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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for TET2 |
 Gene summary |
| Gene information | Gene symbol | TET2 | Gene ID | 54790 |
| Gene name | tet methylcytosine dioxygenase 2 | |
| Synonyms | KIAA1546|MDS | |
| Cytomap | 4q24 | |
| Type of gene | protein-coding | |
| Description | methylcytosine dioxygenase TET2probable methylcytosine dioxygenase TET2tet oncogene family member 2 | |
| Modification date | 20180523 | |
| UniProtAcc | Q6N021 | |
| Context | PubMed: TET2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TET2 | GO:0006211 | 5-methylcytosine catabolic process | 24315485 |
| TET2 | GO:0006493 | protein O-linked glycosylation | 23222540 |
| TET2 | GO:0080111 | DNA demethylation | 24315485 |
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Exon skipping events across known transcript of Ensembl for TET2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for TET2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for TET2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_425372 | 4 | 106068042:106068136:106111516:106111643:106155053:106158114 | 106111516:106111643 | ENSG00000168769.8 | ENST00000545826.1,ENST00000540549.1,ENST00000513237.1 |
| exon_skip_425373 | 4 | 106068089:106068136:106111516:106111662:106155053:106155429 | 106111516:106111662 | ENSG00000168769.8 | ENST00000265149.5,ENST00000380013.4,ENST00000394764.1 |
| exon_skip_425384 | 4 | 106111516:106111662:106155053:106158508:106162495:106162586 | 106155053:106158508 | ENSG00000168769.8 | ENST00000380013.4 |
| exon_skip_425385 | 4 | 106111516:106111662:106155053:106158508:106163990:106164084 | 106155053:106158508 | ENSG00000168769.8 | ENST00000265149.5 |
| exon_skip_425393 | 4 | 106155053:106158508:106162495:106162586:106163990:106164084 | 106162495:106162586 | ENSG00000168769.8 | ENST00000380013.4,ENST00000540549.1,ENST00000513237.1 |
| exon_skip_425400 | 4 | 106163990:106164084:106164726:106164935:106180775:106180926 | 106164726:106164935 | ENSG00000168769.8 | ENST00000545826.1,ENST00000265149.5,ENST00000380013.4,ENST00000540549.1,ENST00000513237.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for TET2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_425373 | 4 | 106068089:106068136:106111516:106111662:106155053:106155429 | 106111516:106111662 | ENSG00000168769.8 | ENST00000380013.4,ENST00000265149.5,ENST00000394764.1 |
| exon_skip_425384 | 4 | 106111516:106111662:106155053:106158508:106162495:106162586 | 106155053:106158508 | ENSG00000168769.8 | ENST00000380013.4 |
| exon_skip_425385 | 4 | 106111516:106111662:106155053:106158508:106163990:106164084 | 106155053:106158508 | ENSG00000168769.8 | ENST00000265149.5 |
| exon_skip_425393 | 4 | 106155053:106158508:106162495:106162586:106163990:106164084 | 106162495:106162586 | ENSG00000168769.8 | ENST00000513237.1,ENST00000540549.1,ENST00000380013.4 |
| exon_skip_425400 | 4 | 106163990:106164084:106164726:106164935:106180775:106180926 | 106164726:106164935 | ENSG00000168769.8 | ENST00000513237.1,ENST00000540549.1,ENST00000545826.1,ENST00000380013.4,ENST00000265149.5 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for TET2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000380013 | 106155053 | 106158508 | 5CDS-5UTR |
| ENST00000380013 | 106111516 | 106111662 | 5UTR-5UTR |
| ENST00000540549 | 106111516 | 106111643 | 5UTR-5UTR |
| ENST00000380013 | 106162495 | 106162586 | Frame-shift |
| ENST00000540549 | 106162495 | 106162586 | Frame-shift |
| ENST00000380013 | 106164726 | 106164935 | Frame-shift |
| ENST00000540549 | 106164726 | 106164935 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000380013 | 106155053 | 106158508 | 5CDS-5UTR |
| ENST00000380013 | 106111516 | 106111662 | 5UTR-5UTR |
| ENST00000380013 | 106162495 | 106162586 | Frame-shift |
| ENST00000540549 | 106162495 | 106162586 | Frame-shift |
| ENST00000380013 | 106164726 | 106164935 | Frame-shift |
