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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for TRIM68 |
 Gene summary |
| Gene information | Gene symbol | TRIM68 | Gene ID | 55128 |
| Gene name | tripartite motif containing 68 | |
| Synonyms | GC109|RNF137|SS-56|SS56 | |
| Cytomap | 11p15.4 | |
| Type of gene | protein-coding | |
| Description | E3 ubiquitin-protein ligase TRIM68RING-type E3 ubiquitin transferase TRIM68Ro/SSA1 related proteinSSA protein SS-56ring finger protein 137tripartite motif-containing protein 68 | |
| Modification date | 20180519 | |
| UniProtAcc | Q6AZZ1 | |
| Context | PubMed: TRIM68 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TRIM68 | GO:0051865 | protein autoubiquitination | 18451177 |
| TRIM68 | GO:0060765 | regulation of androgen receptor signaling pathway | 18451177 |
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Exon skipping events across known transcript of Ensembl for TRIM68 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for TRIM68 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for TRIM68 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_68251 | 11 | 4622029:4622056:4622256:4622357:4622893:4622916 | 4622256:4622357 | ENSG00000167333.8 | ENST00000531101.1,ENST00000526337.1,ENST00000300747.5 |
| exon_skip_68252 | 11 | 4622256:4622357:4622893:4622916:4623381:4623636 | 4622893:4622916 | ENSG00000167333.8 | ENST00000531101.1,ENST00000526337.1,ENST00000300747.5 |
| exon_skip_68255 | 11 | 4623473:4623642:4624474:4624570:4626308:4626791 | 4624474:4624570 | ENSG00000167333.8 | ENST00000532108.1,ENST00000300747.5 |
| exon_skip_68256 | 11 | 4623473:4623642:4624474:4624570:4629256:4629368 | 4624474:4624570 | ENSG00000167333.8 | ENST00000531644.1,ENST00000526337.1 |
| exon_skip_68257 | 11 | 4623473:4623642:4626308:4626791:4629256:4629368 | 4626308:4626791 | ENSG00000167333.8 | ENST00000533021.1 |
| exon_skip_68258 | 11 | 4624474:4624570:4626308:4626791:4629256:4629368 | 4626308:4626791 | ENSG00000167333.8 | ENST00000532108.1,ENST00000531101.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for TRIM68 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_68251 | 11 | 4622029:4622056:4622256:4622357:4622893:4622916 | 4622256:4622357 | ENSG00000167333.8 | ENST00000300747.5,ENST00000531101.1,ENST00000526337.1 |
| exon_skip_68252 | 11 | 4622256:4622357:4622893:4622916:4623381:4623636 | 4622893:4622916 | ENSG00000167333.8 | ENST00000300747.5,ENST00000531101.1,ENST00000526337.1 |
| exon_skip_68255 | 11 | 4623473:4623642:4624474:4624570:4626308:4626791 | 4624474:4624570 | ENSG00000167333.8 | ENST00000300747.5,ENST00000532108.1 |
| exon_skip_68256 | 11 | 4623473:4623642:4624474:4624570:4629256:4629368 | 4624474:4624570 | ENSG00000167333.8 | ENST00000526337.1,ENST00000531644.1 |
| exon_skip_68257 | 11 | 4623473:4623642:4626308:4626791:4629256:4629368 | 4626308:4626791 | ENSG00000167333.8 | ENST00000533021.1 |
| exon_skip_68258 | 11 | 4624474:4624570:4626308:4626791:4629256:4629368 | 4626308:4626791 | ENSG00000167333.8 | ENST00000531101.1,ENST00000532108.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for TRIM68 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000300747 | 4622256 | 4622357 | Frame-shift |
| ENST00000300747 | 4622893 | 4622916 | Frame-shift |
| ENST00000300747 | 4624474 | 4624570 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000300747 | 4622256 | 4622357 | Frame-shift |
| ENST00000300747 | 4622893 | 4622916 | Frame-shift |
