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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for NRIP3 |
 Gene summary |
| Gene information | Gene symbol | NRIP3 | Gene ID | 56675 |
| Gene name | nuclear receptor interacting protein 3 | |
| Synonyms | C11orf14|NY-SAR-105 | |
| Cytomap | 11p15.4 | |
| Type of gene | protein-coding | |
| Description | nuclear receptor-interacting protein 3sarcoma antigen NY-SAR-105 | |
| Modification date | 20180519 | |
| UniProtAcc | Q9NQ35 | |
| Context | PubMed: NRIP3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for NRIP3 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for NRIP3 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for NRIP3 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_68847 | 11 | 9005618:9005671:9007257:9007397:9009094:9009177 | 9007257:9007397 | ENSG00000175352.6 | ENST00000309166.3 |
| exon_skip_68849 | 11 | 9009094:9009177:9009664:9009808:9025308:9025548 | 9009664:9009808 | ENSG00000175352.6 | ENST00000525100.1 |
| exon_skip_68850 | 11 | 9009094:9009177:9009664:9009829:9025308:9025548 | 9009664:9009829 | ENSG00000175352.6 | ENST00000531090.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for NRIP3 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_68847 | 11 | 9005618:9005671:9007257:9007397:9009094:9009177 | 9007257:9007397 | ENSG00000175352.6 | ENST00000309166.3 |
| exon_skip_68849 | 11 | 9009094:9009177:9009664:9009808:9025308:9025548 | 9009664:9009808 | ENSG00000175352.6 | ENST00000525100.1 |
| exon_skip_68850 | 11 | 9009094:9009177:9009664:9009829:9025308:9025548 | 9009664:9009829 | ENSG00000175352.6 | ENST00000531090.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for NRIP3 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000309166 | 9007257 | 9007397 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000309166 | 9007257 | 9007397 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for NRIP3 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for NRIP3 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HNSC | TCGA-BA-4077-01 | exon_skip_68849 | 9009665 | 9009808 | 9009738 | 9009744 | Frame_Shift_Del | TTCGTCT | - | p.K87fs |
| HNSC | TCGA-BA-4077-01 | exon_skip_68849 | 9009665 | 9009808 | 9009738 | 9009744 | Frame_Shift_Del | TTCGTCT | - | p.KTN87fs |
| HNSC | TCGA-BA-4077-01 | exon_skip_68850 | 9009665 | 9009829 | 9009738 | 9009744 | Frame_Shift_Del | TTCGTCT | - | p.K87fs |
| HNSC | TCGA-BA-4077-01 | exon_skip_68850 | 9009665 | 9009829 | 9009738 | 9009744 | Frame_Shift_Del | TTCGTCT | - | p.KTN87fs |
| UCEC | TCGA-B5-A0JY-01 | exon_skip_68847 | 9007258 | 9007397 | 9007398 | 9007398 | Splice_Site | C | T | e4-1 |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HCC2998_LARGE_INTESTINE | 9009665 | 9009808 | 9009677 | 9009678 | Frame_Shift_Ins | - | A | p.L109fs |
| HCC2998_LARGE_INTESTINE | 9009665 | 9009829 | 9009677 | 9009678 | Frame_Shift_Ins | - | A | p.L109fs |
| NH6_AUTONOMIC_GANGLIA | 9007258 | 9007397 | 9007274 | 9007275 | Missense_Mutation | GC | AG | p.C182S |
| SNU213_PANCREAS | 9007258 | 9007397 | 9007274 | 9007275 | Missense_Mutation | GC | AG | p.C182S |
| BHY_UPPER_AERODIGESTIVE_TRACT | 9007258 | 9007397 | 9007274 | 9007275 | Missense_Mutation | GC | AG | p.C182S |
| GCIY_STOMACH | 9007258 | 9007397 | 9007274 | 9007275 | Missense_Mutation | GC | AG | p.C182S |
| NY_BONE | 9007258 | 9007397 | 9007274 | 9007275 | Missense_Mutation | GC | AG | p.C182S |
| OSC20_UPPER_AERODIGESTIVE_TRACT | 9007258 | 9007397 | 9007274 | 9007275 | Missense_Mutation | GC | AG | p.C182S |
| RERFLCMS_LUNG | 9007258 | 9007397 | 9007274 | 9007275 | Missense_Mutation | GC | AG | p.C182S |
| ASH3_THYROID | 9007258 | 9007397 | 9007306 | 9007306 | Missense_Mutation | C | G | p.V172L |
| KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 9007258 | 9007397 | 9007377 | 9007377 | Missense_Mutation | G | T | p.S148Y |
| NCIH841_LUNG | 9009665 | 9009808 | 9009763 | 9009763 | Missense_Mutation | G | A | p.R81C |
| NCIH841_LUNG | 9009665 | 9009829 | 9009763 | 9009763 | Missense_Mutation | G | A | p.R81C |
| MFE319_ENDOMETRIUM | 9009665 | 9009808 | 9009763 | 9009763 | Missense_Mutation | G | A | p.R81C |
| MFE319_ENDOMETRIUM | 9009665 | 9009829 | 9009763 | 9009763 | Missense_Mutation | G | A | p.R81C |
| KYAE1_OESOPHAGUS | 9009665 | 9009808 | 9009703 | 9009703 | Nonsense_Mutation | T | A | p.K101* |
| KYAE1_OESOPHAGUS | 9009665 | 9009829 | 9009703 | 9009703 | Nonsense_Mutation | T | A | p.K101* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NRIP3 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for NRIP3 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for NRIP3 |
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RelatedDrugs for NRIP3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NRIP3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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