ExonSkipDB: functional annotation of exon skipping event in human

Gene summary for INO80

Gene summary

Gene information	Gene symbol	INO80
	Gene ID	54617
	Gene name	INO80 complex subunit
	Synonyms	INO80A\|INOC1\|hINO80
	Cytomap	15q15.1
	Type of gene	protein-coding
	Description	DNA helicase INO80INO80 complex subunit AINO80 homologhomolog of yeast INO80putative DNA helicase INO80 complex homolog 1
	Modification date	20180523
	UniProtAcc	Q9ULG1
	Context	PubMed: INO80 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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Exon skipping events across known transcript of Ensembl for INO80 from UCSC genome browser

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Gene isoform structures and expression levels for INO80

Expression levels of gene isoforms across TCGA.

Expression levels of gene isoforms across GTEx.

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Exon skipping events with PSIs in TCGA for INO80

Information of exkip skipping event in TCGA.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_126157	15	41289774:41289799:41297790:41297885:41308285:41308413	41297790:41297885	ENSG00000128908.11	ENST00000401393.3,ENST00000557849.1,ENST00000361937.3
exon_skip_126158	15	41297790:41297885:41308285:41308413:41313097:41313323	41308285:41308413	ENSG00000128908.11	ENST00000401393.3,ENST00000557849.1,ENST00000361937.3
exon_skip_126161	15	41297790:41297885:41313097:41313323:41319793:41319797	41313097:41313323	ENSG00000128908.11	ENST00000558357.1
exon_skip_126164	15	41308285:41308413:41313097:41313323:41319793:41319797	41313097:41313323	ENSG00000128908.11	ENST00000401393.3,ENST00000361937.3
exon_skip_126167	15	41313097:41313323:41315423:41315544:41319793:41319797	41315423:41315544	ENSG00000128908.11	ENST00000557849.1
exon_skip_126168	15	41313097:41313323:41319793:41319934:41337101:41337244	41319793:41319934	ENSG00000128908.11	ENST00000401393.3,ENST00000361937.3,ENST00000558357.1
exon_skip_126169	15	41342136:41342300:41346126:41346212:41347444:41347562	41346126:41346212	ENSG00000128908.11	ENST00000401393.3,ENST00000361937.3,ENST00000559995.1,ENST00000558357.1
exon_skip_126172	15	41347444:41347562:41348819:41348904:41350836:41350979	41348819:41348904	ENSG00000128908.11	ENST00000401393.3,ENST00000361937.3,ENST00000558357.1
exon_skip_126176	15	41348819:41348904:41350836:41350979:41352064:41352124	41350836:41350979	ENSG00000128908.11	ENST00000401393.3,ENST00000361937.3,ENST00000558357.1
exon_skip_126179	15	41350836:41350979:41352064:41352124:41361767:41361820	41352064:41352124	ENSG00000128908.11	ENST00000401393.3,ENST00000361937.3,ENST00000558357.1
exon_skip_126180	15	41352064:41352124:41361767:41361863:41362664:41362745	41361767:41361863	ENSG00000128908.11	ENST00000401393.3,ENST00000361937.3,ENST00000558357.1
exon_skip_126182	15	41362664:41362745:41364046:41364256:41365625:41365693	41364046:41364256	ENSG00000128908.11	ENST00000401393.3,ENST00000361937.3,ENST00000558357.1
exon_skip_126183	15	41366567:41366763:41371898:41372102:41373217:41373271	41371898:41372102	ENSG00000128908.11	ENST00000401393.3,ENST00000361937.3,ENST00000558357.1
exon_skip_126184	15	41371898:41372102:41373217:41373271:41377566:41377781	41373217:41373271	ENSG00000128908.11	ENST00000401393.3,ENST00000361937.3,ENST00000558357.1
exon_skip_126186	15	41377566:41377781:41379759:41379880:41384224:41384380	41379759:41379880	ENSG00000128908.11	ENST00000401393.3,ENST00000361937.3,ENST00000558357.1
exon_skip_126187	15	41384224:41384380:41387798:41387866:41387956:41388126	41387798:41387866	ENSG00000128908.11	ENST00000401393.3,ENST00000361937.3,ENST00000558357.1

PSI values of skipped exons in TCGA.

