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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for EIF2AK2

check button Gene summary
Gene informationGene symbol

EIF2AK2

Gene ID

5610

Gene nameeukaryotic translation initiation factor 2 alpha kinase 2
SynonymsEIF2AK1|PKR|PPP1R83|PRKR
Cytomap

2p22.2

Type of geneprotein-coding
Descriptioninterferon-induced, double-stranded RNA-activated protein kinaseP1/eIF-2A protein kinasedouble stranded RNA activated protein kinaseeIF-2A protein kinase 2interferon-inducible elF2alpha kinasep68 kinaseprotein kinase Rprotein kinase, interferon-ind
Modification date20180523
UniProtAcc

P19525

ContextPubMed: EIF2AK2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
EIF2AK2

GO:0006468

protein phosphorylation

19189853

EIF2AK2

GO:0017148

negative regulation of translation

12882984

EIF2AK2

GO:0035455

response to interferon-alpha

19840259

EIF2AK2

GO:0046777

protein autophosphorylation

22801494

EIF2AK2

GO:0051092

positive regulation of NF-kappaB transcription factor activity

15121867


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Exon skipping events across known transcript of Ensembl for EIF2AK2 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for EIF2AK2

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for EIF2AK2

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_338302237334488:37334538:37334616:37334670:37336336:3733643837334616:37334670ENSG00000055332.12ENST00000405334.1,ENST00000233057.4,ENST00000395127.2,ENST00000462861.1
exon_skip_338307237336366:37336438:37341873:37342002:37347101:3734728237341873:37342002ENSG00000055332.12ENST00000405334.1,ENST00000233057.4,ENST00000395127.2
exon_skip_338309237347101:37347282:37349648:37349807:37353431:3735353437349648:37349807ENSG00000055332.12ENST00000233057.4,ENST00000395127.2
exon_skip_338312237349648:37349807:37353431:37353554:37362626:3736268937353431:37353554ENSG00000055332.12ENST00000233057.4,ENST00000395127.2
exon_skip_338314237353431:37353554:37362626:37362689:37364125:3736416037362626:37362689ENSG00000055332.12ENST00000233057.4,ENST00000395127.2
exon_skip_338316237365412:37365506:37365651:37365728:37366773:3736690037365651:37365728ENSG00000055332.12ENST00000405334.1,ENST00000233057.4,ENST00000395127.2,ENST00000496059.1
exon_skip_338317237374830:37374965:37375999:37376058:37384050:3738417537375999:37376058ENSG00000055332.12ENST00000411537.2
exon_skip_338318237374830:37374965:37375999:37376082:37384050:3738417537375999:37376082ENSG00000055332.12ENST00000390013.3
exon_skip_338320237374830:37374965:37375999:37376400:37384050:3738417537375999:37376400ENSG00000055332.12ENST00000395127.2

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for EIF2AK2

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_338302237334488:37334538:37334616:37334670:37336336:3733643837334616:37334670ENSG00000055332.12ENST00000233057.4,ENST00000395127.2,ENST00000405334.1,ENST00000462861.1
exon_skip_338307237336366:37336438:37341873:37342002:37347101:3734728237341873:37342002ENSG00000055332.12ENST00000233057.4,ENST00000395127.2,ENST00000405334.1
exon_skip_338309237347101:37347282:37349648:37349807:37353431:3735353437349648:37349807ENSG00000055332.12ENST00000233057.4,ENST00000395127.2
exon_skip_338312237349648:37349807:37353431:37353554:37362626:3736268937353431:37353554ENSG00000055332.12ENST00000233057.4,ENST00000395127.2
exon_skip_338314237353431:37353554:37362626:37362689:37364125:3736416037362626:37362689ENSG00000055332.12ENST00000233057.4,ENST00000395127.2
exon_skip_338316237365412:37365506:37365651:37365728:37366773:3736690037365651:37365728ENSG00000055332.12ENST00000233057.4,ENST00000395127.2,ENST00000405334.1,ENST00000496059.1
exon_skip_338317237374830:37374965:37375999:37376058:37384050:3738417537375999:37376058ENSG00000055332.12ENST00000411537.2
exon_skip_338318237374830:37374965:37375999:37376082:37384050:3738417537375999:37376082ENSG00000055332.12ENST00000390013.3
exon_skip_338320237374830:37374965:37375999:37376400:37384050:3738417537375999:37376400ENSG00000055332.12ENST00000395127.2

