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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for MAPK6 |
 Gene summary |
| Gene information | Gene symbol | MAPK6 | Gene ID | 5597 |
| Gene name | mitogen-activated protein kinase 6 | |
| Synonyms | ERK3|HsT17250|PRKM6|p97MAPK | |
| Cytomap | 15q21.2 | |
| Type of gene | protein-coding | |
| Description | mitogen-activated protein kinase 6ERK-3MAP kinase 6MAP kinase isoform p97MAPK 6extracellular signal-regulated kinase 3extracellular signal-regulated kinase, p97p97-MAPKprotein kinase, mitogen-activated 5protein kinase, mitogen-activated 6 | |
| Modification date | 20180523 | |
| UniProtAcc | Q16659 | |
| Context | PubMed: MAPK6 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for MAPK6 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for MAPK6 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for MAPK6 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_122176 | 15 | 52296376:52296599:52334950:52335030:52338026:52338250 | 52334950:52335030 | ENSG00000069956.7 | ENST00000558063.1 |
| exon_skip_122181 | 15 | 52311434:52311573:52334950:52335030:52338026:52338250 | 52334950:52335030 | ENSG00000069956.7 | ENST00000558100.1 |
| exon_skip_122184 | 15 | 52311434:52311573:52338026:52339212:52342189:52342334 | 52338026:52339212 | ENSG00000069956.7 | ENST00000261845.5 |
| exon_skip_122201 | 15 | 52316777:52316892:52319835:52320070:52338026:52338250 | 52319835:52320070 | ENSG00000069956.7 | ENST00000560774.1 |
| exon_skip_122205 | 15 | 52338026:52339212:52342189:52342334:52350829:52350994 | 52342189:52342334 | ENSG00000069956.7 | ENST00000261845.5 |
| exon_skip_122206 | 15 | 52342189:52342334:52350829:52350994:52353495:52353697 | 52350829:52350994 | ENSG00000069956.7 | ENST00000261845.5 |
| exon_skip_122207 | 15 | 52350829:52350994:52353495:52353697:52356098:52358462 | 52353495:52353697 | ENSG00000069956.7 | ENST00000261845.5 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for MAPK6 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_122176 | 15 | 52296376:52296599:52334950:52335030:52338026:52338250 | 52334950:52335030 | ENSG00000069956.7 | ENST00000558063.1 |
| exon_skip_122181 | 15 | 52311434:52311573:52334950:52335030:52338026:52338250 | 52334950:52335030 | ENSG00000069956.7 | ENST00000558100.1 |
| exon_skip_122184 | 15 | 52311434:52311573:52338026:52339212:52342189:52342334 | 52338026:52339212 | ENSG00000069956.7 | ENST00000261845.5 |
| exon_skip_122201 | 15 | 52316777:52316892:52319835:52320070:52338026:52338250 | 52319835:52320070 | ENSG00000069956.7 | ENST00000560774.1 |
| exon_skip_122205 | 15 | 52338026:52339212:52342189:52342334:52350829:52350994 | 52342189:52342334 | ENSG00000069956.7 | ENST00000261845.5 |
| exon_skip_122206 | 15 | 52342189:52342334:52350829:52350994:52353495:52353697 | 52350829:52350994 | ENSG00000069956.7 | ENST00000261845.5 |
| exon_skip_122207 | 15 | 52350829:52350994:52353495:52353697:52356098:52358462 | 52353495:52353697 | ENSG00000069956.7 | ENST00000261845.5 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for MAPK6 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000261845 | 52338026 | 52339212 | 5CDS-5UTR |
| ENST00000261845 | 52342189 | 52342334 | Frame-shift |
| ENST00000261845 | 52353495 | 52353697 | Frame-shift |
| ENST00000261845 | 52350829 | 52350994 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000261845 | 52338026 | 52339212 | 5CDS-5UTR |
| ENST00000261845 | 52342189 | 52342334 | Frame-shift |
| ENST00000261845 | 52353495 | 52353697 | Frame-shift |
| ENST00000261845 | 52350829 | 52350994 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MAPK6 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000261845 | 4255 | 721 | 52350829 | 52350994 | 1508 | 1672 | 233 | 288 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000261845 | 4255 | 721 | 52350829 | 52350994 | 1508 | 1672 | 233 | 288 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q16659 | 233 | 288 | 1 | 721 | Chain | ID=PRO_0000186257;Note=Mitogen-activated protein kinase 6 |
| Q16659 | 233 | 288 | 20 | 316 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q16659 | 233 | 288 | 237 | 247 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I6L |
| Q16659 | 233 | 288 | 253 | 260 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I6L |
| Q16659 | 233 | 288 | 265 | 270 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I6L |
| Q16659 | 233 | 288 | 278 | 281 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I6L |
| Q16659 | 233 | 288 | 287 | 294 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I6L |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q16659 | 233 | 288 | 1 | 721 | Chain | ID=PRO_0000186257;Note=Mitogen-activated protein kinase 6 |