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Exon skipping events with PSIs in GTEx for INO80

Information of exkip skipping event in GTEx

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_126157	15	41289774:41289799:41297790:41297885:41308285:41308413	41297790:41297885	ENSG00000128908.11	ENST00000361937.3,ENST00000401393.3,ENST00000557849.1
exon_skip_126158	15	41297790:41297885:41308285:41308413:41313097:41313323	41308285:41308413	ENSG00000128908.11	ENST00000361937.3,ENST00000401393.3,ENST00000557849.1
exon_skip_126161	15	41297790:41297885:41313097:41313323:41319793:41319797	41313097:41313323	ENSG00000128908.11	ENST00000558357.1
exon_skip_126164	15	41308285:41308413:41313097:41313323:41319793:41319797	41313097:41313323	ENSG00000128908.11	ENST00000361937.3,ENST00000401393.3
exon_skip_126167	15	41313097:41313323:41315423:41315544:41319793:41319797	41315423:41315544	ENSG00000128908.11	ENST00000557849.1
exon_skip_126168	15	41313097:41313323:41319793:41319934:41337101:41337244	41319793:41319934	ENSG00000128908.11	ENST00000361937.3,ENST00000401393.3,ENST00000558357.1
exon_skip_126169	15	41342136:41342300:41346126:41346212:41347444:41347562	41346126:41346212	ENSG00000128908.11	ENST00000361937.3,ENST00000401393.3,ENST00000558357.1,ENST00000559995.1
exon_skip_126172	15	41347444:41347562:41348819:41348904:41350836:41350979	41348819:41348904	ENSG00000128908.11	ENST00000361937.3,ENST00000401393.3,ENST00000558357.1
exon_skip_126173	15	41347444:41347562:41348819:41348904:41352064:41352124	41348819:41348904	ENSG00000128908.11	ENST00000559995.1
exon_skip_126176	15	41348819:41348904:41350836:41350979:41352064:41352124	41350836:41350979	ENSG00000128908.11	ENST00000361937.3,ENST00000401393.3,ENST00000558357.1
exon_skip_126178	15	41348819:41348904:41352064:41352124:41361767:41361820	41352064:41352124	ENSG00000128908.11	ENST00000559995.1
exon_skip_126179	15	41350836:41350979:41352064:41352124:41361767:41361820	41352064:41352124	ENSG00000128908.11	ENST00000361937.3,ENST00000401393.3,ENST00000558357.1
exon_skip_126180	15	41352064:41352124:41361767:41361863:41362664:41362745	41361767:41361863	ENSG00000128908.11	ENST00000361937.3,ENST00000401393.3,ENST00000558357.1
exon_skip_126182	15	41362664:41362745:41364046:41364256:41365625:41365693	41364046:41364256	ENSG00000128908.11	ENST00000361937.3,ENST00000401393.3,ENST00000558357.1
exon_skip_126183	15	41366567:41366763:41371898:41372102:41373217:41373271	41371898:41372102	ENSG00000128908.11	ENST00000361937.3,ENST00000401393.3,ENST00000558357.1
exon_skip_126184	15	41371898:41372102:41373217:41373271:41377566:41377781	41373217:41373271	ENSG00000128908.11	ENST00000361937.3,ENST00000401393.3,ENST00000558357.1
exon_skip_126186	15	41377566:41377781:41379759:41379880:41384224:41384380	41379759:41379880	ENSG00000128908.11	ENST00000361937.3,ENST00000401393.3,ENST00000558357.1
exon_skip_126187	15	41384224:41384380:41387798:41387866:41387956:41388126	41387798:41387866	ENSG00000128908.11	ENST00000361937.3,ENST00000401393.3,ENST00000558357.1

PSI values of skipped exons in GTEx.