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for EIF2AK2

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000039512737375999373764003UTR-3UTR
ENST000002330573736565137365728Frame-shift
ENST000003951273736565137365728Frame-shift
ENST000002330573733461637334670In-frame
ENST000003951273733461637334670In-frame
ENST000002330573734187337342002In-frame
ENST000003951273734187337342002In-frame
ENST000002330573734964837349807In-frame
ENST000003951273734964837349807In-frame
ENST000002330573735343137353554In-frame
ENST000003951273735343137353554In-frame
ENST000002330573736262637362689In-frame
ENST000003951273736262637362689In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000039512737375999373764003UTR-3UTR
ENST000002330573736565137365728Frame-shift
ENST000003951273736565137365728Frame-shift
ENST000002330573733461637334670In-frame
ENST000003951273733461637334670In-frame
ENST000002330573734187337342002In-frame
ENST000003951273734187337342002In-frame
ENST000002330573734964837349807In-frame
ENST000003951273734964837349807In-frame
ENST000002330573735343137353554In-frame
ENST000003951273735343137353554In-frame
ENST000002330573736262637362689In-frame
ENST000003951273736262637362689In-frame

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Infer the effects of exon skipping event on protein functional features for EIF2AK2

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000023305710059551373626263736268910461108241261
ENST000003951272947551373626263736268912801342241261
ENST0000023305710059551373534313735355411091231262302
ENST000003951272947551373534313735355413431465262302
ENST0000023305710059551373496483734980712321390303355
ENST000003951272947551373496483734980714661624303355
ENST0000023305710059551373418733734200215721700416459
ENST000003951272947551373418733734200218061934416459
ENST0000023305710059551373346163733467018031856493511
ENST000003951272947551373346163733467020372090493511

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000023305710059551373626263736268910461108241261
ENST000003951272947551373626263736268912801342241261
ENST0000023305710059551373534313735355411091231262302
ENST000003951272947551373534313735355413431465262302
ENST0000023305710059551373496483734980712321390303355
ENST000003951272947551373496483734980714661624303355
ENST0000023305710059551373418733734200215721700416459
ENST000003951272947551373418733734200218061934416459
ENST0000023305710059551373346163733467018031856493511
ENST000003951272947551373346163733467020372090493511

