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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for ACTR10

check button Gene summary
Gene informationGene symbol

ACTR10

Gene ID

55860

Gene nameactin related protein 10 homolog
SynonymsACTR11|Arp10|Arp11|HARP11
Cytomap

14q23.1

Type of geneprotein-coding
Descriptionactin-related protein 10actin-related protein 11
Modification date20180522
UniProtAcc

Q9NZ32

ContextPubMed: ACTR10 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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Exon skipping events across known transcript of Ensembl for ACTR10 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for ACTR10

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for ACTR10

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_1068281458666936:58667012:58669572:58669645:58674653:5867473658669572:58669645ENSG00000131966.9ENST00000254286.4,ENST00000554402.2,ENST00000555337.1,ENST00000555229.1,ENST00000556312.1
exon_skip_1068301458669572:58669645:58673766:58673901:58674653:5867473658673766:58673901ENSG00000131966.9ENST00000556243.1
exon_skip_1068311458669572:58669645:58674653:58674736:58675716:5867582558674653:58674736ENSG00000131966.9ENST00000254286.4,ENST00000554402.2,ENST00000555337.1,ENST00000545307.2,ENST00000555229.1,ENST00000556312.1
exon_skip_1068321458674653:58674736:58675716:58675825:58681922:5868200258675716:58675825ENSG00000131966.9ENST00000555337.1,ENST00000556748.1
exon_skip_1068351458675716:58675825:58678009:58678117:58680348:5868041658678009:58678117ENSG00000131966.9ENST00000254286.4,ENST00000554402.2
exon_skip_1068391458675716:58675825:58681922:58682002:58686411:5868644758681922:58682002ENSG00000131966.9ENST00000555337.1,ENST00000556748.1
exon_skip_1068421458680358:58680416:58681922:58682002:58686411:5868644758681922:58682002ENSG00000131966.9ENST00000254286.4,ENST00000554402.2,ENST00000556694.1,ENST00000545307.2,ENST00000555229.1,ENST00000557711.1
exon_skip_1068451458681922:58682002:58686411:58686447:58690339:5869041958686411:58686447ENSG00000131966.9ENST00000254286.4,ENST00000554402.2,ENST00000556694.1,ENST00000545307.2,ENST00000555229.1,ENST00000557711.1,ENST00000556748.1
exon_skip_1068461458681922:58682002:58686411:58686447:58697116:5869719858686411:58686447ENSG00000131966.9ENST00000555337.1
exon_skip_1068581458686411:58686447:58690339:58690419:58690500:5869054558690339:58690419ENSG00000131966.9ENST00000254286.4,ENST00000554402.2,ENST00000556694.1,ENST00000545307.2,ENST00000555229.1,ENST00000557711.1,ENST00000556748.1,ENST00000554790.1
exon_skip_1068621458686411:58686447:58690339:58690574:58697118:5869719458690339:58690574ENSG00000131966.9ENST00000557583.1
exon_skip_1068691458686411:58686447:58697116:58697198:58698783:5869882658697116:58697198ENSG00000131966.9ENST00000555337.1
exon_skip_1068721458690355:58690419:58690500:58690574:58697116:5869719858690500:58690574ENSG00000131966.9ENST00000555965.1,ENST00000254286.4,ENST00000554402.2,ENST00000545307.2,ENST00000555229.1,ENST00000557711.1,ENST00000554790.1
exon_skip_1068741458690355:58690419:58697116:58697198:58698783:5869882658697116:58697198ENSG00000131966.9ENST00000553907.1
exon_skip_1068771458690500:58690574:58697116:58697198:58698783:5869882658697116:58697198ENSG00000131966.9ENST00000555965.1,ENST00000556449.1,ENST00000254286.4,ENST00000545307.2,ENST00000555229.1,ENST00000557711.1,ENST00000554790.1
exon_skip_1068831458697116:58697198:58697797:58697871:58698783:5869882658697797:58697871ENSG00000131966.9ENST00000554402.2
exon_skip_1068861458697116:58697198:58698783:58698985:58701087:5870145258698783:58698985ENSG00000131966.9ENST00000254286.4,ENST00000545307.2,ENST00000555229.1,ENST00000557711.1,ENST00000553907.1

