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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for SNRK |
 Gene summary |
| Gene information | Gene symbol | SNRK | Gene ID | 54861 |
| Gene name | SNF related kinase | |
| Synonyms | HSNFRK | |
| Cytomap | 3p22.1 | |
| Type of gene | protein-coding | |
| Description | SNF-related serine/threonine-protein kinaseSNF-1 related kinaseSNF1-related kinase | |
| Modification date | 20180523 | |
| UniProtAcc | Q9NRH2 | |
| Context | PubMed: SNRK [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| SNRK | GO:0006468 | protein phosphorylation | 12234663 |
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Exon skipping events across known transcript of Ensembl for SNRK from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for SNRK |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for SNRK |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_373552 | 3 | 43328077:43328167:43341245:43341307:43344589:43344715 | 43341245:43341307 | ENSG00000163788.9 | ENST00000296088.7 |
| exon_skip_373554 | 3 | 43328077:43328167:43344589:43345284:43373660:43373802 | 43344589:43345284 | ENSG00000163788.9 | ENST00000429705.2 |
| exon_skip_373558 | 3 | 43331231:43331281:43341245:43341307:43344589:43345284 | 43341245:43341307 | ENSG00000163788.9 | ENST00000454177.1 |
| exon_skip_373560 | 3 | 43344603:43345284:43373660:43373802:43381778:43381883 | 43373660:43373802 | ENSG00000163788.9 | ENST00000429705.2,ENST00000454177.1,ENST00000296088.7 |
| exon_skip_373562 | 3 | 43373660:43373802:43381778:43381991:43384835:43384970 | 43381778:43381991 | ENSG00000163788.9 | ENST00000429705.2,ENST00000437827.1,ENST00000454177.1,ENST00000296088.7 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for SNRK |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_373552 | 3 | 43328077:43328167:43341245:43341307:43344589:43344715 | 43341245:43341307 | ENSG00000163788.9 | ENST00000296088.7 |
| exon_skip_373554 | 3 | 43328077:43328167:43344589:43345284:43373660:43373802 | 43344589:43345284 | ENSG00000163788.9 | ENST00000429705.2 |
| exon_skip_373558 | 3 | 43331231:43331281:43341245:43341307:43344589:43345284 | 43341245:43341307 | ENSG00000163788.9 | ENST00000454177.1 |
| exon_skip_373560 | 3 | 43344603:43345284:43373660:43373802:43381778:43381883 | 43373660:43373802 | ENSG00000163788.9 | ENST00000454177.1,ENST00000429705.2,ENST00000296088.7 |
| exon_skip_373562 | 3 | 43373660:43373802:43381778:43381991:43384835:43384970 | 43381778:43381991 | ENSG00000163788.9 | ENST00000454177.1,ENST00000429705.2,ENST00000296088.7,ENST00000437827.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for SNRK |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000429705 | 43344589 | 43345284 | 5CDS-5UTR |
| ENST00000296088 | 43341245 | 43341307 | 5UTR-5UTR |
| ENST00000454177 | 43341245 | 43341307 | 5UTR-5UTR |
| ENST00000296088 | 43373660 | 43373802 | Frame-shift |
| ENST00000429705 | 43373660 | 43373802 | Frame-shift |
| ENST00000454177 | 43373660 | 43373802 | Frame-shift |
| ENST00000296088 | 43381778 | 43381991 | In-frame |
| ENST00000429705 | 43381778 | 43381991 | In-frame |
| ENST00000454177 | 43381778 | 43381991 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000429705 | 43344589 | 43345284 | 5CDS-5UTR |
| ENST00000296088 | 43341245 | 43341307 | 5UTR-5UTR |
| ENST00000454177 | 43341245 | 43341307 | 5UTR-5UTR |
| ENST00000296088 | 43373660 | 43373802 | Frame-shift |
| ENST00000429705 | 43373660 | 43373802 | Frame-shift |
| ENST00000454177 | 43373660 | 43373802 | Frame-shift |
| ENST00000296088 | 43381778 | 43381991 | In-frame |
| ENST00000429705 | 43381778 | 43381991 | In-frame |
| ENST00000454177 | 43381778 | 43381991 | In-frame |
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Infer the effects of exon skipping event on protein functional features for SNRK |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000296088 | 5200 | 765 | 43381778 | 43381991 | 1036 | 1248 | 244 | 314 |
| ENST00000429705 | 5145 | 765 | 43381778 | 43381991 | 976 | 1188 | 244 | 314 |
| ENST00000454177 | 2978 | 765 | 43381778 | 43381991 | 1114 | 1326 | 244 | 314 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000296088 | 5200 | 765 | 43381778 | 43381991 | 1036 | 1248 | 244 | 314 |
| ENST00000429705 | 5145 | 765 | 43381778 | 43381991 | 976 | 1188 | 244 | 314 |