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
P195252412612551ChainID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P195252412612551ChainID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P19525241261261266HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525241261261266HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525241261242242Modified residueNote=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11152499;Dbxref=PMID:11152499
P19525241261242242Modified residueNote=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11152499;Dbxref=PMID:11152499
P19525241261255255Modified residueNote=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11152499;Dbxref=PMID:11152499
P19525241261255255Modified residueNote=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11152499;Dbxref=PMID:11152499
P19525241261258258Modified residueNote=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11152499;Dbxref=PMID:11152499
P19525241261258258Modified residueNote=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11152499;Dbxref=PMID:11152499
P19525241261242242MutagenesisNote=Moderate loss of activity%3B when associated with A-255 and A-258. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
P19525241261242242MutagenesisNote=Moderate loss of activity%3B when associated with A-255 and A-258. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
P19525241261244296MutagenesisNote=Loss of activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
P19525241261244296MutagenesisNote=Loss of activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
P19525241261255255MutagenesisNote=Moderate loss of activity%3B when associated with A-242 and A-255. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
P19525241261255255MutagenesisNote=Moderate loss of activity%3B when associated with A-242 and A-255. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
P19525241261258258MutagenesisNote=Moderate loss of activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
P19525241261258258MutagenesisNote=Moderate loss of activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
P19525262302263303Alternative sequenceID=VSP_046177;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
P19525262302263303Alternative sequenceID=VSP_046177;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
P19525262302267274Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525262302267274Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525262302276278Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525262302276278Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525262302281286Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525262302281286Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525262302292299Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525262302292299Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525262302296296Binding siteNote=ATP
P19525262302296296Binding siteNote=ATP
P195252623022551ChainID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P195252623022551ChainID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P19525262302267538DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P19525262302267538DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P19525262302261266HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525262302261266HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525262302293293Modified residueNote=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16373505;Dbxref=PMID:16373505
P19525262302293293Modified residueNote=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16373505;Dbxref=PMID:16373505
P19525262302244296MutagenesisNote=Loss of activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
P19525262302244296MutagenesisNote=Loss of activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
P19525262302296296MutagenesisNote=Loss of activity. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
P19525262302296296MutagenesisNote=Loss of activity. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
P19525262302273281Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P19525262302273281Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P19525262302266551RegionNote=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
P19525262302266551RegionNote=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
P19525262302287289TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525262302287289TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525303355263303Alternative sequenceID=VSP_046177;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
P19525303355263303Alternative sequenceID=VSP_046177;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
P19525303355323332Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525303355323332Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P195253033552551ChainID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P195253033552551ChainID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P19525303355267538DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P19525303355267538DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P19525303355303305HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525303355303305HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525303355306314HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525303355306314HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525303355266551RegionNote=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
P19525303355266551RegionNote=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
P19525303355331357RegionNote=2 X 13 AA approximate repeats
P19525303355331357RegionNote=2 X 13 AA approximate repeats
P19525303355331343RepeatNote=1
P19525303355331343RepeatNote=1
P19525303355345357RepeatNote=2
P19525303355345357RepeatNote=2
P19525416459420424Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525416459420424Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525416459427430Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525416459427430Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525416459437440Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525416459437440Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P195254164592551ChainID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P195254164592551ChainID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P19525416459267538DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P19525416459267538DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P19525416459417419HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525416459417419HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525416459457461HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525416459457461HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525416459446446Modified residueNote=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11337501,ECO:0000269|PubMed:16179258;Dbxref=PMID:11337501,PMID:16179258
P19525416459446446Modified residueNote=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11337501,ECO:0000269|PubMed:16179258;Dbxref=PMID:11337501,PMID:16179258
P19525416459451451Modified residueNote=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11337501,ECO:0000269|PubMed:20685959;Dbxref=PMID:11337501,PMID:20685959
P19525416459451451Modified residueNote=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11337501,ECO:0000269|PubMed:20685959;Dbxref=PMID:11337501,PMID:20685959
P19525416459456456Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
P19525416459456456Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
P19525416459446446MutagenesisNote=Significant loss of activity and impairs autophosphorylation of T-451. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
P19525416459446446MutagenesisNote=Significant loss of activity and impairs autophosphorylation of T-451. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
P19525416459451451MutagenesisNote=Loss of activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
P19525416459451451MutagenesisNote=Loss of activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
P19525416459428428Natural variantID=VAR_040474;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56219559,PMID:17344846
P19525416459428428Natural variantID=VAR_040474;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56219559,PMID:17344846
P19525416459439439Natural variantID=VAR_040475;Note=In a lung adenocarcinoma sample%3B somatic mutation. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
P19525416459439439Natural variantID=VAR_040475;Note=In a lung adenocarcinoma sample%3B somatic mutation. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
P19525416459266551RegionNote=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
P19525416459266551RegionNote=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
P19525493511505507Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UIU
P19525493511505507Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UIU
P195254935112551ChainID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P195254935112551ChainID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P19525493511267538DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P19525493511267538DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P19525493511488499HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525493511488499HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525493511509518HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525493511509518HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525493511506506Natural variantID=VAR_040476;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34821155,PMID:17344846
P19525493511506506Natural variantID=VAR_040476;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34821155,PMID:17344846
P19525493511266551RegionNote=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
P19525493511266551RegionNote=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
