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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for NEIL3 |
 Gene summary |
| Gene information | Gene symbol | NEIL3 | Gene ID | 55247 |
| Gene name | nei like DNA glycosylase 3 | |
| Synonyms | FGP2|FPG2|NEI3|ZGRF3|hFPG2|hNEI3 | |
| Cytomap | 4q34.3 | |
| Type of gene | protein-coding | |
| Description | endonuclease 8-like 3DNA glycosylase FPG2DNA glycosylase hFPG2DNA glycosylase/AP lyase Neil3endonuclease VIII-like 3nei endonuclease VIII-like 3nei-like protein 3zinc finger, GRF-type containing 3 | |
| Modification date | 20180523 | |
| UniProtAcc | Q8TAT5 | |
| Context | PubMed: NEIL3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| NEIL3 | GO:0006284 | base-excision repair | 23755964 |
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Exon skipping events across known transcript of Ensembl for NEIL3 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for NEIL3 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for NEIL3 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_427153 | 4 | 178257261:178257475:178260936:178261011:178262629:178262796 | 178260936:178261011 | ENSG00000109674.3 | ENST00000264596.3 |
| exon_skip_427161 | 4 | 178260936:178261011:178262629:178262796:178272533:178272703 | 178262629:178262796 | ENSG00000109674.3 | ENST00000264596.3 |
| exon_skip_427165 | 4 | 178262629:178262796:178272533:178272703:178274461:178274882 | 178272533:178272703 | ENSG00000109674.3 | ENST00000264596.3 |
| exon_skip_427167 | 4 | 178274461:178274882:178281656:178281831:178283442:178284097 | 178281656:178281831 | ENSG00000109674.3 | ENST00000264596.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for NEIL3 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_427153 | 4 | 178257261:178257475:178260936:178261011:178262629:178262796 | 178260936:178261011 | ENSG00000109674.3 | ENST00000264596.3 |
| exon_skip_427161 | 4 | 178260936:178261011:178262629:178262796:178272533:178272703 | 178262629:178262796 | ENSG00000109674.3 | ENST00000264596.3 |
| exon_skip_427165 | 4 | 178262629:178262796:178272533:178272703:178274461:178274882 | 178272533:178272703 | ENSG00000109674.3 | ENST00000264596.3 |
| exon_skip_427167 | 4 | 178274461:178274882:178281656:178281831:178283442:178284097 | 178281656:178281831 | ENSG00000109674.3 | ENST00000264596.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for NEIL3 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000264596 | 178262629 | 178262796 | Frame-shift |
| ENST00000264596 | 178272533 | 178272703 | Frame-shift |
| ENST00000264596 | 178281656 | 178281831 | Frame-shift |
| ENST00000264596 | 178260936 | 178261011 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000264596 | 178262629 | 178262796 | Frame-shift |
| ENST00000264596 | 178272533 | 178272703 | Frame-shift |
| ENST00000264596 | 178281656 | 178281831 | Frame-shift |
| ENST00000264596 | 178260936 | 178261011 | In-frame |
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Infer the effects of exon skipping event on protein functional features for NEIL3 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000264596 | 2425 | 605 | 178260936 | 178261011 | 746 | 820 | 209 | 234 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000264596 | 2425 | 605 | 178260936 | 178261011 | 746 | 820 | 209 | 234 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8TAT5 | 209 | 234 | 2 | 605 | Chain | ID=PRO_0000170910;Note=Endonuclease 8-like 3 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8TAT5 | 209 | 234 | 2 | 605 | Chain | ID=PRO_0000170910;Note=Endonuclease 8-like 3 |
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SNVs in the skipped exons for NEIL3 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LUAD | TCGA-95-7043-01 | exon_skip_427161 | 178262630 | 178262796 | 178262723 | 178262723 | Frame_Shift_Del | T | - | p.F266fs |
| LUSC | TCGA-39-5037-01 | exon_skip_427165 | 178272534 | 178272703 | 178272546 | 178272546 | Frame_Shift_Del | T | - | p.T294fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_427165 | 178272534 | 178272703 | 178272689 | 178272689 | Frame_Shift_Del | C | - | p.T342fs |
| HNSC | TCGA-CN-4742-01 | exon_skip_427165 | 178272534 | 178272703 | 178272610 | 178272610 | Nonsense_Mutation | A | T | p.K316* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| KM12_LARGE_INTESTINE | 178281657 | 178281831 | 178281763 | 178281763 | Frame_Shift_Del | G | - | p.G523fs |
| JSC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 178260937 | 178261011 | 178260962 | 178260962 | Missense_Mutation | T | A | p.I218N |
| SNU520_STOMACH | 178260937 | 178261011 | 178260970 | 178260970 | Missense_Mutation | C | T | p.L221F |
| HSC39_STOMACH | 178272534 | 178272703 | 178272594 | 178272594 | Missense_Mutation | G | A | p.M310I |
| C32_SKIN | 178272534 | 178272703 | 178272599 | 178272599 | Missense_Mutation | C | T | p.S312F |
| HT115_LARGE_INTESTINE | 178272534 | 178272703 | 178272643 | 178272643 | Missense_Mutation | A | G | p.T327A |
| COLO668_LUNG | 178272534 | 178272703 | 178272669 | 178272669 | Missense_Mutation | G | T | p.K335N |
| HGC27_STOMACH | 178281657 | 178281831 | 178281677 | 178281677 | Missense_Mutation | C | A | p.T494K |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 178281657 | 178281831 | 178281713 | 178281713 | Missense_Mutation | G | A | p.R506H |
| NCIH1436_LUNG | 178281657 | 178281831 | 178281763 | 178281763 | Missense_Mutation | G | T | p.G523W |
| HAL01_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 178281657 | 178281831 | 178281764 | 178281764 | Missense_Mutation | G | A | p.G523E |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NEIL3 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for NEIL3 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for NEIL3 |
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RelatedDrugs for NEIL3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NEIL3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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