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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ZNF415 |
 Gene summary |
| Gene information | Gene symbol | ZNF415 | Gene ID | 55786 |
| Gene name | zinc finger protein 415 | |
| Synonyms | Pact|ZfLp | |
| Cytomap | 19q13.42 | |
| Type of gene | protein-coding | |
| Description | zinc finger protein 415 | |
| Modification date | 20180523 | |
| UniProtAcc | Q09FC8 | |
| Context | PubMed: ZNF415 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for ZNF415 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ZNF415 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ZNF415 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_322084 | 19 | 53613129:53613161:53618462:53618560:53618956:53619064 | 53618462:53618560 | ENSG00000170954.7 | ENST00000448501.1,ENST00000595193.1,ENST00000455735.2,ENST00000594011.1,ENST00000599261.1 |
| exon_skip_322085 | 19 | 53613129:53613161:53618462:53618560:53619565:53619686 | 53618462:53618560 | ENSG00000170954.7 | ENST00000597748.1,ENST00000597503.1,ENST00000595813.1,ENST00000421033.1 |
| exon_skip_322087 | 19 | 53613129:53613161:53618956:53619064:53619565:53619686 | 53618956:53619064 | ENSG00000170954.7 | ENST00000440291.1 |
| exon_skip_322089 | 19 | 53613129:53613161:53618956:53619177:53619565:53619686 | 53618956:53619177 | ENSG00000170954.7 | ENST00000598578.1,ENST00000600120.1 |
| exon_skip_322090 | 19 | 53613129:53613161:53619565:53619686:53625656:53625865 | 53619565:53619686 | ENSG00000170954.7 | ENST00000500065.4 |
| exon_skip_322091 | 19 | 53613129:53613161:53619565:53619686:53625914:53625996 | 53619565:53619686 | ENSG00000170954.7 | ENST00000243643.4,ENST00000595174.1,ENST00000601110.1 |
| exon_skip_322093 | 19 | 53618462:53618560:53618956:53619064:53619565:53619686 | 53618956:53619064 | ENSG00000170954.7 | ENST00000448501.1,ENST00000595193.1,ENST00000455735.2,ENST00000594011.1,ENST00000599261.1 |
| exon_skip_322096 | 19 | 53618510:53618585:53618956:53619064:53619565:53619686 | 53618956:53619064 | ENSG00000170954.7 | ENST00000602110.1 |
| exon_skip_322098 | 19 | 53618510:53618585:53618956:53619177:53619565:53619686 | 53618956:53619177 | ENSG00000170954.7 | ENST00000598024.1 |
| exon_skip_322100 | 19 | 53625914:53625996:53626753:53626908:53636108:53636145 | 53626753:53626908 | ENSG00000170954.7 | ENST00000596683.1,ENST00000455735.2,ENST00000594011.1,ENST00000601110.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ZNF415 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_322084 | 19 | 53613129:53613161:53618462:53618560:53618956:53619064 | 53618462:53618560 | ENSG00000170954.7 | ENST00000595193.1,ENST00000594011.1,ENST00000448501.1,ENST00000455735.2,ENST00000599261.1 |
| exon_skip_322085 | 19 | 53613129:53613161:53618462:53618560:53619565:53619686 | 53618462:53618560 | ENSG00000170954.7 | ENST00000597503.1,ENST00000421033.1,ENST00000597748.1,ENST00000595813.1 |
| exon_skip_322087 | 19 | 53613129:53613161:53618956:53619064:53619565:53619686 | 53618956:53619064 | ENSG00000170954.7 | ENST00000440291.1 |
| exon_skip_322089 | 19 | 53613129:53613161:53618956:53619177:53619565:53619686 | 53618956:53619177 | ENSG00000170954.7 | ENST00000600120.1,ENST00000598578.1 |
| exon_skip_322090 | 19 | 53613129:53613161:53619565:53619686:53625656:53625865 | 53619565:53619686 | ENSG00000170954.7 | ENST00000500065.4 |
| exon_skip_322091 | 19 | 53613129:53613161:53619565:53619686:53625914:53625996 | 53619565:53619686 | ENSG00000170954.7 | ENST00000243643.4,ENST00000595174.1,ENST00000601110.1 |
| exon_skip_322093 | 19 | 53618462:53618560:53618956:53619064:53619565:53619686 | 53618956:53619064 | ENSG00000170954.7 | ENST00000595193.1,ENST00000594011.1,ENST00000448501.1,ENST00000455735.2,ENST00000599261.1 |
| exon_skip_322096 | 19 | 53618510:53618585:53618956:53619064:53619565:53619686 | 53618956:53619064 | ENSG00000170954.7 | ENST00000602110.1 |
| exon_skip_322098 | 19 | 53618510:53618585:53618956:53619177:53619565:53619686 | 53618956:53619177 | ENSG00000170954.7 | ENST00000598024.1 |
| exon_skip_322100 | 19 | 53625914:53625996:53626753:53626908:53636108:53636145 | 53626753:53626908 | ENSG00000170954.7 | ENST00000594011.1,ENST00000455735.2,ENST00000601110.1,ENST00000596683.1 |
| exon_skip_322101 | 19 | 53625914:53625996:53626753:53626961:53627045:53627159 | 53626753:53626961 | ENSG00000170954.7 | ENST00000596051.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ZNF415 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for ZNF415 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for ZNF415 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_322093 exon_skip_322096 exon_skip_322087 | 53618957 | 53619064 | 53618981 | 53618981 | Frame_Shift_Del | C | - | p.E74fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_322098 exon_skip_322089 | 53618957 | 53619177 | 53618981 | 53618981 | Frame_Shift_Del | C | - | p.E74fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_322093 exon_skip_322096 exon_skip_322087 | 53618957 | 53619064 | 53619030 | 53619030 | Frame_Shift_Del | G | - | p.P57fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_322098 exon_skip_322089 | 53618957 | 53619177 | 53619030 | 53619030 | Frame_Shift_Del | G | - | p.P57fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_322093 exon_skip_322096 exon_skip_322087 | 53618957 | 53619064 | 53619030 | 53619030 | Frame_Shift_Del | G | - | p.P57fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_322098 exon_skip_322089 | 53618957 | 53619177 | 53619030 | 53619030 | Frame_Shift_Del | G | - | p.P57fs |
| HNSC | TCGA-MZ-A7D7-01 | exon_skip_322091 exon_skip_322090 | 53619566 | 53619686 | 53619585 | 53619585 | Nonsense_Mutation | G | A | p.Q19* |
| THCA | TCGA-DJ-A3VL-01 | exon_skip_322091 exon_skip_322090 | 53619566 | 53619686 | 53619641 | 53619641 | Nonsense_Mutation | T | A | p.K21X |
| SKCM | TCGA-EE-A29V-06 | exon_skip_322091 exon_skip_322090 | 53619566 | 53619686 | 53619642 | 53619642 | Nonsense_Mutation | C | T | p.W20* |
| SKCM | TCGA-EE-A29V-06 | exon_skip_322091 exon_skip_322090 | 53619566 | 53619686 | 53619642 | 53619642 | Nonsense_Mutation | C | T | p.W20X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HEC108_ENDOMETRIUM | 53618463 | 53618560 | 53618487 | 53618487 | Missense_Mutation | C | T | p.A86T |
| NCIH2444_LUNG | 53618463 | 53618560 | 53618509 | 53618509 | Missense_Mutation | A | T | p.I99N |
| OVK18_OVARY | 53618463 | 53618560 | 53618539 | 53618539 | Missense_Mutation | G | A | p.S89F |
| SIMA_AUTONOMIC_GANGLIA | 53618463 | 53618560 | 53618548 | 53618548 | Missense_Mutation | A | G | p.M86T |
| L82_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 53618957 | 53619177 | 53619012 | 53619012 | Missense_Mutation | T | G | p.Q63H |
| L82_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 53618957 | 53619064 | 53619012 | 53619012 | Missense_Mutation | T | G | p.Q63H |
| HT115_LARGE_INTESTINE | 53618957 | 53619177 | 53619050 | 53619050 | Missense_Mutation | A | C | p.W51G |
| HT115_LARGE_INTESTINE | 53618957 | 53619064 | 53619050 | 53619050 | Missense_Mutation | A | C | p.W51G |
| OCILY3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 53619566 | 53619686 | 53619575 | 53619575 | Missense_Mutation | C | A | p.V43F |
| LNCAPCLONEFGC_PROSTATE | 53619566 | 53619686 | 53619624 | 53619624 | Missense_Mutation | T | A | p.T6S |
| D341MED_CENTRAL_NERVOUS_SYSTEM | 53619566 | 53619686 | 53619671 | 53619671 | Missense_Mutation | C | A | p.V11L |
| DMS454_LUNG | 53619566 | 53619686 | 53619671 | 53619671 | Missense_Mutation | C | A | p.V11L |
| SW1271_LUNG | 53618957 | 53619177 | 53619048 | 53619048 | Nonsense_Mutation | C | A | p.G31* |
| SW1271_LUNG | 53618957 | 53619064 | 53619048 | 53619048 | Nonsense_Mutation | C | A | p.G31* |
| NCIH510_LUNG | 53619566 | 53619686 | 53619609 | 53619609 | Nonsense_Mutation | G | A | p.Q11* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZNF415 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_322100 | 19 | 53625914:53625996:53626753:53626908:53636108:53636145 | 53626753:53626908 | ENST00000596683.1,ENST00000455735.2,ENST00000594011.1,ENST00000601110.1 | GBM | rs13344987 | chr19:53626748 | T/C | 6.39e-06 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZNF415 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZNF415 |
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RelatedDrugs for ZNF415 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF415 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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