P195252412612551ChainID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P195252412612551ChainID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P19525241261261266HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525241261261266HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525241261242242Modified residueNote=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11152499;Dbxref=PMID:11152499
P19525241261242242Modified residueNote=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11152499;Dbxref=PMID:11152499
P19525241261255255Modified residueNote=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11152499;Dbxref=PMID:11152499
P19525241261255255Modified residueNote=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11152499;Dbxref=PMID:11152499
P19525241261258258Modified residueNote=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11152499;Dbxref=PMID:11152499
P19525241261258258Modified residueNote=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11152499;Dbxref=PMID:11152499
P19525241261242242MutagenesisNote=Moderate loss of activity%3B when associated with A-255 and A-258. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
P19525241261242242MutagenesisNote=Moderate loss of activity%3B when associated with A-255 and A-258. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
P19525241261244296MutagenesisNote=Loss of activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
P19525241261244296MutagenesisNote=Loss of activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
P19525241261255255MutagenesisNote=Moderate loss of activity%3B when associated with A-242 and A-255. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
P19525241261255255MutagenesisNote=Moderate loss of activity%3B when associated with A-242 and A-255. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
P19525241261258258MutagenesisNote=Moderate loss of activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
P19525241261258258MutagenesisNote=Moderate loss of activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
P19525262302263303Alternative sequenceID=VSP_046177;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
P19525262302263303Alternative sequenceID=VSP_046177;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
P19525262302267274Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525262302267274Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525262302276278Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525262302276278Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525262302281286Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525262302281286Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525262302292299Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525262302292299Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525262302296296Binding siteNote=ATP
P19525262302296296Binding siteNote=ATP
P195252623022551ChainID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P195252623022551ChainID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P19525262302267538DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P19525262302267538DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P19525262302261266HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525262302261266HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525262302293293Modified residueNote=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16373505;Dbxref=PMID:16373505
P19525262302293293Modified residueNote=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16373505;Dbxref=PMID:16373505
P19525262302244296MutagenesisNote=Loss of activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
P19525262302244296MutagenesisNote=Loss of activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
P19525262302296296MutagenesisNote=Loss of activity. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
P19525262302296296MutagenesisNote=Loss of activity. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
P19525262302273281Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P19525262302273281Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P19525262302266551RegionNote=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
P19525262302266551RegionNote=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
P19525262302287289TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525262302287289TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525303355263303Alternative sequenceID=VSP_046177;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
P19525303355263303Alternative sequenceID=VSP_046177;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
P19525303355323332Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525303355323332Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P195253033552551ChainID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P195253033552551ChainID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P19525303355267538DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P19525303355267538DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P19525303355303305HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525303355303305HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525303355306314HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525303355306314HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525303355266551RegionNote=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
P19525303355266551RegionNote=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
P19525303355331357RegionNote=2 X 13 AA approximate repeats
P19525303355331357RegionNote=2 X 13 AA approximate repeats
P19525303355331343RepeatNote=1
P19525303355331343RepeatNote=1
P19525303355345357RepeatNote=2
P19525303355345357RepeatNote=2
P19525416459420424Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525416459420424Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525416459427430Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525416459427430Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525416459437440Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525416459437440Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P195254164592551ChainID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P195254164592551ChainID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P19525416459267538DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P19525416459267538DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P19525416459417419HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525416459417419HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525416459457461HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525416459457461HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525416459446446Modified residueNote=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11337501,ECO:0000269|PubMed:16179258;Dbxref=PMID:11337501,PMID:16179258
P19525416459446446Modified residueNote=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11337501,ECO:0000269|PubMed:16179258;Dbxref=PMID:11337501,PMID:16179258
P19525416459451451Modified residueNote=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11337501,ECO:0000269|PubMed:20685959;Dbxref=PMID:11337501,PMID:20685959
P19525416459451451Modified residueNote=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11337501,ECO:0000269|PubMed:20685959;Dbxref=PMID:11337501,PMID:20685959
P19525416459456456Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
P19525416459456456Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
P19525416459446446MutagenesisNote=Significant loss of activity and impairs autophosphorylation of T-451. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
P19525416459446446MutagenesisNote=Significant loss of activity and impairs autophosphorylation of T-451. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
P19525416459451451MutagenesisNote=Loss of activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
P19525416459451451MutagenesisNote=Loss of activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
P19525416459428428Natural variantID=VAR_040474;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56219559,PMID:17344846
P19525416459428428Natural variantID=VAR_040474;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56219559,PMID:17344846
P19525416459439439Natural variantID=VAR_040475;Note=In a lung adenocarcinoma sample%3B somatic mutation. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
P19525416459439439Natural variantID=VAR_040475;Note=In a lung adenocarcinoma sample%3B somatic mutation. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
P19525416459266551RegionNote=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
P19525416459266551RegionNote=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
P19525493511505507Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UIU
P19525493511505507Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UIU
P195254935112551ChainID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P195254935112551ChainID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P19525493511267538DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P19525493511267538DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P19525493511488499HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525493511488499HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525493511509518HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525493511509518HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
P19525493511506506Natural variantID=VAR_040476;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34821155,PMID:17344846
P19525493511506506Natural variantID=VAR_040476;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34821155,PMID:17344846
P19525493511266551RegionNote=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
P19525493511266551RegionNote=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867