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for ACTR10

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_1068281458666936:58667012:58669572:58669645:58674653:5867473658669572:58669645ENSG00000131966.9ENST00000254286.4,ENST00000555229.1,ENST00000555337.1,ENST00000556312.1,ENST00000554402.2
exon_skip_1068301458669572:58669645:58673766:58673901:58674653:5867473658673766:58673901ENSG00000131966.9ENST00000556243.1
exon_skip_1068311458669572:58669645:58674653:58674736:58675716:5867582558674653:58674736ENSG00000131966.9ENST00000545307.2,ENST00000254286.4,ENST00000555229.1,ENST00000555337.1,ENST00000556312.1,ENST00000554402.2
exon_skip_1068321458674653:58674736:58675716:58675825:58681922:5868200258675716:58675825ENSG00000131966.9ENST00000555337.1,ENST00000556748.1
exon_skip_1068351458675716:58675825:58678009:58678117:58680348:5868041658678009:58678117ENSG00000131966.9ENST00000254286.4,ENST00000554402.2
exon_skip_1068391458675716:58675825:58681922:58682002:58686411:5868644758681922:58682002ENSG00000131966.9ENST00000555337.1,ENST00000556748.1
exon_skip_1068421458680358:58680416:58681922:58682002:58686411:5868644758681922:58682002ENSG00000131966.9ENST00000545307.2,ENST00000254286.4,ENST00000555229.1,ENST00000554402.2,ENST00000556694.1,ENST00000557711.1
exon_skip_1068451458681922:58682002:58686411:58686447:58690339:5869041958686411:58686447ENSG00000131966.9ENST00000545307.2,ENST00000254286.4,ENST00000555229.1,ENST00000556748.1,ENST00000554402.2,ENST00000556694.1,ENST00000557711.1
exon_skip_1068461458681922:58682002:58686411:58686447:58697116:5869719858686411:58686447ENSG00000131966.9ENST00000555337.1
exon_skip_1068581458686411:58686447:58690339:58690419:58690500:5869054558690339:58690419ENSG00000131966.9ENST00000545307.2,ENST00000254286.4,ENST00000555229.1,ENST00000556748.1,ENST00000554402.2,ENST00000556694.1,ENST00000557711.1,ENST00000554790.1
exon_skip_1068621458686411:58686447:58690339:58690574:58697118:5869719458690339:58690574ENSG00000131966.9ENST00000557583.1
exon_skip_1068691458686411:58686447:58697116:58697198:58698783:5869882658697116:58697198ENSG00000131966.9ENST00000555337.1
exon_skip_1068721458690355:58690419:58690500:58690574:58697116:5869719858690500:58690574ENSG00000131966.9ENST00000545307.2,ENST00000254286.4,ENST00000555229.1,ENST00000554402.2,ENST00000557711.1,ENST00000554790.1,ENST00000555965.1
exon_skip_1068741458690355:58690419:58697116:58697198:58698783:5869882658697116:58697198ENSG00000131966.9ENST00000553907.1
exon_skip_1068771458690500:58690574:58697116:58697198:58698783:5869882658697116:58697198ENSG00000131966.9ENST00000545307.2,ENST00000254286.4,ENST00000555229.1,ENST00000557711.1,ENST00000554790.1,ENST00000556449.1,ENST00000555965.1
exon_skip_1068831458697116:58697198:58697797:58697871:58698783:5869882658697797:58697871ENSG00000131966.9ENST00000554402.2
exon_skip_1068861458697116:58697198:58698783:58698985:58701087:5870145258698783:58698985ENSG00000131966.9ENST00000545307.2,ENST00000254286.4,ENST00000555229.1,ENST00000557711.1,ENST00000553907.1

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for ACTR10

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000002542865866957258669645Frame-shift
ENST000002542865867465358674736Frame-shift
ENST000002542865868192258682002Frame-shift
ENST000002542865869033958690419Frame-shift
ENST000002542865869050058690574Frame-shift
ENST000002542865869711658697198Frame-shift
ENST000002542865869878358698985Frame-shift
ENST000002542865867800958678117In-frame
ENST000002542865868641158686447In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000002542865866957258669645Frame-shift
ENST000002542865867465358674736Frame-shift
ENST000002542865868192258682002Frame-shift
ENST000002542865869033958690419Frame-shift
ENST000002542865869050058690574Frame-shift
ENST000002542865869711658697198Frame-shift
ENST000002542865869878358698985Frame-shift
ENST000002542865867800958678117In-frame
ENST000002542865868641158686447In-frame

