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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for PPP2CB |
 Gene summary |
| Gene information | Gene symbol | PPP2CB | Gene ID | 5516 |
| Gene name | protein phosphatase 2 catalytic subunit beta | |
| Synonyms | PP2Abeta|PP2CB | |
| Cytomap | 8p12 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein phosphatase 2A catalytic subunit beta isoformPP2A-betaprotein phosphatase 2 (formerly 2A), catalytic subunit, beta isoformprotein phosphatase 2, catalytic subunit, beta isoformprotein phosphatase 2, catalytic subunit, beta iso | |
| Modification date | 20180522 | |
| UniProtAcc | P62714 | |
| Context | PubMed: PPP2CB [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for PPP2CB from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for PPP2CB |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for PPP2CB |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_489097 | 8 | 30651477:30651594:30651707:30651797:30655096:30655270 | 30651707:30651797 | ENSG00000104695.8 | ENST00000518243.1,ENST00000221138.4 |
| exon_skip_489098 | 8 | 30651713:30651797:30655096:30655270:30657061:30657164 | 30655096:30655270 | ENSG00000104695.8 | ENST00000518243.1,ENST00000221138.4,ENST00000520056.1 |
| exon_skip_489107 | 8 | 30655096:30655270:30657061:30657271:30669835:30670113 | 30657061:30657271 | ENSG00000104695.8 | ENST00000221138.4 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for PPP2CB |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_489097 | 8 | 30651477:30651594:30651707:30651797:30655096:30655270 | 30651707:30651797 | ENSG00000104695.8 | ENST00000221138.4,ENST00000518243.1 |
| exon_skip_489098 | 8 | 30651713:30651797:30655096:30655270:30657061:30657164 | 30655096:30655270 | ENSG00000104695.8 | ENST00000221138.4,ENST00000518243.1,ENST00000520056.1 |
| exon_skip_489107 | 8 | 30655096:30655270:30657061:30657271:30669835:30670113 | 30657061:30657271 | ENSG00000104695.8 | ENST00000221138.4 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for PPP2CB |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000221138 | 30651707 | 30651797 | In-frame |
| ENST00000221138 | 30655096 | 30655270 | In-frame |
| ENST00000221138 | 30657061 | 30657271 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000221138 | 30651707 | 30651797 | In-frame |
| ENST00000221138 | 30655096 | 30655270 | In-frame |
| ENST00000221138 | 30657061 | 30657271 | In-frame |
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Infer the effects of exon skipping event on protein functional features for PPP2CB |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000221138 | 2023 | 309 | 30657061 | 30657271 | 554 | 763 | 34 | 104 |
| ENST00000221138 | 2023 | 309 | 30655096 | 30655270 | 764 | 937 | 104 | 162 |
| ENST00000221138 | 2023 | 309 | 30651707 | 30651797 | 938 | 1027 | 162 | 192 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000221138 | 2023 | 309 | 30657061 | 30657271 | 554 | 763 | 34 | 104 |
| ENST00000221138 | 2023 | 309 | 30655096 | 30655270 | 764 | 937 | 104 | 162 |
| ENST00000221138 | 2023 | 309 | 30651707 | 30651797 | 938 | 1027 | 162 | 192 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P62714 | 34 | 104 | 1 | 309 | Chain | ID=PRO_0000058845;Note=Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform |
| P62714 | 34 | 104 | 57 | 57 | Metal binding | Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P62714 | 34 | 104 | 59 | 59 | Metal binding | Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P62714 | 34 | 104 | 85 | 85 | Metal binding | Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P62714 | 34 | 104 | 85 | 85 | Metal binding | Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P62714 | 104 | 162 | 118 | 118 | Active site | Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P62714 | 104 | 162 | 1 | 309 | Chain | ID=PRO_0000058845;Note=Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform |
| P62714 | 104 | 162 | 117 | 117 | Metal binding | Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P62714 | 162 | 192 | 1 | 309 | Chain | ID=PRO_0000058845;Note=Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform |
| P62714 | 162 | 192 | 167 | 167 | Metal binding | Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P62714 | 34 | 104 | 1 | 309 | Chain | ID=PRO_0000058845;Note=Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform |
| P62714 | 34 | 104 | 57 | 57 | Metal binding | Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P62714 | 34 | 104 | 59 | 59 | Metal binding | Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P62714 | 34 | 104 | 85 | 85 | Metal binding | Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P62714 | 34 | 104 | 85 | 85 | Metal binding | Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P62714 | 104 | 162 | 118 | 118 | Active site | Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P62714 | 104 | 162 | 1 | 309 | Chain | ID=PRO_0000058845;Note=Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform |
| P62714 | 104 | 162 | 117 | 117 | Metal binding | Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P62714 | 162 | 192 | 1 | 309 | Chain | ID=PRO_0000058845;Note=Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform |
| P62714 | 162 | 192 | 167 | 167 | Metal binding | Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
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SNVs in the skipped exons for PPP2CB |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HNSC | TCGA-BA-4075-01 | exon_skip_489107 | 30657062 | 30657271 | 30657106 | 30657106 | Nonsense_Mutation | C | A | p.G90* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 30655097 | 30655270 | 30655186 | 30655186 | Missense_Mutation | A | G | p.C133R |
| BT474_BREAST | 30657062 | 30657271 | 30657165 | 30657165 | Missense_Mutation | C | G | p.R70T |
| HPBALL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 30655097 | 30655270 | 30655180 | 30655180 | Nonsense_Mutation | G | A | p.R135* |
| KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 30655097 | 30655270 | 30655180 | 30655180 | Nonsense_Mutation | G | A | p.R135* |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 30655097 | 30655270 | 30655180 | 30655180 | Nonsense_Mutation | G | A | p.R135* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PPP2CB |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PPP2CB |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PPP2CB |
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RelatedDrugs for PPP2CB |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PPP2CB |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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