ExonSkipDB: functional annotation of exon skipping event in human

Gene summary for MAP2K3

Gene summary

Gene information	Gene symbol	MAP2K3
	Gene ID	5606
	Gene name	mitogen-activated protein kinase kinase 3
	Synonyms	MAPKK3\|MEK3\|MKK3\|PRKMK3\|SAPKK-2\|SAPKK2
	Cytomap	17p11.2
	Type of gene	protein-coding
	Description	dual specificity mitogen-activated protein kinase kinase 3MAP kinase kinase 3MAPK/ERK kinase 3MAPKK 3MEK 3SAPK kinase 2stress-activated protein kinase kinase 2
	Modification date	20180523
	UniProtAcc	P46734
	Context	PubMed: MAP2K3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
MAP2K3	GO:0045860	positive regulation of protein kinase activity	11980910
MAP2K3	GO:0045893	positive regulation of transcription, DNA-templated	11980910

Top

Exon skipping events across known transcript of Ensembl for MAP2K3 from UCSC genome browser

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Gene isoform structures and expression levels for MAP2K3

Expression levels of gene isoforms across TCGA.

Expression levels of gene isoforms across GTEx.

Top

Exon skipping events with PSIs in TCGA for MAP2K3

Information of exkip skipping event in TCGA.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_150075	17	21188021:21188281:21191302:21191403:21198986:21199081	21191302:21191403	ENSG00000034152.14	ENST00000529517.1
exon_skip_150078	17	21188133:21188281:21198986:21199081:21199397:21199455	21198986:21199081	ENSG00000034152.14	ENST00000483928.2
exon_skip_150079	17	21188133:21188281:21198986:21199081:21201724:21201756	21198986:21199081	ENSG00000034152.14	ENST00000479129.1
exon_skip_150081	17	21188133:21188281:21201724:21201791:21202189:21202238	21201724:21201791	ENSG00000034152.14	ENST00000342679.4,ENST00000496046.1,ENST00000583508.1
exon_skip_150088	17	21191357:21191403:21199397:21199522:21201724:21201756	21199397:21199522	ENSG00000034152.14	ENST00000316920.6
exon_skip_150092	17	21198986:21199081:21199397:21199522:21201724:21201756	21199397:21199522	ENSG00000034152.14	ENST00000483928.2
exon_skip_150093	17	21202189:21202238:21203782:21203970:21204185:21204229	21203782:21203970	ENSG00000034152.14	ENST00000583508.1
exon_skip_150094	17	21202189:21202238:21203856:21203970:21204185:21204229	21203856:21203970	ENSG00000034152.14	ENST00000526076.2,ENST00000395491.2,ENST00000342679.4,ENST00000496046.1,ENST00000316920.6,ENST00000361818.5
exon_skip_150096	17	21203856:21203970:21204185:21204305:21205454:21205571	21204185:21204305	ENSG00000034152.14	ENST00000526076.2,ENST00000395491.2,ENST00000342679.4,ENST00000496046.1,ENST00000316920.6,ENST00000361818.5
exon_skip_150102	17	21205454:21205571:21206494:21206546:21207737:21207865	21206494:21206546	ENSG00000034152.14	ENST00000395491.2,ENST00000342679.4,ENST00000316920.6,ENST00000361818.5
exon_skip_150105	17	21207737:21207865:21208362:21208440:21215453:21215593	21208362:21208440	ENSG00000034152.14	ENST00000395491.2,ENST00000342679.4,ENST00000496046.1,ENST00000316920.6,ENST00000361818.5
exon_skip_150106	17	21208362:21208440:21215453:21215593:21216803:21216849	21215453:21215593	ENSG00000034152.14	ENST00000395491.2,ENST00000342679.4,ENST00000496046.1,ENST00000316920.6,ENST00000361818.5

PSI values of skipped exons in TCGA.

Top

Exon skipping events with PSIs in GTEx for MAP2K3

Information of exkip skipping event in GTEx

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_150075	17	21188021:21188281:21191302:21191403:21198986:21199081	21191302:21191403	ENSG00000034152.14	ENST00000529517.1
exon_skip_150078	17	21188133:21188281:21198986:21199081:21199397:21199455	21198986:21199081	ENSG00000034152.14	ENST00000483928.2
exon_skip_150079	17	21188133:21188281:21198986:21199081:21201724:21201756	21198986:21199081	ENSG00000034152.14	ENST00000479129.1
exon_skip_150081	17	21188133:21188281:21201724:21201791:21202189:21202238	21201724:21201791	ENSG00000034152.14	ENST00000342679.4,ENST00000583508.1,ENST00000496046.1
exon_skip_150086	17	21191357:21191403:21198986:21199081:21199397:21199455	21198986:21199081	ENSG00000034152.14	ENST00000529517.1
exon_skip_150088	17	21191357:21191403:21199397:21199522:21201724:21201756	21199397:21199522	ENSG00000034152.14	ENST00000316920.6
exon_skip_150092	17	21198986:21199081:21199397:21199522:21201724:21201756	21199397:21199522	ENSG00000034152.14	ENST00000483928.2
exon_skip_150093	17	21202189:21202238:21203782:21203970:21204185:21204229	21203782:21203970	ENSG00000034152.14	ENST00000583508.1
exon_skip_150094	17	21202189:21202238:21203856:21203970:21204185:21204229	21203856:21203970	ENSG00000034152.14	ENST00000395491.2,ENST00000342679.4,ENST00000496046.1,ENST00000526076.2,ENST00000361818.5,ENST00000316920.6
exon_skip_150096	17	21203856:21203970:21204185:21204305:21205454:21205571	21204185:21204305	ENSG00000034152.14	ENST00000395491.2,ENST00000342679.4,ENST00000496046.1,ENST00000526076.2,ENST00000361818.5,ENST00000316920.6
exon_skip_150102	17	21205454:21205571:21206494:21206546:21207737:21207865	21206494:21206546	ENSG00000034152.14	ENST00000395491.2,ENST00000342679.4,ENST00000361818.5,ENST00000316920.6
exon_skip_150105	17	21207737:21207865:21208362:21208440:21215453:21215593	21208362:21208440	ENSG00000034152.14	ENST00000395491.2,ENST00000342679.4,ENST00000496046.1,ENST00000361818.5,ENST00000316920.6
exon_skip_150106	17	21208362:21208440:21215453:21215593:21216803:21216849	21215453:21215593	ENSG00000034152.14	ENST00000395491.2,ENST00000342679.4,ENST00000496046.1,ENST00000361818.5,ENST00000316920.6

PSI values of skipped exons in GTEx.

* Skipped exon sequences.

Top

Open reading frame (ORF) annotation in the exon skipping event for MAP2K3

Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000342679	21201724	21201791	Frame-shift
ENST00000342679	21206494	21206546	Frame-shift
ENST00000342679	21215453	21215593	Frame-shift
ENST00000342679	21203856	21203970	In-frame
ENST00000342679	21204185	21204305	In-frame
ENST00000342679	21208362	21208440	In-frame

Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000342679	21201724	21201791	Frame-shift
ENST00000342679	21206494	21206546	Frame-shift
ENST00000342679	21215453	21215593	Frame-shift
ENST00000342679	21203856	21203970	In-frame
ENST00000342679	21204185	21204305	In-frame
ENST00000342679	21208362	21208440	In-frame

Top

Infer the effects of exon skipping event on protein functional features for MAP2K3

Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.

Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000342679	2320	347	21203856	21203970	415	528	55	93
ENST00000342679	2320	347	21204185	21204305	529	648	93	133
ENST00000342679	2320	347	21208362	21208440	946	1023	232	258

Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000342679	2320	347	21203856	21203970	415	528	55	93
ENST00000342679	2320	347	21204185	21204305	529	648	93	133
ENST00000342679	2320	347	21208362	21208440	946	1023	232	258

