|
||||||
|
 | |
| |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
| |
|
Gene summary for STK31 |
 Gene summary |
| Gene information | Gene symbol | STK31 | Gene ID | 56164 |
| Gene name | serine/threonine kinase 31 | |
| Synonyms | SGK396|TDRD8 | |
| Cytomap | 7p15.3 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase 31serine/threonine-protein kinase NYD-SPKsugen kinase 396testis tissue sperm-binding protein Li 78mtudor domain containing 8 | |
| Modification date | 20180523 | |
| UniProtAcc | Q9BXU1 | |
| Context | PubMed: STK31 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
Exon skipping events across known transcript of Ensembl for STK31 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
Top |
Gene isoform structures and expression levels for STK31 |
| Expression levels of gene isoforms across TCGA. |
 |
| Expression levels of gene isoforms across GTEx. |
 |
Top |
Exon skipping events with PSIs in TCGA for STK31 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_464887 | 7 | 23768709:23768868:23775156:23775515:23776522:23776697 | 23775156:23775515 | ENSG00000196335.8 | ENST00000355870.3,ENST00000428484.1,ENST00000405627.3,ENST00000354639.3,ENST00000433467.2,ENST00000476399.1 |
| exon_skip_464889 | 7 | 23793933:23794093:23794674:23794815:23802419:23802542 | 23794674:23794815 | ENSG00000196335.8 | ENST00000478321.1 |
| exon_skip_464891 | 7 | 23830442:23830565:23854762:23854831:23871754:23872068 | 23854762:23854831 | ENSG00000196335.8 | ENST00000355870.3,ENST00000428484.1,ENST00000405627.3,ENST00000354639.3 |
| PSI values of skipped exons in TCGA. |
 |
Top |
Exon skipping events with PSIs in GTEx for STK31 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_464889 | 7 | 23793933:23794093:23794674:23794815:23802419:23802542 | 23794674:23794815 | ENSG00000196335.8 | ENST00000478321.1 |
| exon_skip_464891 | 7 | 23830442:23830565:23854762:23854831:23871754:23872068 | 23854762:23854831 | ENSG00000196335.8 | ENST00000355870.3,ENST00000354639.3,ENST00000428484.1,ENST00000405627.3 |
| PSI values of skipped exons in GTEx. |
 |
| * Skipped exon sequences. |
Top |
Open reading frame (ORF) annotation in the exon skipping event for STK31 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000355870 | 23775156 | 23775515 | Frame-shift |
| ENST00000355870 | 23854762 | 23854831 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000355870 | 23854762 | 23854831 | In-frame |
Top |
Infer the effects of exon skipping event on protein functional features for STK31 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
 |
| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000355870 | 3343 | 1019 | 23854762 | 23854831 | 2880 | 2948 | 920 | 943 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000355870 | 3343 | 1019 | 23854762 | 23854831 | 2880 | 2948 | 920 | 943 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9BXU1 | 920 | 943 | 921 | 943 | Alternative sequence | ID=VSP_045210;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9BXU1 | 920 | 943 | 1 | 1019 | Chain | ID=PRO_0000086715;Note=Serine/threonine-protein kinase 31 |
| Q9BXU1 | 920 | 943 | 710 | 1019 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9BXU1 | 920 | 943 | 921 | 943 | Alternative sequence | ID=VSP_045210;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9BXU1 | 920 | 943 | 1 | 1019 | Chain | ID=PRO_0000086715;Note=Serine/threonine-protein kinase 31 |
| Q9BXU1 | 920 | 943 | 710 | 1019 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
Top |
SNVs in the skipped exons for STK31 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LUAD | TCGA-78-7162-01 | exon_skip_464887 | 23775157 | 23775515 | 23775275 | 23775275 | Frame_Shift_Del | A | - | p.E179fs |
| LUAD | TCGA-78-7162-01 | exon_skip_464887 | 23775157 | 23775515 | 23775275 | 23775275 | Frame_Shift_Del | A | - | p.E201fs |
| COAD | TCGA-AZ-4615-01 | exon_skip_464887 | 23775157 | 23775515 | 23775341 | 23775341 | Frame_Shift_Del | A | - | p.E223fs |
| COAD | TCGA-G4-6586-01 | exon_skip_464887 | 23775157 | 23775515 | 23775341 | 23775341 | Frame_Shift_Del | A | - | p.E223fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_464887 | 23775157 | 23775515 | 23775341 | 23775341 | Frame_Shift_Del | A | - | p.E200fs |
| SARC | TCGA-DX-A8BG-01 | exon_skip_464887 | 23775157 | 23775515 | 23775341 | 23775341 | Frame_Shift_Del | A | - | p.K225fs |
| UCEC | TCGA-D1-A174-01 | exon_skip_464887 | 23775157 | 23775515 | 23775341 | 23775341 | Frame_Shift_Del | A | - | p.E223fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_464887 | 23775157 | 23775515 | 23775401 | 23775401 | Frame_Shift_Del | G | - | p.W220fs |
| LIHC | TCGA-BC-A112-01 | exon_skip_464887 | 23775157 | 23775515 | 23775340 | 23775341 | Frame_Shift_Ins | - | A | p.K200fs |
| BLCA | TCGA-E5-A4U1-01 | exon_skip_464887 | 23775157 | 23775515 | 23775422 | 23775422 | Nonsense_Mutation | C | G | p.S227* |
| COAD | TCGA-AD-5900-01 | exon_skip_464891 | 23854763 | 23854831 | 23854762 | 23854762 | Splice_Site | G | A | . |
| SKCM | TCGA-FS-A1ZZ-06 | exon_skip_464891 | 23854763 | 23854831 | 23854762 | 23854762 | Splice_Site | G | A | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LS513_LARGE_INTESTINE | 23775157 | 23775515 | 23775253 | 23775253 | Missense_Mutation | T | G | p.Y194D |
| NCIH2291_LUNG | 23775157 | 23775515 | 23775259 | 23775259 | Missense_Mutation | A | C | p.S196R |
| GSU_STOMACH | 23775157 | 23775515 | 23775325 | 23775325 | Missense_Mutation | A | G | p.T218A |
| KMRC3_KIDNEY | 23775157 | 23775515 | 23775325 | 23775325 | Missense_Mutation | A | G | p.T218A |
| KATOIII_STOMACH | 23775157 | 23775515 | 23775325 | 23775325 | Missense_Mutation | A | G | p.T218A |
| TE5_OESOPHAGUS | 23775157 | 23775515 | 23775450 | 23775450 | Missense_Mutation | A | C | p.L259F |
| SW684_SOFT_TISSUE | 23775157 | 23775515 | 23775452 | 23775452 | Missense_Mutation | G | A | p.S260N |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for STK31 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
Top |
Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STK31 |
Top |
Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STK31 |
Top |
RelatedDrugs for STK31 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for STK31 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|