| ENST00000540549 | 106164726 | 106164935 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for TET2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for TET2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| UCEC | TCGA-D1-A17A-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106155403 | 106155404 | Frame_Shift_Del | TC | - | p.S104fs |
| UCEC | TCGA-D1-A17A-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106155403 | 106155404 | Frame_Shift_Del | TC | - | p.S123fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106155499 | 106155499 | Frame_Shift_Del | G | - | p.G134fs |
| STAD | TCGA-CG-4306-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106155661 | 106155661 | Frame_Shift_Del | A | - | p.G187fs |
| STAD | TCGA-CG-4306-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106155661 | 106155661 | Frame_Shift_Del | A | - | p.G208fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106156759 | 106156759 | Frame_Shift_Del | C | - | p.P555fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106156936 | 106156936 | Frame_Shift_Del | G | - | p.G614fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106157065 | 106157065 | Frame_Shift_Del | C | - | p.P656fs |
| COAD | TCGA-AZ-4615-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106157183 | 106157186 | Frame_Shift_Del | TGTC | - | p.695_696del |
| UCS | TCGA-N5-A4RN-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106157271 | 106157271 | Frame_Shift_Del | T | - | p.H724fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106157462 | 106157462 | Frame_Shift_Del | A | - | p.E788fs |
| KIRC | TCGA-AK-3429-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106157564 | 106157565 | Frame_Shift_Del | CC | - | p.822_822del |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106157657 | 106157657 | Frame_Shift_Del | T | - | p.L874fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106157939 | 106157939 | Frame_Shift_Del | A | - | p.Q947fs |
| DLBC | TCGA-FF-8062-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106158250 | 106158259 | Frame_Shift_Del | CAGAAGCAAG | - | p.1050_1053del |
| LGG | TCGA-DU-6392-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106158447 | 106158447 | Frame_Shift_Del | A | - | p.I1137fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_425400 | 106164727 | 106164935 | 106164773 | 106164773 | Frame_Shift_Del | G | - | p.R1214fs |
| LIHC | TCGA-CC-A3M9-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106155167 | 106155168 | Frame_Shift_Ins | - | T | p.H23fs |
| LIHC | TCGA-CC-A3M9-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106155167 | 106155168 | Frame_Shift_Ins | - | T | p.P23fs |
| LIHC | TCGA-CC-A3M9-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106155168 | 106155169 | Frame_Shift_Ins | - | CA | p.L24fs |
| LIHC | TCGA-CC-A3M9-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106155168 | 106155169 | Frame_Shift_Ins | - | CA | p.P23fs |
| READ | TCGA-EI-6511-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106155778 | 106155779 | Frame_Shift_Ins | - | A | p.E227fs |
| ESCA | TCGA-LN-A8HZ-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106156651 | 106156652 | Frame_Shift_Ins | - | T | p.G520fs |
| LUSC | TCGA-34-5927-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106156934 | 106156935 | Frame_Shift_Ins | - | T | p.P633fs |
| LIHC | TCGA-BC-A112-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106157384 | 106157385 | Frame_Shift_Ins | - | C | p.P762fs |
| STAD | TCGA-CG-5723-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106157548 | 106157549 | Frame_Shift_Ins | - | C | p.S817fs |
| STAD | TCGA-CG-5723-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106157549 | 106157550 | Frame_Shift_Ins | - | C | p.S838fs |
| UCEC | TCGA-AX-A05Z-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106155340 | 106155340 | Nonsense_Mutation | G | T | p.E81* |
| UCEC | TCGA-A5-A0GV-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106155367 | 106155367 | Nonsense_Mutation | C | T | p.Q111* |
| LUAD | TCGA-17-Z003-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106155397 | 106155397 | Nonsense_Mutation | G | T | p.E121* |
| PAAD | TCGA-FB-AAQ2-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106155430 | 106155430 | Nonsense_Mutation | A | T | p.K111* |
| READ | TCGA-EI-6917-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106155544 | 106155544 | Nonsense_Mutation | G | T | p.E149X |
| BLCA | TCGA-BT-A20Q-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106156625 | 106156625 | Nonsense_Mutation | C | G | p.S509* |
| UCEC | TCGA-A5-A0VP-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106156729 | 106156729 | Nonsense_Mutation | C | T | p.R544* |
| HNSC | TCGA-CV-A6JT-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106156747 | 106156747 | Nonsense_Mutation | C | T | p.R571* |
| HNSC | TCGA-CR-7388-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106156786 | 106156786 | Nonsense_Mutation | G | T | p.G563* |
| HNSC | TCGA-CN-5366-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106156862 | 106156862 | Nonsense_Mutation | C | A | p.S588* |
| HNSC | TCGA-CN-5366-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106156862 | 106156862 | Nonsense_Mutation | C | A | p.S609* |
| PAAD | TCGA-IB-8126-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106157130 | 106157130 | Nonsense_Mutation | T | A | p.C677* |
| LGG | TCGA-TM-A84O-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106157155 | 106157155 | Nonsense_Mutation | A | T | p.R707* |
| CESC | TCGA-C5-A7UC-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106157306 | 106157306 | Nonsense_Mutation | C | G | p.S736* |
| READ | TCGA-F5-6814-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106157446 | 106157446 | Nonsense_Mutation | G | T | p.E783X |
| KIRP | TCGA-GL-6846-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106157461 | 106157461 | Nonsense_Mutation | G | T | p.E788* |
| KIRP | TCGA-GL-6846-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106157461 | 106157461 | Nonsense_Mutation | G | T | p.E788X |
| KIRP | TCGA-GL-6846-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106157461 | 106157461 | Nonsense_Mutation | G | T | p.E809* |
| HNSC | TCGA-BA-A6DF-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106157590 | 106157590 | Nonsense_Mutation | C | T | p.Q852* |
| LUAD | TCGA-44-A47A-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106158268 | 106158268 | Nonsense_Mutation | G | T | p.E1078* |
| STAD | TCGA-CD-5813-01 | exon_skip_425385 exon_skip_425384 | 106155054 | 106158508 | 106158510 | 106158510 | Splice_Site | T | C | p.E1137_splice |
| UCEC | TCGA-AX-A06H-01 | exon_skip_425393 | 106162496 | 106162586 | 106162494 | 106162494 | Splice_Site | A | C | e2-2 |
| UCEC | TCGA-AX-A06H-01 | exon_skip_425393 | 106162496 | 106162586 | 106162494 | 106162494 | Splice_Site | A | C | p.E1158_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| TGBC11TKB_STOMACH | 106155054 | 106158508 | 106156321 | 106156321 | Frame_Shift_Del | C | - | p.P411fs |
| CTB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 106155054 | 106158508 | 106156485 | 106156485 | Frame_Shift_Del | T | - | p.S462fs |
| CROAP3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 106155054 | 106158508 | 106156786 | 106156789 | Frame_Shift_Del | GGAT | - | p.GW563fs |
| HC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 106155054 | 106158508 | 106156879 | 106156879 | Frame_Shift_Del | C | - | p.P594fs |
| SISO_CERVIX | 106155054 | 106158508 | 106156936 | 106156936 | Frame_Shift_Del | G | - | p.G614fs |
| GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 106155054 | 106158508 | 106156936 | 106156936 | Frame_Shift_Del | G | - | p.G614fs |
| GOTO_AUTONOMIC_GANGLIA | 106155054 | 106158508 | 106157097 | 106157097 | Frame_Shift_Del | C | - | p.D666fs |
| HUT102_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 106155054 | 106158508 | 106158300 | 106158303 | Frame_Shift_Del | ACAA | - | p.RQ1067fs |
| NCIBL1437_MATCHED_NORMAL_TISSUE | 106164727 | 106164935 | 106164791 | 106164791 | Frame_Shift_Del | C | - | p.T1220fs |
| DU145_PROSTATE | 106155054 | 106158508 | 106155778 | 106155779 | Frame_Shift_Ins | - | A | p.E227fs |
| LS411N_LARGE_INTESTINE | 106155054 | 106158508 | 106155778 | 106155779 | Frame_Shift_Ins | - | A | p.E227fs |