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for INO80

Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000361937	41297790	41297885	Frame-shift
ENST00000401393	41297790	41297885	Frame-shift
ENST00000361937	41308285	41308413	Frame-shift
ENST00000401393	41308285	41308413	Frame-shift
ENST00000361937	41313097	41313323	Frame-shift
ENST00000401393	41313097	41313323	Frame-shift
ENST00000361937	41346126	41346212	Frame-shift
ENST00000401393	41346126	41346212	Frame-shift
ENST00000361937	41348819	41348904	Frame-shift
ENST00000401393	41348819	41348904	Frame-shift
ENST00000361937	41350836	41350979	Frame-shift
ENST00000401393	41350836	41350979	Frame-shift
ENST00000361937	41379759	41379880	Frame-shift
ENST00000401393	41379759	41379880	Frame-shift
ENST00000361937	41387798	41387866	Frame-shift
ENST00000401393	41387798	41387866	Frame-shift
ENST00000361937	41319793	41319934	In-frame
ENST00000401393	41319793	41319934	In-frame
ENST00000361937	41352064	41352124	In-frame
ENST00000401393	41352064	41352124	In-frame
ENST00000361937	41361767	41361863	In-frame
ENST00000401393	41361767	41361863	In-frame
ENST00000361937	41364046	41364256	In-frame
ENST00000401393	41364046	41364256	In-frame
ENST00000361937	41371898	41372102	In-frame
ENST00000401393	41371898	41372102	In-frame
ENST00000361937	41373217	41373271	In-frame
ENST00000401393	41373217	41373271	In-frame

Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000361937	41297790	41297885	Frame-shift
ENST00000401393	41297790	41297885	Frame-shift
ENST00000361937	41308285	41308413	Frame-shift
ENST00000401393	41308285	41308413	Frame-shift
ENST00000361937	41313097	41313323	Frame-shift
ENST00000401393	41313097	41313323	Frame-shift
ENST00000361937	41346126	41346212	Frame-shift
ENST00000401393	41346126	41346212	Frame-shift
ENST00000361937	41348819	41348904	Frame-shift
ENST00000401393	41348819	41348904	Frame-shift
ENST00000361937	41350836	41350979	Frame-shift
ENST00000401393	41350836	41350979	Frame-shift
ENST00000361937	41379759	41379880	Frame-shift
ENST00000401393	41379759	41379880	Frame-shift
ENST00000361937	41387798	41387866	Frame-shift
ENST00000401393	41387798	41387866	Frame-shift
ENST00000361937	41319793	41319934	In-frame
ENST00000401393	41319793	41319934	In-frame
ENST00000361937	41352064	41352124	In-frame
ENST00000401393	41352064	41352124	In-frame
ENST00000361937	41361767	41361863	In-frame
ENST00000401393	41361767	41361863	In-frame
ENST00000361937	41364046	41364256	In-frame
ENST00000401393	41364046	41364256	In-frame
ENST00000361937	41371898	41372102	In-frame
ENST00000401393	41371898	41372102	In-frame
ENST00000361937	41373217	41373271	In-frame
ENST00000401393	41373217	41373271	In-frame

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Infer the effects of exon skipping event on protein functional features for INO80

Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.

Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000361937	6456	1556	41373217	41373271	1299	1352	291	309
ENST00000401393	6006	1556	41373217	41373271	1098	1151	291	309
ENST00000361937	6456	1556	41371898	41372102	1353	1556	309	377
ENST00000401393	6006	1556	41371898	41372102	1152	1355	309	377
ENST00000361937	6456	1556	41364046	41364256	1821	2030	465	535
ENST00000401393	6006	1556	41364046	41364256	1620	1829	465	535
ENST00000361937	6456	1556	41361767	41361863	2112	2207	562	594
ENST00000401393	6006	1556	41361767	41361863	1911	2006	562	594
ENST00000361937	6456	1556	41352064	41352124	2208	2267	594	614
ENST00000401393	6006	1556	41352064	41352124	2007	2066	594	614
ENST00000361937	6456	1556	41319793	41319934	3333	3473	969	1016
ENST00000401393	6006	1556	41319793	41319934	3132	3272	969	1016

Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000361937	6456	1556	41373217	41373271	1299	1352	291	309
ENST00000401393	6006	1556	41373217	41373271	1098	1151	291	309
ENST00000361937	6456	1556	41371898	41372102	1353	1556	309	377
ENST00000401393	6006	1556	41371898	41372102	1152	1355	309	377
ENST00000361937	6456	1556	41364046	41364256	1821	2030	465	535
ENST00000401393	6006	1556	41364046	41364256	1620	1829	465	535
ENST00000361937	6456	1556	41361767	41361863	2112	2207	562	594
ENST00000401393	6006	1556	41361767	41361863	1911	2006	562	594
ENST00000361937	6456	1556	41352064	41352124	2208	2267	594	614
ENST00000401393	6006	1556	41352064	41352124	2007	2066	594	614
ENST00000361937	6456	1556	41319793	41319934	3333	3473	969	1016
ENST00000401393	6006	1556	41319793	41319934	3132	3272	969	1016

Lost protein functional features of individual exon skipping events in TCGA.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q9ULG1	291	309	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
Q9ULG1	291	309	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
Q9ULG1	291	309	280	405	Domain	Note=DBINO;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00746
Q9ULG1	291	309	280	405	Domain	Note=DBINO;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00746
Q9ULG1	291	309	212	526	Region	Note=Assembles INO80 complex module consisting of conserved components ACTR8%2C ACTL6A and YY1;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910
Q9ULG1	291	309	212	526	Region	Note=Assembles INO80 complex module consisting of conserved components ACTR8%2C ACTL6A and YY1;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910
Q9ULG1	309	377	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
Q9ULG1	309	377	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
Q9ULG1	309	377	280	405	Domain	Note=DBINO;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00746
Q9ULG1	309	377	280	405	Domain	Note=DBINO;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00746
Q9ULG1	309	377	212	526	Region	Note=Assembles INO80 complex module consisting of conserved components ACTR8%2C ACTL6A and YY1;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910
Q9ULG1	309	377	212	526	Region	Note=Assembles INO80 complex module consisting of conserved components ACTR8%2C ACTL6A and YY1;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910
Q9ULG1	465	535	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
Q9ULG1	465	535	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
Q9ULG1	465	535	530	701	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00541
Q9ULG1	465	535	530	701	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00541
Q9ULG1	465	535	212	526	Region	Note=Assembles INO80 complex module consisting of conserved components ACTR8%2C ACTL6A and YY1;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910
Q9ULG1	465	535	212	526	Region	Note=Assembles INO80 complex module consisting of conserved components ACTR8%2C ACTL6A and YY1;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910
Q9ULG1	465	535	521	1556	Region	Note=Assembles INO80 complex module consisting of conserved components INO80B%2C INO80C%2C ACTR5%2C RVBL1%2C RVBL2;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910
Q9ULG1	465	535	521	1556	Region	Note=Assembles INO80 complex module consisting of conserved components INO80B%2C INO80C%2C ACTR5%2C RVBL1%2C RVBL2;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910
Q9ULG1	562	594	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
Q9ULG1	562	594	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
Q9ULG1	562	594	530	701	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00541
Q9ULG1	562	594	530	701	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00541
Q9ULG1	562	594	521	1556	Region	Note=Assembles INO80 complex module consisting of conserved components INO80B%2C INO80C%2C ACTR5%2C RVBL1%2C RVBL2;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910
Q9ULG1	562	594	521	1556	Region	Note=Assembles INO80 complex module consisting of conserved components INO80B%2C INO80C%2C ACTR5%2C RVBL1%2C RVBL2;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910
Q9ULG1	594	614	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
Q9ULG1	594	614	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
Q9ULG1	594	614	530	701	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00541
Q9ULG1	594	614	530	701	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00541
Q9ULG1	594	614	521	1556	Region	Note=Assembles INO80 complex module consisting of conserved components INO80B%2C INO80C%2C ACTR5%2C RVBL1%2C RVBL2;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910
Q9ULG1	594	614	521	1556	Region	Note=Assembles INO80 complex module consisting of conserved components INO80B%2C INO80C%2C ACTR5%2C RVBL1%2C RVBL2;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910
Q9ULG1	969	1016	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
Q9ULG1	969	1016	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
Q9ULG1	969	1016	521	1556	Region	Note=Assembles INO80 complex module consisting of conserved components INO80B%2C INO80C%2C ACTR5%2C RVBL1%2C RVBL2;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910
Q9ULG1	969	1016	521	1556	Region	Note=Assembles INO80 complex module consisting of conserved components INO80B%2C INO80C%2C ACTR5%2C RVBL1%2C RVBL2;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910