| ENST00000454177 | 2978 | 765 | 43381778 | 43381991 | 1114 | 1326 | 244 | 314 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9NRH2 | 244 | 314 | 244 | 244 | Alternative sequence | ID=VSP_051959;Note=In isoform 2. D->E;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NRH2 | 244 | 314 | 244 | 244 | Alternative sequence | ID=VSP_051959;Note=In isoform 2. D->E;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NRH2 | 244 | 314 | 244 | 244 | Alternative sequence | ID=VSP_051959;Note=In isoform 2. D->E;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NRH2 | 244 | 314 | 245 | 765 | Alternative sequence | ID=VSP_051960;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NRH2 | 244 | 314 | 245 | 765 | Alternative sequence | ID=VSP_051960;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NRH2 | 244 | 314 | 245 | 765 | Alternative sequence | ID=VSP_051960;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NRH2 | 244 | 314 | 1 | 765 | Chain | ID=PRO_0000225605;Note=SNF-related serine/threonine-protein kinase;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9NRH2 | 244 | 314 | 1 | 765 | Chain | ID=PRO_0000225605;Note=SNF-related serine/threonine-protein kinase;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9NRH2 | 244 | 314 | 1 | 765 | Chain | ID=PRO_0000225605;Note=SNF-related serine/threonine-protein kinase;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9NRH2 | 244 | 314 | 16 | 269 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q9NRH2 | 244 | 314 | 16 | 269 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q9NRH2 | 244 | 314 | 16 | 269 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q9NRH2 | 244 | 314 | 291 | 334 | Domain | Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212 |
| Q9NRH2 | 244 | 314 | 291 | 334 | Domain | Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212 |
| Q9NRH2 | 244 | 314 | 291 | 334 | Domain | Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212 |
| Q9NRH2 | 244 | 314 | 240 | 249 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 240 | 249 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 240 | 249 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 260 | 265 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 260 | 265 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 260 | 265 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 267 | 269 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 267 | 269 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 267 | 269 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 284 | 286 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 284 | 286 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 284 | 286 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 292 | 304 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 292 | 304 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 292 | 304 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 310 | 319 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 310 | 319 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 310 | 319 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 260 | 260 | Natural variant | ID=VAR_041096;Note=L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35624204,PMID:17344846 |
| Q9NRH2 | 244 | 314 | 260 | 260 | Natural variant | ID=VAR_041096;Note=L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35624204,PMID:17344846 |
| Q9NRH2 | 244 | 314 | 260 | 260 | Natural variant | ID=VAR_041096;Note=L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35624204,PMID:17344846 |
| Q9NRH2 | 244 | 314 | 259 | 259 | Sequence conflict | Note=S->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9NRH2 | 244 | 314 | 259 | 259 | Sequence conflict | Note=S->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9NRH2 | 244 | 314 | 259 | 259 | Sequence conflict | Note=S->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9NRH2 | 244 | 314 | 254 | 256 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 254 | 256 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 254 | 256 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9NRH2 | 244 | 314 | 244 | 244 | Alternative sequence | ID=VSP_051959;Note=In isoform 2. D->E;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NRH2 | 244 | 314 | 244 | 244 | Alternative sequence | ID=VSP_051959;Note=In isoform 2. D->E;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NRH2 | 244 | 314 | 244 | 244 | Alternative sequence | ID=VSP_051959;Note=In isoform 2. D->E;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NRH2 | 244 | 314 | 245 | 765 | Alternative sequence | ID=VSP_051960;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NRH2 | 244 | 314 | 245 | 765 | Alternative sequence | ID=VSP_051960;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NRH2 | 244 | 314 | 245 | 765 | Alternative sequence | ID=VSP_051960;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NRH2 | 244 | 314 | 1 | 765 | Chain | ID=PRO_0000225605;Note=SNF-related serine/threonine-protein kinase;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9NRH2 | 244 | 314 | 1 | 765 | Chain | ID=PRO_0000225605;Note=SNF-related serine/threonine-protein kinase;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9NRH2 | 244 | 314 | 1 | 765 | Chain | ID=PRO_0000225605;Note=SNF-related serine/threonine-protein kinase;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9NRH2 | 244 | 314 | 16 | 269 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q9NRH2 | 244 | 314 | 16 | 269 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q9NRH2 | 244 | 314 | 16 | 269 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q9NRH2 | 244 | 314 | 291 | 334 | Domain | Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212 |
| Q9NRH2 | 244 | 314 | 291 | 334 | Domain | Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212 |
| Q9NRH2 | 244 | 314 | 291 | 334 | Domain | Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212 |
| Q9NRH2 | 244 | 314 | 240 | 249 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 240 | 249 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 240 | 249 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 260 | 265 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 260 | 265 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 260 | 265 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 267 | 269 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 267 | 269 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 267 | 269 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 284 | 286 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 284 | 286 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 284 | 286 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 292 | 304 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 292 | 304 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 292 | 304 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 310 | 319 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 310 | 319 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 310 | 319 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 260 | 260 | Natural variant | ID=VAR_041096;Note=L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35624204,PMID:17344846 |
| Q9NRH2 | 244 | 314 | 260 | 260 | Natural variant | ID=VAR_041096;Note=L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35624204,PMID:17344846 |
| Q9NRH2 | 244 | 314 | 260 | 260 | Natural variant | ID=VAR_041096;Note=L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35624204,PMID:17344846 |
| Q9NRH2 | 244 | 314 | 259 | 259 | Sequence conflict | Note=S->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9NRH2 | 244 | 314 | 259 | 259 | Sequence conflict | Note=S->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9NRH2 | 244 | 314 | 259 | 259 | Sequence conflict | Note=S->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9NRH2 | 244 | 314 | 254 | 256 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 254 | 256 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
| Q9NRH2 | 244 | 314 | 254 | 256 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS |
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SNVs in the skipped exons for SNRK |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_373554 | 43344590 | 43345284 | 43344761 | 43344761 | Frame_Shift_Del | G | - | p.L22fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_373554 | 43344590 | 43345284 | 43344814 | 43344814 | Frame_Shift_Del | A | - | p.E40fs |
| BRCA | TCGA-EW-A1OY-01 | exon_skip_373554 | 43344590 | 43345284 | 43344860 | 43344864 | Frame_Shift_Del | AGCTA | - | p.A56fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_373554 | 43344590 | 43345284 | 43344874 | 43344874 | Frame_Shift_Del | T | - | p.L60fs |
