:156038254:156039461:156039542 | 156038060:156038254 | ENSG00000132698.9 | ENST00000361084.5 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for RAB25 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_11876 | 1 | 156031173:156031234:156038060:156038254:156039461:156039542 | 156038060:156038254 | ENSG00000132698.9 | ENST00000487325.1,ENST00000473336.1 |
| exon_skip_11884 | 1 | 156035701:156035897:156038060:156038254:156039461:156039542 | 156038060:156038254 | ENSG00000132698.9 | ENST00000361084.5 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for RAB25 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000361084 | 156038060 | 156038254 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000361084 | 156038060 | 156038254 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for RAB25 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for RAB25 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_11884 exon_skip_11876 | 156038061 | 156038254 | 156038079 | 156038079 | Frame_Shift_Del | G | - | p.V86fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_11884 exon_skip_11876 | 156038061 | 156038254 | 156038190 | 156038190 | Frame_Shift_Del | G | - | p.V123fs |
| BLCA | TCGA-XF-A9T3-01 | exon_skip_11884 exon_skip_11876 | 156038061 | 156038254 | 156038131 | 156038131 | Nonsense_Mutation | G | T | p.E104* |
| PRAD | TCGA-XK-AAIW-01 | exon_skip_11884 exon_skip_11876 | 156038061 | 156038254 | 156038134 | 156038134 | Nonsense_Mutation | C | T | p.R105* |
| SKCM | TCGA-D3-A1Q5-06 | exon_skip_11884 exon_skip_11876 | 156038061 | 156038254 | 156038242 | 156038242 | Nonsense_Mutation | C | T | p.R141* |
| SKCM | TCGA-D3-A1Q5-06 | exon_skip_11884 exon_skip_11876 | 156038061 | 156038254 | 156038242 | 156038242 | Nonsense_Mutation | C | T | p.R141X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| KG1C_CENTRAL_NERVOUS_SYSTEM | 156038061 | 156038254 | 156038092 | 156038092 | Missense_Mutation | G | A | p.V91M |
| JHH7_LIVER | 156038061 | 156038254 | 156038092 | 156038092 | Missense_Mutation | G | A | p.V91M |
| TE1_OESOPHAGUS | 156038061 | 156038254 | 156038092 | 156038092 | Missense_Mutation | G | A | p.V91M |
| MYM12_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 156038061 | 156038254 | 156038092 | 156038092 | Missense_Mutation | G | A | p.V91M |
| GT3TKB_STOMACH | 156038061 | 156038254 | 156038092 | 156038092 | Missense_Mutation | G | A | p.V91M |
| HLE_LIVER | 156038061 | 156038254 | 156038092 | 156038092 | Missense_Mutation | G | A | p.V91M |
| TE8_OESOPHAGUS | 156038061 | 156038254 | 156038092 | 156038092 | Missense_Mutation | G | A | p.V91M |
| FTC133_THYROID | 156038061 | 156038254 | 156038247 | 156038247 | Missense_Mutation | G | T | p.M142I |
| DG75_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 156038061 | 156038254 | 156038251 | 156038251 | Missense_Mutation | G | A | p.A144T |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RAB25 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RAB25 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RAB25 |
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RelatedDrugs for RAB25 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAB25 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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