Lost protein functional features of individual exon skipping events in TCGA.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P46734	55	93	93	93	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P46734	55	93	1	347	Chain	ID=PRO_0000086378;Note=Dual specificity mitogen-activated protein kinase kinase 3
P46734	55	93	64	325	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P46734	55	93	55	55	Natural variant	ID=VAR_061742;Note=R->T;Dbxref=dbSNP:rs36047035
P46734	55	93	68	68	Natural variant	ID=VAR_046063;Note=S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs34105301,PMID:17344846
P46734	55	93	84	84	Natural variant	ID=VAR_046064;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs2305873,PMID:17344846
P46734	55	93	90	90	Natural variant	ID=VAR_046065;Note=M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs36076766,PMID:17344846
P46734	55	93	70	78	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P46734	93	133	93	93	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P46734	93	133	1	347	Chain	ID=PRO_0000086378;Note=Dual specificity mitogen-activated protein kinase kinase 3
P46734	93	133	64	325	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P46734	93	133	94	94	Natural variant	ID=VAR_046066;Note=R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs56067280,PMID:17344846
P46734	93	133	96	96	Natural variant	ID=VAR_046067;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs56216806,PMID:17344846
P46734	232	258	1	347	Chain	ID=PRO_0000086378;Note=Dual specificity mitogen-activated protein kinase kinase 3
P46734	232	258	64	325	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159

Lost protein functional features of individual exon skipping events in GTEx.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P46734	55	93	93	93	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P46734	55	93	1	347	Chain	ID=PRO_0000086378;Note=Dual specificity mitogen-activated protein kinase kinase 3
P46734	55	93	64	325	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P46734	55	93	55	55	Natural variant	ID=VAR_061742;Note=R->T;Dbxref=dbSNP:rs36047035
P46734	55	93	68	68	Natural variant	ID=VAR_046063;Note=S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs34105301,PMID:17344846
P46734	55	93	84	84	Natural variant	ID=VAR_046064;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs2305873,PMID:17344846
P46734	55	93	90	90	Natural variant	ID=VAR_046065;Note=M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs36076766,PMID:17344846
P46734	55	93	70	78	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P46734	93	133	93	93	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P46734	93	133	1	347	Chain	ID=PRO_0000086378;Note=Dual specificity mitogen-activated protein kinase kinase 3
P46734	93	133	64	325	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P46734	93	133	94	94	Natural variant	ID=VAR_046066;Note=R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs56067280,PMID:17344846
P46734	93	133	96	96	Natural variant	ID=VAR_046067;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs56216806,PMID:17344846
P46734	232	258	1	347	Chain	ID=PRO_0000086378;Note=Dual specificity mitogen-activated protein kinase kinase 3
P46734	232	258	64	325	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159

Top

SNVs in the skipped exons for MAP2K3

- Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.

- Differential PSIs between mutated versus non-mutated samples.

- Non-synonymous mutations located in the skipped exons in TCGA.

Cancer type	Sample	ESID	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
KIRP	TCGA-2Z-A9JP-01	exon_skip_150093	21203783	21203970	21203904	21203904	Frame_Shift_Del	C	-	p.G71fs
KIRP	TCGA-2Z-A9JP-01	exon_skip_150094	21203857	21203970	21203904	21203904	Frame_Shift_Del	C	-	p.G71fs
LUAD	TCGA-50-5936-01	exon_skip_150096	21204186	21204305	21204251	21204251	Frame_Shift_Del	G	-	p.M115fs
LIHC	TCGA-DD-A39Y-01	exon_skip_150096	21204186	21204305	21204266	21204266	Frame_Shift_Del	T	-	p.C120fs
LIHC	TCGA-G3-A3CJ-01	exon_skip_150106	21215454	21215593	21215497	21215497	Frame_Shift_Del	C	-	p.T273fs
LIHC	TCGA-BC-A112-01	exon_skip_150106	21215454	21215593	21215501	21215502	Frame_Shift_Ins	-	T	p.P275fs
LIHC	TCGA-DD-AAE7-01	exon_skip_150093	21203783	21203970	21203863	21203863	Nonsense_Mutation	G	T	p.E58X
LIHC	TCGA-DD-AAE7-01	exon_skip_150094	21203857	21203970	21203863	21203863	Nonsense_Mutation	G	T	p.E58X
HNSC	TCGA-BA-4076-01	exon_skip_150096	21204186	21204305	21204272	21204272	Nonsense_Mutation	C	G	p.Y122*
LUSC	TCGA-21-5787-01	exon_skip_150096	21204186	21204305	21204287	21204287	Nonsense_Mutation	C	G	p.Y127*
GBM	TCGA-76-6280-01	exon_skip_150081	21201725	21201791	21201792	21201792	Splice_Site	G	A	p.T39_splice
LUAD	TCGA-69-7980-01	exon_skip_150081	21201725	21201791	21201792	21201792	Splice_Site	G	C	p.T39_splice
UVM	TCGA-YZ-A985-01	exon_skip_150081	21201725	21201791	21201792	21201792	Splice_Site	G	A	.