| LUAD | TCGA-67-3771-01 | exon_skip_373554 | 43344590 | 43345284 | 43345163 | 43345166 | Frame_Shift_Del | GACA | - | p.LT156fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_373562 | 43381779 | 43381991 | 43381894 | 43381894 | Frame_Shift_Del | C | - | p.P283fs |
| PAAD | TCGA-IB-7651-01 | exon_skip_373554 | 43344590 | 43345284 | 43344702 | 43344702 | Nonsense_Mutation | G | T | p.G3* |
| PAAD | TCGA-IB-7651-01 | exon_skip_373554 | 43344590 | 43345284 | 43344702 | 43344702 | Nonsense_Mutation | G | T | p.G3X |
| HNSC | TCGA-CR-7368-01 | exon_skip_373554 | 43344590 | 43345284 | 43344765 | 43344765 | Nonsense_Mutation | C | T | p.R24* |
| COAD | TCGA-DM-A28H-01 | exon_skip_373562 | 43381779 | 43381991 | 43381975 | 43381975 | Nonsense_Mutation | C | T | p.R310X |
| SKCM | TCGA-DA-A1IA-06 | exon_skip_373562 | 43381779 | 43381991 | 43381975 | 43381975 | Nonsense_Mutation | C | T | p.R310* |
| SKCM | TCGA-DA-A1IA-06 | exon_skip_373562 | 43381779 | 43381991 | 43381975 | 43381975 | Nonsense_Mutation | C | T | p.R310X |
| SKCM | TCGA-EE-A29R-06 | exon_skip_373562 | 43381779 | 43381991 | 43381975 | 43381975 | Nonsense_Mutation | C | T | p.R310* |
| SKCM | TCGA-EE-A2GD-06 | exon_skip_373562 | 43381779 | 43381991 | 43381975 | 43381975 | Nonsense_Mutation | C | T | p.R310* |
| HNSC | TCGA-CR-7394-01 | exon_skip_373562 | 43381779 | 43381991 | 43381993 | 43381993 | Splice_Site | T | C | p.E315_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| OVCA433_OVARY | 43344590 | 43345284 | 43344857 | 43344871 | In_Frame_Del | TCTAGCTACTGGTCA | - | p.LATGH55del |
| HEC251_ENDOMETRIUM | 43344590 | 43345284 | 43344726 | 43344726 | Missense_Mutation | A | C | p.K11Q |
| SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 43344590 | 43345284 | 43344780 | 43344780 | Missense_Mutation | G | A | p.V29M |
| JIYOYEP2003_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 43344590 | 43345284 | 43344835 | 43344835 | Missense_Mutation | T | C | p.I47T |
| U266B1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 43344590 | 43345284 | 43344924 | 43344924 | Missense_Mutation | C | T | p.R77C |
| CHLA06ATRT_SOFT_TISSUE | 43344590 | 43345284 | 43344940 | 43344940 | Missense_Mutation | T | C | p.I82T |
| SARC9371_BONE | 43344590 | 43345284 | 43345119 | 43345119 | Missense_Mutation | C | T | p.P142S |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 43344590 | 43345284 | 43345165 | 43345165 | Missense_Mutation | C | T | p.T157I |
| 22RV1_PROSTATE | 43344590 | 43345284 | 43345239 | 43345239 | Missense_Mutation | G | A | p.A182T |
| KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 43373661 | 43373802 | 43373709 | 43373709 | Missense_Mutation | C | T | p.P213L |
| HEC251_ENDOMETRIUM | 43381779 | 43381991 | 43381810 | 43381810 | Missense_Mutation | A | G | p.K255E |
| NOS1_BONE | 43381779 | 43381991 | 43381825 | 43381825 | Missense_Mutation | T | G | p.L260V |
| HCC1187_MATCHED_NORMAL_TISSUE | 43381779 | 43381991 | 43381826 | 43381826 | Missense_Mutation | T | C | p.L260S |
| SKMEL28_SKIN | 43381779 | 43381991 | 43381859 | 43381859 | Missense_Mutation | G | A | p.G271E |
| HCC1569_BREAST | 43381779 | 43381991 | 43381928 | 43381928 | Missense_Mutation | A | G | p.E294G |
| EW13_BONE | 43381779 | 43381991 | 43381961 | 43381961 | Missense_Mutation | G | A | p.G305E |
| HEC251_ENDOMETRIUM | 43381779 | 43381991 | 43381972 | 43381972 | Missense_Mutation | G | A | p.D309N |
| JHUEM1_ENDOMETRIUM | 43381779 | 43381991 | 43381981 | 43381981 | Missense_Mutation | G | A | p.A312T |
| RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 43381779 | 43381991 | 43381981 | 43381981 | Missense_Mutation | G | A | p.A312T |
| TGBC11TKB_STOMACH | 43381779 | 43381991 | 43381981 | 43381981 | Missense_Mutation | G | A | p.A312T |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SNRK |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SNRK |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SNRK |
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RelatedDrugs for SNRK |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q9NRH2 | DB12010 | Fostamatinib | SNF-related serine/threonine-protein kinase | small molecule | approved|investigational |
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RelatedDiseases for SNRK |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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