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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for YTHDF1

check button Gene summary
Gene informationGene symbol

YTHDF1

Gene ID

54915

Gene nameYTH N6-methyladenosine RNA binding protein 1
SynonymsC20orf21
Cytomap

20q13.33

Type of geneprotein-coding
DescriptionYTH domain-containing family protein 1DACA-1YTH N(6)-methyladenosine RNA binding protein 1YTH domain family 1YTH domain family protein 1YTH domain family, member 1dermatomyositis associated with cancer putative autoantigen 1
Modification date20180519
UniProtAcc

Q9BYJ9

ContextPubMed: YTHDF1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
YTHDF1

GO:0045948

positive regulation of translational initiation

26046440


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Exon skipping events across known transcript of Ensembl for YTHDF1 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for YTHDF1

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for YTHDF1

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_3586062061827830:61828086:61833638:61835159:61845215:6184529561833638:61835159ENSG00000149658.13ENST00000370339.3
exon_skip_3586072061833638:61835159:61845215:61845295:61846928:6184695361845215:61845295ENSG00000149658.13ENST00000370339.3
exon_skip_3586132061845215:61845295:61846928:61846953:61847217:6184749161846928:61846953ENSG00000149658.13ENST00000370334.4

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for YTHDF1

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_3586062061827830:61828086:61833638:61835159:61845215:6184529561833638:61835159ENSG00000149658.13ENST00000370339.3
exon_skip_3586072061833638:61835159:61845215:61845295:61846928:6184695361845215:61845295ENSG00000149658.13ENST00000370339.3
exon_skip_3586132061845215:61845295:61846928:61846953:61847217:6184749161846928:61846953ENSG00000149658.13ENST00000370334.4

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for YTHDF1

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003703396184521561845295Frame-shift
ENST000003703396183363861835159In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003703396184521561845295Frame-shift
ENST000003703396183363861835159In-frame

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Infer the effects of exon skipping event on protein functional features for YTHDF1

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000037033933185596183363861835159475199544551

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000037033933185596183363861835159475199544551

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q9BYJ9445511190Alternative sequenceID=VSP_006815;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q9BYJ944551191260Alternative sequenceID=VSP_006816;Note=In isoform 2. KIGDVSSSAVKTVGSVVSSVALTGVLSGNGGTNVNMPVSKPTSWAAIASKPAKPQPKMKTKSGPVMGGGL->MLFLGSLGAWGTTSISTGSIFSLKTLRSQHGGQVGLKVSRPRAPRMGAATPTPRAPWVARWLMGSQAFTATPSAR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID
Q9BYJ944551383559Alternative sequenceID=VSP_006817;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q9BYJ944551390397Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551434440Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551443452Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551457459Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551465467Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551473485Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551401401Binding siteNote=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RCJ,ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
Q9BYJ944551441441Binding siteNote=N6-methyladenosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y5A9
Q9BYJ944551465465Binding siteNote=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RCJ,ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
Q9BYJ944551470470Binding siteNote=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RCJ,ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
Q9BYJ9445512559ChainID=PRO_0000223073;Note=YTH domain-containing family protein 1
Q9BYJ944551241331Compositional biasNote=Gln/Pro-rich
Q9BYJ944551389523DomainNote=YTH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00225
Q9BYJ944551366374HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551399408HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551415428HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551486488HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551495497HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551502504HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551513525HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551532535HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551536550HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551182182Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9BYJ944551397397MutagenesisNote=Strongly reduced binding to N6-methyladenosine (m6A)-containing RNAs. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
Q9BYJ944551401401MutagenesisNote=Increased binding to N6-methyladenosine (m6A)-containing RNAs. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
Q9BYJ944551411411MutagenesisNote=Abolished binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
Q9BYJ944551465465MutagenesisNote=Abolished binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
Q9BYJ944551470470MutagenesisNote=Abolished binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
Q9BYJ944551506506MutagenesisNote=Reduced binding to N6-methyladenosine (m6A)-containing RNAs. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
Q9BYJ944551395397RegionNote=N6-methyladenosine binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RCJ,ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
Q9BYJ944551411412RegionNote=N6-methyladenosine binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RCJ,ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
Q9BYJ944551123124Sequence conflictNote=FP->AR;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BYJ944551283284Sequence conflictNote=AP->PH;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BYJ944551489491TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q9BYJ9445511190Alternative sequenceID=VSP_006815;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q9BYJ944551191260Alternative sequenceID=VSP_006816;Note=In isoform 2. KIGDVSSSAVKTVGSVVSSVALTGVLSGNGGTNVNMPVSKPTSWAAIASKPAKPQPKMKTKSGPVMGGGL->MLFLGSLGAWGTTSISTGSIFSLKTLRSQHGGQVGLKVSRPRAPRMGAATPTPRAPWVARWLMGSQAFTATPSAR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID
Q9BYJ944551383559Alternative sequenceID=VSP_006817;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q9BYJ944551390397Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551434440Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551443452Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551457459Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551465467Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551473485Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551401401Binding siteNote=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RCJ,ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
Q9BYJ944551441441Binding siteNote=N6-methyladenosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y5A9
Q9BYJ944551465465Binding siteNote=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RCJ,ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
Q9BYJ944551470470Binding siteNote=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RCJ,ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
Q9BYJ9445512559ChainID=PRO_0000223073;Note=YTH domain-containing family protein 1
Q9BYJ944551241331Compositional biasNote=Gln/Pro-rich
Q9BYJ944551389523DomainNote=YTH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00225
Q9BYJ944551366374HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551399408HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551415428HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551486488HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551495497HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551502504HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551513525HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551532535HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551536550HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
Q9BYJ944551182182Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9BYJ944551397397MutagenesisNote=Strongly reduced binding to N6-methyladenosine (m6A)-containing RNAs. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
Q9BYJ944551401401MutagenesisNote=Increased binding to N6-methyladenosine (m6A)-containing RNAs. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
Q9BYJ944551411411MutagenesisNote=Abolished binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
Q9BYJ944551465465MutagenesisNote=Abolished binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
Q9BYJ944551470470MutagenesisNote=Abolished binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
Q9BYJ944551506506MutagenesisNote=Reduced binding to N6-methyladenosine (m6A)-containing RNAs. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
Q9BYJ944551395397RegionNote=N6-methyladenosine binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RCJ,ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
Q9BYJ944551411412RegionNote=N6-methyladenosine binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RCJ,ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
Q9BYJ944551123124Sequence conflictNote=FP->AR;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BYJ944551283284Sequence conflictNote=AP->PH;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BYJ944551489491TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ


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SNVs in the skipped exons for YTHDF1

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.
YTHDF1_BRCA_exon_skip_358606_psi_boxplot.png
boxplot
YTHDF1_KIRC_exon_skip_358606_psi_boxplot.png
boxplot
YTHDF1_LIHC_exon_skip_358606_psi_boxplot.png
boxplot
YTHDF1_LUAD_exon_skip_358606_psi_boxplot.png
boxplot
YTHDF1_UCS_exon_skip_358606_psi_boxplot.png
boxplot

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
KIRCTCGA-A3-3346-01exon_skip_358606
61833639618351596183373861833738Frame_Shift_DelT-p.Q518fs
LIHCTCGA-DD-A3A0-01exon_skip_358606
61833639618351596183385261833852Frame_Shift_DelA-p.F480fs
LIHCTCGA-G3-A3CJ-01exon_skip_358606
61833639618351596183385261833852Frame_Shift_DelA-p.F480fs
LIHCTCGA-DD-A39Y-01exon_skip_358606
61833639618351596183419461834194Frame_Shift_DelG-p.P366fs
STADTCGA-CD-A4MI-01exon_skip_358606
61833639618351596183482861834828Frame_Shift_DelG-p.P155fs
LUADTCGA-97-A4M0-01exon_skip_358606
61833639618351596183488461834884Frame_Shift_DelC-p.G136fs
LIHCTCGA-DD-A3A0-01exon_skip_358606
61833639618351596183505461835054Frame_Shift_DelC-p.D80fs
UCSTCGA-N6-A4VG-01exon_skip_358606
61833639618351596183507561835075Frame_Shift_DelC-p.A73fs
LIHCTCGA-DD-A1EG-01exon_skip_358606
61833639618351596183508461835084Frame_Shift_DelG-p.L70fs
BLCATCGA-K4-A5RI-01exon_skip_358606
61833639618351596183443261834433Frame_Shift_Ins-Gp.Q287fs
STADTCGA-BR-A4IY-01exon_skip_358606
61833639618351596183404961834049Nonsense_MutationCAp.E415*
STADTCGA-BR-A4IY-01exon_skip_358606
61833639618351596183404961834049Nonsense_MutationCAp.E415X
THYMTCGA-5U-AB0D-01exon_skip_358606
61833639618351596183406861834068Nonsense_MutationGTp.Y408X
BRCATCGA-A2-A0YK-01exon_skip_358606
61833639618351596183514361835143Nonsense_MutationGCp.S50*
HNSCTCGA-BA-5152-01exon_skip_358613
61846929618469536184695461846954Splice_SiteCGp.R10_splice