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SNVs in the skipped exons for EIF2AK2

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-DD-A1EG-01exon_skip_338302
37334617373346703733462037334620Frame_Shift_DelT-p.K510fs
SKCMTCGA-EE-A3JI-06exon_skip_338302
37334617373346703733463637334637Frame_Shift_DelTC-p.505_505del
SKCMTCGA-EE-A3JI-06exon_skip_338302
37334617373346703733463637334637Frame_Shift_DelTC-p.D505fs
COADTCGA-CM-6171-01exon_skip_338302
37334617373346703733466637334666Frame_Shift_DelA-p.F495fs
LIHCTCGA-DD-A1EG-01exon_skip_338309
37349649373498073734965837349658Frame_Shift_DelT-p.N353fs
LIHCTCGA-DD-A1EG-01exon_skip_338312
37353432373535543735353937353539Frame_Shift_DelA-p.F267fs
LIHCTCGA-DD-A1EG-01exon_skip_338316
37365652373657283736569937365699Frame_Shift_DelA-p.F182fs
UCECTCGA-D1-A17Q-01exon_skip_338302
37334617373346703733461937334619Nonsense_MutationCAp.E511*
LUADTCGA-49-4488-01exon_skip_338309
37349649373498073734965237349652Nonsense_MutationGCp.S355*
LUADTCGA-50-7109-01exon_skip_338309
37349649373498073734980037349800Nonsense_MutationCAp.E306*
LUADTCGA-50-7109-01exon_skip_338309
37349649373498073734980037349801Nonsense_MutationCCAAp.E306*

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
RT4_URINARY_TRACT37362627373626893736263637362636Frame_Shift_DelA-p.V259fs
NCIH1437_LUNG37341874373420023734193637341936Missense_MutationGCp.L439V
CA922_UPPER_AERODIGESTIVE_TRACT37341874373420023734196437341964Missense_MutationCAp.K429N
LB373EBV_MATCHED_NORMAL_TISSUE37341874373420023734196837341968Missense_MutationATp.V428E
LB373MELD_SKIN37341874373420023734196837341968Missense_MutationATp.V428E
SNU1040_LARGE_INTESTINE37353432373535543735345037353450Missense_MutationCTp.R297H
HT115_LARGE_INTESTINE37353432373535543735346737353467Missense_MutationCAp.K291N
NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE37353432373535543735351737353517Missense_MutationATp.S275T
CCK81_LARGE_INTESTINE37362627373626893736263637362636Missense_MutationAGp.V259A
SW1088_CENTRAL_NERVOUS_SYSTEM37365652373657283736568637365686Missense_MutationCTp.E187K
HCC1438_LUNG37365652373657283736571237365712Missense_MutationGAp.S178F
JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE37365652373657283736571937365719Missense_MutationAGp.Y176H
JHUEM7_ENDOMETRIUM37353432373535543735352937353529Nonsense_MutationCAp.E271*
JHUEM7_ENDOMETRIUM37353432373535543735353537353535Nonsense_MutationCAp.E269*
SNU1040_LARGE_INTESTINE37353432373535543735343337353433Splice_SiteCTp.E303K