Lost protein functional features of individual exon skipping events in GTEx.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q9ULG1	291	309	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
Q9ULG1	291	309	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
Q9ULG1	291	309	280	405	Domain	Note=DBINO;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00746
Q9ULG1	291	309	280	405	Domain	Note=DBINO;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00746
Q9ULG1	291	309	212	526	Region	Note=Assembles INO80 complex module consisting of conserved components ACTR8%2C ACTL6A and YY1;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910
Q9ULG1	291	309	212	526	Region	Note=Assembles INO80 complex module consisting of conserved components ACTR8%2C ACTL6A and YY1;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910
Q9ULG1	309	377	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
Q9ULG1	309	377	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
Q9ULG1	309	377	280	405	Domain	Note=DBINO;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00746
Q9ULG1	309	377	280	405	Domain	Note=DBINO;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00746
Q9ULG1	309	377	212	526	Region	Note=Assembles INO80 complex module consisting of conserved components ACTR8%2C ACTL6A and YY1;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910
Q9ULG1	309	377	212	526	Region	Note=Assembles INO80 complex module consisting of conserved components ACTR8%2C ACTL6A and YY1;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910
Q9ULG1	465	535	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
Q9ULG1	465	535	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
Q9ULG1	465	535	530	701	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00541
Q9ULG1	465	535	530	701	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00541
Q9ULG1	465	535	212	526	Region	Note=Assembles INO80 complex module consisting of conserved components ACTR8%2C ACTL6A and YY1;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910
Q9ULG1	465	535	212	526	Region	Note=Assembles INO80 complex module consisting of conserved components ACTR8%2C ACTL6A and YY1;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910
Q9ULG1	465	535	521	1556	Region	Note=Assembles INO80 complex module consisting of conserved components INO80B%2C INO80C%2C ACTR5%2C RVBL1%2C RVBL2;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910
Q9ULG1	465	535	521	1556	Region	Note=Assembles INO80 complex module consisting of conserved components INO80B%2C INO80C%2C ACTR5%2C RVBL1%2C RVBL2;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910
Q9ULG1	562	594	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
Q9ULG1	562	594	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
Q9ULG1	562	594	530	701	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00541
Q9ULG1	562	594	530	701	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00541
Q9ULG1	562	594	521	1556	Region	Note=Assembles INO80 complex module consisting of conserved components INO80B%2C INO80C%2C ACTR5%2C RVBL1%2C RVBL2;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910
Q9ULG1	562	594	521	1556	Region	Note=Assembles INO80 complex module consisting of conserved components INO80B%2C INO80C%2C ACTR5%2C RVBL1%2C RVBL2;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910
Q9ULG1	594	614	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
Q9ULG1	594	614	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
Q9ULG1	594	614	530	701	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00541
Q9ULG1	594	614	530	701	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00541
Q9ULG1	594	614	521	1556	Region	Note=Assembles INO80 complex module consisting of conserved components INO80B%2C INO80C%2C ACTR5%2C RVBL1%2C RVBL2;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910
Q9ULG1	594	614	521	1556	Region	Note=Assembles INO80 complex module consisting of conserved components INO80B%2C INO80C%2C ACTR5%2C RVBL1%2C RVBL2;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910
Q9ULG1	969	1016	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
Q9ULG1	969	1016	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
Q9ULG1	969	1016	521	1556	Region	Note=Assembles INO80 complex module consisting of conserved components INO80B%2C INO80C%2C ACTR5%2C RVBL1%2C RVBL2;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910
Q9ULG1	969	1016	521	1556	Region	Note=Assembles INO80 complex module consisting of conserved components INO80B%2C INO80C%2C ACTR5%2C RVBL1%2C RVBL2;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21303910;Dbxref=PMID:21303910