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Infer the effects of exon skipping event on protein functional features for ACTR10

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000025428618324175867800958678117423530114150
ENST0000025428618324175868641158686447679714199211

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000025428618324175867800958678117423530114150
ENST0000025428618324175868641158686447679714199211

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q9NZ321141501417ChainID=PRO_0000089131;Note=Actin-related protein 10
Q9NZ321992111417ChainID=PRO_0000089131;Note=Actin-related protein 10


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q9NZ321141501417ChainID=PRO_0000089131;Note=Actin-related protein 10
Q9NZ321992111417ChainID=PRO_0000089131;Note=Actin-related protein 10


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SNVs in the skipped exons for ACTR10

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-G3-A3CJ-01exon_skip_106835
58678010586781175867811558678115Frame_Shift_DelC-p.P150fs
LIHCTCGA-DD-A39Y-01exon_skip_106845
exon_skip_106846
58686412586864475868644458686444Frame_Shift_DelA-p.K211fs
LIHCTCGA-DD-A3A0-01exon_skip_106862
58690340586905745869051358690513Frame_Shift_DelC-p.P244fs
LIHCTCGA-DD-A3A0-01exon_skip_106872
58690501586905745869051358690513Frame_Shift_DelC-p.P244fs
UCSTCGA-ND-A4WC-01exon_skip_106874
exon_skip_106877
exon_skip_106869
58697117586971985869716458697164Nonsense_MutationCAp.S279*
COADTCGA-CM-5861-01exon_skip_106886
58698784586989855869891058698910Nonsense_MutationA-p.Y332X

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
HSC39_STOMACH58669573586696455866963958669639Missense_MutationGAp.M48I
BICR18_UPPER_AERODIGESTIVE_TRACT58669573586696455866964058669640Missense_MutationCTp.P49S
BICR18_UPPER_AERODIGESTIVE_TRACT58674654586747365867466158674661Missense_MutationGAp.R53K
MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE58674654586747365867468058674680Missense_MutationCGp.I59M
AN3CA_ENDOMETRIUM58675717586758255867574358675743Missense_MutationGAp.R87H
HCC2998_LARGE_INTESTINE58675717586758255867576058675760Missense_MutationGAp.E93K
SNU81_LARGE_INTESTINE58675717586758255867576058675760Missense_MutationGAp.E93K
MFE319_ENDOMETRIUM58678010586781175867801658678016Missense_MutationTCp.S117P
JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE58678010586781175867801958678019Missense_MutationGAp.V118I
SET2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE58678010586781175867808958678089Missense_MutationGAp.C141Y
HCC827GR5_LUNG58681923586820025868197658681976Missense_MutationAGp.K191R
DU145_PROSTATE58690340586905745869038758690387Missense_MutationGAp.A228T
DU145_PROSTATE58690340586904195869038758690387Missense_MutationGAp.A228T
JHU011_UPPER_AERODIGESTIVE_TRACT58690501586905745869052058690520Missense_MutationATp.N245I
JHU011_UPPER_AERODIGESTIVE_TRACT58690340586905745869052058690520Missense_MutationATp.N245I
SNUC2B_LARGE_INTESTINE58697117586971985869712258697122Missense_MutationCTp.S265L
QIMRWIL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE58697117586971985869716658697166Missense_MutationGTp.V280F
KARPAS422_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE58697117586971985869718458697184Missense_MutationGTp.D286Y
HEC251_ENDOMETRIUM58698784586989855869893858698938Missense_MutationGAp.R342Q
SNU1040_LARGE_INTESTINE58698784586989855869893858698938Missense_MutationGAp.R342Q
SNU81_LARGE_INTESTINE58698784586989855869893858698938Missense_MutationGAp.R342Q
UMUC1_URINARY_TRACT58698784586989855869894358698943Missense_MutationCTp.H344Y
KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE58698784586989855869896458698964Missense_MutationACp.N351H
RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE58698784586989855869896858698968Missense_MutationGAp.C352Y

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ACTR10

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ACTR10


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ACTR10


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RelatedDrugs for ACTR10

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ACTR10

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource