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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ARL15 |
 Gene summary |
| Gene information | Gene symbol | ARL15 | Gene ID | 54622 |
| Gene name | ADP ribosylation factor like GTPase 15 | |
| Synonyms | ARFRP2 | |
| Cytomap | 5q11.2 | |
| Type of gene | protein-coding | |
| Description | ADP-ribosylation factor-like protein 15ADP-ribosylation factor-like 15ADP-ribosylation factor-related protein 2ARF-related protein 2 | |
| Modification date | 20180519 | |
| UniProtAcc | Q9NXU5 | |
| Context | PubMed: ARL15 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for ARL15 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ARL15 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ARL15 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_442096 | 5 | 53182274:53182543:53409031:53409240:53450409:53450469 | 53409031:53409240 | ENSG00000185305.6 | ENST00000510591.2,ENST00000502271.1,ENST00000504924.1 |
| exon_skip_442100 | 5 | 53409031:53409240:53450409:53450469:53467613:53467758 | 53450409:53450469 | ENSG00000185305.6 | ENST00000507646.2,ENST00000510591.2,ENST00000505630.1,ENST00000504924.1 |
| exon_skip_442106 | 5 | 53450409:53450469:53467613:53467758:53606124:53606245 | 53467613:53467758 | ENSG00000185305.6 | ENST00000510591.2 |
| exon_skip_442107 | 5 | 53450409:53450469:53467613:53467758:53606261:53606403 | 53467613:53467758 | ENSG00000185305.6 | ENST00000505383.1,ENST00000507646.2,ENST00000505630.1,ENST00000504924.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ARL15 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_442096 | 5 | 53182274:53182543:53409031:53409240:53450409:53450469 | 53409031:53409240 | ENSG00000185305.6 | ENST00000502271.1,ENST00000504924.1,ENST00000510591.2 |
| exon_skip_442100 | 5 | 53409031:53409240:53450409:53450469:53467613:53467758 | 53450409:53450469 | ENSG00000185305.6 | ENST00000504924.1,ENST00000510591.2,ENST00000507646.2,ENST00000505630.1 |
| exon_skip_442106 | 5 | 53450409:53450469:53467613:53467758:53606124:53606245 | 53467613:53467758 | ENSG00000185305.6 | ENST00000510591.2 |
| exon_skip_442107 | 5 | 53450409:53450469:53467613:53467758:53606261:53606403 | 53467613:53467758 | ENSG00000185305.6 | ENST00000504924.1,ENST00000507646.2,ENST00000505630.1,ENST00000505383.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ARL15 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000504924 | 53409031 | 53409240 | Frame-shift |
| ENST00000504924 | 53467613 | 53467758 | Frame-shift |
| ENST00000504924 | 53450409 | 53450469 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000504924 | 53409031 | 53409240 | Frame-shift |
| ENST00000504924 | 53467613 | 53467758 | Frame-shift |
| ENST00000504924 | 53450409 | 53450469 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ARL15 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000504924 | 2503 | 204 | 53450409 | 53450469 | 288 | 347 | 64 | 84 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000504924 | 2503 | 204 | 53450409 | 53450469 | 288 | 347 | 64 | 84 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9NXU5 | 64 | 84 | 1 | 204 | Chain | ID=PRO_0000282387;Note=ADP-ribosylation factor-like protein 15 |
| Q9NXU5 | 64 | 84 | 82 | 86 | Nucleotide binding | Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9NXU5 | 64 | 84 | 1 | 204 | Chain | ID=PRO_0000282387;Note=ADP-ribosylation factor-like protein 15 |
| Q9NXU5 | 64 | 84 | 82 | 86 | Nucleotide binding | Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
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SNVs in the skipped exons for ARL15 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| KIRC | TCGA-B0-4710-01 | exon_skip_442096 | 53409032 | 53409240 | 53409047 | 53409047 | Frame_Shift_Del | A | - | p.R150fs |
| KIRC | TCGA-B0-4710-01 | exon_skip_442096 | 53409032 | 53409240 | 53409049 | 53409049 | Frame_Shift_Del | C | - | p.A149fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_442096 | 53409032 | 53409240 | 53409081 | 53409081 | Frame_Shift_Del | A | - | p.L138fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_442106 exon_skip_442107 | 53467614 | 53467758 | 53467671 | 53467671 | Frame_Shift_Del | T | - | p.T46fs |
| UCS | TCGA-QN-A5NN-01 | exon_skip_442106 exon_skip_442107 | 53467614 | 53467758 | 53467719 | 53467719 | Nonsense_Mutation | G | A | p.R30* |
| UCS | TCGA-QN-A5NN-01 | exon_skip_442106 exon_skip_442107 | 53467614 | 53467758 | 53467719 | 53467719 | Nonsense_Mutation | G | A | p.R30X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LNCAPCLONEFGC_PROSTATE | 53409032 | 53409240 | 53409073 | 53409073 | Missense_Mutation | C | A | p.A141S |
| CW2_LARGE_INTESTINE | 53409032 | 53409240 | 53409162 | 53409162 | Missense_Mutation | G | T | p.S111Y |
| F36P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 53409032 | 53409240 | 53409189 | 53409189 | Missense_Mutation | C | A | p.G102V |
| RL952_ENDOMETRIUM | 53409032 | 53409240 | 53409225 | 53409225 | Missense_Mutation | C | T | p.R90Q |
| MHHCALL3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 53409032 | 53409240 | 53409226 | 53409226 | Missense_Mutation | G | A | p.R90W |
| KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 53450410 | 53450469 | 53450434 | 53450434 | Missense_Mutation | T | C | p.I77V |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 53450410 | 53450469 | 53450434 | 53450434 | Missense_Mutation | T | C | p.I77V |
| HCC1195_LUNG | 53450410 | 53450469 | 53450446 | 53450446 | Missense_Mutation | A | G | p.F73L |
| GP2D_LARGE_INTESTINE | 53467614 | 53467758 | 53467623 | 53467623 | Missense_Mutation | A | G | p.S62P |
| CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 53467614 | 53467758 | 53467646 | 53467646 | Missense_Mutation | C | T | p.S54N |
| GSS_STOMACH | 53467614 | 53467758 | 53467670 | 53467670 | Missense_Mutation | G | A | p.T46I |
| HEC6_ENDOMETRIUM | 53467614 | 53467758 | 53467676 | 53467676 | Missense_Mutation | C | T | p.G44D |
| HEC251_ENDOMETRIUM | 53467614 | 53467758 | 53467707 | 53467707 | Missense_Mutation | C | A | p.D34Y |
| CAS1_CENTRAL_NERVOUS_SYSTEM | 53467614 | 53467758 | 53467727 | 53467727 | Missense_Mutation | G | T | p.P27Q |
| HT115_LARGE_INTESTINE | 53450410 | 53450469 | 53450419 | 53450419 | Nonsense_Mutation | C | A | p.E82* |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 53409032 | 53409240 | 53409239 | 53409239 | Splice_Site | C | T | p.G85G |
| NB5_AUTONOMIC_GANGLIA | 53450410 | 53450469 | 53450469 | 53450469 | Splice_Site | C | T | p.G65D |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ARL15 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ARL15 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ARL15 |
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RelatedDrugs for ARL15 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARL15 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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