|
||||||
|
 | |
| |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
| |
|
Gene summary for PAQR5 |
 Gene summary |
| Gene information | Gene symbol | PAQR5 | Gene ID | 54852 |
| Gene name | progestin and adipoQ receptor family member 5 | |
| Synonyms | MPRG | |
| Cytomap | 15q23 | |
| Type of gene | protein-coding | |
| Description | membrane progestin receptor gammamPR gammamembrane progesterone P4 receptor gammamembrane progesterone receptor gammaprogesterone and adipoQ receptor family member 5progestin and adipoQ receptor family member V | |
| Modification date | 20180519 | |
| UniProtAcc | Q9NXK6 | |
| Context | PubMed: PAQR5 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
Exon skipping events across known transcript of Ensembl for PAQR5 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
Top |
Gene isoform structures and expression levels for PAQR5 |
| Expression levels of gene isoforms across TCGA. |
 |
| Expression levels of gene isoforms across GTEx. |
 |
Top |
Exon skipping events with PSIs in TCGA for PAQR5 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_123154 | 15 | 69629679:69629840:69652304:69652470:69672221:69672349 | 69652304:69652470 | ENSG00000137819.9 | ENST00000340965.3,ENST00000395407.2 |
| exon_skip_123163 | 15 | 69672221:69672349:69675194:69675312:69677015:69677221 | 69675194:69675312 | ENSG00000137819.9 | ENST00000561027.1 |
| exon_skip_123165 | 15 | 69672221:69672349:69677015:69677221:69681992:69682082 | 69677015:69677221 | ENSG00000137819.9 | ENST00000340965.3,ENST00000558684.1,ENST00000395407.2,ENST00000561153.1 |
| exon_skip_123174 | 15 | 69677015:69677221:69681992:69682119:69689806:69689903 | 69681992:69682119 | ENSG00000137819.9 | ENST00000340965.3,ENST00000395407.2,ENST00000561153.1 |
| exon_skip_123177 | 15 | 69681992:69682119:69689806:69689903:69692312:69692454 | 69689806:69689903 | ENSG00000137819.9 | ENST00000340965.3,ENST00000395407.2,ENST00000561153.1 |
| exon_skip_123182 | 15 | 69689806:69689903:69692312:69692454:69695919:69696778 | 69692312:69692454 | ENSG00000137819.9 | ENST00000340965.3,ENST00000395407.2,ENST00000561153.1 |
| PSI values of skipped exons in TCGA. |
 |
Top |
Exon skipping events with PSIs in GTEx for PAQR5 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_123154 | 15 | 69629679:69629840:69652304:69652470:69672221:69672349 | 69652304:69652470 | ENSG00000137819.9 | ENST00000395407.2,ENST00000340965.3 |
| exon_skip_123165 | 15 | 69672221:69672349:69677015:69677221:69681992:69682082 | 69677015:69677221 | ENSG00000137819.9 | ENST00000395407.2,ENST00000558684.1,ENST00000561153.1,ENST00000340965.3 |
| exon_skip_123177 | 15 | 69681992:69682119:69689806:69689903:69692312:69692454 | 69689806:69689903 | ENSG00000137819.9 | ENST00000395407.2,ENST00000561153.1,ENST00000340965.3 |
| exon_skip_123182 | 15 | 69689806:69689903:69692312:69692454:69695919:69696778 | 69692312:69692454 | ENSG00000137819.9 | ENST00000395407.2,ENST00000561153.1,ENST00000340965.3 |
| PSI values of skipped exons in GTEx. |
 |
| * Skipped exon sequences. |
Top |
Open reading frame (ORF) annotation in the exon skipping event for PAQR5 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000340965 | 69652304 | 69652470 | 5CDS-5UTR |
| ENST00000395407 | 69652304 | 69652470 | 5CDS-5UTR |
| ENST00000340965 | 69677015 | 69677221 | Frame-shift |
| ENST00000395407 | 69677015 | 69677221 | Frame-shift |
| ENST00000561153 | 69677015 | 69677221 | Frame-shift |
| ENST00000340965 | 69681992 | 69682119 | Frame-shift |
| ENST00000395407 | 69681992 | 69682119 | Frame-shift |
| ENST00000561153 | 69681992 | 69682119 | Frame-shift |
| ENST00000340965 | 69689806 | 69689903 | Frame-shift |
| ENST00000395407 | 69689806 | 69689903 | Frame-shift |
| ENST00000561153 | 69689806 | 69689903 | Frame-shift |
| ENST00000340965 | 69692312 | 69692454 | Frame-shift |
| ENST00000395407 | 69692312 | 69692454 | Frame-shift |
| ENST00000561153 | 69692312 | 69692454 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000340965 | 69652304 | 69652470 | 5CDS-5UTR |
| ENST00000395407 | 69652304 | 69652470 | 5CDS-5UTR |
| ENST00000340965 | 69677015 | 69677221 | Frame-shift |
| ENST00000395407 | 69677015 | 69677221 | Frame-shift |
| ENST00000561153 | 69677015 | 69677221 | Frame-shift |
| ENST00000340965 | 69689806 | 69689903 | Frame-shift |
| ENST00000395407 | 69689806 | 69689903 | Frame-shift |
| ENST00000561153 | 69689806 | 69689903 | Frame-shift |
| ENST00000340965 | 69692312 | 69692454 | Frame-shift |
| ENST00000395407 | 69692312 | 69692454 | Frame-shift |
| ENST00000561153 | 69692312 | 69692454 | Frame-shift |
Top |
Infer the effects of exon skipping event on protein functional features for PAQR5 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
 |
| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Top |
SNVs in the skipped exons for PAQR5 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_123154 | 69652305 | 69652470 | 69652465 | 69652465 | Frame_Shift_Del | C | - | p.P16fs |
| BLCA | TCGA-GV-A3QI-01 | exon_skip_123165 | 69677016 | 69677221 | 69677081 | 69677081 | Nonsense_Mutation | G | A | p.W82* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| EW24_BONE | 69677016 | 69677221 | 69677151 | 69677151 | Frame_Shift_Del | C | - | p.S106fs |
| MFE280_ENDOMETRIUM | 69692313 | 69692454 | 69692428 | 69692428 | Frame_Shift_Del | T | - | p.L242fs |
| M1203273_SKIN | 69677016 | 69677221 | 69677113 | 69677113 | Missense_Mutation | G | A | p.V93M |
| SNU182_LIVER | 69677016 | 69677221 | 69677200 | 69677200 | Missense_Mutation | G | A | p.A122T |
| EN_ENDOMETRIUM | 69681993 | 69682119 | 69682088 | 69682088 | Missense_Mutation | A | G | p.I161V |
| RCCMF_KIDNEY | 69689807 | 69689903 | 69689817 | 69689817 | Missense_Mutation | A | T | p.I175F |
| MN60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 69692313 | 69692454 | 69692337 | 69692337 | Missense_Mutation | G | A | p.A212T |
| HEC265_ENDOMETRIUM | 69692313 | 69692454 | 69692403 | 69692403 | Missense_Mutation | T | C | p.Y234H |
| NH12_AUTONOMIC_GANGLIA | 69692313 | 69692454 | 69692409 | 69692409 | Missense_Mutation | G | C | p.A236P |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PAQR5 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
Top |
Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PAQR5 |
Top |
Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PAQR5 |
Top |
RelatedDrugs for PAQR5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for PAQR5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|