| Q16659 | 233 | 288 | 20 | 316 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q16659 | 233 | 288 | 237 | 247 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I6L |
| Q16659 | 233 | 288 | 253 | 260 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I6L |
| Q16659 | 233 | 288 | 265 | 270 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I6L |
| Q16659 | 233 | 288 | 278 | 281 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I6L |
| Q16659 | 233 | 288 | 287 | 294 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I6L |
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SNVs in the skipped exons for MAPK6 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_122184 | 52338027 | 52339212 | 52338726 | 52338726 | Frame_Shift_Del | A | - | p.L23fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_122205 | 52342190 | 52342334 | 52342203 | 52342203 | Frame_Shift_Del | A | - | p.E190fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_122207 | 52353496 | 52353697 | 52353652 | 52353652 | Frame_Shift_Del | T | - | p.I341fs |
| HNSC | TCGA-BA-4075-01 | exon_skip_122184 | 52338027 | 52339212 | 52338753 | 52338754 | Frame_Shift_Ins | - | T | p.G33fs |
| STAD | TCGA-VQ-A8DL-01 | exon_skip_122184 | 52338027 | 52339212 | 52339019 | 52339020 | Frame_Shift_Ins | - | G | p.Q121fs |
| STAD | TCGA-VQ-A8DL-01 | exon_skip_122184 | 52338027 | 52339212 | 52339019 | 52339020 | Frame_Shift_Ins | - | G | p.R121fs |
| LUSC | TCGA-70-6722-01 | exon_skip_122207 | 52353496 | 52353697 | 52353666 | 52353666 | Nonsense_Mutation | G | T | p.E346* |
| UCEC | TCGA-D1-A17D-01 | exon_skip_122207 | 52353496 | 52353697 | 52353495 | 52353495 | Splice_Site | G | A | e4-1 |
| UCEC | TCGA-D1-A17D-01 | exon_skip_122207 | 52353496 | 52353697 | 52353495 | 52353495 | Splice_Site | G | A | p.A289_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| 42MGBA_CENTRAL_NERVOUS_SYSTEM | 52350830 | 52350994 | 52350860 | 52350860 | Frame_Shift_Del | T | - | p.I244fs |
| PCM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 52338027 | 52339212 | 52338769 | 52338769 | Missense_Mutation | G | A | p.V38I |
| SW1463_LARGE_INTESTINE | 52338027 | 52339212 | 52338793 | 52338793 | Missense_Mutation | G | T | p.V46L |
| KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 52338027 | 52339212 | 52338880 | 52338880 | Missense_Mutation | G | A | p.D75N |
| DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 52338027 | 52339212 | 52338907 | 52338907 | Missense_Mutation | C | T | p.L84F |
| CW2_LARGE_INTESTINE | 52338027 | 52339212 | 52339042 | 52339042 | Missense_Mutation | G | A | p.A129T |
| HN_UPPER_AERODIGESTIVE_TRACT | 52338027 | 52339212 | 52339069 | 52339069 | Missense_Mutation | C | G | p.R138G |
| LU135_LUNG | 52338027 | 52339212 | 52339084 | 52339084 | Missense_Mutation | A | G | p.I143V |
| MCC26_SKIN | 52338027 | 52339212 | 52339168 | 52339168 | Missense_Mutation | G | C | p.D171H |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 52342190 | 52342334 | 52342268 | 52342268 | Missense_Mutation | G | A | p.A212T |
| FARAGE_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 52342190 | 52342334 | 52342281 | 52342281 | Missense_Mutation | G | T | p.W216L |
| CORL47_LUNG | 52342190 | 52342334 | 52342295 | 52342295 | Missense_Mutation | A | G | p.I221V |
| NCIH23_LUNG | 52342190 | 52342334 | 52342307 | 52342307 | Missense_Mutation | A | T | p.M225L |
| DJM1_SKIN | 52342190 | 52342334 | 52342331 | 52342331 | Missense_Mutation | G | T | p.A233S |
| HOP62_LUNG | 52342190 | 52342334 | 52342331 | 52342331 | Missense_Mutation | G | C | p.A233P |
| NCIH1155_LUNG | 52350830 | 52350994 | 52350835 | 52350835 | Missense_Mutation | C | T | p.H236Y |
| HEC1A_ENDOMETRIUM | 52350830 | 52350994 | 52350986 | 52350986 | Missense_Mutation | G | A | p.S286N |
| ESS1_ENDOMETRIUM | 52353496 | 52353697 | 52353627 | 52353627 | Missense_Mutation | C | A | p.H333N |
| COV504_OVARY | 52353496 | 52353697 | 52353688 | 52353688 | Missense_Mutation | A | C | p.N353T |
| HCC2450_LUNG | 52338027 | 52339212 | 52338982 | 52338982 | Nonsense_Mutation | G | T | p.E109* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAPK6 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAPK6 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAPK6 |
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RelatedDrugs for MAPK6 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAPK6 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| MAPK6 | C0020507 | Hyperplasia | 1 | CTD_human |
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