- Depth of coverage in the three exons composing exon skipping event

Depth of coverage in three exons	Mutation description
	Sample: TCGA-DD-AAE7-01
	Cancer type: LIHC
	ESID: exon_skip_150094
	Skipped exon start: 21203857
	Skipped exon end: 21203970
	Mutation start: 21203863
	Mutation end: 21203863
	Mutation type: Nonsense_Mutation
	Reference seq: G
	Mutation seq: T
	AAchange: p.E58X
	Sample: TCGA-DD-AAE7-01
	Cancer type: LIHC
	ESID: exon_skip_150093
	Skipped exon start: 21203783
	Skipped exon end: 21203970
	Mutation start: 21203863
	Mutation end: 21203863
	Mutation type: Nonsense_Mutation
	Reference seq: G
	Mutation seq: T
	AAchange: p.E58X
exon_skip_150093_LIHC_TCGA-DD-AAE7-01.png
	Sample: TCGA-2Z-A9JP-01
	Cancer type: KIRP
	ESID: exon_skip_150094
	Skipped exon start: 21203857
	Skipped exon end: 21203970
	Mutation start: 21203904
	Mutation end: 21203904
	Mutation type: Frame_Shift_Del
	Reference seq: C
	Mutation seq: -
	AAchange: p.G71fs
	Sample: TCGA-2Z-A9JP-01
	Cancer type: KIRP
	ESID: exon_skip_150093
	Skipped exon start: 21203783
	Skipped exon end: 21203970
	Mutation start: 21203904
	Mutation end: 21203904
	Mutation type: Frame_Shift_Del
	Reference seq: C
	Mutation seq: -
	AAchange: p.G71fs
exon_skip_150093_KIRP_TCGA-2Z-A9JP-01.png

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
HEC1A_ENDOMETRIUM	21201725	21201791	21201728	21201728	Missense_Mutation	A	C	p.K18T
HEC1_ENDOMETRIUM	21201725	21201791	21201728	21201728	Missense_Mutation	A	C	p.K18T
HEC1B_ENDOMETRIUM	21201725	21201791	21201728	21201728	Missense_Mutation	A	C	p.K18T
NCIH1385_LUNG	21201725	21201791	21201737	21201737	Missense_Mutation	G	A	p.R21K
NCIH727_LUNG	21201725	21201791	21201773	21201773	Missense_Mutation	C	A	p.P33Q
ISHIKAWAHERAKLIO02ER_ENDOMETRIUM	21201725	21201791	21201782	21201782	Missense_Mutation	C	T	p.P36L
HEC6_ENDOMETRIUM	21203857	21203970	21203873	21203873	Missense_Mutation	C	T	p.A61V
HEC6_ENDOMETRIUM	21203783	21203970	21203873	21203873	Missense_Mutation	C	T	p.A61V
HEC251_ENDOMETRIUM	21203857	21203970	21203928	21203928	Missense_Mutation	G	T	p.E79D
HEC251_ENDOMETRIUM	21203783	21203970	21203928	21203928	Missense_Mutation	G	T	p.E79D
REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	21203857	21203970	21203933	21203933	Missense_Mutation	T	G	p.V81G
REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	21203783	21203970	21203933	21203933	Missense_Mutation	T	G	p.V81G
SNU175_LARGE_INTESTINE	21203857	21203970	21203935	21203935	Missense_Mutation	C	T	p.R82W
SNU175_LARGE_INTESTINE	21203783	21203970	21203935	21203935	Missense_Mutation	C	T	p.R82W
MOLT16_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	21203857	21203970	21203965	21203965	Missense_Mutation	G	A	p.V92M
MOLT16_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	21203783	21203970	21203965	21203965	Missense_Mutation	G	A	p.V92M
NCIH2030_LUNG	21204186	21204305	21204237	21204237	Missense_Mutation	C	A	p.L111M
RL952_ENDOMETRIUM	21204186	21204305	21204258	21204258	Missense_Mutation	G	A	p.V118I
HT115_LARGE_INTESTINE	21206495	21206546	21206501	21206501	Missense_Mutation	C	T	p.R175W
SW48_LARGE_INTESTINE	21206495	21206546	21206501	21206501	Missense_Mutation	C	T	p.R175W
SNU1040_LARGE_INTESTINE	21206495	21206546	21206501	21206501	Missense_Mutation	C	T	p.R175W
HOS_BONE	21206495	21206546	21206527	21206527	Missense_Mutation	G	T	p.K183N
HTK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	21206495	21206546	21206527	21206527	Missense_Mutation	G	T	p.K183N
NCIH1944_LUNG	21206495	21206546	21206531	21206531	Missense_Mutation	T	C	p.S185P
HCC1569_BREAST	21208363	21208440	21208373	21208373	Missense_Mutation	T	A	p.I236N
EGI1_BILIARY_TRACT	21208363	21208440	21208378	21208378	Missense_Mutation	C	T	p.P238S
NCIH2342_LUNG	21208363	21208440	21208379	21208379	Missense_Mutation	C	A	p.P238Q
DV90_LUNG	21208363	21208440	21208385	21208385	Missense_Mutation	T	A	p.L240Q
SNU175_LARGE_INTESTINE	21208363	21208440	21208395	21208395	Missense_Mutation	G	T	p.K243N
SNU175_LARGE_INTESTINE	21215454	21215593	21215472	21215472	Missense_Mutation	C	T	p.R265W
HCC1569_BREAST	21215454	21215593	21215475	21215475	Missense_Mutation	T	C	p.F266L
DJM1_SKIN	21215454	21215593	21215484	21215484	Missense_Mutation	G	A	p.E269K
FTC133_THYROID	21215454	21215593	21215500	21215500	Missense_Mutation	C	T	p.P274L
NCIH647_LUNG	21215454	21215593	21215503	21215503	Missense_Mutation	T	C	p.F275S
COLO668_LUNG	21215454	21215593	21215518	21215518	Missense_Mutation	A	T	p.Q280L
EMCBAC1_LUNG	21201725	21201791	21201739	21201739	Nonsense_Mutation	A	T	p.K22*
NCIH2077_LUNG	21203857	21203970	21203857	21203857	Splice_Site	A	G	p.N56D
NCIH2077_LUNG	21203783	21203970	21203857	21203857	Splice_Site	A	G	p.N56D
SW48_LARGE_INTESTINE	21208363	21208440	21208364	21208364	Splice_Site	C	A	p.P233H

Top

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAP2K3

sQTL information located at the skipped exons.