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SNVs in the skipped exons for INO80

- Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.

- Differential PSIs between mutated versus non-mutated samples.

INO80_STAD_exon_skip_126182_psi_boxplot.png
boxplot

- Non-synonymous mutations located in the skipped exons in TCGA.

Cancer type	Sample	ESID	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
LIHC	TCGA-DD-A39Y-01	exon_skip_126164 exon_skip_126161	41313098	41313323	41313239	41313239	Frame_Shift_Del	C	-	p.A1046fs
LIHC	TCGA-DD-A3A0-01	exon_skip_126168	41319794	41319934	41319813	41319813	Frame_Shift_Del	A	-	p.L1010fs
LIHC	TCGA-G3-A3CJ-01	exon_skip_126183	41371899	41372102	41372021	41372021	Frame_Shift_Del	G	-	p.R338fs
LIHC	TCGA-DD-A39Y-01	exon_skip_126183	41371899	41372102	41372054	41372054	Frame_Shift_Del	G	-	p.Q326fs
LIHC	TCGA-DD-A3A0-01	exon_skip_126187	41387799	41387866	41387816	41387816	Frame_Shift_Del	T	-	p.S122fs
LIHC	TCGA-DD-A1EG-01	exon_skip_126187	41387799	41387866	41387842	41387842	Frame_Shift_Del	A	-	p.L113fs
PRAD	TCGA-G9-6499-01	exon_skip_126168	41319794	41319934	41319812	41319813	Frame_Shift_Ins	-	A	p.L1010fs
UCEC	TCGA-BS-A0UL-01	exon_skip_126176	41350837	41350979	41350942	41350943	Frame_Shift_Ins	-	C	p.V627fs
CHOL	TCGA-W6-AA0S-01	exon_skip_126157	41297791	41297885	41297827	41297827	Nonsense_Mutation	G	T	p.S1154X
HNSC	TCGA-QK-A8Z9-01	exon_skip_126164 exon_skip_126161	41313098	41313323	41313173	41313173	Nonsense_Mutation	G	A	p.Q1067*
ACC	TCGA-OR-A5JB-01	exon_skip_126164 exon_skip_126161	41313098	41313323	41313297	41313297	Nonsense_Mutation	G	C	p.Y1025*
UCEC	TCGA-BG-A187-01	exon_skip_126168	41319794	41319934	41319796	41319796	Nonsense_Mutation	G	A	p.R1016*
BLCA	TCGA-BT-A42F-01	exon_skip_126168	41319794	41319934	41319874	41319874	Nonsense_Mutation	G	A	p.Q990*
SKCM	TCGA-EE-A2GR-06	exon_skip_126172	41348820	41348904	41348837	41348837	Nonsense_Mutation	G	A	p.Q685*
SKCM	TCGA-EE-A2GR-06	exon_skip_126172	41348820	41348904	41348837	41348837	Nonsense_Mutation	G	A	p.Q685X
HNSC	TCGA-CV-6942-01	exon_skip_126176	41350837	41350979	41350928	41350928	Nonsense_Mutation	G	A	p.Q632*
COAD	TCGA-D5-5537-01	exon_skip_126180	41361768	41361863	41361849	41361849	Nonsense_Mutation	C	T	p.W567X
STAD	TCGA-HF-7132-01	exon_skip_126182	41364047	41364256	41364223	41364223	Nonsense_Mutation	G	A	p.R477*
STAD	TCGA-HF-7132-01	exon_skip_126182	41364047	41364256	41364223	41364223	Nonsense_Mutation	G	A	p.R477X
LGG	TCGA-DU-6392-01	exon_skip_126183	41371899	41372102	41372072	41372072	Nonsense_Mutation	G	A	p.R320*
BLCA	TCGA-CU-A0YO-01	exon_skip_126183	41371899	41372102	41372084	41372084	Nonsense_Mutation	T	A	p.K316*