| MZ1B_MATCHED_NORMAL_TISSUE | 106155054 | 106158508 | 106156042 | 106156043 | Frame_Shift_Ins | - | A | p.S315fs |
| NCIH1694_LUNG | 106155054 | 106158508 | 106156276 | 106156277 | Frame_Shift_Ins | - | C | p.S393fs |
| SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 106155054 | 106158508 | 106158218 | 106158219 | Frame_Shift_Ins | - | A | p.F1041fs |
| HS936T_SKIN | 106155054 | 106158508 | 106155146 | 106155146 | Missense_Mutation | C | T | p.P16L |
| EN_ENDOMETRIUM | 106155054 | 106158508 | 106155274 | 106155274 | Missense_Mutation | A | G | p.S59G |
| SNU1040_LARGE_INTESTINE | 106155054 | 106158508 | 106155386 | 106155386 | Missense_Mutation | G | A | p.R96H |
| HEC108_ENDOMETRIUM | 106155054 | 106158508 | 106155431 | 106155431 | Missense_Mutation | A | G | p.K111R |
| NCIH661_LUNG | 106155054 | 106158508 | 106155466 | 106155466 | Missense_Mutation | C | T | p.R123C |
| SKNDZ_AUTONOMIC_GANGLIA | 106155054 | 106158508 | 106155467 | 106155467 | Missense_Mutation | G | A | p.R123H |
| SW684_SOFT_TISSUE | 106155054 | 106158508 | 106155502 | 106155502 | Missense_Mutation | G | A | p.E135K |
| A2058_SKIN | 106155054 | 106158508 | 106155514 | 106155514 | Missense_Mutation | C | T | p.P139S |
| A2058_SKIN | 106155054 | 106158508 | 106155514 | 106155515 | Missense_Mutation | CC | TT | p.P139L |
| A2058_SKIN | 106155054 | 106158508 | 106155515 | 106155515 | Missense_Mutation | C | T | p.P139L |
| EKVX_LUNG | 106155054 | 106158508 | 106155518 | 106155518 | Missense_Mutation | A | G | p.N140S |
| SNU81_LARGE_INTESTINE | 106155054 | 106158508 | 106155928 | 106155928 | Missense_Mutation | G | A | p.A277T |
| NCIH1573_LUNG | 106155054 | 106158508 | 106156019 | 106156019 | Missense_Mutation | T | G | p.L307R |
| NCIBL209_MATCHED_NORMAL_TISSUE | 106155054 | 106158508 | 106156019 | 106156019 | Missense_Mutation | T | G | p.L307R |
| NCIH209_LUNG | 106155054 | 106158508 | 106156019 | 106156019 | Missense_Mutation | T | G | p.L307R |
| KASUMI2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 106155054 | 106158508 | 106156139 | 106156139 | Missense_Mutation | C | T | p.A347V |
| MON_SOFT_TISSUE | 106155054 | 106158508 | 106156171 | 106156171 | Missense_Mutation | A | G | p.S358G |
| SNUC2A_LARGE_INTESTINE | 106155054 | 106158508 | 106156196 | 106156196 | Missense_Mutation | G | T | p.S366I |
| KYM1_SOFT_TISSUE | 106155054 | 106158508 | 106156255 | 106156255 | Missense_Mutation | G | T | p.V386L |
| HEC50B_ENDOMETRIUM | 106155054 | 106158508 | 106156271 | 106156271 | Missense_Mutation | C | T | p.S391F |
| IOMMLEE_CENTRAL_NERVOUS_SYSTEM | 106155054 | 106158508 | 106156337 | 106156337 | Missense_Mutation | C | A | p.P413Q |
| RH28_SOFT_TISSUE | 106155054 | 106158508 | 106156430 | 106156430 | Missense_Mutation | C | T | p.T444I |
| OVSAHO_OVARY | 106155054 | 106158508 | 106156468 | 106156468 | Missense_Mutation | G | T | p.A457S |
| U2OS_BONE | 106155054 | 106158508 | 106156493 | 106156493 | Missense_Mutation | C | T | p.P465L |
| COV362_OVARY | 106155054 | 106158508 | 106156520 | 106156520 | Missense_Mutation | C | T | p.P474L |
| SKMEL5_SKIN | 106155054 | 106158508 | 106156529 | 106156529 | Missense_Mutation | C | T | p.S477F |
| SW684_SOFT_TISSUE | 106155054 | 106158508 | 106156535 | 106156535 | Missense_Mutation | G | A | p.R479K |
| NCIH2172_LUNG | 106155054 | 106158508 | 106156546 | 106156546 | Missense_Mutation | A | G | p.N483D |
| RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 106155054 | 106158508 | 106156811 | 106156811 | Missense_Mutation | G | A | p.R571H |
| NCIH2591_PLEURA | 106155054 | 106158508 | 106156841 | 106156841 | Missense_Mutation | G | A | p.R581H |
| KYSE410_OESOPHAGUS | 106155054 | 106158508 | 106156895 | 106156895 | Missense_Mutation | A | G | p.Q599R |
| JHH1_LIVER | 106155054 | 106158508 | 106156895 | 106156895 | Missense_Mutation | A | G | p.Q599R |
| HS274T_BREAST | 106155054 | 106158508 | 106156973 | 106156973 | Missense_Mutation | C | T | p.T625I |
| JHH6_LIVER | 106155054 | 106158508 | 106157066 | 106157066 | Missense_Mutation | C | G | p.P656R |
| HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 106155054 | 106158508 | 106157072 | 106157072 | Missense_Mutation | A | C | p.H658P |