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description
YTHDF1_61827830_61828086_61833638_61835159_61845215_61845295_TCGA-A2-A0YK-01Sample: TCGA-A2-A0YK-01
Cancer type: BRCA
ESID: exon_skip_358606
Skipped exon start: 61833639
Skipped exon end: 61835159
Mutation start: 61835143
Mutation end: 61835143
Mutation type: Nonsense_Mutation
Reference seq: G
Mutation seq: C
AAchange: p.S50*
exon_skip_358606_BRCA_TCGA-A2-A0YK-01.png
boxplot

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61833639618351596183436361834363Frame_Shift_DelG-p.P310fs
HEC265_ENDOMETRIUM61833639618351596183451961834519Frame_Shift_DelC-p.G259fs
MOLT3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61833639618351596183482861834828Frame_Shift_DelG-p.P155fs
NCIH630_LARGE_INTESTINE61833639618351596183482861834828Frame_Shift_DelG-p.P155fs
CCK81_LARGE_INTESTINE61833639618351596183364961833649Missense_MutationATp.V548E
DV90_LUNG61833639618351596183365261833652Missense_MutationTAp.E547V
JHUEM2_ENDOMETRIUM61833639618351596183365261833652Missense_MutationTAp.E547V
HCT15_LARGE_INTESTINE61833639618351596183367861833678Missense_MutationGTp.H538Q
T84_LARGE_INTESTINE61833639618351596183369661833696Missense_MutationGCp.I532M
RCCJF_KIDNEY61833639618351596183372561833725Missense_MutationTAp.I523F
FARAGE_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61833639618351596183390761833907Missense_MutationGTp.A462D
MERO48A_LUNG61833639618351596183391761833917Missense_MutationCTp.G459S
P30OHK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61833639618351596183400861834008Missense_MutationCTp.M428I
A4FUK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61833639618351596183403761834037Missense_MutationTCp.K419E
KON_UPPER_AERODIGESTIVE_TRACT61833639618351596183408961834089Missense_MutationGTp.D401E
TE11_OESOPHAGUS61833639618351596183415461834154Missense_MutationTCp.K380E
HEC1A_ENDOMETRIUM61833639618351596183421761834217Missense_MutationCTp.A359T
HCC2998_LARGE_INTESTINE61833639618351596183427061834270Missense_MutationCTp.S341N
MMACSF_SKIN61833639618351596183427661834276Missense_MutationCAp.G339V
SNU1040_LARGE_INTESTINE61833639618351596183427661834276Missense_MutationCTp.G339E
HEC59_ENDOMETRIUM61833639618351596183429861834298Missense_MutationGAp.R332C
SW684_SOFT_TISSUE61833639618351596183442061834421Missense_MutationGAATp.S291I
SNU1040_LARGE_INTESTINE61833639618351596183445761834457Missense_MutationGAp.P279S
L540_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61833639618351596183448161834481Missense_MutationTCp.I271V
RAJI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61833639618351596183453461834534Missense_MutationCGp.G253A
HEC59_ENDOMETRIUM61833639618351596183463461834634Missense_MutationCTp.G220S
LU65_LUNG61833639618351596183489561834895Missense_MutationCGp.G133R
NCIH345_LUNG61833639618351596183489561834895Missense_MutationCAp.G133W
HT115_LARGE_INTESTINE61833639618351596183494861834948Missense_MutationAGp.I115T
LAN6_AUTONOMIC_GANGLIA61833639618351596183496061834960Missense_MutationAGp.L111P
LNZ308_CENTRAL_NERVOUS_SYSTEM61833639618351596183504261835042Missense_MutationGCp.P84A
LB1047EBV_MATCHED_NORMAL_TISSUE61833639618351596183506361835063Missense_MutationTCp.T77A
LB1047RCC_KIDNEY61833639618351596183506361835063Missense_MutationTCp.T77A
SKMEL2_SKIN61833639618351596183514061835140Missense_MutationAGp.M51T
SW954_VULVA61845216618452956184528661845286Missense_MutationCGp.G21A
D336MG_CENTRAL_NERVOUS_SYSTEM61833639618351596183437061834370Nonsense_MutationGAp.Q308*

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for YTHDF1

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value
exon_skip_3586062061827830:61828086:61833638:61835159:61845215:6184529561833638:61835159ENST00000370339.3BRCArs6122103chr20:61834695G/A6.48e-06
exon_skip_3586062061827830:61828086:61833638:61835159:61845215:6184529561833638:61835159ENST00000370339.3LGGrs6122103chr20:61834695G/A2.85e-03

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for YTHDF1


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for YTHDF1


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RelatedDrugs for YTHDF1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for YTHDF1

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource