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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for RHOT1 |
 Gene summary |
| Gene information | Gene symbol | RHOT1 | Gene ID | 55288 |
| Gene name | ras homolog family member T1 | |
| Synonyms | ARHT1|MIRO-1|MIRO1 | |
| Cytomap | 17q11.2 | |
| Type of gene | protein-coding | |
| Description | mitochondrial Rho GTPase 1mitochondrial Rho (MIRO) GTPase 1rac-GTP binding protein-like proteinras homolog gene family, member T1 | |
| Modification date | 20180527 | |
| UniProtAcc | Q8IXI2 | |
| Context | PubMed: RHOT1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for RHOT1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for RHOT1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for RHOT1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_150754 | 17 | 30469698:30469748:30498061:30498120:30500849:30500931 | 30498061:30498120 | ENSG00000126858.12 | ENST00000394692.2,ENST00000358365.3,ENST00000581031.1,ENST00000581094.1,ENST00000545287.2 |
| exon_skip_150757 | 17 | 30469698:30469748:30498065:30498120:30500849:30500931 | 30498065:30498120 | ENSG00000126858.12 | ENST00000354266.3 |
| exon_skip_150764 | 17 | 30498065:30498120:30499955:30500079:30500849:30500931 | 30499955:30500079 | ENSG00000126858.12 | ENST00000578205.1,ENST00000583994.1 |
| exon_skip_150768 | 17 | 30500849:30500931:30502337:30502381:30502980:30503034 | 30502337:30502381 | ENSG00000126858.12 | ENST00000394692.2,ENST00000358365.3,ENST00000333942.6,ENST00000581031.1,ENST00000578205.1,ENST00000583994.1,ENST00000581094.1,ENST00000545287.2,ENST00000354266.3 |
| exon_skip_150772 | 17 | 30502980:30503034:30503179:30503232:30509775:30509884 | 30503179:30503232 | ENSG00000126858.12 | ENST00000394692.2,ENST00000358365.3,ENST00000333942.6,ENST00000581031.1,ENST00000578205.1,ENST00000583994.1,ENST00000581094.1,ENST00000545287.2,ENST00000354266.3 |
| exon_skip_150773 | 17 | 30503179:30503232:30509775:30509884:30510189:30510291 | 30509775:30509884 | ENSG00000126858.12 | ENST00000394692.2,ENST00000358365.3,ENST00000333942.6,ENST00000581031.1,ENST00000578205.1,ENST00000583994.1,ENST00000581094.1,ENST00000545287.2,ENST00000354266.3 |
| exon_skip_150776 | 17 | 30527974:30528075:30529788:30529919:30530908:30530992 | 30529788:30529919 | ENSG00000126858.12 | ENST00000394692.2,ENST00000358365.3,ENST00000333942.6,ENST00000581031.1,ENST00000578205.1,ENST00000583994.1,ENST00000581094.1,ENST00000545287.2,ENST00000354266.3 |
| exon_skip_150779 | 17 | 30529788:30529919:30530908:30530992:30533928:30534048 | 30530908:30530992 | ENSG00000126858.12 | ENST00000394692.2,ENST00000358365.3,ENST00000333942.6,ENST00000581031.1,ENST00000578205.1,ENST00000583994.1,ENST00000581094.1,ENST00000545287.2,ENST00000354266.3 |
| exon_skip_150782 | 17 | 30530955:30530992:30533928:30534048:30535125:30535328 | 30533928:30534048 | ENSG00000126858.12 | ENST00000394692.2,ENST00000358365.3,ENST00000333942.6,ENST00000581031.1,ENST00000578205.1,ENST00000583994.1,ENST00000582602.1,ENST00000581094.1,ENST00000545287.2,ENST00000354266.3,ENST00000580392.1 |
| exon_skip_150783 | 17 | 30533968:30534048:30534530:30534582:30535125:30535328 | 30534530:30534582 | ENSG00000126858.12 | ENST00000584692.1 |
| exon_skip_150786 | 17 | 30535320:30535328:30536368:30536464:30538134:30538214 | 30536368:30536464 | ENSG00000126858.12 | ENST00000358365.3 |
| exon_skip_150789 | 17 | 30535320:30535328:30536368:30536464:30551634:30551979 | 30536368:30536464 | ENSG00000126858.12 | ENST00000394692.2,ENST00000583994.1 |
| exon_skip_150794 | 17 | 30535320:30535328:30538134:30538257:30551634:30551979 | 30538134:30538257 | ENSG00000126858.12 | ENST00000545287.2 |
| exon_skip_150796 | 17 | 30535320:30535328:30538134:30538257:30580103:30580393 | 30538134:30538257 | ENSG00000126858.12 | ENST00000584852.1 |
| exon_skip_150801 | 17 | 30536406:30536464:30538134:30538257:30551634:30551979 | 30538134:30538257 | ENSG00000126858.12 | ENST00000358365.3 |
| exon_skip_150808 | 17 | 30538134:30538257:30548067:30548205:30551634:30551979 | 30548067:30548205 | ENSG00000126858.12 | ENST00000581031.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for RHOT1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_150754 | 17 | 30469698:30469748:30498061:30498120:30500849:30500931 | 30498061:30498120 | ENSG00000126858.12 | ENST00000358365.3,ENST00000545287.2,ENST00000581031.1,ENST00000581094.1,ENST00000394692.2 |
| exon_skip_150757 | 17 | 30469698:30469748:30498065:30498120:30500849:30500931 | 30498065:30498120 | ENSG00000126858.12 | ENST00000354266.3 |
| exon_skip_150764 | 17 | 30498065:30498120:30499955:30500079:30500849:30500931 | 30499955:30500079 | ENSG00000126858.12 | ENST00000583994.1,ENST00000578205.1 |
| exon_skip_150768 | 17 | 30500849:30500931:30502337:30502381:30502980:30503034 | 30502337:30502381 | ENSG00000126858.12 | ENST00000333942.6,ENST00000358365.3,ENST00000583994.1,ENST00000545287.2,ENST00000354266.3,ENST00000581031.1,ENST00000581094.1,ENST00000578205.1,ENST00000394692.2 |
| exon_skip_150772 | 17 | 30502980:30503034:30503179:30503232:30509775:30509884 | 30503179:30503232 | ENSG00000126858.12 | ENST00000333942.6,ENST00000358365.3,ENST00000583994.1,ENST00000545287.2,ENST00000354266.3,ENST00000581031.1,ENST00000581094.1,ENST00000578205.1,ENST00000394692.2 |
| exon_skip_150773 | 17 | 30503179:30503232:30509775:30509884:30510189:30510291 | 30509775:30509884 | ENSG00000126858.12 | ENST00000333942.6,ENST00000358365.3,ENST00000583994.1,ENST00000545287.2,ENST00000354266.3,ENST00000581031.1,ENST00000581094.1,ENST00000578205.1,ENST00000394692.2 |
| exon_skip_150776 | 17 | 30527974:30528075:30529788:30529919:30530908:30530992 | 30529788:30529919 | ENSG00000126858.12 | ENST00000333942.6,ENST00000358365.3,ENST00000583994.1,ENST00000545287.2,ENST00000354266.3,ENST00000581031.1,ENST00000581094.1,ENST00000578205.1,ENST00000394692.2 |
| exon_skip_150779 | 17 | 30529788:30529919:30530908:30530992:30533928:30534048 | 30530908:30530992 | ENSG00000126858.12 | ENST00000333942.6,ENST00000358365.3,ENST00000583994.1,ENST00000545287.2,ENST00000354266.3,ENST00000581031.1,ENST00000581094.1,ENST00000578205.1,ENST00000394692.2 |
| exon_skip_150782 | 17 | 30530955:30530992:30533928:30534048:30535125:30535328 | 30533928:30534048 | ENSG00000126858.12 | ENST00000333942.6,ENST00000358365.3,ENST00000583994.1,ENST00000545287.2,ENST00000354266.3,ENST00000581031.1,ENST00000581094.1,ENST00000578205.1,ENST00000394692.2,ENST00000582602.1,ENST00000580392.1 |
| exon_skip_150783 | 17 | 30533968:30534048:30534530:30534582:30535125:30535328 | 30534530:30534582 | ENSG00000126858.12 | ENST00000584692.1 |
| exon_skip_150786 | 17 | 30535320:30535328:30536368:30536464:30538134:30538214 | 30536368:30536464 | ENSG00000126858.12 | ENST00000358365.3 |
| exon_skip_150789 | 17 | 30535320:30535328:30536368:30536464:30551634:30551979 | 30536368:30536464 | ENSG00000126858.12 | ENST00000583994.1,ENST00000394692.2 |
| exon_skip_150794 | 17 | 30535320:30535328:30538134:30538257:30551634:30551979 | 30538134:30538257 | ENSG00000126858.12 | ENST00000545287.2 |
| exon_skip_150796 | 17 | 30535320:30535328:30538134:30538257:30580103:30580393 | 30538134:30538257 | ENSG00000126858.12 | ENST00000584852.1 |
| exon_skip_150801 | 17 | 30536406:30536464:30538134:30538257:30551634:30551979 | 30538134:30538257 | ENSG00000126858.12 | ENST00000358365.3 |
| exon_skip_150808 | 17 | 30538134:30538257:30548067:30548205:30551634:30551979 | 30548067:30548205 | ENSG00000126858.12 | ENST00000581031.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for RHOT1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000333942 | 30502337 | 30502381 | Frame-shift |
| ENST00000333942 | 30503179 | 30503232 | Frame-shift |
| ENST00000333942 | 30509775 | 30509884 | Frame-shift |
| ENST00000333942 | 30529788 | 30529919 | Frame-shift |
| ENST00000333942 | 30530908 | 30530992 | In-frame |
| ENST00000333942 | 30533928 | 30534048 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000333942 | 30502337 | 30502381 | Frame-shift |
| ENST00000333942 | 30503179 | 30503232 | Frame-shift |
| ENST00000333942 | 30509775 | 30509884 | Frame-shift |
| ENST00000333942 | 30529788 | 30529919 | Frame-shift |
| ENST00000333942 | 30530908 | 30530992 | In-frame |
| ENST00000333942 | 30533928 | 30534048 | In-frame |
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Infer the effects of exon skipping event on protein functional features for RHOT1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000333942 | 3150 | 618 | 30530908 | 30530992 | 1572 | 1655 | 444 | 472 |
| ENST00000333942 | 3150 | 618 | 30533928 | 30534048 | 1656 | 1775 | 472 | 512 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000333942 | 3150 | 618 | 30530908 | 30530992 | 1572 | 1655 | 444 | 472 |
| ENST00000333942 | 3150 | 618 | 30533928 | 30534048 | 1656 | 1775 | 472 | 512 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for RHOT1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_150773 | 30509776 | 30509884 | 30509782 | 30509782 | Frame_Shift_Del | T | - | p.P112fs |
| MESO | TCGA-3H-AB3O-01 | exon_skip_150776 | 30529789 | 30529919 | 30529792 | 30529792 | Frame_Shift_Del | C | - | p.T402fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_150782 | 30533929 | 30534048 | 30534041 | 30534041 | Frame_Shift_Del | T | - | p.I510fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_150789 exon_skip_150786 | 30536369 | 30536464 | 30536453 | 30536453 | Frame_Shift_Del | A | - | p.L608fs |
| STAD | TCGA-BR-8361-01 | exon_skip_150776 | 30529789 | 30529919 | 30529800 | 30529801 | Frame_Shift_Ins | - | A | p.D404fs |
| BLCA | TCGA-XF-A9ST-01 | exon_skip_150782 | 30533929 | 30534048 | 30533948 | 30533948 | Nonsense_Mutation | C | A | p.S479* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| 639V_URINARY_TRACT | 30503180 | 30503232 | 30503183 | 30503183 | Missense_Mutation | A | G | p.T94A |
| H4_CENTRAL_NERVOUS_SYSTEM | 30503180 | 30503232 | 30503211 | 30503211 | Missense_Mutation | A | G | p.E103G |
| PANC0813_PANCREAS | 30509776 | 30509884 | 30509781 | 30509781 | Missense_Mutation | C | T | p.P112L |
| HEC251_ENDOMETRIUM | 30529789 | 30529919 | 30529797 | 30529797 | Missense_Mutation | G | T | p.D404Y |
| NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 30529789 | 30529919 | 30529811 | 30529811 | Missense_Mutation | C | A | p.D408E |
| LS411N_LARGE_INTESTINE | 30529789 | 30529919 | 30529840 | 30529840 | Missense_Mutation | T | C | p.V418A |
| HEC151_ENDOMETRIUM | 30529789 | 30529919 | 30529852 | 30529852 | Missense_Mutation | A | C | p.N422T |
| FARAGE_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 30530909 | 30530992 | 30530928 | 30530928 | Missense_Mutation | A | G | p.E451G |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 30530909 | 30530992 | 30530929 | 30530929 | Missense_Mutation | A | T | p.E451D |
| UMUC3_URINARY_TRACT | 30533929 | 30534048 | 30533935 | 30533935 | Missense_Mutation | G | A | p.D475N |
| CHAGOK1_LUNG | 30533929 | 30534048 | 30533948 | 30533948 | Missense_Mutation | C | T | p.S479L |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 30533929 | 30534048 | 30534008 | 30534008 | Missense_Mutation | G | C | p.S499T |
| NCIH1155_LUNG | 30533929 | 30534048 | 30534023 | 30534023 | Missense_Mutation | T | G | p.F504C |
| NCIH630_LARGE_INTESTINE | 30503180 | 30503232 | 30503216 | 30503217 | Nonsense_Mutation | AC | TA | p.T105* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RHOT1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RHOT1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RHOT1 |
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RelatedDrugs for RHOT1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RHOT1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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