| RKO_LARGE_INTESTINE | 106155054 | 106158508 | 106157132 | 106157132 | Missense_Mutation | G | A | p.G678D |
| TCCSUP_URINARY_TRACT | 106155054 | 106158508 | 106157180 | 106157180 | Missense_Mutation | T | G | p.L694R |
| CCK81_LARGE_INTESTINE | 106155054 | 106158508 | 106157182 | 106157182 | Missense_Mutation | A | G | p.M695V |
| VMCUB1_URINARY_TRACT | 106155054 | 106158508 | 106157196 | 106157196 | Missense_Mutation | G | T | p.L699F |
| TE9_OESOPHAGUS | 106155054 | 106158508 | 106157212 | 106157212 | Missense_Mutation | C | G | p.Q705E |
| SW1088_CENTRAL_NERVOUS_SYSTEM | 106155054 | 106158508 | 106157219 | 106157219 | Missense_Mutation | C | A | p.A707D |
| QGP1_PANCREAS | 106155054 | 106158508 | 106157435 | 106157435 | Missense_Mutation | C | G | p.T779S |
| LNCAPCLONEFGC_PROSTATE | 106155054 | 106158508 | 106157482 | 106157482 | Missense_Mutation | A | G | p.S795G |
| AMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 106155054 | 106158508 | 106157485 | 106157485 | Missense_Mutation | G | A | p.E796K |
| EJM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 106155054 | 106158508 | 106157521 | 106157521 | Missense_Mutation | G | A | p.E808K |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 106155054 | 106158508 | 106157592 | 106157592 | Missense_Mutation | G | T | p.Q831H |
| 22RV1_PROSTATE | 106155054 | 106158508 | 106157650 | 106157650 | Missense_Mutation | C | T | p.P851S |
| MDAMB453_BREAST | 106155054 | 106158508 | 106157740 | 106157740 | Missense_Mutation | A | G | p.R881G |
| HMVII_SKIN | 106155054 | 106158508 | 106158448 | 106158448 | Missense_Mutation | A | G | p.K1117E |
| CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 106155054 | 106158508 | 106158503 | 106158503 | Missense_Mutation | G | A | p.C1135Y |
| HCC2450_LUNG | 106162496 | 106162586 | 106162516 | 106162516 | Missense_Mutation | G | A | p.E1144K |
| OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 106162496 | 106162586 | 106162529 | 106162529 | Missense_Mutation | A | G | p.Y1148C |
| SNUC4_LARGE_INTESTINE | 106164727 | 106164935 | 106164773 | 106164773 | Missense_Mutation | G | A | p.R1214Q |
| DMS53_LUNG | 106164727 | 106164935 | 106164890 | 106164890 | Missense_Mutation | G | C | p.R1253T |
| MELJUSO_SKIN | 106164727 | 106164935 | 106164913 | 106164913 | Missense_Mutation | C | T | p.R1261C |
| NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 106164727 | 106164935 | 106164914 | 106164914 | Missense_Mutation | G | A | p.R1261H |
| EBC1_LUNG | 106155054 | 106158508 | 106155902 | 106155902 | Nonsense_Mutation | C | A | p.S268* |
| HCC1954_MATCHED_NORMAL_TISSUE | 106155054 | 106158508 | 106156480 | 106156480 | Nonsense_Mutation | C | T | p.Q461* |
| OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 106155054 | 106158508 | 106157573 | 106157573 | Nonsense_Mutation | C | A | p.S825* |
| CROAP3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 106164727 | 106164935 | 106164897 | 106164897 | Nonsense_Mutation | C | A | p.Y1255* |
| MCCAR_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 106164727 | 106164935 | 106164897 | 106164897 | Nonsense_Mutation | C | A | p.Y1255* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TET2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TET2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TET2 |
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RelatedDrugs for TET2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TET2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| TET2 | C0079774 | Peripheral T-Cell Lymphoma | 2 | CTD_human |
| TET2 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
| TET2 | C0020981 | Angioimmunoblastic Lymphadenopathy | 1 | CTD_human |
| TET2 | C0023487 | Acute Promyelocytic Leukemia | 1 | CTD_human |
| TET2 | C0027643 | Neoplasm Recurrence, Local | 1 | CTD_human |
| TET2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| TET2 | C0036920 | Sezary Syndrome | 1 | CTD_human |
| TET2 | C3463824 | MYELODYSPLASTIC SYNDROME | 1 | CTD_human;HPO |
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