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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for AZGP1 |
 Gene summary |
| Gene information | Gene symbol | AZGP1 | Gene ID | 563 |
| Gene name | alpha-2-glycoprotein 1, zinc-binding | |
| Synonyms | ZA2G|ZAG | |
| Cytomap | 7q22.1 | |
| Type of gene | protein-coding | |
| Description | zinc-alpha-2-glycoproteinAlpha-2-glycoprotein, zincZn-alpha2-glycoproteintesticular tissue protein Li 227zn-alpha-2-GPzn-alpha-2-glycoprotein | |
| Modification date | 20180527 | |
| UniProtAcc | P25311 | |
| Context | PubMed: AZGP1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| AZGP1 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste | 24248522 |
| AZGP1 | GO:0007155 | cell adhesion | 9813179 |
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Exon skipping events across known transcript of Ensembl for AZGP1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for AZGP1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for AZGP1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_477652 | 7 | 99564890:99564909:99565777:99566053:99569368:99569629 | 99565777:99566053 | ENSG00000160862.8 | ENST00000292401.4 |
| exon_skip_477675 | 7 | 99565777:99566053:99569368:99569629:99573567:99573640 | 99569368:99569629 | ENSG00000160862.8 | ENST00000292401.4,ENST00000411734.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for AZGP1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_477652 | 7 | 99564890:99564909:99565777:99566053:99569368:99569629 | 99565777:99566053 | ENSG00000160862.8 | ENST00000292401.4 |
| exon_skip_477675 | 7 | 99565777:99566053:99569368:99569629:99573567:99573640 | 99569368:99569629 | ENSG00000160862.8 | ENST00000292401.4,ENST00000411734.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for AZGP1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000292401 | 99565777 | 99566053 | In-frame |
| ENST00000292401 | 99569368 | 99569629 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000292401 | 99565777 | 99566053 | In-frame |
| ENST00000292401 | 99569368 | 99569629 | In-frame |
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Infer the effects of exon skipping event on protein functional features for AZGP1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000292401 | 1324 | 298 | 99569368 | 99569629 | 214 | 474 | 25 | 112 |
| ENST00000292401 | 1324 | 298 | 99565777 | 99566053 | 475 | 750 | 112 | 204 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000292401 | 1324 | 298 | 99569368 | 99569629 | 214 | 474 | 25 | 112 |
| ENST00000292401 | 1324 | 298 | 99565777 | 99566053 | 475 | 750 | 112 | 204 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P25311 | 25 | 112 | 27 | 39 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 25 | 112 | 42 | 44 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZAG |
| P25311 | 25 | 112 | 46 | 53 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 25 | 112 | 56 | 62 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 25 | 112 | 79 | 81 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ES6 |
| P25311 | 25 | 112 | 21 | 298 | Chain | ID=PRO_0000019012;Note=Zinc-alpha-2-glycoprotein |
| P25311 | 25 | 112 | 109 | 109 | Glycosylation | Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10206894,ECO:0000269|PubMed:16740002,ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:19139490,ECO:0000269|P |
| P25311 | 25 | 112 | 112 | 112 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:16740002,ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:1915 |
| P25311 | 25 | 112 | 72 | 76 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 25 | 112 | 83 | 107 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 25 | 112 | 33 | 33 | Sequence conflict | Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P25311 | 25 | 112 | 85 | 85 | Sequence conflict | Note=Q->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P25311 | 25 | 112 | 96 | 97 | Sequence conflict | Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P25311 | 25 | 112 | 63 | 65 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 112 | 204 | 116 | 126 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 112 | 204 | 129 | 139 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 112 | 204 | 142 | 148 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 112 | 204 | 153 | 156 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 112 | 204 | 21 | 298 | Chain | ID=PRO_0000019012;Note=Zinc-alpha-2-glycoprotein |
| P25311 | 112 | 204 | 123 | 186 | Disulfide bond | . |
| P25311 | 112 | 204 | 112 | 112 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:16740002,ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:1915 |
| P25311 | 112 | 204 | 128 | 128 | Glycosylation | Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10206894,ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:15 |
| P25311 | 112 | 204 | 159 | 168 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 112 | 204 | 173 | 183 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 112 | 204 | 185 | 196 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 112 | 204 | 198 | 201 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 112 | 204 | 149 | 152 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P25311 | 25 | 112 | 27 | 39 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 25 | 112 | 42 | 44 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZAG |
| P25311 | 25 | 112 | 46 | 53 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 25 | 112 | 56 | 62 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 25 | 112 | 79 | 81 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ES6 |