- Depth of coverage in the three exons composing exon skipping event

Depth of coverage in three exons	Mutation description
	Sample: TCGA-HF-7132-01
	Cancer type: STAD
	ESID: exon_skip_126182
	Skipped exon start: 41364047
	Skipped exon end: 41364256
	Mutation start: 41364223
	Mutation end: 41364223
	Mutation type: Nonsense_Mutation
	Reference seq: G
	Mutation seq: A
	AAchange: p.R477X
	Sample: TCGA-HF-7132-01
	Cancer type: STAD
	ESID: exon_skip_126182
	Skipped exon start: 41364047
	Skipped exon end: 41364256
	Mutation start: 41364223
	Mutation end: 41364223
	Mutation type: Nonsense_Mutation
	Reference seq: G
	Mutation seq: A
	AAchange: p.R477*
exon_skip_106588_STAD_TCGA-HF-7132-01.png
exon_skip_109033_STAD_TCGA-HF-7132-01.png
exon_skip_10918_STAD_TCGA-HF-7132-01.png
exon_skip_126182_STAD_TCGA-HF-7132-01.png
exon_skip_298309_STAD_TCGA-HF-7132-01.png
exon_skip_307491_STAD_TCGA-HF-7132-01.png
exon_skip_463061_STAD_TCGA-HF-7132-01.png
exon_skip_469364_STAD_TCGA-HF-7132-01.png
exon_skip_498070_STAD_TCGA-HF-7132-01.png
exon_skip_498077_STAD_TCGA-HF-7132-01.png
exon_skip_503611_STAD_TCGA-HF-7132-01.png
exon_skip_7033_STAD_TCGA-HF-7132-01.png
exon_skip_77155_STAD_TCGA-HF-7132-01.png