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for EIF2AK2

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value
exon_skip_338320237374830:37374965:37375999:37376400:37384050:3738417537375999:37376400ENST00000395127.2CESCrs2307466chr2:37376314C/G2.46e-04
exon_skip_338320237374830:37374965:37375999:37376400:37384050:3738417537375999:37376400ENST00000395127.2BLCArs2254958chr2:37376291A/G8.19e-10
exon_skip_338320237374830:37374965:37375999:37376400:37384050:3738417537375999:37376400ENST00000395127.2BLCArs2307466chr2:37376314C/G5.22e-05
exon_skip_338320237374830:37374965:37375999:37376400:37384050:3738417537375999:37376400ENST00000395127.2ESCArs2254958chr2:37376291A/G7.19e-08
exon_skip_338320237374830:37374965:37375999:37376400:37384050:3738417537375999:37376400ENST00000395127.2HNSCrs2307466chr2:37376314C/G9.09e-16
exon_skip_338320237374830:37374965:37375999:37376400:37384050:3738417537375999:37376400ENST00000395127.2HNSCrs2254958chr2:37376291A/G3.92e-10
exon_skip_338320237374830:37374965:37375999:37376400:37384050:3738417537375999:37376400ENST00000395127.2BRCArs2307466chr2:37376314C/G5.54e-11
exon_skip_338320237374830:37374965:37375999:37376400:37384050:3738417537375999:37376400ENST00000395127.2BRCArs2254958chr2:37376291A/G9.50e-07
exon_skip_338320237374830:37374965:37375999:37376400:37384050:3738417537375999:37376400ENST00000395127.2LGGrs2307466chr2:37376314C/G2.11e-06
exon_skip_338320237374830:37374965:37375999:37376400:37384050:3738417537375999:37376400ENST00000395127.2LGGrs2254958chr2:37376291A/G1.06e-03
exon_skip_338320237374830:37374965:37375999:37376400:37384050:3738417537375999:37376400ENST00000395127.2KIRCrs2307466chr2:37376314C/G1.52e-07
exon_skip_338320237374830:37374965:37375999:37376400:37384050:3738417537375999:37376400ENST00000395127.2LUADrs2254958chr2:37376291A/G2.97e-07
exon_skip_338320237374830:37374965:37375999:37376400:37384050:3738417537375999:37376400ENST00000395127.2LUSCrs2254958chr2:37376291A/G1.98e-12
exon_skip_338320237374830:37374965:37375999:37376400:37384050:3738417537375999:37376400ENST00000395127.2LUSCrs2307466chr2:37376314C/G2.16e-12
exon_skip_338320237374830:37374965:37375999:37376400:37384050:3738417537375999:37376400ENST00000395127.2PRADrs2254958chr2:37376291A/G8.68e-07
exon_skip_338320237374830:37374965:37375999:37376400:37384050:3738417537375999:37376400ENST00000395127.2TGCTrs2307466chr2:37376314C/G1.97e-04
exon_skip_338320237374830:37374965:37375999:37376400:37384050:3738417537375999:37376400ENST00000395127.2STADrs2307466chr2:37376314C/G1.81e-14
exon_skip_338320237374830:37374965:37375999:37376400:37384050:3738417537375999:37376400ENST00000395127.2STADrs2254958chr2:37376291A/G8.50e-10
exon_skip_338320237374830:37374965:37375999:37376400:37384050:3738417537375999:37376400ENST00000395127.2THCArs2307466chr2:37376314C/G1.04e-04

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for EIF2AK2


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for EIF2AK2


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RelatedDrugs for EIF2AK2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
P19525DB12010FostamatinibInterferon-induced, double-stranded RNA-activated protein kinasesmall moleculeapproved|investigational

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RelatedDiseases for EIF2AK2

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
EIF2AK2C0021400Influenza1CTD_human
EIF2AK2C0033578Prostatic Neoplasms1CTD_human
EIF2AK2C0038220Status Epilepticus1CTD_human