| P25311 | 25 | 112 | 21 | 298 | Chain | ID=PRO_0000019012;Note=Zinc-alpha-2-glycoprotein |
| P25311 | 25 | 112 | 109 | 109 | Glycosylation | Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10206894,ECO:0000269|PubMed:16740002,ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:19139490,ECO:0000269|P |
| P25311 | 25 | 112 | 112 | 112 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:16740002,ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:1915 |
| P25311 | 25 | 112 | 72 | 76 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 25 | 112 | 83 | 107 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 25 | 112 | 33 | 33 | Sequence conflict | Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P25311 | 25 | 112 | 85 | 85 | Sequence conflict | Note=Q->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P25311 | 25 | 112 | 96 | 97 | Sequence conflict | Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P25311 | 25 | 112 | 63 | 65 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 112 | 204 | 116 | 126 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 112 | 204 | 129 | 139 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 112 | 204 | 142 | 148 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 112 | 204 | 153 | 156 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 112 | 204 | 21 | 298 | Chain | ID=PRO_0000019012;Note=Zinc-alpha-2-glycoprotein |
| P25311 | 112 | 204 | 123 | 186 | Disulfide bond | . |
| P25311 | 112 | 204 | 112 | 112 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:16740002,ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:1915 |
| P25311 | 112 | 204 | 128 | 128 | Glycosylation | Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10206894,ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:15 |
| P25311 | 112 | 204 | 159 | 168 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 112 | 204 | 173 | 183 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 112 | 204 | 185 | 196 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 112 | 204 | 198 | 201 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
| P25311 | 112 | 204 | 149 | 152 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V |
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SNVs in the skipped exons for AZGP1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_477652 | 99565778 | 99566053 | 99565983 | 99565983 | Frame_Shift_Del | T | - | p.K133fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_477675 | 99569369 | 99569629 | 99569571 | 99569571 | Frame_Shift_Del | G | - | p.P42fs |
| HNSC | TCGA-CR-7399-01 | exon_skip_477652 | 99565778 | 99566053 | 99565930 | 99565930 | Nonsense_Mutation | C | T | p.W151* |
| HNSC | TCGA-CR-7399-01 | exon_skip_477652 | 99565778 | 99566053 | 99565930 | 99565930 | Nonsense_Mutation | C | T | p.W154* |
| LUAD | TCGA-55-6969-01 | exon_skip_477652 | 99565778 | 99566053 | 99565997 | 99565997 | Nonsense_Mutation | C | A | p.G129* |
| LUAD | TCGA-17-Z023-01 | exon_skip_477675 | 99569369 | 99569629 | 99569382 | 99569382 | Nonsense_Mutation | G | C | p.Y105* |
| STAD | TCGA-BR-8361-01 | exon_skip_477652 | 99565778 | 99566053 | 99565777 | 99565777 | Splice_Site | C | T | . |
| STAD | TCGA-BR-8361-01 | exon_skip_477652 | 99565778 | 99566053 | 99565777 | 99565777 | Splice_Site | C | T | p.D205_splice |
| STAD | TCGA-CD-8527-01 | exon_skip_477652 | 99565778 | 99566053 | 99565777 | 99565777 | Splice_Site | C | T | . |
| STAD | TCGA-CD-8527-01 | exon_skip_477652 | 99565778 | 99566053 | 99565777 | 99565777 | Splice_Site | C | T | p.D205_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| MAC2A_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 99565778 | 99566053 | 99565783 | 99565783 | Missense_Mutation | C | G | p.R203P |
| SW48_LARGE_INTESTINE | 99565778 | 99566053 | 99565819 | 99565819 | Missense_Mutation | C | T | p.R191Q |
| HEC108_ENDOMETRIUM | 99565778 | 99566053 | 99565828 | 99565828 | Missense_Mutation | G | A | p.A188V |
| SNU1040_LARGE_INTESTINE | 99565778 | 99566053 | 99565904 | 99565904 | Missense_Mutation | T | C | p.I163V |
| ES2_OVARY | 99565778 | 99566053 | 99565912 | 99565912 | Missense_Mutation | G | T | p.A160E |
| SW954_VULVA | 99565778 | 99566053 | 99565994 | 99565994 | Missense_Mutation | C | T | p.A133T |
| JHH7_LIVER | 99565778 | 99566053 | 99566014 | 99566014 | Missense_Mutation | T | C | p.E126G |
| SW620_LARGE_INTESTINE | 99569369 | 99569629 | 99569378 | 99569378 | Missense_Mutation | C | T | p.D110N |
| MCC13_SKIN | 99569369 | 99569629 | 99569430 | 99569431 | Missense_Mutation | GG | AA | p.A92V |
| MCC13_SKIN | 99569369 | 99569629 | 99569431 | 99569431 | Missense_Mutation | G | A | p.A92V |
| HT115_LARGE_INTESTINE | 99569369 | 99569629 | 99569513 | 99569513 | Missense_Mutation | C | A | p.D65Y |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for AZGP1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for AZGP1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for AZGP1 |
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RelatedDrugs for AZGP1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AZGP1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| AZGP1 | C0001418 | Adenocarcinoma | 1 | CTD_human |
| AZGP1 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| AZGP1 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
| AZGP1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| AZGP1 | C0037199 | Sinusitis | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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