| ENST00000300747 | 4624474 | 4624570 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TRIM68 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000300747 | 3369 | 485 | 4624474 | 4624570 | 717 | 812 | 142 | 174 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000300747 | 3369 | 485 | 4624474 | 4624570 | 717 | 812 | 142 | 174 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for TRIM68 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_68256 exon_skip_68255 | 4624475 | 4624570 | 4624552 | 4624552 | Frame_Shift_Del | G | - | p.L149fs |
| SKCM | TCGA-EE-A3AA-06 | exon_skip_68258 exon_skip_68257 | 4626309 | 4626791 | 4626492 | 4626492 | Frame_Shift_Del | T | - | p.K81fs |
| HNSC | TCGA-CV-A6K1-01 | exon_skip_68256 exon_skip_68255 | 4624475 | 4624570 | 4624492 | 4624492 | Nonsense_Mutation | G | A | p.R169* |
| KICH | TCGA-KN-8428-01 | exon_skip_68256 exon_skip_68255 | 4624475 | 4624570 | 4624492 | 4624492 | Nonsense_Mutation | G | A | p.R169* |
| KICH | TCGA-KN-8428-01 | exon_skip_68256 exon_skip_68255 | 4624475 | 4624570 | 4624492 | 4624492 | Nonsense_Mutation | G | A | p.R169X |
| BLCA | TCGA-C4-A0EZ-01 | exon_skip_68258 exon_skip_68257 | 4626309 | 4626791 | 4626603 | 4626603 | Nonsense_Mutation | C | T | p.W44* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LC1F_LUNG | 4622894 | 4622916 | 4622898 | 4622898 | Missense_Mutation | T | A | p.N268Y |
| LC1SQSF_LUNG | 4622894 | 4622916 | 4622898 | 4622898 | Missense_Mutation | T | A | p.N268Y |
| LC1SQ_LUNG | 4622894 | 4622916 | 4622898 | 4622898 | Missense_Mutation | T | A | p.N268Y |
| HT115_LARGE_INTESTINE | 4624475 | 4624570 | 4624491 | 4624491 | Missense_Mutation | C | T | p.R169Q |
| NCIH810_LUNG | 4624475 | 4624570 | 4624524 | 4624524 | Missense_Mutation | T | G | p.E158A |
| JHUEM7_ENDOMETRIUM | 4624475 | 4624570 | 4624549 | 4624549 | Missense_Mutation | C | T | p.E150K |
| SNU466_CENTRAL_NERVOUS_SYSTEM | 4626309 | 4626791 | 4626388 | 4626388 | Missense_Mutation | A | G | p.M116T |
| PL18_PANCREAS | 4626309 | 4626791 | 4626402 | 4626402 | Missense_Mutation | C | G | p.E111D |
| NCIH1694_LUNG | 4626309 | 4626791 | 4626433 | 4626433 | Missense_Mutation | T | A | p.H101L |
| SNU1040_LARGE_INTESTINE | 4626309 | 4626791 | 4626437 | 4626437 | Missense_Mutation | G | A | p.R100C |
| A3KAW_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 4626309 | 4626791 | 4626499 | 4626499 | Missense_Mutation | A | C | p.V79G |
| HCT15_LARGE_INTESTINE | 4626309 | 4626791 | 4626526 | 4626526 | Missense_Mutation | C | T | p.R70Q |
| OMC1_CERVIX | 4626309 | 4626791 | 4626527 | 4626527 | Missense_Mutation | G | A | p.R70W |
| HEC1A_ENDOMETRIUM | 4626309 | 4626791 | 4626535 | 4626535 | Missense_Mutation | C | A | p.R67M |
| HEC1A_ENDOMETRIUM | 4626309 | 4626791 | 4626610 | 4626610 | Missense_Mutation | C | T | p.G42E |
| PACADD188_PANCREAS | 4626309 | 4626791 | 4626724 | 4626724 | Missense_Mutation | G | A | p.T4I |
| NCIH196_LUNG | 4624475 | 4624570 | 4624549 | 4624549 | Nonsense_Mutation | C | A | p.E150* |
| MDAMB330_BREAST | 4624475 | 4624570 | 4624558 | 4624558 | Nonsense_Mutation | C | A | p.E147* |
| NCIH1092_LUNG | 4626309 | 4626791 | 4626584 | 4626584 | Nonsense_Mutation | G | A | p.Q51* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TRIM68 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TRIM68 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TRIM68 |
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RelatedDrugs for TRIM68 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRIM68 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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