Exon skip ID	Chromosome	Three exons	Skippped exon	ENST	Cancer type	SNP id	Location	DNA change (ref/var)	P-value
exon_skip_150096	17	21203856:21203970:21204185:21204305:21205454:21205571	21204185:21204305	ENST00000526076.2,ENST00000395491.2,ENST00000342679.4,ENST00000496046.1,ENST00000316920.6,ENST00000361818.5	CESC	rs2230435	chr17:21204266	T/C	3.39e-05
exon_skip_150096	17	21203856:21203970:21204185:21204305:21205454:21205571	21204185:21204305	ENST00000526076.2,ENST00000395491.2,ENST00000342679.4,ENST00000496046.1,ENST00000316920.6,ENST00000361818.5	CESC	rs2230435	chr17:21204266	T/C	1.65e-04
exon_skip_150096	17	21203856:21203970:21204185:21204305:21205454:21205571	21204185:21204305	ENST00000526076.2,ENST00000395491.2,ENST00000342679.4,ENST00000496046.1,ENST00000316920.6,ENST00000361818.5	HNSC	rs2230435	chr17:21204266	T/C	1.17e-06
exon_skip_150096	17	21203856:21203970:21204185:21204305:21205454:21205571	21204185:21204305	ENST00000526076.2,ENST00000395491.2,ENST00000342679.4,ENST00000496046.1,ENST00000316920.6,ENST00000361818.5	HNSC	rs2230435	chr17:21204266	T/C	5.80e-05
exon_skip_150096	17	21203856:21203970:21204185:21204305:21205454:21205571	21204185:21204305	ENST00000526076.2,ENST00000395491.2,ENST00000342679.4,ENST00000496046.1,ENST00000316920.6,ENST00000361818.5	LAML	rs2230435	chr17:21204266	T/C	9.20e-09
exon_skip_150096	17	21203856:21203970:21204185:21204305:21205454:21205571	21204185:21204305	ENST00000526076.2,ENST00000395491.2,ENST00000342679.4,ENST00000496046.1,ENST00000316920.6,ENST00000361818.5	KIRP	rs2230435	chr17:21204266	T/C	5.11e-05
exon_skip_150096	17	21203856:21203970:21204185:21204305:21205454:21205571	21204185:21204305	ENST00000526076.2,ENST00000395491.2,ENST00000342679.4,ENST00000496046.1,ENST00000316920.6,ENST00000361818.5	LGG	rs2230435	chr17:21204266	T/C	6.53e-04
exon_skip_150096	17	21203856:21203970:21204185:21204305:21205454:21205571	21204185:21204305	ENST00000526076.2,ENST00000395491.2,ENST00000342679.4,ENST00000496046.1,ENST00000316920.6,ENST00000361818.5	KIRC	rs2230435	chr17:21204266	T/C	6.32e-13
exon_skip_150096	17	21203856:21203970:21204185:21204305:21205454:21205571	21204185:21204305	ENST00000526076.2,ENST00000395491.2,ENST00000342679.4,ENST00000496046.1,ENST00000316920.6,ENST00000361818.5	KIRC	rs2230435	chr17:21204266	T/C	2.16e-04
exon_skip_150096	17	21203856:21203970:21204185:21204305:21205454:21205571	21204185:21204305	ENST00000526076.2,ENST00000395491.2,ENST00000342679.4,ENST00000496046.1,ENST00000316920.6,ENST00000361818.5	LUAD	rs2230435	chr17:21204266	T/C	1.52e-17
exon_skip_150096	17	21203856:21203970:21204185:21204305:21205454:21205571	21204185:21204305	ENST00000526076.2,ENST00000395491.2,ENST00000342679.4,ENST00000496046.1,ENST00000316920.6,ENST00000361818.5	LUAD	rs2230435	chr17:21204266	T/C	1.20e-04
exon_skip_150096	17	21203856:21203970:21204185:21204305:21205454:21205571	21204185:21204305	ENST00000526076.2,ENST00000395491.2,ENST00000342679.4,ENST00000496046.1,ENST00000316920.6,ENST00000361818.5	PRAD	rs2230435	chr17:21204266	T/C	6.85e-12
exon_skip_150096	17	21203856:21203970:21204185:21204305:21205454:21205571	21204185:21204305	ENST00000526076.2,ENST00000395491.2,ENST00000342679.4,ENST00000496046.1,ENST00000316920.6,ENST00000361818.5	PRAD	rs2230435	chr17:21204266	T/C	2.22e-05
exon_skip_150096	17	21203856:21203970:21204185:21204305:21205454:21205571	21204185:21204305	ENST00000526076.2,ENST00000395491.2,ENST00000342679.4,ENST00000496046.1,ENST00000316920.6,ENST00000361818.5	THCA	rs2230435	chr17:21204266	T/C	5.44e-09
exon_skip_150096	17	21203856:21203970:21204185:21204305:21205454:21205571	21204185:21204305	ENST00000526076.2,ENST00000395491.2,ENST00000342679.4,ENST00000496046.1,ENST00000316920.6,ENST00000361818.5	THCA	rs2230435	chr17:21204266	T/C	7.98e-06
exon_skip_150096	17	21203856:21203970:21204185:21204305:21205454:21205571	21204185:21204305	ENST00000526076.2,ENST00000395491.2,ENST00000342679.4,ENST00000496046.1,ENST00000316920.6,ENST00000361818.5	THCA	rs2230435	chr17:21204266	T/C	2.30e-04

Top

Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAP2K3

Top

Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAP2K3

Top

RelatedDrugs for MAP2K3

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
	P46734	DB12010	Fostamatinib	Dual specificity mitogen-activated protein kinase kinase 3	small molecule	approved\|investigational

Top

RelatedDiseases for MAP2K3

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in TCGA
	Exon skipping events with PSIs in GTEx
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	SNVs in the skipped exons with depth of coverage
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Splicing Quantitative Trait Methylation (sQTM) in the skipped exon
	Related drugs with this gene
	Related diseases with this gene

Home

Download

Statistics

Landscape

Help

Contact