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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ING3 |
 Gene summary |
| Gene information | Gene symbol | ING3 | Gene ID | 54556 |
| Gene name | inhibitor of growth family member 3 | |
| Synonyms | Eaf4|ING2|MEAF4|p47ING3 | |
| Cytomap | 7q31.31 | |
| Type of gene | protein-coding | |
| Description | inhibitor of growth protein 3 | |
| Modification date | 20180519 | |
| UniProtAcc | Q9NXR8 | |
| Context | PubMed: ING3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ING3 | GO:0043065 | positive regulation of apoptotic process | 16387653 |
| ING3 | GO:0043967 | histone H4 acetylation | 14966270|16387653 |
| ING3 | GO:0043968 | histone H2A acetylation | 14966270|16387653 |
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Exon skipping events across known transcript of Ensembl for ING3 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ING3 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ING3 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_470846 | 7 | 120590848:120590978:120591217:120591289:120593357:120593458 | 120591217:120591289 | ENSG00000071243.11 | ENST00000339121.5,ENST00000427726.1,ENST00000445699.1 |
| exon_skip_470847 | 7 | 120595612:120595678:120604795:120604892:120606679:120606751 | 120604795:120604892 | ENSG00000071243.11 | ENST00000315870.5,ENST00000431467.1 |
| exon_skip_470849 | 7 | 120595612:120595678:120606679:120606751:120607582:120607702 | 120606679:120606751 | ENSG00000071243.11 | ENST00000427726.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ING3 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_470846 | 7 | 120590848:120590978:120591217:120591289:120593357:120593458 | 120591217:120591289 | ENSG00000071243.11 | ENST00000339121.5,ENST00000427726.1,ENST00000445699.1 |
| exon_skip_470847 | 7 | 120595612:120595678:120604795:120604892:120606679:120606751 | 120604795:120604892 | ENSG00000071243.11 | ENST00000315870.5,ENST00000431467.1 |
| exon_skip_470849 | 7 | 120595612:120595678:120606679:120606751:120607582:120607702 | 120606679:120606751 | ENSG00000071243.11 | ENST00000427726.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ING3 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000315870 | 120604795 | 120604892 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000315870 | 120604795 | 120604892 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for ING3 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for ING3 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| STAD | TCGA-VQ-A8P2-01 | exon_skip_470847 | 120604796 | 120604892 | 120604802 | 120604802 | Nonsense_Mutation | C | T | p.R92* |
| STAD | TCGA-VQ-A8P2-01 | exon_skip_470847 | 120604796 | 120604892 | 120604802 | 120604802 | Nonsense_Mutation | C | T | p.R92X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-VQ-A8P2-01 |
| Cancer type: STAD | |
| ESID: exon_skip_470847 | |
| Skipped exon start: 120604796 | |
| Skipped exon end: 120604892 | |
| Mutation start: 120604802 | |
| Mutation end: 120604802 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: C | |
| Mutation seq: T | |
| AAchange: p.R92X | |
| Sample: TCGA-VQ-A8P2-01 |
| Cancer type: STAD | |
| ESID: exon_skip_470847 | |
| Skipped exon start: 120604796 | |
| Skipped exon end: 120604892 | |
| Mutation start: 120604802 | |
| Mutation end: 120604802 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: C | |
| Mutation seq: T | |
| AAchange: p.R92* | |
exon_skip_102588_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_122541_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_128780_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_143382_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_143383_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_148114_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_287192_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_291811_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_320689_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_320690_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_328488_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_356820_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_356824_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_375393_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_381459_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_3837_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_387613_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_431990_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_440277_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_443275_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_448545_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_470847_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_481483_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_5195_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_5826_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_74538_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_91142_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_91143_STAD_TCGA-VQ-A8P2-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HEC108_ENDOMETRIUM | 120604796 | 120604892 | 120604841 | 120604841 | Frame_Shift_Del | A | - | p.K105fs |
| IGR37_SKIN | 120591218 | 120591289 | 120591226 | 120591226 | Missense_Mutation | C | A | p.Q13K |
| OE33_OESOPHAGUS | 120591218 | 120591289 | 120591251 | 120591251 | Missense_Mutation | G | C | p.R21P |
| GP5D_LARGE_INTESTINE | 120604796 | 120604892 | 120604799 | 120604799 | Missense_Mutation | G | A | p.D91N |
| HH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 120606680 | 120606751 | 120606698 | 120606698 | Missense_Mutation | C | T | p.T128I |
| NCIH2342_LUNG | 120591218 | 120591289 | 120591259 | 120591259 | Nonsense_Mutation | G | T | p.E24* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ING3 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ING3 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ING3 |
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RelatedDrugs for ING3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ING3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| ING3 | C1168401 | Squamous cell carcinoma of the head and neck | 1 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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