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	41297791	41297885	41297814	41297815	Frame_Shift_Ins	-	TC	p.D1158fs
HEC251_ENDOMETRIUM	41297791	41297885	41297801	41297801	Missense_Mutation	A	C	p.F1163V
KM12_LARGE_INTESTINE	41297791	41297885	41297807	41297807	Missense_Mutation	C	T	p.A1161T
SNU1040_LARGE_INTESTINE	41297791	41297885	41297827	41297827	Missense_Mutation	G	A	p.S1154L
NCIH596_LUNG	41297791	41297885	41297846	41297846	Missense_Mutation	C	G	p.D1148H
HCT15_LARGE_INTESTINE	41297791	41297885	41297864	41297864	Missense_Mutation	G	A	p.H1142Y
L33_PANCREAS	41297791	41297885	41297879	41297879	Missense_Mutation	T	C	p.M1137V
LOXIMVI_SKIN	41313098	41313323	41313209	41313209	Missense_Mutation	G	A	p.P1055S
SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	41313098	41313323	41313268	41313268	Missense_Mutation	C	A	p.R1035M
TE6_OESOPHAGUS	41319794	41319934	41319816	41319816	Missense_Mutation	A	G	p.F1009S
SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	41319794	41319934	41319843	41319843	Missense_Mutation	C	T	p.R1000H
KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	41319794	41319934	41319847	41319847	Missense_Mutation	G	A	p.R999C
BICR18_UPPER_AERODIGESTIVE_TRACT	41319794	41319934	41319884	41319884	Missense_Mutation	C	A	p.Q986H
SARC9371_BONE	41350837	41350979	41350897	41350897	Missense_Mutation	T	G	p.Q642P
ZR7530_BREAST	41352065	41352124	41352071	41352071	Missense_Mutation	C	G	p.W612C
L428_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	41364047	41364256	41364057	41364057	Missense_Mutation	A	G	p.L532P
L428_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	41364047	41364256	41364096	41364096	Missense_Mutation	T	C	p.K519R
L428_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	41364047	41364256	41364196	41364196	Missense_Mutation	T	C	p.K486E
UMUC6_URINARY_TRACT	41364047	41364256	41364241	41364241	Missense_Mutation	C	T	p.E471K
MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	41371899	41372102	41372017	41372017	Missense_Mutation	C	T	p.R338H
HT1376_URINARY_TRACT	41371899	41372102	41372018	41372018	Missense_Mutation	G	A	p.R338C
SNU175_LARGE_INTESTINE	41371899	41372102	41372021	41372021	Missense_Mutation	G	A	p.R337C
SCC4_UPPER_AERODIGESTIVE_TRACT	41371899	41372102	41372023	41372023	Missense_Mutation	G	T	p.A336D
LOVO_LARGE_INTESTINE	41371899	41372102	41372068	41372068	Missense_Mutation	G	A	p.A321V
DU4475_BREAST	41371899	41372102	41372074	41372074	Missense_Mutation	C	T	p.R319H
NCIH1048_LUNG	41371899	41372102	41372075	41372075	Missense_Mutation	G	A	p.R319C
HCC2998_LARGE_INTESTINE	41373218	41373271	41373258	41373258	Missense_Mutation	T	G	p.K296T
SCMCRM2_SOFT_TISSUE	41379760	41379880	41379814	41379814	Missense_Mutation	G	A	p.R202W
MDAPCA2B_PROSTATE	41379760	41379880	41379814	41379814	Missense_Mutation	G	A	p.R202W
MELJUSO_SKIN	41379760	41379880	41379843	41379843	Missense_Mutation	G	A	p.S192F
SNGM_ENDOMETRIUM	41379760	41379880	41379858	41379858	Missense_Mutation	C	G	p.S187T
HEC251_ENDOMETRIUM	41387799	41387866	41387832	41387832	Missense_Mutation	G	T	p.F116L
2313287_STOMACH	41297791	41297885	41297819	41297819	Nonsense_Mutation	G	A	p.R1157*
RCHACV_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	41313098	41313323	41313179	41313179	Nonsense_Mutation	G	A	p.R1065*
HCC2998_LARGE_INTESTINE	41364047	41364256	41364249	41364249	Nonsense_Mutation	G	T	p.S468*
MFE319_ENDOMETRIUM	41371899	41372102	41371900	41371900	Splice_Site	T	C	p.E377G

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for INO80

sQTL information located at the skipped exons.

Exon skip ID

Chromosome

Three exons

Skippped exon

ENST

Cancer type

SNP id

Location

DNA change (ref/var)

P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for INO80

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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for INO80

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RelatedDrugs for INO80

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for INO80

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in TCGA
	Exon skipping events with PSIs in GTEx
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	SNVs in the skipped exons with depth of coverage
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Splicing Quantitative Trait Methylation (sQTM) in the skipped exon
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for INO80

Exon skipping events across known transcript of Ensembl for INO80 from UCSC genome browser

Gene isoform structures and expression levels for INO80

Exon skipping events with PSIs in TCGA for INO80

Exon skipping events with PSIs in GTEx for INO80

Open reading frame (ORF) annotation in the exon skipping event for INO80

Infer the effects of exon skipping event on protein functional features for INO80

SNVs in the skipped exons for INO80

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for INO80

Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for INO80

Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for INO80

RelatedDrugs for INO80

RelatedDiseases for INO80